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Temporal patterns of broad isoform expression during the development of neuronal lineages in DrosophilaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data show the potential for diverse functions of Broad within the developing CNS. The Br-Z3 isoform appears in all interneurons, but not motoneurons, when they first begin to interact with potential targets. Its function during this early sorting phase needs to be defined. Two other Broad isoforms, by contrast, are stably expressed in cohorts of neurons in all lineages and are the first examples of persisting molecular 'time-stamps' for Drosophila postembryonic neurons. (Source: Neural Development)
Source: Neural Development - November 2, 2009 Category: Neurology Authors: Baohua ZhouDarren WilliamsJanet AltmanLynn RiddifordJames Truman Source Type: journals

Promotion of embryonic cortico-cerebral neuronogenesis by miR-124Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We show that miR-124 expression is progressively up-regulated in the mouse embryonic neocortex during the apical to basal transition of neural precursor cells and upon their exit from cell cycle, and that miR-124 is involved in the fine regulation of these processes. (Source: Neural Development)
Source: Neural Development - November 2, 2009 Category: Neurology Authors: Nicola Antonio MaioranoAntonello Mallamaci Source Type: journals

Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results indicate that the activation of the Wnt pathway through Frizzled-1 occurs at the presynaptic level, and suggest that the synaptic effects of the Wnt signaling pathway could be modulated by local activation through synaptic Frizzled receptors. (Source: Neural Development)
Source: Neural Development - November 2, 2009 Category: Neurology Authors: Lorena Varela-NallarCatalina GrabowskiIvan AlfaroAlejandra AlvarezNibaldo Inestrosa Source Type: journals

Notch activity in the nervous system: to switch or not switch?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Notch pathway is instrumental for cell fate diversification during development. Pioneer studies conducted in Drosophila and more recent work performed in vertebrates have shown that in the nervous system, Notch is reiteratively employed when cells choose between two alternative fates, a process referred to as a binary fate decision. While the early (neural versus epidermal) fate decisions mainly involve an inhibitory effect of Notch on the neural fate, late fate decisions (choice between different subtypes of neural cells) have been proposed to involve a binary switch activity whereby Notch would be instructive for one...
Source: Neural Development - October 1, 2009 Category: Neurology Authors: Elise CauPatrick Blader Source Type: journals

Multidendritic sensory neurons in the adult Drosophila abdomen: origins, dendritic morphology, and segment- and age-dependent programmed cell deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study provides the basis on which we can investigate the genetic programs controlling dendritic remodeling and programmed cell death of adult neurons, and the life-long maintenance of dendritic arbors. (Source: Neural Development)
Source: Neural Development - October 1, 2009 Category: Neurology Authors: Kohei ShimonoAzusa FujimotoTaiichi TsuyamaMisato Yamamoto-KochiMotohiko SatoYukako HattoriKaoru SugimuraTadao UsuiKen-ichi KimuraTadashi Uemura Source Type: journals

The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results indicate that the Arp2/3 complex is required cell-autonomously for axon guidance and growth cone filopodia initiation. Furthermore, they show that two other actin-binding proteins, UNC-115/abLIM and UNC-34/Enabled, also control growth cone filopodia formation, possibly in parallel to Arp2/3. These studies indicate that, in vivo, multiple actin modulatory pathways including the Arp2/3 complex contribute to growth cone filopodia formation during growth cone outgrowth. (Source: Neural Development)
Source: Neural Development - October 1, 2009 Category: Neurology Authors: Adam NorrisJamie DyerErik Lundquist Source Type: journals

Glypican-1 controls brain size through regulation of FGF signaling in early neurogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data add to a growing literature that implicates the glypican family of HSPGs in organ size control. They also argue that, among heparan sulfate-dependent signaling molecules, FGFs are disproportionately sensitive to loss of HSPGs. Finally, because heterozygous Gpc1 mutant mice were found to have brain sizes half-way between homozygous and wild type, the data imply that endogenous HSPG levels quantitatively control growth factor signaling, a finding that is both novel and relevant to the general question of how the activities of co-receptors are exploited during development. (Source: Neural Development)
Source: Neural Development - September 3, 2009 Category: Neurology Authors: Yi-Huei JenMichele MusacchioArthur Lander Source Type: journals

Ptf1a is expressed transiently in all types of amacrine cells in the embryonic zebrafish retinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The timing of Ptf1a expression suggests that it is involved in the very early stages or steps in the differentiation of amacrine cells, which, due to the perdurance of the Ptf1a:GFP, can be seen to rapidly diversify into a large number of subtypes. This work sets the stage for future studies looking at genetic specification of amacrine subtypes. (Source: Neural Development)
Source: Neural Development - September 3, 2009 Category: Neurology Authors: Patricia JusufWilliam Harris Source Type: journals

Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The forebrain is exposed to a multitude of Wnts and Wnt inhibitors that are expressed in a highly dynamic and complex fashion, precluding simple correlative conclusions about their respective functions or signalling mechanisms. In various biological systems, Wnts are antagonised by Shh signalling. By demonstrating that Wnt4 expression in the thalamus is repressed by Shh from the ZLI we reveal an additional level of interaction between these two pathways and provide an example for the cross-regulation between patterning centres during forebrain regionalisation. (Source: Neural Development)
Source: Neural Development - September 3, 2009 Category: Neurology Authors: Robyn QuinlanManuela GrafIvor MasonAndrew LumsdenClemens Kiecker Source Type: journals

The Drosophilaimmunoglobulin gene turtleencodes guidance molecules involved in axon pathfindingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings indicate that the turtle proteins function as axon guidance cues that promote midline attraction, axon branching, and axonal invasiveness. The latter two capabilities are required by migrating axons to explore densely packed targets. (Source: Neural Development)
Source: Neural Development - August 16, 2009 Category: Neurology Authors: Bader Al-AnziRobert Wyman Source Type: journals

The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfindingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings indicate that the turtle proteins function as axon guidance cues that promote midline attraction, axon branching, and axonal invasiveness. The latter two capabilities are required by migrating axons to explore densely packed targets. (Source: Neural Development)
Source: Neural Development - August 16, 2009 Category: Neurology Authors: Bader Al-AnziRobert Wyman Source Type: journals

Dynamic Pax6 expression during the neurogenic cell cycle influences proliferation and cell fate choices of retinal progenitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These studies demonstrate for the first time quantitative changes in Pax6 protein expression during the preneurogenic to neurogenic transition and during the neurogenic cell cycle. The results indicate that Pax6 protein levels are stringently controlled in proliferating progenitors. Maintaining a relatively low Pax6 protein level is necessary for S phase re-entry, whereas rapid accumulation or reduction of Pax6 protein during the G2/M phase of the cell cycle may be required for specific neuronal fates. These findings thus provide novel insights on the dynamic regulation of Pax6 protein among neurogenic progeni...
Source: Neural Development - August 16, 2009 Category: Neurology Authors: Yi-Wen HsiehXian-Jie Yang Source Type: journals

Homer regulates calcium signalling in growth cone turningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These experiments provide evidence that Homer1 is an essential component of the calcium signalling repertoire within motile growth cones, regulating guidance-cue-induced calcium release and maintaining basal cytosolic calcium. (Source: Neural Development)
Source: Neural Development - August 2, 2009 Category: Neurology Authors: Robert GasperiniDerek Choi-LundbergMichael ThompsonCamilla MitchellLisa Foa Source Type: journals

Single cell cultures of Drosophila neuroectodermal and mesectodermal central nervous system progenitors reveal different degrees of developmental autonomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This in vitro analysis allows for the first time a comparison of the developmental capacities in situ and in vitro of individual neural precursors of defined spatial and temporal origin. The data reveal that cells isolated at the pre-mitotic and pre-delamination stage express characteristics of the progenitor type appropriate to their site of origin in the embryo. However, presumptive neuroblasts, once specified in the neuroectoderm, exhibit a higher degree of autonomy regarding generation of their lineages compared to mesectodermal midline progenitors. (Source: Neural Development)
Source: Neural Development - August 2, 2009 Category: Neurology Authors: Karin LuerGerhard Technau Source Type: journals

Dendrites differ from axons in patterns of microtubule stability and polymerization during developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Both immunocytochemical and live imaging analyses showed that newly formed microtubules predominated at the distal end of axons and dendrites, suggesting a common mechanism that incorporates increased microtubule polymerization at growing process tips. Dendrites had more immature, dynamic microtubules throughout the entire arbor than did axons, however. Identifying these differences in microtubule stability and polymerization is a necessary first step toward understanding how they are developmentally regulated, and may reveal novel mechanisms underlying neuron maturation and dendritic plasticity that extend be...
Source: Neural Development - July 13, 2009 Category: Neurology Authors: Katherine KollinsRobert BellMatthew ButtsGinger Withers Source Type: journals

Chick Lrrn2, a novel downstream effector of Hoxb1 and Shh, functions in the selective targeting of rhombomere 4 motor neuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Lrrn2 acts downstream of Hoxb1 and plays a role in the selective targeting of r4 motor neurons to BA2. (Source: Neural Development)
Source: Neural Development - July 13, 2009 Category: Neurology Authors: Laura AndreaeAndrew LumsdenJonathan Gilthorpe Source Type: journals

Mathematical modeling supports substantial mouse neural progenitor cell deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We demonstrate that uniformly low-level neural progenitor cell death, as concluded in previous models, is incompatible with normal mouse cortical development. Levels of neural progenitor cell death up to and exceeding 50% are compatible with normal cortical development and may operate to prevent forebrain overgrowth as observed following cell death attenuation, as occurs in caspase 3-null mutant mice. (Source: Neural Development)
Source: Neural Development - July 13, 2009 Category: Neurology Authors: Michael McConnellHugh MacMillanJerold Chun Source Type: journals

Viewpoints: contrasting opinions in Neural DevelopmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No description available (Source: Neural Development)
Source: Neural Development - July 5, 2009 Category: Neurology Authors: Andrew LumsdenBill HarrisJoshua SanesRachel Wong Source Type: journals

Retinal waves are likely to instruct the formation of eye-specific retinogeniculate projectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prior to eye-opening and the development of visual responses, the retina exhibits highly correlated spontaneous firing pattens termed retinal waves. Disruption of the normal spontaneous firing pattern either genetically or pharmacologically prevents the eye-specific refinement of retinogeniculate afferents. Here I provide the evidence that retinal waves play an instructive role in this process. In addition, I argue that a full understanding requires an identification of the features of retinal activity that drive the refinement as well as an understanding of mechanisms that transform these signals into axonal rearrangement...
Source: Neural Development - July 5, 2009 Category: Neurology Authors: Marla Feller Source Type: journals

Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In all mammalian species the projections of the two eyes to the dorsal lateral geniculate nucleus are initially overlapping before gradually forming the eye-specific domains evident at maturity. It is widely thought that retinal waves of neuronal activity play an instructional role in this developmental process. Here, I discuss the myriad reasons why retinal waves are unlikely to have such a role, and suggest that eye-specific molecular cues in combination with neuronal activity are most probably involved in the formation of eye-specific retinogeniculate projections. (Source: Neural Development)
Source: Neural Development - July 5, 2009 Category: Neurology Authors: Leo Chalupa Source Type: journals

Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafishEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our analyses of nsf mutant zebrafish reveal an unexpected role for NSF in hypothalamic development, with mutant 5-days-post-fertilization larvae exhibiting a stage-dependent loss of neuroendocrine transcripts and a corresponding accumulation of neuropeptides in the soma. Based on our collective findings, we speculate that neuroendocrine transcriptional programs adapt dynamically to both the supply and demand for neuropeptides to ensure adequate homeostatic responses. (Source: Neural Development)
Source: Neural Development - June 22, 2009 Category: Neurology Authors: Deborah KurraschLinda NevinJinny WongHerwig BaierHolly Ingraham Source Type: journals

Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The Lim-HD proteins Lhx9 and Lhx1 serve as a binary switch in controlling the rostral versus caudal longitudinal turning of the caudal commissural axons. Lhx1 determines caudal turning and Lhx9 triggers rostral turning. (Source: Neural Development)
Source: Neural Development - June 18, 2009 Category: Neurology Authors: Oshri AvrahamYoav HadasLilach ValdSophie ZismanAdi SchejterAxel ViselAvihu Klar Source Type: journals

Molecular components underlying nongenomic thyroid hormone signaling in embryonic zebrafish neuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: T4's nongenomic regulation of sodium current occurs in different neuronal subtypes, requires the activity of specific phosphorylation pathways, and requires both integrin alphaVbeta3 and Nav1.6a. Our in vivo analyses identify molecules required for T4's rapid regulation of voltage-gated sodium current. (Source: Neural Development)
Source: Neural Development - June 8, 2009 Category: Neurology Authors: Marc YonkersAngeles Ribera Source Type: journals

Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings indicate that ventral telencephalic Pax6 is important for formation of the Islet1-expressing corridor and the thalamic and cortical axons that grow through it. We suggest that Pax6 might affect thalamic axonal growth indirectly via its effect on the corridor. (Source: Neural Development)
Source: Neural Development - June 5, 2009 Category: Neurology Authors: T. Ian SimpsonThomas PrattJohn MasonDavid Price Source Type: journals

Semaphorin 5B mediates synapse elimination in hippocampal neuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results demonstrate that in addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, proteolytic cleavage of Sema5B results in the release of a potentially diffusible semaphorin domain that is a necessary component for its biological function in the regulation of synapse morphology. (Source: Neural Development)
Source: Neural Development - May 23, 2009 Category: Neurology Authors: Timothy O'ConnorKatie CockburnWenyan WangLucia TapiaErin CurrieShernaz Bamji Source Type: journals

Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that axodendritic contact leads to rapid accumulation of Nlg1, recruitment of NMDARs co-transported with Nlg1 soon thereafter, followed by a slower, independent recruitment of PSD-95 to those nascent synapses. (Source: Neural Development)
Source: Neural Development - May 18, 2009 Category: Neurology Authors: Stephanie L Barrow, John R.L. Constable, Eliana Clark, Faten El-Sabeawy, A. Kimberley McAllister and Philip Washbourne Source Type: journals

Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: UNC-7S and UNC-9 are widely expressed and contribute to a large number of the gap junctions identified in the locomotory nervous system. Proper AVB:B gap junction formation requires UNC-7S expression in AVB interneurons and UNC-9 expression in B motor neurons. More broadly, this illustrates that innexin identity is critical for electrical synapse specificity, but differential (compartmentalized) innexin expression cannot account for all of the specificity seen in C. elegans, and other factors must influence the determination of synaptic partners. (Source: Neural Development)
Source: Neural Development - May 11, 2009 Category: Neurology Authors: Todd A Starich, Ji Xu, I. Martha Skerrett, Bruce J Nicholson and Jocelyn E Shaw Source Type: journals

Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings show that cyclin D1 has important roles in RPC cell cycle regulation and retinal histogenesis. The reduction in the RPC population due to a longer cell cycle time and to an enhanced rate of cell cycle exit are likely to be the primary factors driving retinal hypocellularity and altered output of precursor populations in the embryonic Ccnd1-/- retina. (Source: Neural Development)
Source: Neural Development - May 5, 2009 Category: Neurology Authors: Gaurav Das, Yoon Choi, Piotr Sicinski and Edward M Levine Source Type: journals

Vsx2 in the zebrafish retina: restricted lineages through derepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data thus suggest Vsx2-positive RPCs are fully multipotent retinal progenitors and that when Vsx2 is downregulated, Vsx2-negative progenitors escape Vsx2 repression and so are able to express factors that restrict lineage potential. (Source: Neural Development)
Source: Neural Development - April 3, 2009 Category: Neurology Authors: Marta Vitorino, Patricia R Jusuf, Daniel Maurus, Yukiko Yukiko, Shin-ichi Higashijima and William A Harris Source Type: journals

Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results provide evidence that zebrafish gbx1 is involved in positioning the MHB in the early neural plate by refining the otx2 expression domain. In addition to its role in MHB formation, we have shown that gbx1 is a novel mediator of Wnt8 signaling during hindbrain patterning. (Source: Neural Development)
Source: Neural Development - April 2, 2009 Category: Neurology Authors: Muriel Rhinn, Klaus Lun, Reiner Ahrendt, Michaela Geffarth and Michael Brand Source Type: journals

IgCAMs redundantly control axon outgrowth in Caenorhabditis elegansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Genetic interactions involving multiple IgCAMs affecting axon outgrowth demonstrate functional overlap among IgCAMs during nervous system development. (Source: Neural Development)
Source: Neural Development - April 2, 2009 Category: Neurology Authors: Valentin Schwarz, Jie Pan, Susanne Voltmer-Irsch and Harald Hutter Source Type: journals

Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study links the survival function of the Engrailed genes in developing mesDA neurons to the regulation of P75NTR and the sensitivity of these neurons to mitochondrial insult. The similarities to the disease etiology in combination with the nigral phenotype of En1+/-;En2-/- mice suggests that haplotype variations in the Engrailed genes and/or P75NTR that alter their expression levels could, in part, determine susceptibility to Parkinson's disease. (Source: Neural Development)
Source: Neural Development - March 16, 2009 Category: Neurology Authors: Kambiz N Alavian, Paola Sgado, Lavinia Alberi, Srinivasa Subramaniam and Horst H Simon Source Type: journals

The Neuroscience Peer Review ConsortiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As the Neuroscience Peer Review Consortium (NPRC) ends its first year, it is worth looking back to see how the experiment has worked. In order to encourage dissemination of the details outlined in this Editorial, it will also be published in other journals in the Neuroscience Peer Review Consortium. (Source: Neural Development)
Source: Neural Development - March 12, 2009 Category: Neurology Authors: Clifford B. Saper and John H.R. Maunsell Source Type: journals

Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicate that cytoplasmic polyadenylation and CPE-mediated translational regulation are involved in retinal axon development, but that CPEB1 may not be the key regulator of polyadenylation in the developing retina. (Source: Neural Development)
Source: Neural Development - March 2, 2009 Category: Neurology Authors: Andrew C Lin, Chin Lik Tan, Chien-Ling Lin, Laure Strochlic, Yi-Shuian Huang, Joel D Richter and Christine E Holt Source Type: journals

Cell proliferation in the Drosophila adult brain revealed by clonal analysis and bromodeoxyuridine labellingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We have observed cell proliferation in the Drosophila adult brain. The dividing cells may be adult stem cells, generating glial and/or non-glial cell types. (Source: Neural Development)
Source: Neural Development - March 2, 2009 Category: Neurology Authors: Jakob W von Trotha, Boris Egger and Andrea H Brand Source Type: journals

Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results provide in vivo evidence that Wnts chemoattract mammalian FBM neurons and that Wnt5a is a candidate to mediate this process. Molecules of the PCP pathway and the JNK and ROCK kinases also play a role in the FBM migration and are likely mediators of Wnt signalling. (Source: Neural Development)
Source: Neural Development - February 11, 2009 Category: Neurology Authors: Valerie Vivancos, Ping Chen, Nathalie Spassky, Dong Qian, Alain Dabdoub, Matthew Kelley, Michele Studer and Sarah Guthrie Source Type: journals

Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Activation of Fgfr3 selectively promotes growth of caudolateral (occipitotemporal) cortex. These observations support the 'radial unit' and 'radial amplification' hypotheses and may explain premature sulcation of the occipitotemporal cortex in thanatophoric dysplasia, a human FGFR3 disorder. Together with previous work, this study suggests that formation of rostral and caudal areas are differentially regulated by Fgf signaling in the cerebral cortex. (Source: Neural Development)
Source: Neural Development - February 3, 2009 Category: Neurology Authors: Rachel E Thomson, Peter C Kind, Nicholas A Graham, Michelle L Etherson, John Kennedy, Ana C Fernandes, Catia S Marques, Robert F Hevner and Tomoko Iwata Source Type: journals

Neural tube derived Wnt signals cooperate with FGF signaling in the formation and differentiation of the trigeminal placodesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We demonstrate the identity of inductive signals that are necessary for trigeminal ganglion formation. This is the first report that describes how isthmic derived Wnt signals act in concert with fibroblast growth factor signaling. Together, both are necessary and sufficient for the establishment and differentiation of the ophthalmic and maxillomandibular placodes and, consequently, the trigeminal ganglion. (Source: Neural Development)
Source: Neural Development - December 15, 2008 Category: Neurology Authors: Claire A Canning, Lily Lee, Sarah Xinwei Luo, Anthony Graham and C Michael Jones Source Type: journals

Drosophila olfactory local interneurons and projection neurons derive from a common neuroblast lineage specified by the empty spiracles gene.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We find that the lateral neuroblast of the deutocerebrum gives rise to a large and remarkably diverse set of local interneurons as well as to projection neurons in the antennal lobe. Moreover, we show that specific combinations of these two neuron types are produced in specific time windows in this neuroblast lineage. The development of both these cell types in this lineage requires the function of the empty spiracles gene. (Source: Neural Development)
Source: Neural Development - December 3, 2008 Category: Neurology Authors: Abhijit Das, Sonia Sen, Robert Lichtneckert, Ryuichi Okada, Kei Ito, Veronica Rodrigues and Heinrich Reichert Source Type: journals

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our observations suggest that the pro- and antisynaptogenic effects of Wnt proteins are associated with the activation of the canonical and noncanonical Wnt signaling pathways. (Source: Neural Development)
Source: Neural Development - November 5, 2008 Category: Neurology Authors: Elizabeth K Davis, Yimin Zou and Anirvan Ghosh Source Type: journals

Correction: FGF15 promotes neurnogenesis and opposes FGF8 function during neocortical developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
After publication of this work [1], we noted that we inadvertently failed to include the complete list of all co-authors. The full list of authors has now been added and the Authors' contributions and Competing interests section modified accordingly. (Source: Neural Development)
Source: Neural Development - November 5, 2008 Category: Neurology Authors: Ugo Borello, Inma Cobos, Jason E Long, John R McWhirter, Cornelis Murre and John LR Rubenstein Source Type: journals

A negative modulatory role for Rho and Rho-associated kinase signaling in delamination of neural crest cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Rho-GTPases, through Rock, act downstream of BMP and of G1/S transition to negatively regulate crest delamination by modifying cytoskeleton assembly and intercellular adhesion. (Source: Neural Development)
Source: Neural Development - October 22, 2008 Category: Neurology Authors: Maya Groysman, Irit Shoval and Chaya Kalcheim Source Type: journals

Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: BMP-4 may serve to promote specific chromaffin traits, but is not sufficient to convert sympathetic neurons into a chromaffin phenotype. (Source: Neural Development)
Source: Neural Development - October 22, 2008 Category: Neurology Authors: Katrin Huber, Aylin Franke, Barbara Bruhl, Shlomi Krispin, Uwe Ernsberger, Andreas Schober, Oliver von Bohlen und Halbach, Hermann Rohrer, Chaya Kalcheim and Klaus Unsicker Source Type: journals

A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study reports the first temporal analysis of a neural kinase activity using the chemical-genetic system. It reveals that neuronal polarity and synaptic organization have distinct temporal requirements for SAD-1. (Source: Neural Development)
Source: Neural Development - September 22, 2008 Category: Neurology Authors: Joanne SM Kim, Brendan N Lilley, Chao Zhang, Kevan M Shokat, Joshua R Sanes and Mei Zhen Source Type: journals

Expressing exogenous functional odorant receptors in cultured olfactory sensory neuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This culture technique provided an efficient method to culture olfactory sensory neurons whose morphology, molecular characteristics and maturation progression resembled those observed in vivo. Using this system, regulation of odorant receptor expression and its ligand specificity can be studied in its intrinsic cellular environment. (Source: Neural Development)
Source: Neural Development - September 11, 2008 Category: Neurology Authors: Huaiyang Chen, Sepher Dadsetan, Alla F. Fomina and Qizhi Gong Source Type: journals

The Met receptor tyrosine kinase prevents zebrafish primary motoneurons from expressing an incorrect neurotransmitterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We provide evidence that Met is necessary for normal development of zebrafish primary and secondary motoneurons. Despite their many similarities, our results show that these two motoneuron subtypes have different requirements for Met function during development, and raise the possibility that Met may act through different intracellular signaling cascades in primary and secondary motoneurons. Surprisingly, although met is not expressed in primary motoneurons until many hours after they have extended axons to and innervated their muscle targets, Met knockdown causes some of these cells to develop a hybrid phenot...
Source: Neural Development - July 29, 2008 Category: Neurology Authors: Alexandra Tallafuss and Judith S Eisen Source Type: journals

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings indicate that APPs-α regulates the function of APP in neurite outgrowth via the novel mechanism of competing with the binding of APP to Itgβ1. (Source: Neural Development)
Source: Neural Development - June 23, 2008 Category: Neurology Authors: Tracy L Young-Pearse, Allen C Chen, Rui Chang, Cesar Marquez and Dennis J Selkoe Source Type: journals

Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest that HOP participates in the regulation of the adult mouse hippocampal stem cell niche by negatively affecting cell survival. In addition, HOP may work as a tumor suppressor in a subset of glioblastomas. HOP function thus appears to be critical in the adult brain in a region of continued plasticity, and its deregulation may contribute to disease. (Source: Neural Development)
Source: Neural Development - May 28, 2008 Category: Neurology Authors: Arianna De Toni, Marie Zbinden, Jonathan A Epstein, Ariel Ruiz i Altaba, Alain Prochiantz and Isabelle Caille Source Type: journals

The abdomen of Drosophila: does planar cell polarity orient the neurons of mechanosensory bristles?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PCP genes, such as starry night and dachsous orient the bristles and position the neuronal cell body and affect the shape of the dendrites. However, these PCP genes do not appear to change the paths followed by the sensory axons, which must, therefore, be polarised by other factors. (Source: Neural Development)
Source: Neural Development - April 30, 2008 Category: Neurology Authors: Caroline CG Fabre, Jose Casal and Peter A Lawrence Source Type: journals

UV laser mediated cell selective destruction by confocal microscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Analysis of cell-cell interactions, function and lineages greatly benefits of selective destruction techniques, which, at present, rely on dedicated, high energy, pulsed lasers and are limited to cells that are detectable by conventional microscopy. We here present a high resolution/sensitivity technique based on confocal microscopy and relying on commonly used UV lasers. Coupling this technique with time-lapse allows for destroying and following of any cell(s) in any pattern(s) in living animals as well as in cell culture systems. (Source: Neural Development)
Source: Neural Development - April 28, 2008 Category: Neurology Authors: Laurent Soustelle, Benoit Aigouy, Marie-Laure Asensio and Angela Giangrande Source Type: journals