Dopamine ‑iron homeostasis interaction rescues mitochondrial fitness in Parkinson's disease
In this study, we investigated the interplay between iron, dopamine, and mitochondrial activity in neuroblastoma SH-SY5Y cells and human induced pluripotent stem cell (hiPSC)-derived dopaminergic neurons differentiated from a healthy control and a PD patient with a mutation in the α-synuclein (SNCA) gene. In SH-SY5Y cells, dopamine treatment resulted in increased expression of the transmembrane iron transporters transferrin receptor 1 (TFR1), ferroportin (FPN), and mitoferrin2 (MFRN2) and intracellular iron accumulation, suggesting that dopamine may promote iron uptake. Furthermore, dopamine supplementation led to reduced...
Source: Neurobiology of Disease - April 22, 2024 Category: Neurology Authors: Chiara Buoso Markus Seifert Martin Lang Corey M Griffith Bego ña Talavera Andújar Maria Paulina Castelo Rueda Christine Fischer Carolina Doerrier Heribert Talasz Alessandra Zanon Peter P Pramstaller Emma L Schymanski Irene Pichler Guenter Weiss Source Type: research
Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis
Neurobiol Dis. 2024 Apr 19:106485. doi: 10.1016/j.nbd.2024.106485. Online ahead of print.ABSTRACTResearch evidence indicating common metabolic mechanisms through which type 2 diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has accumulated over recent decades. The aim of this systematic review is to provide a comprehensive review of common mechanisms, which have hitherto been discussed in separate perspectives, and to assemble and evaluate candidate loci and epigenetic modifications contributing to polygenic risk linkages between T2DM and LOAD. For the systematic review on pathophysiologica...
Source: Neurobiology of Disease - April 21, 2024 Category: Neurology Authors: Erwin Lemche Richard Killick Jackie Mitchell Paul W Caton Pratik Choudhary Jane K Howard Source Type: research
Targeting dysregulated lipid metabolism for the treatment of Alzheimer's disease and Parkinson's disease: Current advancements and future prospects
Neurobiol Dis. 2024 Apr 18:106505. doi: 10.1016/j.nbd.2024.106505. Online ahead of print.ABSTRACTAlzheimer's and Parkinson's diseases are two of the most frequent neurological diseases. The clinical features of AD are memory decline and cognitive dysfunction, while PD mainly manifests as motor dysfunction such as limb tremors, muscle rigidity abnormalities, and slow gait. Abnormalities in cholesterol, sphingolipid, and glycerophospholipid metabolism have been demonstrated to directly exacerbate the progression of AD by stimulating Aβ deposition and tau protein tangles. Indirectly, abnormal lipids can increase the burden o...
Source: Neurobiology of Disease - April 20, 2024 Category: Neurology Authors: Bin Tong Yaoqi Ba Zhengyang Li Caidi Yang Kangtai Su Haodong Qi Deju Zhang Xiao Liu Yuting Wu Yixuan Chen Jitao Ling Jing Zhang Peng Yu Xiaoping Yin Source Type: research
Low and high-order topological disruption of functional networks in multiple system atrophy with freezing of gait: A resting-state study
CONCLUSION: This study identified a disrupted topology of functional interactions at both low and high levels with extensive alterations in topological properties in MSA patients with FOG, especially those associated with damage to the FPN. These findings offer new insights into the dysfunctional mechanisms of complex networks and suggest potential neuroimaging biomarkers for FOG in patients with MSA.PMID:38615913 | DOI:10.1016/j.nbd.2024.106504 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - April 14, 2024 Category: Neurology Authors: Guoguang Fan Mengwan Zhao Huize Pang Xiaolu Li Shuting Bu Juzhou Wang Yu Liu Yueluan Jiang Source Type: research
Low and high-order topological disruption of functional networks in multiple system atrophy with freezing of gait: A resting-state study
CONCLUSION: This study identified a disrupted topology of functional interactions at both low and high levels with extensive alterations in topological properties in MSA patients with FOG, especially those associated with damage to the FPN. These findings offer new insights into the dysfunctional mechanisms of complex networks and suggest potential neuroimaging biomarkers for FOG in patients with MSA.PMID:38615913 | DOI:10.1016/j.nbd.2024.106504 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - April 14, 2024 Category: Neurology Authors: Guoguang Fan Mengwan Zhao Huize Pang Xiaolu Li Shuting Bu Juzhou Wang Yu Liu Yueluan Jiang Source Type: research
Low and high-order topological disruption of functional networks in multiple system atrophy with freezing of gait: A resting-state study
CONCLUSION: This study identified a disrupted topology of functional interactions at both low and high levels with extensive alterations in topological properties in MSA patients with FOG, especially those associated with damage to the FPN. These findings offer new insights into the dysfunctional mechanisms of complex networks and suggest potential neuroimaging biomarkers for FOG in patients with MSA.PMID:38615913 | DOI:10.1016/j.nbd.2024.106504 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - April 14, 2024 Category: Neurology Authors: Guoguang Fan Mengwan Zhao Huize Pang Xiaolu Li Shuting Bu Juzhou Wang Yu Liu Yueluan Jiang Source Type: research
Disrupted autonomic pathways in spinal cord injury: Implications for the immune regulation
Neurobiol Dis. 2024 Apr 11:106500. doi: 10.1016/j.nbd.2024.106500. Online ahead of print.ABSTRACTSpinal Cord Injury (SCI) disrupts critical autonomic pathways responsible for the regulation of the immune function. Consequently, individuals with SCI often exhibit a spectrum of immune dysfunctions ranging from the development of damaging pro-inflammatory responses to severe immunosuppression. Thus, it is imperative to gain a more comprehensive understanding of the extent and mechanisms through which SCI-induced autonomic dysfunction influences the immune response. In this review, we provide an overview of the anatomical orga...
Source: Neurobiology of Disease - April 13, 2024 Category: Neurology Authors: Maria M Moura Andreia Monteiro Ant ónio J Salgado Nuno A Silva Susana Monteiro Source Type: research
Nigrostriatal loop - from basics and beyond
Neurobiol Dis. 2024 Apr 13:106503. doi: 10.1016/j.nbd.2024.106503. Online ahead of print.NO ABSTRACTPMID:38614276 | DOI:10.1016/j.nbd.2024.106503 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - April 13, 2024 Category: Neurology Authors: Mariana H G Monje J Blesa Source Type: research
Disrupted autonomic pathways in spinal cord injury: Implications for the immune regulation
Neurobiol Dis. 2024 Apr 11:106500. doi: 10.1016/j.nbd.2024.106500. Online ahead of print.ABSTRACTSpinal Cord Injury (SCI) disrupts critical autonomic pathways responsible for the regulation of the immune function. Consequently, individuals with SCI often exhibit a spectrum of immune dysfunctions ranging from the development of damaging pro-inflammatory responses to severe immunosuppression. Thus, it is imperative to gain a more comprehensive understanding of the extent and mechanisms through which SCI-induced autonomic dysfunction influences the immune response. In this review, we provide an overview of the anatomical orga...
Source: Neurobiology of Disease - April 13, 2024 Category: Neurology Authors: Maria M Moura Andreia Monteiro Ant ónio J Salgado Nuno A Silva Susana Monteiro Source Type: research
Nigrostriatal loop - from basics and beyond
Neurobiol Dis. 2024 Apr 11:106503. doi: 10.1016/j.nbd.2024.106503. Online ahead of print.NO ABSTRACTPMID:38614276 | DOI:10.1016/j.nbd.2024.106503 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - April 13, 2024 Category: Neurology Authors: Mariana H G Monje J Blesa Source Type: research
BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease
Neurobiol Dis. 2024 Apr 10:106502. doi: 10.1016/j.nbd.2024.106502. Online ahead of print.ABSTRACTSynaptic changes are early manifestations of neuronal dysfunction in Huntington's disease (HD). However, the mechanisms by which mutant HTT protein impacts synaptogenesis and function are not well understood. Herein we explored HD pathogenesis in the BACHD mouse model by examining synaptogenesis and function in long term primary cortical cultures. At DIV14 (days in vitro), BACHD cortical neurons showed no difference from WT neurons in synaptogenesis as revealed by colocalization of a pre-synaptic (Synapsin I) and a post-synapti...
Source: Neurobiology of Disease - April 12, 2024 Category: Neurology Authors: Yingli Gu Alexander Pope Charlene Smith Christopher Carmona Aaron Johnstone Linda Shi Xuqiao Chen Sarai Santos Claire Cecile Bacon-Brenes Thomas Shoff Korbin M Kleczko Judith Frydman Leslie M Thompson William C Mobley Chengbiao Wu Source Type: research
Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy
Neurobiol Dis. 2024 Apr 7;195:106499. doi: 10.1016/j.nbd.2024.106499. Online ahead of print.ABSTRACTThe gut-brain axis is a bidirectional communication network linking the gut and the brain, overseeing digestive functions, emotional responses, body immunity, brain development, and overall health. Substantial research highlights a connection between disruptions of the gut-brain axis and various psychiatric and neurological conditions, including depression and Alzheimer's disease. Given the impact of the gut-brain axis on behavior, cognition, and brain diseases, some studies have started to pay attention to the role of the a...
Source: Neurobiology of Disease - April 8, 2024 Category: Neurology Authors: Xin Wang Xiaoyue Wen Shiying Yuan Jiancheng Zhang Source Type: research
Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy
Neurobiol Dis. 2024 Apr 7;195:106499. doi: 10.1016/j.nbd.2024.106499. Online ahead of print.ABSTRACTThe gut-brain axis is a bidirectional communication network linking the gut and the brain, overseeing digestive functions, emotional responses, body immunity, brain development, and overall health. Substantial research highlights a connection between disruptions of the gut-brain axis and various psychiatric and neurological conditions, including depression and Alzheimer's disease. Given the impact of the gut-brain axis on behavior, cognition, and brain diseases, some studies have started to pay attention to the role of the a...
Source: Neurobiology of Disease - April 8, 2024 Category: Neurology Authors: Xin Wang Xiaoyue Wen Shiying Yuan Jiancheng Zhang Source Type: research
Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy
Neurobiol Dis. 2024 Apr 6:106499. doi: 10.1016/j.nbd.2024.106499. Online ahead of print.ABSTRACTThe gut-brain axis is a bidirectional communication network linking the gut and the brain, overseeing digestive functions, emotional responses, body immunity, brain development, and overall health. Substantial research highlights a connection between disruptions of the gut-brain axis and various psychiatric and neurological conditions, including depression and Alzheimer's disease. Given the impact of the gut-brain axis on behavior, cognition, and brain diseases, some studies have started to pay attention to the role of the axis ...
Source: Neurobiology of Disease - April 8, 2024 Category: Neurology Authors: Xin Wang Xiaoyue Wen Shiying Yuan Jiancheng Zhang Source Type: research
Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy
Neurobiol Dis. 2024 Apr 6:106499. doi: 10.1016/j.nbd.2024.106499. Online ahead of print.ABSTRACTThe gut-brain axis is a bidirectional communication network linking the gut and the brain, overseeing digestive functions, emotional responses, body immunity, brain development, and overall health. Substantial research highlights a connection between disruptions of the gut-brain axis and various psychiatric and neurological conditions, including depression and Alzheimer's disease. Given the impact of the gut-brain axis on behavior, cognition, and brain diseases, some studies have started to pay attention to the role of the axis ...
Source: Neurobiology of Disease - April 8, 2024 Category: Neurology Authors: Xin Wang Xiaoyue Wen Shiying Yuan Jiancheng Zhang Source Type: research
