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Low-Dose Darbepoetin alpha Attenuates Progression of a Mouse Model of Aristolochic Acid Nephropathy through Early Tubular Protection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Low-dose DPO treatment conferred protection against acute tubular damage and attenuated interstitial fibrosis in a mouse model of AA nephropathy. Early administration of low-dose DPO may prevent the progression of acute tubular necrosis and the subsequent renal fibrosis in human AA nephropathy. PMID: 19907192 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - November 7, 2009 Category: Urology & Nephrology Authors: Hamano Y, Aoki T, Shirai R, Hatano M, Kimura R, Ogawa M, Yokosuka O, Ueda S Tags: Nephron Exp Nephrol Source Type: journals

Tesaglitazar, a Dual Peroxisome Proliferator- Activated Receptor Agonist (PPARalpha/gamma), Improves Metabolic Abnormalities and Reduces Renal Injury in Obese Zucker Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metabolic syndrome increases the risk of developing diabetes as well as cardiovascular and kidney diseases. This research studied the effects of tesaglitazar, a dual-acting peroxisome proliferator-activated receptor (PPAR)alpha/gamma agonist, on metabolic abnormalities and kidney injury in obese Zucker rats (OZR). Lean Zucker rats (LZR) and OZR were used as control groups. Tesaglitazar (1 mumol/kg/day) was given for 8 weeks in the treatment group (OZR-T). Metabolic parameters, 24-hour urine albumin excretion, and tail blood pressure were measured. Glomerular filtration rate by inulin clearance, abdominal fat and renal ...
Source: Nephron Experimental Nephrology - November 4, 2009 Category: Urology & Nephrology Authors: Liao J, Soltani Z, Ebenezer P, Isidro-Carrión AA, Zhang R, Asghar A, Aguilar E, Francis J, Hu X, Ferder L, Reisin E Tags: Nephron Exp Nephrol Source Type: journals

Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease. Industry has launched huge programs for the development of chemokine antagonists, and clinical trials with chemokine and chemokine receptor antagonists are ongoing. However, chemokine biology remains an area of unexpected discoveries. Here we discuss a number of questions which need to be addressed to further explore the potential of chemokine antagonism in renal inflammation: Why does renal expression of chemokines and chemokine receptors not always correlate with t...
Source: Nephron Experimental Nephrology - November 3, 2009 Category: Urology & Nephrology Authors: Anders HJ, Sayyed SA, Vielhauer V Tags: Nephron Exp Nephrol Source Type: journals

Fibrinogen That Appears in Bowman's Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-Like Receptors 2 and 4 in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that plasma macromolecules that appear in Bowman's space in proteinuric conditions have the capacity to induce podocyte cytokines through TLRs, and thereby accelerate podocyte injury. PMID: 19887845 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - November 3, 2009 Category: Urology & Nephrology Authors: Motojima M, Matsusaka T, Kon V, Ichikawa I Tags: Nephron Exp Nephrol Source Type: journals

Myoglobin Induces Vascular Cell Adhesion Molecule-1 Expression through c-Src Kinase-Activator Protein-1/Nuclear Factor-kappaB Pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: VCAM-1 expression via c-Src kinase-AP-1/NF-kappaB pathways might be one of the possible mechanisms linking myoglobin to tubular injury. Losartan and simvastatin might be beneficial in attenuating myoglobin-induced tubular injury. PMID: 19887846 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - November 3, 2009 Category: Urology & Nephrology Authors: Kim SH, Chang JW, Kim SB, Park SK, Park JS, Lee SK Tags: Nephron Exp Nephrol Source Type: journals

Questions about Chemokine and Chemokine Receptor Antagonism in Renal InflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2010;114:e33-e38 (DOI:10.1159/000254389) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - November 2, 2009 Category: Neurology Source Type: journals

Fibrinogen That Appears in Bowman's Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-Like Receptors 2 and 4 in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2010;114:e39-e47 (DOI:10.1159/000254390) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - November 2, 2009 Category: Neurology Source Type: journals

Myoglobin Induces Vascular Cell Adhesion Molecule-1 Expression through c-Src Kinase-Activator Protein-1/Nuclear Factor-kB PathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2010;114:e48-e60 (DOI:10.1159/000254391) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - November 2, 2009 Category: Neurology Source Type: journals

Role of Cyclooxygenase and Derived Reactive Oxygen Species in rho-Kinase-Mediated Impairment of Endothelium-Dependent Vasodilation and Blood Flow after Ischemia-Reperfusion of the Rat Kidney.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Activation of rho-kinase impairs endothelium-dependent vasodilation and perfusion following renal IR, independently of COX and resultant ROS. In contrast, the vasodilatory effect of rho-kinase inhibition may be partly mediated by decreasing ROS, unrelated to COX and resultant vasoconstricting prostanoids. PMID: 19816046 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 8, 2009 Category: Urology & Nephrology Authors: Versteilen AM, Korstjens IJ, Musters RJ, Groeneveld AB, Sipkema P Tags: Nephron Exp Nephrol Source Type: journals

Multi-Glycoside of Tripterygium wilfordii Hook f. Ameliorates Prolonged Mesangial Lesions in Experimental Progressive Glomerulonephritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: GTW ameliorates prolonged glomerular lesions presumably through suppression of cytokine production (TGF-beta, IL-2, and IFN-gamma). GTW could be an effective therapeutic agent for treatment of chronic renal diseases. PMID: 19816047 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 8, 2009 Category: Urology & Nephrology Authors: Wan Y, Sun W, Zhang H, Yan Q, Chen P, Dou C, Yang H, Ge M Tags: Nephron Exp Nephrol Source Type: journals

Sp1 Specifically Binds to an Evolutionarily Conserved DNA Segment within a Region Necessary for Podocyte-Specific Expression of Nephrin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have analyzed a conserved 237-bp segment located in a 1.9-kb upstream region of the nephrin gene, previously shown to contain kidney specific enhancer element(s). Electromobility shift assay was used to identify a 20-nucleotide region specifically recognized and bound by protein factors in nuclear extracts from immortalized podocyte and human embryonic kidney cell lines. The region was further narrowed down by competition assays to a stretch of 6 consecutive guanines, which are conserved at this location in multiple species. Introduction of mutations in this sequence abolished all protein binding activity whereas mu...
Source: Nephron Experimental Nephrology - October 8, 2009 Category: Urology & Nephrology Authors: Beltcheva O, Hjorleifsdottir EE, Kontusaari S, Tryggvason K Tags: Nephron Exp Nephrol Source Type: journals

BMP-7 Blocks the Cyclosporine-A-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data suggest that BMP-7 can block CsA-induced EMT by downregulating the expression of CTGF, a downstream mediator of EMT. PMID: 19816049 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 8, 2009 Category: Urology & Nephrology Authors: Xu Y, Wan J, Jiang D, Wu X Tags: Nephron Exp Nephrol Source Type: journals

Role of Cyclooxygenase and Derived Reactive Oxygen Species in r-Kinase-Mediated Impairment of Endothelium-Dependent Vasodilation and Blood Flow after Ischemia-Reperfusion of the Rat KidneyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2010;114:e1-e6 (DOI:10.1159/000245060) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 8, 2009 Category: Neurology Source Type: journals

Multi-Glycoside of Tripterygium wilfordii Hook f. Ameliorates Prolonged Mesangial Lesions in Experimental Progressive GlomerulonephritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2010;114:e7-e14 (DOI:10.1159/000245061) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 8, 2009 Category: Neurology Source Type: journals

Sp1 Specifically Binds to an Evolutionarily Conserved DNA Segment within a Region Necessary for Podocyte-Specific Expression of NephrinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2010;114:e15-e22 (DOI:10.1159/000245062) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 8, 2009 Category: Neurology Source Type: journals

BMP-7 Blocks the Cyclosporine-A-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2010;114:e23-e31 (DOI:10.1159/000245063) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - October 8, 2009 Category: Neurology Source Type: journals

Alpha-Lipoic Acid Attenuates Cisplatin-Induced Tubulointerstitial Injuries through Inhibition of Mitochondrial Bax Translocation in Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We demonstrated that LA attenuates cisplatin-induced renal tubular damages by inhibition of mitochondrial bax translocation in vivo. PMID: 19713707 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - August 26, 2009 Category: Urology & Nephrology Authors: Lee YM, Bae SY, Won NH, Pyo HJ, Kwon YJ Tags: Nephron Exp Nephrol Source Type: journals

Cortactin Interacts with Podocalyxin and Mediates Morphological Change of Podocytes through Its Phosphorylation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicate that cortactin mediates interaction between podocalyxin and actin filaments in podocytes and that alteration of this interaction may play a role in the process of morphological change of podocytes. PMID: 19684413 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - August 13, 2009 Category: Urology & Nephrology Authors: Kobayashi T, Notoya M, Shinosaki T, Kurihara H Tags: Nephron Exp Nephrol Source Type: journals

Pathogenesis of Thrombotic Microangiopathy: Insights from Animal Models.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Animal models are important experimental tools for investigating the molecular mechanisms, environmental and genetic susceptibilities underlying the development of thrombotic microangiopathies. Large mammal, small animal models, knockout, transgenic and conditional knockout mouse models are available to investigate haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura and vascular endothelial growth factor-associated thrombotic microangiopathy. These models have shown that it is possible to model the human conditions. However, differences in human and rodent physiology mean that caution is required when inte...
Source: Nephron Experimental Nephrology - August 12, 2009 Category: Urology & Nephrology Authors: Richards A, Kavanagh D Tags: Nephron Exp Nephrol Source Type: journals

Inhibition of Human Mesangial Cell Proliferation by Targeting T-Type Calcium Channels.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results demonstrate for the first time an important role for T-CaCN in human MC proliferation. This could potentially lead to a novel therapy in the treatment of proliferative renal diseases. PMID: 19672121 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - August 10, 2009 Category: Urology & Nephrology Authors: Mulgrew CJ, Cove-Smith A, McLatchie LM, Brooks G, Shattock MJ, Hendry BM Tags: Nephron Exp Nephrol Source Type: journals

Combination Effects of Enalapril and Losartan on Lipid Peroxidation in the Kidneys of KK-A/Ta Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It appears that enalapril and/or losartan, especially in combination, inhibited accumulation of CML/MDA/4-HNE in diabetic renal tissues. These effects might be related to lipid peroxidation via tissue-specific activation of adiponectin and AMPK. PMID: 19609084 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - July 15, 2009 Category: Urology & Nephrology Authors: Yamazaki T, Tanimoto M, Gohda T, Ohara I, Hagiwara S, Murakoshi M, Matsumoto M, Kaneko S, Aoki T, Toyoda H, Ishikawa Y, Funabiki K, Horikoshi S, Tomino Y Tags: Nephron Exp Nephrol Source Type: journals

Expression of the Chemokine Fractalkine (FKN/CX3CL1) by Podocytes in Normal and Proteinuric Rat Kidney Glomerulus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The expression of FKN/CX3CL1 in normal podocytes and the increased expression of the membrane-anchored form in nephrotic glomeruli strongly suggest that FKN/CX3CL1 may play roles in glomerular physiology such as maintaining glomerular filtration barrier. PMID: 19590241 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - July 9, 2009 Category: Urology & Nephrology Authors: Katsuyama K, Fujinaka H, Yamamoto K, Nameta M, Yaoita E, Yoshida Y, Tomizawa S, Uchiyama M, Yamamoto T Tags: Nephron Exp Nephrol Source Type: journals

Effect of dsRNA on Mesangial Cell Synthesis of Plasminogen Activator Inhibitor Type 1 and Tissue Plasminogen Activator.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: For the first time a link between the activation of viral receptors on MC and potentially causative agents in the development of glomerulosclerosis and tubulointerstitial fibrosis is shown. The progression of inflammatory processes to glomerulosclerosis can be postulated to be directly enhanced by viral infection. PMID: 19590242 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - July 9, 2009 Category: Urology & Nephrology Authors: Wörnle M, Roeder M, Sauter M, Merkle M, Ribeiro A Tags: Nephron Exp Nephrol Source Type: journals

Author Index Vol. 112, 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e99 (DOI:10.1159/000233954) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - July 9, 2009 Category: Neurology Source Type: journals

Subject Index Vol. 112, 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e100 (DOI:10.1159/000233955) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - July 9, 2009 Category: Neurology Source Type: journals

Contents Vol. 112, 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:I-IV (DOI:10.1159/000233958) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - July 9, 2009 Category: Neurology Source Type: journals

Toll-Like Receptors and Renal Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Toll-like receptors (TLRs) play a central role in the response of both the innate and the adaptive immune system to microbial ligands. There is also evidence that they are stimulated by endogenous ligands. In this review, I discuss evidence that they are important in renal disease. This discussion considers the role of both endogenous and microbial ligands, and also the contribution of TLRs present on leucocytes and on intrinsic renal cells. There is strong evidence of a role for TLR2 and TLR4 in renal ischaemia-reperfusion injury, with the effects probably mediated by endogenous ligands. In systemic lupus erythematosu...
Source: Nephron Experimental Nephrology - July 8, 2009 Category: Urology & Nephrology Authors: Robson MG Tags: Nephron Exp Nephrol Source Type: journals

The Importance of Cellular VEGF Bioactivity in the Development of Glomerular Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the bioactivity of glomerular VEGF is regulated by many factors that are themselves moderated by changes in the local glomerular environment, such as mechanical strain and hyperglycaemia. Thus, to understand VEGF signalling in glomerular disease progression, we must examine it in the context of other appropriate cellular factors. PMID: 19590237 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - July 8, 2009 Category: Urology & Nephrology Authors: Foster RR Tags: Nephron Exp Nephrol Source Type: journals

Y-Box Protein 1 Stimulates Mesangial Cell Proliferation via Activation of ERK1/2.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: YB-1 has an apparent stimulatory effect on c-Raf, MEK1/2, ERK1/2 and cell-cycle progression in MCs, after which activated ERK1/2 goes on to upregulate YB-1 expression and augment the proliferative effect of YB-1. PMID: 19590238 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - July 8, 2009 Category: Urology & Nephrology Authors: Feng Q, Huang S, Zhang A, Chen Q, Guo X, Chen R, Yang T Tags: Nephron Exp Nephrol Source Type: journals

Aldosterone Induces Apoptosis in Rat Podocytes: Role of PI3-K/Akt and p38MAPK Signaling Pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: ALD induces apoptosis in rat podocytes through inhibition of PI3-K/Akt and stimulation of p38 MAPK signaling pathways. Spironolactone attenuates ALD-induced podocyte apoptosis, thereby positioning this compound as a potential promising target of intervention in human renal damage. PMID: 19590239 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - July 8, 2009 Category: Urology & Nephrology Authors: Chen C, Liang W, Jia J, van Goor H, Singhal PC, Ding G Tags: Nephron Exp Nephrol Source Type: journals

Heme Oxygenase-1 Inducer Hemin Attenuates the Progression of Remnant Kidney Model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Hemin treatment attenuates the progression of chronic kidney disease and appears more efficient than losartan in our rat model hypothetically because of the impact of hemin on the renal expression of BMP-7. PMID: 19590240 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - July 8, 2009 Category: Urology & Nephrology Authors: Desbuards N, Hyvelin JM, Machet MC, Eder V, Garrigue MA, Halimi JM, Antier D Tags: Nephron Exp Nephrol Source Type: journals

Microarray and bioinformatics analysis of gene expression in experimental membranous nephropathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: We show for the first time the complex interplay between multiple different genes in experimental membranous nephropathy, supporting a role for genomic approaches to better understanding and defining specific disease processes. PMID: 19390219 [PubMed - in process] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - June 28, 2009 Category: Urology & Nephrology Authors: Hauser PV, Perco P, Mühlberger I, Pippin J, Blonski M, Mayer B, Alpers CE, Oberbauer R, Shankland SJ Tags: Nephron Exp Nephrol Source Type: journals

Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The administration of mizoribine prevented the progression of peritoneal fibrosis in this rat model. Mizoribine may represent a novel therapy for peritoneal sclerosis in patients undergoing long-term PD. PMID: 19390220 [PubMed - in process] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - June 28, 2009 Category: Urology & Nephrology Authors: Takahashi S, Taniguchi Y, Nakashima A, Arakawa T, Kawai T, Doi S, Ito T, Masaki T, Kohno N, Yorioka N Tags: Nephron Exp Nephrol Source Type: journals

TGF-Beta Auto-Induction and Connective Tissue Growth Factor Expression in Human Renal Tubule Epithelial Cells Requires N-Ras.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results establish that the Ras/MAP kinase pathway, specifically through N-Ras, mediates TGFbeta1 auto-induction and TGFbeta1-induced CTGF expression in human renal tubule epithelial cells. PMID: 19494553 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - June 28, 2009 Category: Urology & Nephrology Authors: Dockrell ME, Phanish MK, Hendry BM Tags: Nephron Exp Nephrol Source Type: journals

Mesangial Cells Connected by the N-Cadherin-Catenin System in the Rat KidneyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e92-e98 (DOI:10.1159/000224797) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - June 16, 2009 Category: Neurology Source Type: journals

Lipopolysaccharide-Triggered Acute Aggravation of Mesangioproliferative Glomerulonephritis through Activation of Coagulation in a High IgA Strain of ddY MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e81-e91 (DOI:10.1159/000224798) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - June 16, 2009 Category: Neurology Source Type: journals

Lipopolysaccharide-Triggered Acute Aggravation of Mesangioproliferative Glomerulonephritis through Activation of Coagulation in a High IgA Strain of ddY Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present data suggest that tissue factor and factor V induction by LPS may in part accelerate mesangioproliferative glomerulonephritis through activation of factor X and downstream proinflammatory and procoagulant mechanisms. PMID: 19546589 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - June 15, 2009 Category: Urology & Nephrology Authors: Shimosawa M, Sakamoto K, Tomari Y, Kamikado K, Otsuka H, Liu N, Kitamura H, Uemura K, Nogaki F, Mori N, Muso E, Yoshida H, Ono T Tags: Nephron Exp Nephrol Source Type: journals

Mesangial Cells Connected by the N-Cadherin-Catenin System in the Rat Kidney.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: N-cadherin interconnects mesangial cells, suggesting that the cadherin-catenin-actin filament system in the mesangium may play a role in the counteraction of the hydraulic pressure gradient across the capillary wall. PMID: 19546590 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - June 15, 2009 Category: Urology & Nephrology Authors: Nameta M, Yaoita E, Kato N, Zhao L, Zhang Y, Fujinaka H, Xu B, Yoshida Y, Yamamoto T Tags: Nephron Exp Nephrol Source Type: journals

TGF-Beta Auto-Induction and Connective Tissue Growth Factor Expression in Human Renal Tubule Epithelial Cells Requires N-RasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e71-e79 (DOI:10.1159/000221834) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - May 30, 2009 Category: Neurology Source Type: journals

Mizoribine Suppresses the Progression of Experimental Peritoneal Fibrosis in a Rat ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e59-e69 (DOI:10.1159/000213896) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - April 22, 2009 Category: Neurology Source Type: journals

Microarray and Bioinformatics Analysis of Gene Expression in Experimental Membranous NephropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e43-e58 (DOI:10.1159/000213505) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - April 20, 2009 Category: Neurology Source Type: journals

Endoplasmic Reticulum Stress in the Kidney as a Novel Mediator of Kidney InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e1-e9 (DOI:10.1159/000210573) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - April 3, 2009 Category: Neurology Source Type: journals

Effect of Chronic Antioxidant Therapy with Superoxide Dismutase-Mimetic Drug, Tempol, on Progression of Renal Disease in Rats with Renal Mass ReductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e31-e42 (DOI:10.1159/000210577) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - April 3, 2009 Category: Neurology Source Type: journals

Diverse Sources of Stem Cells to Treat Acute Kidney InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e29-e30 (DOI:10.1159/000210576) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - April 3, 2009 Category: Neurology Source Type: journals

Administration of Neural Precursor Cells Ameliorates Renal Ischemia-Reperfusion InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e20-e28 (DOI:10.1159/000210575) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - April 3, 2009 Category: Neurology Source Type: journals

Effects of Losartan Pretreatment in an Experimental Model of Ischemic Acute Kidney InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephron Exp Nephrol 2009;112:e10-e19 (DOI:10.1159/000210574) (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - April 3, 2009 Category: Neurology Source Type: journals

Endoplasmic Reticulum Stress in the Kidney as a Novel Mediator of Kidney Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The endoplasmic reticulum (ER) plays an important role in the maintenance of protein homeostasis through its control of the concentration, conformation, folding, and trafficking of client proteins. Disturbances such as hypoxia, glucose depletion, and oxidative stress may lead to ER dysfunction, which can induce ER stress and the subsequent unfolded protein response (UPR). The UPR initially serves as an adaptive response, but will also induce apoptosis in cells under severe or prolonged ER stress. Oxidative stress and inflammation are compounded by ER stress via the UPR, suggesting the potential pathophysiological signi...
Source: Nephron Experimental Nephrology - April 3, 2009 Category: Urology & Nephrology Authors: Inagi R Tags: Nephron Exp Nephrol Source Type: journals

Effects of Losartan Pretreatment in an Experimental Model of Ischemic Acute Kidney Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Renoprotection of the high losartan dose would be mainly mediated by its anti-inflammatory actions. Our results show a potential pathophysiological role of AT1 activation in promoting renal dysfunction, structural injury, inflammation and aldosterone elevation after IR injury. PMID: 19342869 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - April 3, 2009 Category: Urology & Nephrology Authors: Molinas SM, Cortés-González C, González-Bobadilla Y, Monasterolo LA, Cruz C, Elías MM, Bobadilla NA, Trumper L Tags: Nephron Exp Nephrol Source Type: journals

Administration of Neural Precursor Cells Ameliorates Renal Ischemia-Reperfusion Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we evaluated whether administration of stem cells of neural origin (neural precursor cells, NPCs) could be protective against renal ischemia-reperfusion injury (IRI). We hypothesized that stem cell outcomes are not tissue-specific and that NPCs can improve tissue damage through paracrine mechanisms, especially due to immunomodulation. To this end, Wistar rats (200-250 g) were submitted to 1-hour ischemia and treated with NPCs (4 x 10(6) cells/animal) at 4 h of reperfusion. To serve as controls, ischemic animals were treated with cerebellum homogenate harvested from adult rat brain. All groups were sacrificed ...
Source: Nephron Experimental Nephrology - April 3, 2009 Category: Urology & Nephrology Authors: Wang PH, Schwindt TT, Barnabé GF, Motta FL, Semedo P, Beraldo FC, Mazzali M, Dos Reis MA, Teixeira VD, Pacheco-Silva A, Mello LE, Câmara NO Tags: Nephron Exp Nephrol Source Type: journals

Diverse Sources of Stem Cells to Treat Acute Kidney Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19342871 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - April 3, 2009 Category: Urology & Nephrology Authors: Zakaria A, Huang Y, Womer K, Rabb H Tags: Nephron Exp Nephrol Source Type: journals