Changes in Visual Long-term Potentiation Show Preserved Cyclicity in Human Females Taking Combined Oral Contraceptives
Conclusion s: This study provides objective evidence of preserved cyclicity in COC users through enhanced LTP on day 21 compared to day 3 of a 28-day COC regimen, indicating that relatively higher excitation in the brain despite peripheral gonadal suppression may underlie and exacerbate menstrual cycle-related disorders. (Source: Neuroendocrinology)
Source: Neuroendocrinology - April 24, 2023 Category: Endocrinology Source Type: research
Alpha-melanocyte-stimulating hormone-mediated appetite regulation in the central nervous system
Understanding the complex action mechanism of appetite regulation peptides can significantly impact therapeutic options in the treatment of obesity and other metabolic diseases. Hypothalamic α-melanocyte-stimulating hormone (α-MSH) is an anorexigenic peptide, closely related to the occurrence of obesity, playing a central role in food intake and energy expenditure. In the central nervous system (CNS), α-MSH is cleaved from proopiomelanocortin (POMC) and then released into different h ypothalamic regions to act on melanocortin 3/4 receptor (MC3/4R)-expressing neurons, lowering food intake and raising energy expenditure v...
Source: Neuroendocrinology - April 24, 2023 Category: Endocrinology Source Type: research
Prognostic Value of SSTR-derived Volumetric Parameters from a Hybrid Standardized Uptake Value Thresholding Method in Patients with 68Ga-DOTATATE-avid Stage IV Neuroendocrine Neoplasms: A preliminary study
Introduction: The ability of PET/CT imaging to delineate neuroendocrine neoplasms (NENs) and predict prognosis in affected patients is often compromised by substantial uptake heterogeneity. We hereby proposed a hybrid standardized uptake value (SUV) thresholding algorithm to extract volumetric parameters from somatostatin receptor (SSTR) PET/CT imaging, and investigate their prognostic performance in patients with 68Ga-DOTATATE-avid stage IV NENs.
Methods: For 38 retrospectively enrolled patients, we used either fixed SUV thresholding of normal liver parenchyma (method A), 41% of the SUVmax for each lesion (method B), or ...
Source: Neuroendocrinology - April 21, 2023 Category: Endocrinology Source Type: research
Cortexin ® Ameliorates High Glucose-Induced Neuropathy in Cultured Rat Sensory Neurons
Introduction: The aim of this study was to investigate whether Cortexin ®, a brain peptide containing agent, has any mitigating effect on high glucose-induced neuropathy using primary cultured rat sensory neurons.
Materials and Methods: Dorsal root ganglia (DRG) were excised from decapitated adult rats. Individual neurons were isolated following enzymatic and mechanica l procedures. Cells were seeded on E-Plate® with gold microelectrodes, and maintained in conventional culture media in a CO2 incubator at 37 ºC. After allowing for 24 hours for cell adhesion and recovery from acute enzymatic trauma, neurons were exposed t...
Source: Neuroendocrinology - April 20, 2023 Category: Endocrinology Source Type: research
Variant in the dopamine-4-receptor gene (DRD4) in patients with type 1 diabetes
Conclusion
Our data imply that the dopaminergic signaling pathways may play an important role in the etiology of DM1 as well as its comorbidities and will provide a new insight into the DM1 risk management. The -521C>T DRD4 gene polymorphism could be considered a genetic marker to predict susceptibility to DM1 as well as retinopathy and dyslipidemia progress in patients with already established disease. (Source: Neuroendocrinology)
Source: Neuroendocrinology - April 20, 2023 Category: Endocrinology Source Type: research
Glucocorticoids and Water Balance: Implications for Hyponatremia Management and Pituitary Surgery
Water balance is fundamental to all homeostasis. The hypothalamic pituitary adrenal (HPA) axis influences water balance through the effects of corticotropin releasing hormone (CRH) and cortisol on arginine vasopressin (AVP) secretion, and the peripheral effects of cortisol on hemodynamic and renal water handling. In this review, we explore the complex interplay of glucocorticoids with water balance, with particular attention to hyponatremia and pituitary surgery. (Source: Neuroendocrinology)
Source: Neuroendocrinology - April 15, 2023 Category: Endocrinology Source Type: research
Sex Differences in Cocaine Sensitization Vary by Mouse Strain
Conclusions: While sex differences in drug addiction may be observed, these effects can be mitigated, or even reversed, dependent on genetic background. The clinical implications being that absent of understanding the genetic variables underlying vulnerability to addiction, sex provides little information regarding the predisposition of an individual to drug abuse. (Source: Neuroendocrinology)
Source: Neuroendocrinology - April 11, 2023 Category: Endocrinology Source Type: research
The Effects of Chronic Asprosin Administration on Sense of Smell and Sexual Behavior in Female Rats
Conclusion
These data suggest that chronic administration of asprosin can result in increased sexual incentive motivation for opposite-sex in female rats over increased olfactory performance and changes in reproductive hormones. (Source: Neuroendocrinology)
Source: Neuroendocrinology - April 11, 2023 Category: Endocrinology Source Type: research
MiRNA-383 AND MiRNA-384 SUPPRESS PROOPIOMELANOCORTIN GENE EXPRESSION IN THE HYPOTHALAMUS: EFFECTS OF EARLY LIFE ETHANOL EXPOSURE
Conclusion: These data suggest that miR-383 and miR-384 suppress Pomc gene expression and may contribute to the ethanol-induced alteration of the stress axis functions. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 22, 2023 Category: Endocrinology Source Type: research
Second primary malignancies in patients with a neuroendocrine neoplasm in England
Conclusion
This study found that patients with a NEN experienced a metachronous tumour of the lung, prostate, kidney, colon and thyroid at a higher rate than the general population of England. Surveillance and engagement in existing scree ning programmes is required to enable earlier diagnosis of second non-NEN tumours in these patients. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 20, 2023 Category: Endocrinology Source Type: research
Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice
Conclusion: This study revealed various changes in CRFR1 across the postpartum period, which may contribute to stress-related behavior changes in postpartum mice. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 14, 2023 Category: Endocrinology Source Type: research
Changes in corticotropin releasing factor receptor type 1, co-expression with tyrosine hydroxylase and oxytocin neurons, and anxiety-like behaviors across the postpartum period in mice
Conclusion: This study revealed various changes in CRFR1 across the postpartum period, which may contribute to stress-related behavior changes in postpartum mice. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 14, 2023 Category: Endocrinology Source Type: research
Chromosome 18 loss of heterozygosity in small intestinal neuroendocrine tumours: Multi-omic and tumour composition analyses
Conclusions: We identify a small number of genes which appear to be linked to the 18LOH status of siNETs, and find evidence of potential epigenetic dysregulation of these genes. We also find a potential prognostic marker for worse progression free outcomes in the form of higher CD14 infiltration in non-18LOH siNETs. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 10, 2023 Category: Endocrinology Source Type: research
Estradiol Enhances the Development of Addiction-Like Features in a Female Rat Model of Opioid Use Disorder
Conclusion: These results indicate that, as with findings with psychostimulants and alcohol, estradiol enhances vulnerability in females to developing opioid addiction-like features and serious opioid-related health complications. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 6, 2023 Category: Endocrinology Source Type: research
Estradiol Enhances the Development of Addition-Like Features in a Female Rat Model of Opioid Use Disorder
Conclusion: These results indicate that, as with findings with psychostimulants and alcohol, estradiol enhances vulnerability in females to developing opioid addiction-like features and serious opioid-related health complications. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 6, 2023 Category: Endocrinology Source Type: research
