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CalendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Tags: DEPARTMENTS Source Type: journals

Incidental mri anomalies suggestive of multiple sclerosis: the radiologically isolated syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Moore, F., Okuda, D. T. Tags: CORRESPONDENCE Source Type: journals

Migraine and suicidal ideation in adolescents aged 13 to 15 yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Parisi, P., Wang, S.-J., Fuh, J.-L., Juang, K.-D., Lu, S.-R. Tags: CORRESPONDENCE Source Type: journals

Voluntary brain processing in disorders of consciousnessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Derakhshan, I., Schnakers, C., Laureys, S. Tags: CORRESPONDENCE Source Type: journals

Warm and cold complex regional pain syndromes: differences beyond skin temperature?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Bruggeman, A. W.A., Oerlemans, M. H., Frolke, J. P. M., Eberle, T., Birklein, F. Tags: CORRESPONDENCE Source Type: journals

Suicidality, depression screening, and antiepileptic drugs: reaction to the fda alertEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Janati, A., Shneker, B. F., Cios, J. S., Elliott, J. O. Tags: CORRESPONDENCE Source Type: journals

Extrapyramidal signs are a common feature of spinocerebellar ataxia type 17Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Lee, W. -W., Kim, S. Y., Kim, J. Y., Kim, H. J., Park, S. S., Jeon, B. S. Tags: Dystonia, Parkinson's disease/Parkinsonism, Chorea, Spinocerebellar ataxia CLINICAL/SCIENTIFIC NOTES Source Type: journals

Neurosurgical treatment of tremor in anti-myelin-associated glycoprotein neuropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: McMaster, J., Gibson, G., Castro-Prado, F., Vitali, A., Honey, C. R. Tags: All Movement Disorders, Tremor, Peripheral neuropathy, Class IV, All Demyelinating disease (CNS) CLINICAL/SCIENTIFIC NOTES Source Type: journals

Hiv-related immune reconstitution cryptococcal meningoradiculitis: corticosteroid responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Brunel, A., Makinson, A., de Champfleur, N. M., Thouvenot, E., Le Moing, V., Lefalher, G., Bonafe, A., Reynes, J. Tags: MRI, Meningitis, Fungal infections, HIV, Spinal cord infection CLINICAL/SCIENTIFIC NOTES Source Type: journals

The locus ceruleus norepinephrine system: Functional organization and potential clinical significanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Benarroch, E. E. Tags: CLINICAL IMPLICATIONS OF NEUROSCIENCE RESEARCH Source Type: journals

Smoking may be considered an established risk factor for sporadic ALSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Smoking may be considered an established risk factor for sporadic amyotrophic lateral sclerosis (ALS) (level A rating; 3 class II studies, 1 class III study). Evidence-based analysis of epidemiologic data shows concordance among results of better-designed studies linking smoking to ALS, and lets those results drive the conclusions. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Armon, C. Tags: Amyotrophic lateral sclerosis, Risk factors in epidemiology VIEWS AND REVIEWS Source Type: journals

Study of 962 patients indicates progressive muscular atrophy is a form of ALSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although patients with progressive muscular atrophy (PMA) tended to live longer than those with amyotrophic lateral sclerosis (ALS), shorter survival in PMA is associated with the same risk factors that predict poor survival in ALS. Additionally, PMA is relentlessly progressive, and UMN involvement can occur, as also reported in imaging and postmortem studies. For these reasons, PMA should be considered a form of ALS. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Kim, W. -K., Liu, X., Sandner, J., Pasmantier, M., Andrews, J., Rowland, L. P., Mitsumoto, H. Tags: MRS, Anterior nerve cell disease, Amyotrophic lateral sclerosis, Class III, Cohort studies ARTICLES Source Type: journals

Lower serum lipid levels are related to respiratory impairment in patients with ALSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings do not support the observation that patients with amyotrophic lateral sclerosis have hyperlipidemia or that hyperlipidemia in this population is related to longer survival. However, some evidence emerged that respiratory impairment, but not a worse clinical status or a lower body mass index, is related to a decrease in blood lipids and LDL/HDL ratio. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Chio, A., Calvo, A., Ilardi, A., Cavallo, E., Moglia, C., Mutani, R., Palmo, A., Galletti, R., Marinou, K., Papetti, L., Mora, G. Tags: Amyotrophic lateral sclerosis ARTICLES Source Type: journals

Bevacizumab for recurrent ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The radiographic response rate to bevacizumab-containing regimens is high. A prospective study is warranted. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Green, R. M., Cloughesy, T. F., Stupp, R., DeAngelis, L. M., Woyshner, E. A., Ney, D. E., Lassman, A. B. Tags: All Oncology, Primary brain tumor, Spinal cord tumor, Chemotherapy-tumor ARTICLES Source Type: journals

History of falls in Parkinson disease is associated with reduced cholinergic activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Unlike nigrostriatal dopaminergic denervation, cholinergic hypofunction is associated with fall status in Parkinson disease (PD). Thalamic AChE activity in part represents cholinergic output of the pedunculopontine nucleus (PPN), a key node for gait control. Our results are consistent with other data indicating that PPN degeneration is a major factor leading to impaired postural control and gait dysfunction in PD. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Bohnen, N. I., Muller, M. L.T.M., Koeppe, R. A., Studenski, S. A., Kilbourn, M. A., Frey, K. A., Albin, R. L. Tags: PET, Parkinson's disease/Parkinsonism, Motor Control ARTICLES Source Type: journals

Safety and tolerability of putaminal AADC gene therapy for Parkinson diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study provides class IV evidence that bilateral intrastriatal infusion of adeno-associated viral type 2 vector containing the human AADC gene improves mean scores on the Unified Parkinson’s Disease Rating Scale by approximately 30% in the on and off states, but the surgical procedure may be associated with an increased risk of intracranial hemorrhage and self-limited headache. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Christine, C. W., Starr, P. A., Larson, P. S., Eberling, J. L., Jagust, W. J., Hawkins, R. A., VanBrocklin, H. F., Wright, J. F., Bankiewicz, K. S., Aminoff, M. J. Tags: PET, Parkinson's disease/Parkinsonism, Gene therapy ARTICLES Source Type: journals

Determinants of survival in behavioral variant frontotemporal dementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients with definite frontotemporal dementia have a poor prognosis which is worse if language deficits are also present. This contrasts with the extremely good outcome in those with the phenocopy syndrome: of our 24 patients only 1 has died (of coincident pathology) despite, in some cases, many years of follow-up. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Garcin, B., Lillo, P., Hornberger, M., Piguet, O., Dawson, K., Nestor, P. J., Hodges, J. R. Tags: Prognosis, Frontotemporal dementia ARTICLES Source Type: journals

Cortical event-related potentials in preclinical familial Alzheimer diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Auditory sensory and cognitive cortical potentials in persons with familial Alzheimer disease (FAD) mutations are abnormal approximately 10 years before dementia will be manifest. Longer event-related potential latencies suggest slowing of cortical information processing in FAD mutation carriers. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Golob, E. J., Ringman, J. M., Irimajiri, R., Bright, S., Schaffer, B., Medina, L. D., Starr, A. Tags: Memory, Alzheimer's disease, Evoked Potentials/Auditory, Assessment of cognitive disorders/dementia, MCI (mild cognitive impairment) ARTICLES Source Type: journals

Teaching NeuroImages: Acute hemorrhagic leukoencephalitis after mumpsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Kumar R., S., Kuruvilla, A. Tags: MRI, DWI, All Infections, Post-infectious, Acute disseminated encephalomyelitis RESIDENT AND FELLOW SECTION Source Type: journals

Teaching Video NeuroImages: Wernicke encephalopathy without mental status changesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: MacDonald, R. J., Stanich, P. P., Monrad, P. A., Mateen, F. J. Tags: Nutritional, Ocular motility, All Education RESIDENT AND FELLOW SECTION Source Type: journals

Impaired kidney function and cerebral microbleeds in patients with acute ischemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Impaired kidney function is associated with the presence of cerebral microbleeds in acute ischemic stroke. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Cho, A. -H., Lee, S. B., Han, S. J., Shon, Y. -M., Yang, D. -W., Kim, B. S. Tags: All Cerebrovascular disease/Stroke ARTICLES Source Type: journals

Rapid appearance of new cerebral microbleeds after acute ischemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study suggests that new microbleeds (MBs) can develop rapidly after acute ischemic stroke. Baseline MBs and severe small vessel disease are predictors for the development of new MBs. Further studies will be needed to investigate the clinical implications and mechanisms of these findings. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Jeon, S. -B., Kwon, S. U., Cho, A. -H., Yun, S. -C., Kim, J. S., Kang, D. -W. Tags: MRI, All Cerebrovascular disease/Stroke, Infarction ARTICLES Source Type: journals

Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This consistency of pathologic findings and uniformity of courses indicates that aquaporin 4–specific autoantibodies as the initiator of the neuromyelitis optica (NMO) lesion consistently play an important common role in the pathogenicity through the entire course, consisting of both limited and definite forms, and NMO continuously displays homogeneity of pathogenic effector immune mechanisms through terminal stages, whereas multiple sclerosis should be recognized as the heterogeneous 2-stage disease that could switch from inflammatory to degenerative phase. This report is a significant description compar...
Source: Neurology - November 16, 2009 Category: Neurology Authors: Yanagawa, K., Kawachi, I., Toyoshima, Y., Yokoseki, A., Arakawa, M., Hasegawa, A., Ito, T., Kojima, N., Koike, R., Tanaka, K., Kosaka, T., Tan, C. -F., Kakita, A., Okamoto, K., Tsujita, M., Sakimura, K., Takahashi, H., Nishizawa, M. Tags: All Immunology, All Spinal Cord, Multiple sclerosis, Devic's syndrome ARTICLES Source Type: journals

Poor PASAT performance correlates with MRI contrast enhancement in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Paced Auditory Serial Addition Test performance is affected by the appearance of Gd enhancement as surrogate marker of inflammatory activity in otherwise physically stable patients with multiple sclerosis, which may indicate that Gd enhancement causes a diffuse impairment of cerebral connectivity with a negative impact on cognitive functioning. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Bellmann-Strobl, J., Wuerfel, J., Aktas, O., Dorr, J., Wernecke, K. D., Zipp, F., Paul, F. Tags: MRI, Multiple sclerosis ARTICLES Source Type: journals

Impact of multiple sclerosis relapses on progression diminishes with timeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Relapses within the first 5 years of disease impacted on disease progression over the short term. However, the long-term impact was minimal, either for early or later relapses. Long-term disease progression was least affected by relapses in patients with an extended disease duration (>10 years) or already in the secondary progressive phase. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Tremlett, H., Yousefi, M., Devonshire, V., Rieckmann, P., Zhao, Y., On behalf of the UBC Neurologists Tags: Multiple sclerosis, Cohort studies, Natural history studies (prognosis), Risk factors in epidemiology ARTICLES Source Type: journals

Red meets white: Do microbleeds link hemorrhagic and ischemic cerebrovascular disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Kidwell, C. S., Greenberg, S. M. Tags: MRI, All Cerebrovascular disease/Stroke, Infarction EDITORIALS Source Type: journals

Relapses in multiple sclerosis: Important or not?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Marrie, R. A., Cutter, G. Tags: Multiple sclerosis EDITORIALS Source Type: journals

This week in Neurology(R): Highlights of the November 17 issueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Tags: THIS WEEK IN NEUROLOGY Source Type: journals

CalendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Tags: DEPARTMENTS Source Type: journals

Normal and mutant HTT interact to affect clinical severity and progression in Huntington diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Tags: CORRECTIONS Source Type: journals

Factors associated with resistance to dementia despite high alzheimer disease pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Fotuhi, M., Hachinski, V., Kivipelto, M., Whitehouse, P., Erten-Lyons, D., Kaye, J. Tags: CORRESPONDENCE Source Type: journals

Corpus callosum dysgenesis limits mri changes to one hemisphere in status epilepticusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Janati, A., DeGeorgia, M., Grommes, C. Tags: CORRESPONDENCE Source Type: journals

Neuropathic pruritus following wallenberg syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Oaklander, A. L., Seo, W.-K., Ho Park, M. Tags: CORRESPONDENCE Source Type: journals

Posterior reversible encephalopathy syndrome in neuromyelitis optica spectrum disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Ito, S., Weinshenker, B. G., Magana, S. M., Matiello, M., Rabinstein, A. A. Tags: CORRESPONDENCE Source Type: journals

Reflections for NovemberEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Botwinick, I. Tags: REFLECTIONS: NEUROLOGY AND THE HUMANITIES Source Type: journals

CONGENITAL MUSCULAR DYSTROPHY WITH DEFECTIVE {alpha}-DYSTROGLYCAN, CEREBELLAR HYPOPLASIA, AND EPILEPSYEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Messina, S., Tortorella, G., Concolino, D., Spano, M., D'Amico, A., Bruno, C., Santorelli, F. M., Mercuri, E., Bertini, E. Tags: Muscle disease CLINICAL/SCIENTIFIC NOTES Source Type: journals

Possible jcv granular cell neuronopathy in a patient with hiv infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Tan, I. L., Brew, B. J. Tags: Viral infections, HIV, Gait disorders/ataxia CLINICAL/SCIENTIFIC NOTES Source Type: journals

A case of late-onset proximal and distal muscle weaknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Barohn, R. J., Watts, G. D.J., Amato, A. A. Tags: NEUROLOGY CLINICAL PATHOLOGICAL CONFERENCE Source Type: journals

International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The Non-Motor Symptoms Scale is an acceptable, reproducible, valid, and precise assessment instrument for nonmotor symptoms in Parkinson disease. (Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Martinez-Martin, P., Rodriguez-Blazquez, C., Abe, K., Bhattacharyya, K. B., Bloem, B. R., Carod-Artal, F. J., Prakash, R., Esselink, R.A.J., Falup-Pecurariu, C., Gallardo, M., Mir, P., Naidu, Y., Nicoletti, A., Sethi, K., Tsuboi, Y., van Hilten, J. J., Vi Tags: Outcome research, Clinical neurology examination, Parkinson's disease/Parkinsonism ARTICLES Source Type: journals

Feasibility and validity of computerized ambulatory monitoring in stroke patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Support was found for the feasibility and validity of computerized ambulatory monitoring with stroke patients. The application of these novel methods with stroke patients should provide complementary information that is inaccessible to standard hospital-based assessments and permit increased understanding of the significance of clinical results and test scores for daily life experience. DSM-IV-R = Diagnostic and Statistical Manual of Mental Disorders, 4th edition, revised; EMA = ecologic momentary assessment; ESM = experience sampling method; HAM-A = Hamilton Anxiety Rating Scale; HAM-D = Hamilton Depression Ra...
Source: Neurology - November 9, 2009 Category: Neurology Authors: Johnson, E. I., Sibon, I., Renou, P., Rouanet, F., Allard, M., Swendsen, J. Tags: Stroke prevention, Other cerebrovascular disease/ Stroke, Clinical neurology examination, All Cerebrovascular disease/Stroke, Assessment of cognitive disorders/dementia ARTICLES Source Type: journals

Clinical syndromes associated with posterior atrophy: Early age at onset AD spectrumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Logopenic progressive aphasia and posterior cortical atrophy showed largely overlapping anatomic and biologic features with early age at onset of Alzheimer disease, suggesting that these clinical syndromes represent the spectrum of clinical manifestation of the nontypical form of Alzheimer disease that presents at an early age. AD = Alzheimer disease; CBD = corticobasal degeneration; EO-AD = early age at onset of Alzheimer disease; LPA = logopenic progressive aphasia; MAC = Memory and Aging Center; PCA = posterior cortical atrophy; PIB = Pittsburgh Compound-B; PPA = primary progressive aphasia; UCSF = Universi...
Source: Neurology - November 9, 2009 Category: Neurology Authors: Migliaccio, R., Agosta, F., Rascovsky, K., Karydas, A., Bonasera, S., Rabinovici, G. D., Miller, B. L., Gorno-Tempini, M. L. Tags: MRI, Volumetric MRI, Alzheimer's disease, Dementia aphasia ARTICLES Source Type: journals

Hippocampal correlates of pain in healthy elderly adults: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Older adults who report more severe acute or chronic pain have smaller hippocampal volumes and lower levels of hippocampal N-acetylaspartate/creatine, a marker of neuronal integrity. Future studies should consider the role of the hippocampus and other brain structures in the development and experience of pain in healthy elderly and individuals with Alzheimer disease. (Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Zimmerman, M. E., Pan, J. W., Hetherington, H. P., Lipton, M. L., Baigi, K., Lipton, R. B. Tags: MRI, MRS, Volumetric MRI, All Pain, Cognitive aging ARTICLES Source Type: journals

Adiposity indicators and dementia over 32 years in SwedenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Among survivors to age 70, high midlife waist-to-hip ratio may increase odds of dementia. Traditional Cox models do not evidence this relationship. Changing anthropometric parameters in years preceding dementia onset indicate the dynamic nature of this seemingly simple relationship. There are midlife and late-life implications for dementia prevention, and analytical considerations related to identifying risk factors for dementia. ADCVD = AD with cerebrovascular disease; BMI = body mass index; DBP = diastolic blood pressure; DSM-III-R = Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised...
Source: Neurology - November 9, 2009 Category: Neurology Authors: Gustafson, D. R., Backman, K., Waern, M., Ostling, S., Guo, X., Zandi, P., Mielke, M. M., Bengtsson, C., Skoog, I. Tags: All Cognitive Disorders/Dementia, Alzheimer's disease, Vascular dementia, Cohort studies, Risk factors in epidemiology ARTICLES Source Type: journals

Determinants of survival in progressive multifocal leukoencephalopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The presence of JC virus (JCV)-specific cytotoxic T-lymphocytes (CTL) was associated with a trend toward longer survival in patients with progressive multifocal leukoencephalopathy (PML), which was more pronounced than the impact of CD4 count in HIV+ patients with PML early after diagnosis. Despite the association of contrast enhancement and immune reconstitution inflammatory syndrome with JCV-specific CTL, these cannot be considered as surrogate markers for the prognostic value of the CTL. Strategies aiming at improving the cellular immune response may improve the course of PML. CE = contrast enhancement; CI ...
Source: Neurology - November 9, 2009 Category: Neurology Authors: Marzocchetti, A., Tompkins, T., Clifford, D. B., Gandhi, R. T., Kesari, S., Berger, J. R., Simpson, D. M., Prosperi, M., De Luca, A., Koralnik, I. J. Tags: All Immunology, Viral infections, HIV, All Demyelinating disease (CNS) ARTICLES Source Type: journals

Body size and risk of MS in two cohorts of US womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Obese adolescents have an increased risk of developing multiple sclerosis (MS). Although the mechanisms of this association remain uncertain, this result suggests that prevention of adolescent obesity may contribute to reduced MS risk. 25(OH)D = 25-hydroxyvitamin D; BMI = body mass index; CI = confidence interval; MS = multiple sclerosis; NHS = Nurses’ Health Study; NHSII = Nurses’ Health Study II; RR = relative risk. (Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Munger, K. L., Chitnis, T., Ascherio, A. Tags: Multiple sclerosis, Cohort studies, Risk factors in epidemiology ARTICLES Source Type: journals

A reassessment of the plateauing relationship between T2 lesion load and disability in MSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We showed that the plateauing relationship between T2 lesion volume and disability in multiple sclerosis is not always present and is likely due to the reduced frequency of "inflammatory" events in the most common form of secondary progressive multiple sclerosis. (Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Sormani, M. P., Rovaris, M., Comi, G., Filippi, M. Tags: MRI, Clinical trials Methodology/study design, Multiple sclerosis ARTICLES Source Type: journals

Children with autism show specific handwriting impairmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We addressed how different elements of handwriting contribute to impairments observed in children with autism. Our results suggest that training targeting letter formation, in combination with general training of fine motor control, may be the best direction for improving handwriting performance in children with autism. (Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Fuentes, C. T., Mostofsky, S. H., Bastian, A. J. Tags: All Rehabilitation, Motor Control ARTICLES Source Type: journals

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: BRAF rearrangement represents the most common genetic alteration in sporadic, but not neurofibromatosis type 1-associated, pilocytic astrocytomas (PAs). These findings implicate BRAF in the pathogenesis of these common low-grade astrocytomas in children, and suggest that PAs arise either from NF1 inactivation or BRAF gain of function. (Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Yu, J., Deshmukh, H., Gutmann, R. J., Emnett, R. J., Rodriguez, F. J., Watson, M. A., Nagarajan, R., Gutmann, D. H. Tags: Primary brain tumor, Gene expression studies, Neurofibromatosis ARTICLES Source Type: journals

MRI lesion loads and disability relationships in MS: More similar than different?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Wolinsky, J. S. Tags: MRI, Clinical trials Methodology/study design, Multiple sclerosis EDITORIALS Source Type: journals

Pathologic intracellular signaling in childhood pilocytic astrocytomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Pomeroy, S. L. Tags: Primary brain tumor, Gene expression studies, Neurofibromatosis EDITORIALS Source Type: journals