Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research

Albumin-to-D-dimer ratios: A novel prognostic factor for evaluating first-line chemotherapy efficacy in advanced lung adenocarcinoma patients
Neoplasma. 2024 Feb;71(1):77-87. doi: 10.4149/neo_2024_230413N205.ABSTRACTThe prognosis of advanced lung adenocarcinoma (LUAD) remains unfavorable, with chemotherapy constituting a primary treatment modality. Discerning the efficacy of chemotherapy for advanced LUAD is imperative. Prior investigations have demonstrated the prognostic value of albumin and D-dimer individually for malignancies; however, the predictive capacity of albumin-to-D-dimer ratios (ADR) for advanced LUAD subjected to first-line platinum-based chemotherapy remains unexplored. A cohort of 313 patients with advanced LUAD was retrospectively examined in ...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Liqun Zhang Xing Li Zhuo Wang Zhiyan Zhang Lei Zhang Zhaoyang Liu Lisha Zhang Shuowen Wang Tatiana Vitalevna Khorobrykh Mingze He Jiawen Xiao Source Type: research

Three years follow-up of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer
Neoplasma. 2024 Feb;71(1):88-97. doi: 10.4149/neo_2024_230517N262.ABSTRACTNeoadjuvant chemoimmunotherapy plays a crucial role in resectable non-small cell lung cancer (NSCLC). Neoadjuvant chemotherapy before sleeve lobectomy was safe and feasible, but the impact of neoadjuvant chemoimmunotherapy before sleeve lobectomy was unclear. In our retrospective study, patients diagnosed as stage IIB to IIIB resectable NSCLC between December 1, 2018 and December 1, 2020 in the Department of Thoracic Surgery, Zhejiang Cancer Hospital were collected. We analyzed the efficacy and safety of neoadjuvant chemoimmunotherapy for resectable ...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Wenhao Ji Youhua Jiang Yuetong Li Weimin Mao Lisong Teng Source Type: research

The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway
This study investigates the molecular mechanism of HMGA2-mediated regulation of IGFBP2 expression in the PI3K/AKT/VEGFA signaling pathway, which is involved in angiogenesis and LUAD metastasis. Target genes with prognostic implications for LUAD patients were selected using bioinformatics, and previously published literature was referenced to predict the molecular regulatory mechanisms. A549 cells were used for in vitro validation. Cell proliferation and viability were assessed using CCK-8 and EdU assays, while cell migration ability was evaluated using Transwell and wound healing assays. Changes in angiogenesis were examin...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Shuai Qian Fengping Wang Wenliang Liao Jun Liu Source Type: research

microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2
Neoplasma. 2024 Feb;71(1):60-69. doi: 10.4149/neo_2024_230915N489.ABSTRACTIn various malignant tumors (including bladder cancer) poor prognosis is associated with hypoxia and therapeutic resistance. Evidence indicates that in bladder cancer, microRNAs (miRNAs) have vital functions in acquired drug resistance. However, the involvement of miRNAs in hypoxia-mediated bladder cancer doxorubicin (Dox) resistance is unknown. Herein, we showed that hypoxia and Dox treatment downregulated miR-15a-5p expression. Using UM-UC-3 and J82 bladder cancer cell lines and in vivo mouse models of bladder cancer, we confirmed that miR-15a-5p a...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Jinsong Yang Haoyi Xiang Mengjing Cheng Xue Jiang Ying Chen Lingyan Zheng Senxiang Yan Shufen Zhang Cheng Zhang Wei Chen Dajin Chen Source Type: research

Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research

Albumin-to-D-dimer ratios: A novel prognostic factor for evaluating first-line chemotherapy efficacy in advanced lung adenocarcinoma patients
Neoplasma. 2024 Feb;71(1):77-87. doi: 10.4149/neo_2024_230413N205.ABSTRACTThe prognosis of advanced lung adenocarcinoma (LUAD) remains unfavorable, with chemotherapy constituting a primary treatment modality. Discerning the efficacy of chemotherapy for advanced LUAD is imperative. Prior investigations have demonstrated the prognostic value of albumin and D-dimer individually for malignancies; however, the predictive capacity of albumin-to-D-dimer ratios (ADR) for advanced LUAD subjected to first-line platinum-based chemotherapy remains unexplored. A cohort of 313 patients with advanced LUAD was retrospectively examined in ...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Liqun Zhang Xing Li Zhuo Wang Zhiyan Zhang Lei Zhang Zhaoyang Liu Lisha Zhang Shuowen Wang Tatiana Vitalevna Khorobrykh Mingze He Jiawen Xiao Source Type: research

Three years follow-up of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer
Neoplasma. 2024 Feb;71(1):88-97. doi: 10.4149/neo_2024_230517N262.ABSTRACTNeoadjuvant chemoimmunotherapy plays a crucial role in resectable non-small cell lung cancer (NSCLC). Neoadjuvant chemotherapy before sleeve lobectomy was safe and feasible, but the impact of neoadjuvant chemoimmunotherapy before sleeve lobectomy was unclear. In our retrospective study, patients diagnosed as stage IIB to IIIB resectable NSCLC between December 1, 2018 and December 1, 2020 in the Department of Thoracic Surgery, Zhejiang Cancer Hospital were collected. We analyzed the efficacy and safety of neoadjuvant chemoimmunotherapy for resectable ...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Wenhao Ji Youhua Jiang Yuetong Li Weimin Mao Lisong Teng Source Type: research

The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway
This study investigates the molecular mechanism of HMGA2-mediated regulation of IGFBP2 expression in the PI3K/AKT/VEGFA signaling pathway, which is involved in angiogenesis and LUAD metastasis. Target genes with prognostic implications for LUAD patients were selected using bioinformatics, and previously published literature was referenced to predict the molecular regulatory mechanisms. A549 cells were used for in vitro validation. Cell proliferation and viability were assessed using CCK-8 and EdU assays, while cell migration ability was evaluated using Transwell and wound healing assays. Changes in angiogenesis were examin...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Shuai Qian Fengping Wang Wenliang Liao Jun Liu Source Type: research

microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2
Neoplasma. 2024 Feb;71(1):60-69. doi: 10.4149/neo_2024_230915N489.ABSTRACTIn various malignant tumors (including bladder cancer) poor prognosis is associated with hypoxia and therapeutic resistance. Evidence indicates that in bladder cancer, microRNAs (miRNAs) have vital functions in acquired drug resistance. However, the involvement of miRNAs in hypoxia-mediated bladder cancer doxorubicin (Dox) resistance is unknown. Herein, we showed that hypoxia and Dox treatment downregulated miR-15a-5p expression. Using UM-UC-3 and J82 bladder cancer cell lines and in vivo mouse models of bladder cancer, we confirmed that miR-15a-5p a...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Jinsong Yang Haoyi Xiang Mengjing Cheng Xue Jiang Ying Chen Lingyan Zheng Senxiang Yan Shufen Zhang Cheng Zhang Wei Chen Dajin Chen Source Type: research

Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research

Albumin-to-D-dimer ratios: A novel prognostic factor for evaluating first-line chemotherapy efficacy in advanced lung adenocarcinoma patients
Neoplasma. 2024 Feb;71(1):77-87. doi: 10.4149/neo_2024_230413N205.ABSTRACTThe prognosis of advanced lung adenocarcinoma (LUAD) remains unfavorable, with chemotherapy constituting a primary treatment modality. Discerning the efficacy of chemotherapy for advanced LUAD is imperative. Prior investigations have demonstrated the prognostic value of albumin and D-dimer individually for malignancies; however, the predictive capacity of albumin-to-D-dimer ratios (ADR) for advanced LUAD subjected to first-line platinum-based chemotherapy remains unexplored. A cohort of 313 patients with advanced LUAD was retrospectively examined in ...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Liqun Zhang Xing Li Zhuo Wang Zhiyan Zhang Lei Zhang Zhaoyang Liu Lisha Zhang Shuowen Wang Tatiana Vitalevna Khorobrykh Mingze He Jiawen Xiao Source Type: research

Three years follow-up of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer
Neoplasma. 2024 Feb;71(1):88-97. doi: 10.4149/neo_2024_230517N262.ABSTRACTNeoadjuvant chemoimmunotherapy plays a crucial role in resectable non-small cell lung cancer (NSCLC). Neoadjuvant chemotherapy before sleeve lobectomy was safe and feasible, but the impact of neoadjuvant chemoimmunotherapy before sleeve lobectomy was unclear. In our retrospective study, patients diagnosed as stage IIB to IIIB resectable NSCLC between December 1, 2018 and December 1, 2020 in the Department of Thoracic Surgery, Zhejiang Cancer Hospital were collected. We analyzed the efficacy and safety of neoadjuvant chemoimmunotherapy for resectable ...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Wenhao Ji Youhua Jiang Yuetong Li Weimin Mao Lisong Teng Source Type: research

The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway
This study investigates the molecular mechanism of HMGA2-mediated regulation of IGFBP2 expression in the PI3K/AKT/VEGFA signaling pathway, which is involved in angiogenesis and LUAD metastasis. Target genes with prognostic implications for LUAD patients were selected using bioinformatics, and previously published literature was referenced to predict the molecular regulatory mechanisms. A549 cells were used for in vitro validation. Cell proliferation and viability were assessed using CCK-8 and EdU assays, while cell migration ability was evaluated using Transwell and wound healing assays. Changes in angiogenesis were examin...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Shuai Qian Fengping Wang Wenliang Liao Jun Liu Source Type: research

microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2
Neoplasma. 2024 Feb;71(1):60-69. doi: 10.4149/neo_2024_230915N489.ABSTRACTIn various malignant tumors (including bladder cancer) poor prognosis is associated with hypoxia and therapeutic resistance. Evidence indicates that in bladder cancer, microRNAs (miRNAs) have vital functions in acquired drug resistance. However, the involvement of miRNAs in hypoxia-mediated bladder cancer doxorubicin (Dox) resistance is unknown. Herein, we showed that hypoxia and Dox treatment downregulated miR-15a-5p expression. Using UM-UC-3 and J82 bladder cancer cell lines and in vivo mouse models of bladder cancer, we confirmed that miR-15a-5p a...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Jinsong Yang Haoyi Xiang Mengjing Cheng Xue Jiang Ying Chen Lingyan Zheng Senxiang Yan Shufen Zhang Cheng Zhang Wei Chen Dajin Chen Source Type: research