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Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Structural & Molecular Biology 16, 909 (2009). doi:10.1038/nsmb0909-909 (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 22, 2009 Category: Molecular Biology Tags: Research Highlights Source Type: journals

Dangerous play—splitting the message may leave you empty handedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dangerous play—splitting the message may leave you empty handed Nature Structural & Molecular Biology 16, 907 (2009). doi:10.1038/nsmb0909-907 Authors: Yvonne Klaue & Klemens J Hertel An important aspect of eukaryotic gene expression is the efficient integration of transcription, pre-mRNA processing and nuclear export. A new study demonstrates that pre-mRNA transcript continuity is an essential component for maintaining productive coupling of transcription and RNA processing events. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 22, 2009 Category: Molecular Biology Authors: Yvonne KlaueKlemens J Hertel Tags: News and Views Source Type: journals

New functions for an ancient domainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Structural & Molecular Biology 16, 904 (2009). doi:10.1038/nsmb0909-904 Author: W Lee Kraus Macrodomains function as binding modules for metabolites of NAD+, including poly(ADP-ribose). Three new studies explore how binding of poly(ADP-ribose) by the macrodomains of histone variant macroH2A1.1 and the ATP-dependent chromatin-remodeling protein ALC1 (also called CHD1L) leads to the modulation of chromatin structure, regulating nuclear functions such as DNA-damage detection and repair. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 22, 2009 Category: Molecular Biology Authors: W Lee Kraus Tags: News and Views Source Type: journals

When chromatin meets splicingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J Blencowe Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 22, 2009 Category: Molecular Biology Authors: Alberto R KornblihttIgnacio E SchorMariano AlloBenjamin J Blencowe Tags: News and Views Source Type: journals

The p53 transcriptional synapse: activation on demandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
eppert The adequate and on-time response of cellular transcription to internal needs and external stimuli is a delicate task. Is the transcriptional regulator p53 on call to permit rapid activation of its target genes? A new study reports interplay of p53 with a previously unidentified regulator, calcineurin-binding protein 1 (Cabin1), and provides evidence for such a mechanism. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 22, 2009 Category: Molecular Biology Authors: Genrich V TolstonogWolfgang Deppert Tags: News and Views Source Type: journals

The unsung reviewerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Structural & Molecular Biology 16, 899 (2009). doi:10.1038/nsmb0909-899 Manuscript peer reviewing is at the heart of the scientific system, but it seems that these duties are often not properly (if at all) recognized by universities, funding agencies or even the rest of the scientific community. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 22, 2009 Category: Molecular Biology Tags: Editorial Source Type: journals

Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Structural & Molecular Biology 16, 909 (2009). doi:10.1038/nsmb0909-909 (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 3, 2009 Category: Molecular Biology Tags: Research Highlights Source Type: journals

Dangerous play—splitting the message may leave you empty handedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dangerous play—splitting the message may leave you empty handed Nature Structural & Molecular Biology 16, 907 (2009). doi:10.1038/nsmb0909-907 Authors: Yvonne Klaue & Klemens J Hertel An important aspect of eukaryotic gene expression is the efficient integration of transcription, pre-mRNA processing and nuclear export. A new study demonstrates that pre-mRNA transcript continuity is an essential component for maintaining productive coupling of transcription and RNA processing events. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 3, 2009 Category: Molecular Biology Authors: Yvonne KlaueKlemens J Hertel Tags: News and Views Source Type: journals

New functions for an ancient domainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Structural & Molecular Biology 16, 904 (2009). doi:10.1038/nsmb0909-904 Author: W Lee Kraus Macrodomains function as binding modules for metabolites of NAD+, including poly(ADP-ribose). Three new studies explore how binding of poly(ADP-ribose) by the macrodomains of histone variant macroH2A1.1 and the ATP-dependent chromatin-remodeling protein ALC1 (also called CHD1L) leads to the modulation of chromatin structure, regulating nuclear functions such as DNA-damage detection and repair. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 3, 2009 Category: Molecular Biology Authors: W Lee Kraus Tags: News and Views Source Type: journals

When chromatin meets splicingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J Blencowe Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 3, 2009 Category: Molecular Biology Authors: Alberto R KornblihttIgnacio E SchorMariano AlloBenjamin J Blencowe Tags: News and Views Source Type: journals

The p53 transcriptional synapse: activation on demandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
eppert The adequate and on-time response of cellular transcription to internal needs and external stimuli is a delicate task. Is the transcriptional regulator p53 on call to permit rapid activation of its target genes? A new study reports interplay of p53 with a previously unidentified regulator, calcineurin-binding protein 1 (Cabin1), and provides evidence for such a mechanism. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 3, 2009 Category: Molecular Biology Authors: Genrich V TolstonogWolfgang Deppert Tags: News and Views Source Type: journals

The unsung reviewerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Structural & Molecular Biology 16, 899 (2009). doi:10.1038/nsmb0909-899 Manuscript peer reviewing is at the heart of the scientific system, but it seems that these duties are often not properly (if at all) recognized by universities, funding agencies or even the rest of the scientific community. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - September 3, 2009 Category: Molecular Biology Tags: Editorial Source Type: journals

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ Nature Structural & Molecular Biology 16, 979 (2009). doi:10.1038/nsmb.1663 Authors: Michael K Swan, Robert E Johnson, Louise Prakash, Satya Prakash & Aneel K Aggarwal (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 29, 2009 Category: Molecular Biology Authors: Michael K SwanRobert E JohnsonLouise PrakashSatya PrakashAneel K Aggarwal Tags: Article Source Type: journals

Template strand scrunching during DNA gap repair synthesis by human polymerase λEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Template strand scrunching during DNA gap repair synthesis by human polymerase λ Nature Structural & Molecular Biology 16, 967 (2009). doi:10.1038/nsmb.1654 Authors: Miguel Garcia-Diaz, Katarzyna Bebenek, Andres A Larrea, Jody M Havener, Lalith Perera, Joseph M Krahn, Lars C Pedersen, Dale A Ramsden & Thomas A Kunkel (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 22, 2009 Category: Molecular Biology Authors: Miguel Garcia-DiazKatarzyna BebenekAndres A LarreaJody M HavenerLalith PereraJoseph M KrahnLars C PedersenDale A RamsdenThomas A Kunkel Tags: Article Source Type: journals

Dynamics and function of compact nucleosome arraysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
than Widom (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 22, 2009 Category: Molecular Biology Authors: Michael G PoirierEugene OhHannah S TimsJonathan Widom Tags: Article Source Type: journals

Fast ribozyme cleavage releases transcripts from RNA polymerase II and aborts co-transcriptional pre-mRNA processingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
id L Bentley (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 22, 2009 Category: Molecular Biology Authors: Nova FongMarie ÖhmanDavid L Bentley Tags: Article Source Type: journals

Nucleosome positioning as a determinant of exon recognitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Roderic Guigó (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 15, 2009 Category: Molecular Biology Authors: Hagen TilgnerChristoforos NikolaouSonja AlthammerMichael SammethMiguel BeatoJuan ValcárcelRoderic Guigó Tags: Analysis Source Type: journals

Chromatin organization marks exon-intron structureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gil Ast (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 15, 2009 Category: Molecular Biology Authors: Schraga SchwartzEran MeshorerGil Ast Tags: Analysis Source Type: journals

Molecular mechanisms for protein-encoded inheritanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& David Eisenberg (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 15, 2009 Category: Molecular Biology Authors: Jed J W WiltziusMeytal LandauRebecca NelsonMichael R SawayaMarcin I ApostolLukasz GoldschmidtAngela B SoriagaDuilio CascioKanagalaghatta RajashankarDavid Eisenberg Tags: Article Source Type: journals

Structural determinants of miRNAs for RISC loading and slicer-independent unwindingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ihide Tomari (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 15, 2009 Category: Molecular Biology Authors: Tomoko KawamataHervé SeitzYukihide Tomari Tags: Article Source Type: journals

A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
stopher D Lima (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 15, 2009 Category: Molecular Biology Authors: Firaz MohideenAllan D CapiliParizad M BilimoriaTomoko YamadaAzad BonniChristopher D Lima Tags: Article Source Type: journals

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
r & Andreas G Ladurner (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 12, 2009 Category: Molecular Biology Authors: Gyula TiminszkySusanne TillPaul O HassaMichael HothornGeorg KustatscherBianca NijmeijerJulien ColombelliMatthias AltmeyerErnst H K StelzerKlaus ScheffzekMichael O HottigerAndreas G Ladurner Tags: Article Source Type: journals

Insights into anaphase promoting complex TPR subdomain assembly from a CDC26–APC6 structureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insights into anaphase promoting complex TPR subdomain assembly from a CDC26–APC6 structure Nature Structural & Molecular Biology 16, 987 (2009). doi:10.1038/nsmb.1645 Authors: Jing Wang, Billy T Dye, Kanagalaghatta R Rajashankar, Igor Kurinov & Brenda A Schulman The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Not...
Source: Nature Structural and Molecular Biology - August 8, 2009 Category: Molecular Biology Authors: Jing WangBilly T DyeKanagalaghatta R RajashankarIgor KurinovBrenda A Schulman Tags: Brief Communication Source Type: journals

Existence of a microRNA pathway in anucleate plateletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
atrick Provost (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 8, 2009 Category: Molecular Biology Authors: Patricia LandryIsabelle PlanteDominique L OuelletMarjorie P PerronGuy RousseauPatrick Provost Tags: Article Source Type: journals

The molecular basis for the regulation of the cap-binding complex by the importinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
rd A Cerione (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 8, 2009 Category: Molecular Biology Authors: Sandra M G DiasKristin F WilsonKatherine S RojasAndre L B AmbrosioRichard A Cerione Tags: Article Source Type: journals

Cabin1 restrains p53 activity on chromatinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
g-Duk Youn (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 8, 2009 Category: Molecular Biology Authors: Hyonchol JangSoo-Youn ChoiEun-Jung ChoHong-Duk Youn Tags: Article Source Type: journals

Erratum: The nucleotide binding dynamics of human MSH2–MSH3 are lesion dependentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Erratum: The nucleotide binding dynamics of human MSH2–MSH3 are lesion dependent Nature Structural & Molecular Biology 16, 897 (2009). doi:10.1038/nsmb0809-897a Author: Barbara A L Owen, Walter H Lang & Cynthia T McMurray (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 5, 2009 Category: Molecular Biology Authors: Barbara A L OwenWalter H LangCynthia T McMurray Tags: Erratum Source Type: journals

Corrigendum: Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughoutEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Structural & Molecular Biology 16, 897 (2009). doi:10.1038/nsmb0809-897b Author: Julie L Hodgkinson, Ashley Horsley, David Stabat, Martha Simon, Steven Johnson, Paula C A da Fonseca, Edward P Morris, Joseph S Wall, Susan M Lea & Ariel J Blocker (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 5, 2009 Category: Molecular Biology Authors: Julie L HodgkinsonAshley HorsleyDavid StabatMartha SimonSteven JohnsonPaula C A da FonsecaEdward P MorrisJoseph S WallSusan M LeaAriel J Blocker Tags: Corrigendum Source Type: journals

Research highlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Structural & Molecular Biology 16, 807 (2009). doi:10.1038/nsmb0809-807 (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 5, 2009 Category: Molecular Biology Tags: Research Highlights Source Type: journals

Kill the messenger: bacterial antisense RNA promotes mRNA decayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Structural & Molecular Biology 16, 804 (2009). doi:10.1038/nsmb0809-804 Author: E Gerhart H Wagner Bacterial antisense RNAs target translation initiation regions (TIRs) to compete with ribosome binding, thus repressing translation and—secondarily—causing degradation of the naked mRNA. A new study reports on an antisense RNA that directly accelerates mRNA decay by targeting a sequence deep within the coding region, far downstream of the TIR. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 5, 2009 Category: Molecular Biology Authors: E Gerhart H Wagner Tags: News and Views Source Type: journals

Grb-ing hold of insulin signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
icheri It is just as important to shut off a signaling pathway as it is to turn it on. A new study on the tandem Ras-associating (RA) and pleckstrin-homology (PH) domains of Grb10 and Grb14 provides important insight into a multicomponent assembly for downregulating insulin receptor signaling. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 5, 2009 Category: Molecular Biology Authors: Derek F J CeccarelliFrank Sicheri Tags: News and Views Source Type: journals

Hit and run: X marks the spot!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
orkman Male fruitflies upregulate transcription of nearly all genes on their single X chromosome to equalize expression with the two X chromosomes in females. A new study shows that the distribution of the histone acetylation mark associated with this upregulation is much broader than that of the MSL complex responsible for depositing this mark. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 5, 2009 Category: Molecular Biology Authors: Vikki M WeakeJerry L Workman Tags: News and Views Source Type: journals

Mre11: roles in DNA repair beyond homologous recombinationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ck W Alt The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now, several new studies reveal that Mre11 also has a role in mammalian DNA double-strand break repair by nonhomologous end joining. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 5, 2009 Category: Molecular Biology Authors: Shan ZhaCristian BoboilaFrederick W Alt Tags: News and Views Source Type: journals

A different perspective on scienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Structural & Molecular Biology 16, 797 (2009). doi:10.1038/nsmb0809-797 A recent survey revealed striking differences between the public and scientists' views of US scientific achievement and its societal benefits. This reinforces the fact that more must be done to effectively communicate with, educate and engage the public. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 5, 2009 Category: Molecular Biology Tags: Editorial Source Type: journals

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hubbard (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 1, 2009 Category: Molecular Biology Authors: Rafael S DepetrisJinhua WuStevan R Hubbard Tags: Article Source Type: journals

Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
tzi I Kuroda (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - August 1, 2009 Category: Molecular Biology Authors: Marnie E GelbartErica LarschanShouyong PengPeter J ParkMitzi I Kuroda Tags: Article Source Type: journals