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Statins in the Management of Patients with Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Existing RCTs suggest that statins reduce DINDs, with a possible trend toward lower mortality. These findings are not supported by observational research. Although not assessed in all studies, current data do not indicate that statins improve neurological outcomes. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s12028-009-9306-9Authors Andreas H. Kramer, University of Calgary Departments of Critical Care Medicine and Clinical Neurosciences, Hotchkiss Brain Institute Foothills Medical Center, Room EG23J, 1403 29th St. N.W. Calgary AB T2N 2T9 CanadaJeffrey J. Fletcher, University of Michig...
Source: Neurocritical Care - November 18, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Impact of Pattern of Admission on ICH OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Patients with ICH brought directly to our ED had significantly better outcomes than IHT; we hypothesize this may be caused by delays in optimizing management prior to arrival at the facility with a dedicated Neuro-ICU. Nevertheless, other equally plausible hypotheses need to be prospectively tested. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9302-0Authors Neeraj Sunderrajan Naval, Oregon Health & Science University Portland OR USAJ. Ricardo Carhuapoma, Johns Hopkins University Baltimore MD USA Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN...
Source: Neurocritical Care - November 14, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured AdultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions DCS measurements of CBF and NIRS measurements of tissue blood oxygenation were successfully obtained in neurocritical care patients. The potential for DCS to provide continuous, noninvasive bedside monitoring for the purpose of CBF management and individualized care is demonstrated. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9305-xAuthors Meeri N. Kim, University of Pennsylvania Department of Physics and Astronomy 209 South 33rd Street Philadelphia PA 19104 USATurgut Durduran, University of Pennsylvania Department of Physics and Astronomy 209 South 33rd Str...
Source: Neurocritical Care - November 12, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

A Giant Bilateral Calcified Chronic Subdural HematomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our case of a calcified chronic subdural hematoma presents with an uncommon imaging pattern with more than four hematoma cavities bounded by predominantly convex- and concave-configured thin calcified inner membranes. Content Type Journal ArticleCategory NeuroimageDOI 10.1007/s12028-009-9303-zAuthors N. Galldiks, University Hospital of Cologne Department of Neurology Kerpener Str. 62 50924 Cologne GermanyC. Dohmen, University Hospital of Cologne Department of Neurology Kerpener Str. 62 50924 Cologne GermanyM. Neveling, University Hospital of Cologne Department of Neurology Kerpener Str. 62 ...
Source: Neurocritical Care - November 10, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Prospective, Randomized, Single-Blinded Comparative Trial of Intravenous Levetiracetam Versus Phenytoin for Seizure ProphylaxisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study of LEV versus PHT for seizure prevention in the NSICU showed improved long-term outcomes of LEV-treated patients vis-à-vis PHT-treated patients. LEV appears to be an alternative to PHT for seizure prophylaxis in this setting. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9304-yAuthors Jerzy P. Szaflarski, University of Cincinnati Academic Health Center Department of Neurology 260 Stetson Street, Rm. 2350 Cincinnati OH 45267-0525 USAKiranpal S. Sangha, The University Hospital Department of Pharmacy Services Cincinnati OH USAChristopher J. Lindsell, U...
Source: Neurocritical Care - November 7, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

The Hemodynamic Response of the Cerebral Bridging Veins to Changes in ICPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The cerebral bridging veins dilation and blood flow velocity decrease indicate the venous relative stasis in response to the elevated ICP. This response is proposed to be caused by an ICP-dependent increase in resistance to the outflow from the cerebral bridging veins. Content Type Journal ArticleCategory Translational ResearchDOI 10.1007/s12028-009-9299-4Authors Yanbing Yu, The China-Japan Friendship Hospital The Department of Neurosurgery East Yinghua Road, He Pingli, Chao Yang District 100029 Beijing People’s Republic of ChinaJie Chen, Shandong University The Department of Neurosurger...
Source: Neurocritical Care - November 7, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Sequential Escalation of Therapy in “Malignant” Cerebral Venous and Sinus ThrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This first description on the combined treatment with local thrombolysis and hemicraniectomy illustrates that even in severely affected individuals, therapeutic nihilism is unwarranted and that all available therapeutic options including local thrombolysis and hemicraniectomy should be taken into consideration. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9301-1Authors Christian Dohmen, University Hospital of Cologne Department of Neurology Kerpenerstr. 62 50924 Cologne GermanyNorbert Galldiks, University Hospital of Cologne Department of Neurology Kerpenerstr...
Source: Neurocritical Care - November 7, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

How I Manage the Adult Potential Organ Donor: Donation After Cardiac Death (Part 2)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To address the gap between organs available for transplant and the number of patients on the transplant waiting list, the Joint Commission on the Accreditation of Healthcare Organizations, Institute of Medicine, United Network for Organ Sharing and the federal government have recommended the increased used of donation after cardiac death (DCD) (JCAHOnline http://www.jointcommission.org/Library/JCAHOnline/jo_06.06.htm; UNOS, Highlights of the June Board Meeting, 2006). DCD is defined as organ donation once death is declared after irreversible cessation of circulatory and respiratory functions, as oppo...
Source: Neurocritical Care - October 27, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Comparison of Hematoma Shape and Volume Estimates in Warfarin Versus Non-Warfarin-Related Intracerebral HemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Hematoma shape was not statistically significantly different in patients with OAT-ICH. Among bedside approaches, the standard ABC/2 method offers reasonable approximation of hematoma volume in OAT-ICH and non-OAT-ICH. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9296-7Authors Kevin N. Sheth, University of Maryland Medical Center Division of Neurology Baltimore MD USATracy A. Cushing, Mt. Auburn Hospital Department of Emergency Medicine Boston MA USALauren Wendell, Massachusetts General Hospital Department of Neurology Boston MA USAMichael H. Lev, Massachusetts...
Source: Neurocritical Care - October 27, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

How I Treat Patients with EEG Patterns on the Ictal–Interictal Continuum in the Neuro ICUEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Refractory status epilepticus (RSE) is associated with a high risk of poor outcome and treated by most neurointensivists with continuous intravenous antiepileptic medications (cIV-AEDs). Continuous EEG monitoring has allowed us to unveil a number of epileptiform patterns of less certain significance. These have been labeled ictal to interictal continuum (IIC), many of which are associated with poor outcome. It is unclear to which extent individual patterns are epiphenomena or lead to additional brain injury. The treatment of these patterns is highly controversial and guidelines how to manage them ar...
Source: Neurocritical Care - October 22, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Brain Tissue Oxygenation in Children Diagnosed With Brain DeathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Preliminary data from this study suggest that PbtO2 decreases to 0 mmHg when brain death occurs in children. Further study is needed to determine the limitations, and the sensitivity and specificity of this finding in a larger group of children. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9298-5Authors Anthony A. Figaji, University of Cape Town Cape Town South AfricaSamuel J. Kent, University of Aberdeen Aberdeen Scotland, UK Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN 1541-6933 (Source: Neurocritical Care)
Source: Neurocritical Care - October 22, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Acute Granulomatous Acanthamoeba Encephalitis in an Immunocompetent PatientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This case report demonstrates successful treatment of usually lethal GAE in an immunocompetent patient with high dose meropenem, linezolid, moxifloxacin and fluconazole followed by a partially adapted antimicrobial combination therapy. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9291-zAuthors Peter Lackner, Innsbruck Medical University Department of Neurology 6020 Innsbruck, Anichstrasse 35 Austria EuropeRonny Beer, Innsbruck Medical University Department of Neurology 6020 Innsbruck, Anichstrasse 35 Austria EuropeGregor Broessner, Innsbruck Medical University ...
Source: Neurocritical Care - October 22, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Atypical Acute Hemorrhagic Leukoencephalitis (Hurst’s disease) Presenting with Focal Hemorrhagic Brainstem LesionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions AHL may present as a solitary brainstem lesion with gross hemorrhage and should be considered in patients with isolated enhancing brainstem lesions. AHL may be fatal even despite early, aggressive immunomodulatory therapy. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9293-xAuthors Nuhad E. Abou Zeid, Department of Neurology, Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USAJoseph D. Burns, Department of Neurology, Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USAEelco F. M. Wijdicks, Department of Neurology, May...
Source: Neurocritical Care - October 22, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Role of Antiplatelet Agents in Hematoma Expansion During The Acute Period of Intracerebral HemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Patients reporting antiplatelet use experienced similar degrees of hematoma expansion compared to patients not reporting antiplatelet use. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9290-0Authors Michael Moussouttas, Thomas Jefferson Medical Center Division of Cerebrovascular and Critical Care Neurology 900 Walnut Street, Suite 200 Philadelphia PA 19107 USARishi Malhotra, Columbia University Medical Center Neurocritical Care Division New York NY USALuis Fernandez, Columbia University Medical Center Neurocritical Care Division New York NY USAMitchell Maltenfo...
Source: Neurocritical Care - October 21, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

How I Manage the Adult Potential Organ Donor: Donation After Neurological Death (Part 1)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes intensive care management practices that can optimize organ donation. Content Type Journal ArticleCategory Tell Me Something I Need to KnowDOI 10.1007/s12028-009-9292-yAuthors Jennifer A. Frontera, Mount Sinai School of Medicine New York NY USAThomas Kalb, Mount Sinai School of Medicine New York NY USA Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN 1541-6933 (Source: Neurocritical Care)
Source: Neurocritical Care - October 21, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Intracranial Venous Thrombosis After Placement of a Lumbar DrainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions When a lumbar drain is placed for treatment of a spinal CSF leak, the patient should remain flat in bed. Any patient with post-dural injury headache that intensifies after an initial plateau, persists for longer than a week, or loses its orthostatic character should be evaluated for intracranial sinus or venous thrombosis. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9278-9Authors Mitchell G. Miglis, New York University School of Medicine Department of Neurology, RIRM-311 400 East 34th Street New York NY 10016 USADavid N. Levine, New York University School of ...
Source: Neurocritical Care - October 16, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

International and Specialty Trends in the Use of Prophylactic Antibiotics to Prevent Infectious Complications after Insertion of External Ventricular Drainage DevicesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The use of antibiotics prophylaxis after EVD placement is disparate among specialties that deal with EVD placement and complications. There is no consistent practice pattern based on specialty, locale, and years of practice. The majority of all responders felt a prospective trial was warranted. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9284-yAuthors Paul J. McCarthy, Louisiana State University Health Sciences Center Department of Neurosurgery 1501 Kings Hwy Shreveport LA 71130 USAShashikant Patil, Louisiana State University Health Sciences Center Department...
Source: Neurocritical Care - October 16, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Effect of Shivering on Brain Tissue Oxygenation During Induced Normothermia in Patients With Severe Brain InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In patients with severe brain injury treated with induced normothermia, shivering was associated with a significant decrease of PbtO2, which correlated with the intensity of cooling. Monitoring of therapeutic cooling with computerized thermoregulatory systems may help prevent shivering and optimize the management of induced normothermia. The clinical significance of shivering-induced decrease in brain tissue oxygenation remains to be determined. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9280-2Authors Mauro Oddo, University of Pennsylvania Medical Center De...
Source: Neurocritical Care - October 10, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Correlation of Clinical Outcome with Pressure-, Oxygen-, and Flow-Related Indices of Cerebrovascular Reactivity in Patients Following Aneurysmal SAHEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Due to the low number of included subjects, the obtained results are preliminary. However, they indicate that either the present technique of index-determination is not sensitive enough or that there is no strong relation between the measured indices and clinical outcome. Future verification is required of continuous against already established non-continuous monitoring techniques of CR in order to relate both to clinical outcome. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9287-8Authors Martin Barth, Medical Faculty Mannheim of the Karl-Ruprecht-University...
Source: Neurocritical Care - October 9, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Cerebral Vasospasm and Concurrent Left Ventricular Outflow Tract Obstruction: Requirement for Modification of Hyperdynamic Therapy RegimenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Medical treatment for cerebral vasospasm with inotropic pressor agents may result in paradoxical decreases in hemodynamic parameters and cerebral perfusion in patients with LVOT obstruction. While HOCM is the most likely structural abnormality to cause this phenomenon, it can be induced by several physiological conditions encountered in the neurocritical care setting. Modifications in triple H therapy regimens may be required in order to optimize cerebral perfusion and prevent cerebral ischemia and stroke in these patients. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12...
Source: Neurocritical Care - October 9, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

One Thing Leads to Another: GBS Complicated by PRES and Takotsubo CardiomyopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The autonomic effects of GBS may cause a variety of reversible clinical syndromes associated with sympathetic dysfunction including PRES and takotsubo cardiomyopathy; both of which are self-limited. Relative hypotension in GBS may be caused in part by neurogenic stunned myocardium. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9279-8Authors Jennifer E. Fugate, Mayo Clinic Department of Neurology 200 First Street SW Rochester MN 55905 USAEelco F. Wijdicks, Mayo Clinic Department of Neurology 200 First Street SW Rochester MN 55905 USAGautam Kumar, Mayo Clinic Dep...
Source: Neurocritical Care - October 8, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Neurocritical Care Society 7th Annual MeetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s12028-009-9282-0 Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN 1541-6933 (Source: Neurocritical Care)
Source: Neurocritical Care - October 8, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Prevalence and Characterization of ECG Abnormalities After Intracerebral HemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In ICH patients ECG abnormalities are common. QTc prolongation seems associated with insular cortex involvement, with the presence of intraventricular blood, and with hydrocephalus. A larger cohort of continuously monitored ICH patients is necessary to investigate whether these ECG abnormalities are associated with poor outcome or death. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9283-zAuthors Maurits D. R. van Bree, Academic Medical Centre Amsterdam Department of Neurology Meibergdreef 9 1105 AZ Amsterdam The NetherlandsYvo B. W. E. M. Roos, Academic Medic...
Source: Neurocritical Care - October 8, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Electroconvulsive Therapy for Refractory Status Epilepticus: A Case SeriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion ECT may be an effective therapy for refractory status epilepticus and warrants further study for this indication. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9288-7Authors Hooman Kamel, University of California Department of Neurology 505 Parnassus Ave Box 0114 San Francisco CA 94143 USASusannah Brock Cornes, University of California Department of Neurology 505 Parnassus Ave Box 0114 San Francisco CA 94143 USAManu Hegde, University of California Department of Neurology 505 Parnassus Ave Box 0114 San Francisco CA 94143 USAStephen E. Hall, University of Californi...
Source: Neurocritical Care - October 7, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Cerebral Autoregulation is Influenced by Carbon Dioxide Levels in Patients with Septic ShockEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions According to these data, CA is impaired in the majority of patients with septic shock, especially in the presence of hypercapnia. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9289-6Authors Fabio Silvio Taccone, Erasme University Hospital, Université Libre de Bruxelles (ULB) Department of Intensive Care Route de Lennik, 808 1070 Brussels BelgiumDiego Castanares-Zapatero, Erasme University Hospital, Université Libre de Bruxelles (ULB) Department of Intensive Care Route de Lennik, 808 1070 Brussels BelgiumDaliana Peres-Bota, Erasme University Hospital, Universit...
Source: Neurocritical Care - October 6, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Arginine-Vasopressin V1 but not V2 Receptor Antagonism Modulates Infarct Volume, Brain Water Content, and Aquaporin-4 Expression Following Experimental StrokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These data demonstrate that following experimental stroke AVP V1 receptor antagonism: (1) attenuates injury volume and ischemia-evoked cerebral edema; (2) modulates AQP4 expression; and (3) may serve as an important therapeutic target for neuroprotection and ischemia-evoked cerebral edema. Content Type Journal ArticleCategory Translational ResearchDOI 10.1007/s12028-009-9277-xAuthors Xiaoqin Liu, Oregon Health & Science University Department of Anesthesiology and Peri-Operative Medicine Portland OR USAShin Nakayama, Oregon Health & Science University Department of Anesthesiology and Peri-Op...
Source: Neurocritical Care - October 6, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Acute Coagulopathy in Isolated Blunt Traumatic Brain InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Coagulopathy upon ER admission is frequent after isolated blunt TBI and represents a powerful, independent predictor related to prognosis. Future research should aim to determine the beneficial effects of early treatment of TBI-associated coagulopathy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9281-1Authors Arasch Wafaisade, University of Witten/Herdecke, Cologne-Merheim Medical Center (CMMC) Department of Trauma and Orthopedic Surgery Ostmerheimerstr. 200 51109 Cologne GermanyRolf Lefering, University of Witten/Herdecke, Cologne-Merheim Medical Center (CMMC...
Source: Neurocritical Care - October 6, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Ventilator-Associated Pneumonia in a Neurologic Intensive Care Unit Does Not Lead to Increased MortalityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions VAP in neurocritical care patients is associated with increased LOS and ventilator hours, but is not associated with increased mortality, contrary to prior studies in medical ICU patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9285-xAuthors S. Andrew Josephson, University of California San Francisco Department of Neurology Box 0114 505 Parnassus Avenue; M-798 San Francisco CA 94143-0114 USAAsma M. Moheet, University of California San Francisco Department of Neurology Box 0114 505 Parnassus Avenue; M-798 San Francisco CA 94143-0114 USAMichael A. Gropper,...
Source: Neurocritical Care - October 6, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Revascularization of Onyx Induced Intra-Operative Occlusion of Vertebro-Basilar Artery Using the Merci DeviceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Reflux embolization of patent vessels is a rare complication of using Onyx to treat AVMs. It can be successfully managed by retrieving the Onyx substance using mechanical retrieval devices like the Merci device. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9272-2Authors Shon G. Michael, Upstate Medical University Department of Neurology, 7135 University Hospital 750 East Adams Street Syracuse NY 13210 USAAmar S. Swarnkar, Upstate Medical University Department of Radiology, University Hospital Syracuse NY USAJulius Gene S. Latorre, Upstate Medical University Depa...
Source: Neurocritical Care - September 24, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Efficiency and Safety of a Standardized Protocol for Intravenous Insulin Therapy in ICU Patients with Neurovascular or Head InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The intravenous insulin infusion protocol improved the safety and efficiency of glycemic control for ICU patients with neurovascular or head injury. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9275-zAuthors Salmaan Kanji, The Ottawa Hospital Department of Pharmacy 501 Smyth Rd Ottawa ON K1H 8L6 CanadaErika Jones, The Ottawa Hospital Department of Pharmacy 501 Smyth Rd Ottawa ON K1H 8L6 CanadaRob Goddard, The Ottawa Hospital Department of Pharmacy 501 Smyth Rd Ottawa ON K1H 8L6 CanadaHilary E. Meggison, The Ottawa Hospital Departments of Endocrinology and Meta...
Source: Neurocritical Care - September 24, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Factors Associated with the Development of Anemia After Subarachnoid HemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions It may be possible to predict those most likely to develop anemia using simple baseline clinical variables. Anemia was strongly related to surgery, likely through greater blood loss, and greater systemic inflammatory response on admission, possibly explained by cytokine-mediated inhibition of RBC production. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9273-1Authors Tomoko R. Sampson, Washington University School of Medicine Department of Neurology 660 S. Euclid Ave, Campus Box 8111 Saint Louis MO 63110 USARajat Dhar, Washington University School of Medicine ...
Source: Neurocritical Care - September 24, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Clinical Presentation and Long-Term Outcome of Cerebral Venous ThrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The demographics, clinical presentation, imaging findings, and risk factors in this large North American cohort of CVT patients strongly support the observations of previous European case series. In addition, the favorable long-term outcome and recanalization rates observed lend further support to the safety and efficacy of acute heparin therapy for the treatment of symptomatic CVT (irrespective of the presence of ICH). Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9234-8Authors Joey D. English, University of California, San Francisco Department of Neurology ...
Source: Neurocritical Care - September 24, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Polyneuropathy Associated with Cholesterol Crystal EmbolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The clinical presentation indicates a direct association of cholesterol crystal embolism and polyneuropathy. Although cholesterol crystal embolism represents a rare cause of polyneuropathy, it should be considered in patients with acute onset polyneuropathy and sudden onset multiorgan disease after arterial catheterization. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9233-9Authors Matthias Klein, University Hospital Munich-Grosshadern, Ludwig-Maximilian University Department of Neurology Marchioninistr. 15 81377 Munich GermanyB. Hartmann, University Hospital M...
Source: Neurocritical Care - September 24, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Immunomodulatory Therapies in Neurologic Critical CareEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions There is good evidence for the efficacy and tolerability of immunomodulatory therapies in GBS, myasthenia gravis, and acute central nervous system demyelination, though data to establish superiority of one therapeutic regimen over another remains lacking. For most other conditions, the data for immunomodulatory therapies are limited, and further research is required. Content Type Journal ArticleCategory ReviewDOI 10.1007/s12028-009-9274-0Authors Logan M. McDaneld, Oregon Health & Science University Departments of Neurology Portland OR USAJeremy D. Fields, Oregon Health & Science University...
Source: Neurocritical Care - September 24, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

High-Mobility Group Box 1 Protein in CSF of Patients with Subarachnoid HemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions HMGB1 was increased in the CSF of SAH patients with an unfavorable outcome, as were the other cytokines. These results suggest that HMGB1 and cytokines are related to the brain damage observed after SAH. HMGB1 might play a key role in the inflammatory response in the CNS of SAH patients. Content Type Journal ArticleDOI 10.1007/s12028-009-9276-yAuthors Takashi Nakahara, Yamaguchi University Hospital Advanced Medical Emergency and Critical Care Center 1-1-1 Minamikogushi Ube Yamaguchi JapanRyosuke Tsuruta, Yamaguchi University Hospital Advanced Medical Emergency and Critical Care Center 1-1-...
Source: Neurocritical Care - September 24, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Quantitative EEG Correlates of Low Cerebral Perfusion in Severe StrokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Despite considerable changes in baseline activity due to deep sedation and severe brain injury, we found evidence for disturbed neuronal function during drops in CPP. Thus, continuous EEG monitoring may add clinically relevant information on neuronal function in the setting of multimodality brain monitoring. Further studies are needed to implement real-time data analysis in the ICU setting. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9236-6Authors Jennifer Diedler, University of Heidelberg Department of Neurology Im Neuenheimer Feld 400 69120 Heidelberg Germ...
Source: Neurocritical Care - September 3, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Prolonged Hypothermia as a Bridge to Recovery for Cerebral Edema and Intracranial Hypertension Associated with Fulminant Hepatic FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In patients with FHF and cerebral edema from acetaminophen overdose, prolonged therapeutic hypothermia could potentially be used as a life saving therapy and a bridge to hepatic and neurological recovery. A clinical trial of hypothermia in patients with this condition is warranted. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9266-0Authors Shibin Jacob, The Medical College of Wisconsin Division of Pulmonary and Critical Care Medicine 9200 West Wisconsin Ave. Milwaukee WI 53226 USAAhmed Khan, The Medical College of Wisconsin Division of Pulmonary and Critical Ca...
Source: Neurocritical Care - September 3, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

CNS Immune Responses Following Experimental StrokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These data show that LPS, but not other inflammatory stimuli, increase the likelihood of developing a detrimental autoimmune response to an array of brain antigens. Content Type Journal ArticleCategory Translational ResearchDOI 10.1007/s12028-009-9270-4Authors Dannielle Zierath, University of Washington School of Medicine, Harborview Medical Center Department of Neurology Box 359775 HMC 325 9th Ave Seattle WA 98104-2499 USAMatthew Thullbery, University of Washington School of Medicine, Harborview Medical Center Department of Neurology Box 359775 HMC 325 9th Ave Seattle WA 98104-2499 USAJess...
Source: Neurocritical Care - August 28, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Decompressive Craniectomy in Aneurysmal Subarachnoid Hemorrhage: Relation to Cerebral Perfusion Pressure and MetabolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Outcome was poor in all SAH patients with intracranial hypertension. Although glucose utilization was improved after DC, no improvement in outcome could be shown for this small patient population. Future studies will have to demonstrate whether markers of cerebral crisis may support the decision for DC in aneurysmal SAH patients. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s12028-009-9269-xAuthors Alexandra Nagel, Charité - Universitätsmedizin Berlin Department of Neurosurgery Berlin GermanyDaniela Graetz, Charité - Universitätsmedizin Berlin Department of Neurosurg...
Source: Neurocritical Care - August 28, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Is Platelet Activity Important in Acute Intracerebral Hemorrhage?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s12028-009-9271-3Authors Christine A. C. Wijman, Stanford University Medical Center, Stanford Stroke Center Department of Neurology and Neurological Sciences 701 Welch Road, B325 Palo Alto CA 94304 USA Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN 1541-6933 (Source: Neurocritical Care)
Source: Neurocritical Care - August 28, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Favorable Outcome From A Locked-In State Despite Extensive Pontine Infarction By MRIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Patients who are in a locked-in state may have substantial functional recovery despite DWI evidence of extensive pontine infarction. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9268-yAuthors Edgar Andres Samaniego, Stanford Stroke Center 701 Welch Road, Bldg B, Ste 325 Palo Alto CA 94304-1702 USAMaarten G. Lansberg, Stanford Stroke Center 701 Welch Road, Bldg B, Ste 325 Palo Alto CA 94304-1702 USAMichael DeGeorgia, Stanford Stroke Center 701 Welch Road, Bldg B, Ste 325 Palo Alto CA 94304-1702 USAChitra Venkatasubramanian, Stanford Stroke Center 701 Welch Road, B...
Source: Neurocritical Care - August 26, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Vasospasm and Statin Therapy: Yet Another Cautionary TaleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Spanning The GlobeDOI 10.1007/s12028-009-9267-zAuthors Alejandro A. Rabinstein, Mayo Clinic College of Medicine Division of Critical Care Neurology, Department of Neurology, W8B 200 First Street SW Rochester MN 55905 USA Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN 1541-6933 (Source: Neurocritical Care)
Source: Neurocritical Care - August 26, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Bedside Ultrasound Screening for Pretracheal Vascular Structures May Minimize the Risks of Percutaneous Dilatational TracheostomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Bedside ultrasound screening allows for easy identification of pretracheal vascular structures that might pose a hemorrhage risk during PDT. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9259-zAuthors Alexander C. Flint, Kaiser Permanente Neurocritical Care and Pulmonary Critical Care, Head and Neck Surgery 1150 Veterans Blvd Redwood City CA 94063 USARaghu Midde, Kaiser Permanente Neurocritical Care and Pulmonary Critical Care, Head and Neck Surgery 1150 Veterans Blvd Redwood City CA 94063 USAVivek A. Rao, Kaiser Permanente Neurocritical Care and Pulmonary Critic...
Source: Neurocritical Care - August 19, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Intracranial Hemorrhage Following Thrombolytic Use for Stroke Caused by Infective EndocarditisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Infective endocarditis related strokes are associated with a higher risk of hemorrhagic complications and our experience suggests that IV t-PA use may potentiate that risk. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9253-5Authors Parita Bhuva, Baylor College of Medicine Department of Neurology 6550 Fannin, Suite 1801 Houston TX 77030 USASheng-Han Kuo, Baylor College of Medicine Department of Neurology 6550 Fannin, Suite 1801 Houston TX 77030 USAJ. Claude Hemphill, University of California San Francisco Department of Neurology San Francisco CA USAGeorge A. Lope...
Source: Neurocritical Care - August 18, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Imaging Findings in Pyogenic VentriculitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Neuroimaging is crucial in clearly depicting pyogenic ventriculitis. A contrast-enhanced CT scan, but especially MR imaging, is an ideal tool to reliably diagnose this life-threatening cerebral infection. Content Type Journal ArticleCategory NeuroimageDOI 10.1007/s12028-009-9263-3Authors Philippe G. Jorens, University of Antwerp Department of (neurological) Critical Care Medicine, Antwerp University Hospital Wilrijkstraat 10 B-2650 Edegem BelgiumMaurits H. Voormolen, University of Antwerp Department of Radiology, Antwerp University Hospital Edegem BelgiumDominique Robert, University of Antwe...
Source: Neurocritical Care - August 18, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Relationship Between Increases in Pancreatic Enzymes and Cerebral Events in Children After Traumatic Brain InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Increases in PE, often used as the only measures of pancreatitis in children with other severe injuries, are common in children after severe TBI and delayed presentation appears related to intracranial events. This suggests a possible interaction between the brain and the gastrointestinal system, implying that disturbances in cerebral hemodynamics may lead to pancreatic dysfunction. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9265-1Authors Joan Sanchez de Toledo, University of Pittsburgh Department of Critical Care Medicine Pittsburgh PA USAP. David Adelson,...
Source: Neurocritical Care - August 11, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Is Daily Awakening Always Safe in Severely Brain Injured Patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s12028-009-9262-4Authors Raimund Helbok, Columbia University Division of Critical Care Neurology, Department of Neurology, Milstein Hospital 8 Center 177 Fort Washington Ave New York NY 10032 USANeeraj Badjatia, Columbia University Division of Critical Care Neurology, Department of Neurology, Milstein Hospital 8 Center 177 Fort Washington Ave New York NY 10032 USA Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN 1541-6933 (Source: Neurocritical Care)
Source: Neurocritical Care - August 9, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Multimodality Neuromonitoring and Decompressive Hemicraniectomy After Subarachnoid HemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Delayed rescue hemicraniectomy can be life-saving after poor grade SAH. The role of multimodality brain monitoring for determining the optimal timing of hemicraniectomy deserves further study. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9264-2Authors Robert Morgan Stuart, Columbia University College of Physicians and Surgeons Department of Neurological Surgery New York NY 10032 USAJan Claassen, Columbia University College of Physicians and Surgeons Division of Critical Care Neurology, Department of Neurology New York NY 10032 USAMichael Schmidt, Columbia Unive...
Source: Neurocritical Care - August 9, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Continuous Electroencephalography in the Medical ICUEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Spanning The GlobeDOI 10.1007/s12028-009-9260-6Authors Alejandro A. Rabinstein, Mayo Clinic College of Medicine Division of Critical Care Neurology, Department of Neurology, W8B 200 First Street SW Rochester MN 55905 USA Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN 1541-6933 (Source: Neurocritical Care)
Source: Neurocritical Care - August 6, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Elucidating the Value of Continuous Brain Oxygen MonitoringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Spanning The GlobeDOI 10.1007/s12028-009-9261-5Authors Alejandro A. Rabinstein, Mayo Clinic College of Medicine Division of Critical Care Neurology–Department of Neurology 200 First Street SW Rochester MN 55905 USA Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN 1541-6933 (Source: Neurocritical Care)
Source: Neurocritical Care - August 6, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals