NeuromicsThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2

86 records returned

NPY Y2R and IHC-Mouse Distal ColonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lixin Wang, Guillaume Gourcerol, Pu-Qing Yuan, S. Vincent Wu, Mulugeta Million, Muriel Larauche, and Yvette Taché. Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious mice. Am J Physiol Gastrointest Liver Physiol (November 5, 2009). doi:10.1152/ajpgi.00349.2009. ...Note: Excellent IHC staining of myenteric plexus and submucosal (mouse distal colon) tissue-Free floating submucosal and LMMP whole mounts of both proximal and distal colon from 3 naïve mice were treated in 10% normal goat serum each for 30 min, and followed by incubation with polyclonal rabbit anti- NPY Y2 Recepto...
Source: Neuromics - November 13, 2009 Category: Neuroscience Tags: NPY Y2R antibody Neuropeptide Y Receptor Antibodies Immunohistochemistry Neuropeptide Receptor Antibodies Neuropeptide Antibodies Source Type: organizations

More Pubs Referencing Neuromics' mGluRsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Jakob S. Satz, Alisdair R. Philp, Huy Nguyen, Hajime Kusano, Jane Lee, Rolf Turk, Megan J. Riker, Jasmine Hernández, Robert M. Weiss, Michael G. Anderson, Robert F. Mullins, Steven A. Moore, Edwin M. Stone, and Kevin P. Campbell. Visual Impairment in the Absence of Dystroglycan. J. Neurosci., Oct 2009; 29: 13136 - 13146 ; doi:10.1523/JNEUROSCI.0474-09.2009. ....anti-mGluR6 (Neuromics)...Lasani S. Wijetunge, Sally M. Till, Thomas H. Gillingwater, Cali A. Ingham, and Peter C. Kind. mGluR5 Regulates Glutamate-Dependent Development of the Mouse Somatosensory Cortex. The Journal of Neuroscience, December 3, 2008, 28(49):13028-...
Source: Neuromics - November 13, 2009 Category: Neuroscience Tags: Immunohistochemistry Western Blot mGluR6 antibody mGluR5 antibody Western Blotting Glutamate Receptors Source Type: organizations

gp130, IL-6 and Expression and Neuropathic PainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We wanted to post yet another publication referencing use of one of our Pain and Inflammation Research Antibodies. Here the researchers used our Mouse Monoclonal gp130/CD130 for Immunohistochemistry.Manfred Andratsch, Norbert Mair, Cristina E. Constantin, Nadja Scherbakov, Camilla Benetti, Serena Quarta, Christian Vogl, Claudia A. Sailer, Nurcan Üceyler, Johannes Brockhaus, Rudolf Martini, Claudia Sommer, Hanns Ulrich Zeilhofer, Werner Müller, Rohini Kuner, John B. Davis, Stefan Rose-John, and Michaela Kress. A Key Role for gp130 Expressed on Peripheral Sensory Nerves in Pathological Pain. J. Neurosci., Oct 2009; 29: 134...
Source: Neuromics - November 6, 2009 Category: Neuroscience Tags: sensory neurons TRPV1 antibodies Immunohistochemistry gp130 antibody Neuropathic Pain Cancer-evoked Pain IL-6 antibody Source Type: organizations

Reagents that work for Drug Discovery and Basic Research.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have redesigned our website! New capabilities easier for visitors to find products and related product content:Reagents that work for Drug Discovery and Basic Research.Posted using ShareThis (Source: Neuromics)
Source: Neuromics - November 2, 2009 Category: Neuroscience Tags: Stem Cell Research Recombinant and Natural Proteins Neuromics Antibodies Neural Stem Cell Markers Apotosis Detection Transfection Reagents Source Type: organizations

NSE and TUJ-1 and Parkinson's Disease ResearchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I would like to thank Meghan Coakley from University College Cork for alerting me to a new publication referencing our Chicken NSE (Neuron-Specific Enolase) and Tuj 1 (Neuron-specific class III beta-tubulin) antibodies.Here's her feedback: "Just letting you know we published our paper using the beta-III-Tubulin and NSE antibodies you supplied to us – Timmons et al., Neuroscience Letters, Oct 1, 2009 [Epub ahead of print]. The antibodies were excellent and I’m sure we’ll be using Neuromics again in the future."Timmons S, Coakley MF, Moloney AM, O' Neill C. Akt signal transduction dysfunction in Parkinson's disease. Ne...
Source: Neuromics - October 19, 2009 Category: Neuroscience Tags: Neuron Specific Enolase Antibody Tuj 1 (Neuron-specific class III beta-tubulin) antibody Parkinson's Disease WB NSE Antibody Western Blotting Tuj-1 antibody. Western Blots Source Type: organizations

More Success with TRPV1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Irmgard Tegeder and team have been using our VR1 N-Terminus (TRPV1) as a marker to study how B kinase (IKK) plays a role in sensory neuron excitability and nociception.The antibody was used for both Western Blot and Immunohistochemistry. Here's a recent publication of their results:Vanessa Bockhart, Cristina Elena Constantin, Annett Häussler, Nina Wijnvoord, Maike Kanngiesser, Thekla Myrczek, Geethanjali Pickert,Laura Popp, Jürgen-Markus Sobotzik, Manolis Pasparakis, Rohini Kuner, Gerd Geisslinger, Christian Schultz, Michaela Kress, and Irmgard Tegeder. Inhibitor B Kinase β Deficiency in Primary Nociceptive Neurons ...
Source: Neuromics - October 17, 2009 Category: Neuroscience Tags: Dr. Irmgard Tegeder TRPV1 antibodies Vanilloid Receptors Vanilloid Receptor Antibodies TRPV1 antibody Nociceptive Pain TKK Receptor Pain Research Vanilloid Receptor Antibody VR1-N Antibody Source Type: organizations

MMP-9 SquaredEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We are feverishly working on adding reagents for studying Autoimmunity and Immune Response. In this context, we wanted to alert you to 2 new publications referencing our Matrix Metalloproteinase 9 (MMP-9) antibody.Zhi-Yuan Zhang, Zhiren Zhang, Caroline Zug, Barbara Nuesslein-Hildesheim, David Leppert and Hermann J. Schluesener. AUY954, a selective S1P1 modulator, prevents experimental autoimmune neuritis. doi:10.1016/j.jneuroim.2009.09.010.Abstract:Experimental autoimmune neuritis (EAN) is a T cell-mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system and an animal model of human inflammat...
Source: Neuromics - October 9, 2009 Category: Neuroscience Tags: airway inflammation Autoimmunity autoimmune neuritis Pneumonia immune response MMP-9 antibodies MMP Antibodies Matrix Metalloproteinase Antibodies Source Type: organizations

Rock Solid Tuj-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The feedback from customers on our Tuj 1 (Neuron-specific class III beta-tubulin) is that it works!This is confirmed by the growing list of references in key publications. Here's the latest:S A Sakowski, S B Heavener, J S Lunn, K Fung, S S Oh, S K Spratt, N D Hogikyan and E L Feldman. Neuroprotection using gene therapy to induce vascular endothelial growth factor-A expression. Gene Therapy advance online publication 3 September 2009; doi: 10.1038/gt.2009.111....TUJ1 (Neuromics, Edina, MN, USA). ...Tuj 1 (Neuron-specific class III beta-tubulin)Related Reagents:NestinMusashi-1Other Reagents to Consider:Stem Cell ReagentsNeur...
Source: Neuromics - September 30, 2009 Category: Neuroscience Tags: Stem Cell Research Tuj-1 antibodies Neuron Markers Tuj 1 (Neuron-specific class III beta-tubulin) antibody Source Type: organizations

Prodynorphin at WorkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We would like to Dr. Andrew Todd for sharing this excellent IHC image using our Guinea Pig ProDynorphin (rat) antibody. Image: Staining of adult rat spinal cord.The tissue is perfusion-fixed (4% freshly prepared formaldehyde) adult rat spinal cord, reacted overnight with the PPD at 1:1000 and then o/n in Alexa488 secondary (raised in donkey, Invitrogen, 1:500).The confocal image stack was taken through a 60x oil lens (Bio-Rad Radiance confocal) - pixel size is 0.196 micrometre and this is a projection of 10 confocal optical sections at 0.5 micrometre z-spacing.Customer PublicationsRelated Reagents:proDynorphin (guinea pig)...
Source: Neuromics - September 28, 2009 Category: Neuroscience Tags: Dr. Andrew Todd Prodynorphin antibody. Immunohistochemistry Opioid Receptors Antibodies Nociceptive Pain GP10110 Pain Research pro-Dynorhin Antibody Spinal Cord Tissue IHC Source Type: organizations

CAMKIIs and Neurotransmitters.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Here's an update on recent developments. First, we wanted to share a recent publication referencing 2 of our Neurotransmission Research Antibodies:Haifeng Zhaoa, Qiong Li, Xinrong Pei, Zhaofeng Zhang, Ruiyue Yang, Junbo Wang and Yong Li. Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus. Behavioural Brain Research Volume 201, Issue 2, 12 August 2009, Pages 311-317. doi:10.1016/j.bbr.2009.03.002. ...anti-phospho-CaMKII (Thr286) and anti- CaMKII (Neuromics, USA)...Second, we continue to bulk up on reagents for Neurotr...
Source: Neuromics - September 16, 2009 Category: Neuroscience Tags: GABA antibodies G-Protein Coupled Receptors NMDA antibodies Neuromodulation Synaptic Plasticity Gate coupled ion channels CAMKII antibodies Neurotransmission Source Type: organizations

TRPV1 Antibodies in ActionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We would like to thank Dr. Fletcher White, LUMC, for Sharing this data with us:Images: The CCR2 chemokine receptor colocalized with IB4 and TRPV1, markers of nociceptive neurons, after injury. A) Many lumbar DRG neurons in vehicle-treated rat sensory neurons were positive for IB4, a neuronal phenotype that distinguishes some C-fiber nociceptors (red cells), however there was no expression of the CCR2 protein. B) After perineural gp120/hCD4 treatment, CCR2 protein expression (green cells) was upregulated, and co-localized with IB4. C) Both gp120/hCD4 and ddC treatment resulted in an upregulation of CCR2 expression (green ce...
Source: Neuromics - September 10, 2009 Category: Neuroscience Tags: TRPV1 antibodies TRPV1-C Antibody Vaniloid Receptor Antibody Vanilloid Receptor Antibodies TRPV1 antibody Pain Research Source Type: organizations

Tracking STEMEZ hNP1 Progenitor Cell FateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We would like to promote an important new discovery using our STEMEZ(TM) hNP1 Human Neural Progenitors Discovery Kit.Human embryonic stem cell–derived neural progenitors (NP) present an important tool for understanding human development and disease. Optimal utilization of NP cells, however, requires an enhanced ability to monitor these cells in vitro and in vivo. Here we report production of the first genetically modified self-renewing human embryonic stem cell–derived NP cells that express fluorescent proteins under constitutive as well as lineage-specific promoters, enabling tracking and monitoring of cell fate. Nucl...
Source: Neuromics - August 28, 2009 Category: Neuroscience Tags: Stem Cell Research Human embyonic stem cells. Tyrosine Hydroxlase antibody STEMEZ hNP1 Neural Progenitors GFP Reporter Musashi-1 Antibody nestin antibody Tuj1 antibody TH Source Type: organizations

STEMEZ hNP1 Neural Progenitors Now AvailableEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We are pleased to announce the introduction of our STEMEZ TMhNP1 Human Neural Progenitors Discovery Kit. The kit was developed by our partner, ArunA Biomedical. Description/Data:STEMEZTM hNP1 Human Progenitors are fully differentiated are derived as adherent cells from hESC WA09 line. The cells are shipped frozen in a vial with 1 x 106 cells; once thawed they should be immediately plated on a Matrigel (or other suitable extracellular matrix protein)-coated dish and maintained in the accompanying serum-free medium. The neurons should be used within 14 days of thawing. These cells have the capabilities to:Display immunoreact...
Source: Neuromics - August 20, 2009 Category: Neuroscience Tags: Stem Cell Research STEMEZ hNP1 Neural Progenitors embryonic stem cells Stem Research Reagents Stem Cell Differentiation Aruna Biomedical Neural Progenitor Cells Source Type: organizations

Regenerating Axons Can Be Guided And Reform Connections After Spinal Cord InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is an interesting updateRegenerating Axons Can Be Guided And Reform Connections After Spinal Cord InjuryWe support this Spinal Cord Injury and Repair with: Axon Growth and Guidance Antibodies Neurotrophins-Neuron/Glial Marker Stem Cell Research ReagentsSTEMEZ (TM) Human Neuron Discovery KitsShared via AddThis (Source: Neuromics)
Source: Neuromics - August 18, 2009 Category: Neuroscience Tags: axons axonal regeneration axonal guidance Spinal cord injury repair Neurotrophin Antibodies spinal cord regeneration Source Type: organizations

Link Between Inflammation and Tau Pathology in Alzheimer's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Providing reagents for Alzheimer's Disease Researchers is a strategic focus area for us. This includes making a variety of Primary Neuronal Cultures available to these researchers.We evolve the strategy based on Researcher input and how the cultures are being referenced in publications. This reference is especially satisfying because of the vangaurd findings:Lisette T. Arnaud, Natura Myeku and Maria E. Figueiredo-Pereira. Proteasome–caspase–cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells. Journal of Neurochemistry. Volume 110 Issue 1, Pages 328 - 342."Our data suggest a potenti...
Source: Neuromics - August 16, 2009 Category: Neuroscience Tags: tau pathology prostaglandin J2 Primary Human Neurons Apoptosis Detection Alzheimer's Disease e-18 Primary Rat Cortical Neurons Apoptosis Reagents caspase • cathepsin • inflammation Source Type: organizations

survival of efferent synapses on mammalian outer hair cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr Douglas Vetter (Tufts University School of Medicine) and team recently published a study that amplifies the understanding of the development, function and maintenance of auditory system function.Their data strongly suggest that hair cell responses induced and/or modulated by Olivocochlear (OC) activation are necessary for the survival of OC innervation and that these responses must involve SK2-mediated hyperpolarization.It also includes an excellent image of Olivocochlear fibers degeneration in SK2−/− mice. One of the makers used was our Tuj 1 (Neuron-specific class III beta-tubulin).Vidya Murthy, Stéphane F. Maiso...
Source: Neuromics - August 16, 2009 Category: Neuroscience Tags: Neuron-specific class III beta-tubulin Neuron Markers Tuj 1 Neuron-specific class III beta-tubulin antibody Dr. Douglas Vetter Neuronal Markers Tuj1 antibody Tuj-1 antibody Source Type: organizations

ENS Development MarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is an excellent study on the developing Enteric Nervous Stem (ENS). This system is often referred to as the "second brain".Despite this, neurogenesis has been much less studied in the ENS than in the brain. Understanding how neurons are formed in the gut is the foundation for finding cures for ENS disorders. The key finding here is that the ability of 5-HT4 receptors to unmask a regulation of enteric neurogenesis in adult animals suggests that the mature ENS is capable of an unexpected degree of plasticity (potentially good new for discovering therapies for ENS related disorders).Min-Tsai Liu, Yung-Hui Kuan, Jingwen W...
Source: Neuromics - August 9, 2009 Category: Neuroscience Tags: S100B Antibody ICC Neurofilament-H Antibody Neurogenesis Musashi-1 Antibody Western Blot Enteric Neurvous System NF-H antibody MSI1 Antibody Glial Markers Immunocytochemistry Source Type: organizations

Spinal Cord Injury RepairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neuromics has featured an overview of Dr. Matt Ramer's Research on Spinal Cord Injury and "Finding Fixes for Injured Nerves" on our Neuroscience News Blog.We wanted to share a recent publication authored by Dr. Mark Tuszynski and his team of researchers at USCD. Here's the good news:"NT-3 expression in the correct target led to reinnervation of the nucleus gracilis in a dose-related fashion, whereas NT-3 expression in the reticular formation led to mistargeting of regenerating axons. Axons regenerating into the nucleus gracilis formed axodendritic synapses containing rounded vesicles, reflective of pre-injury synaptic arch...
Source: Neuromics - August 5, 2009 Category: Neuroscience Tags: NT-3 antibody axonal regeneration Neurotrophins NT Antibodies Neurotrophin-3 antibody chemotropic axon guidance Dr. Mark H Tuszynski Spinal cord injury repair Neurotrophin Antibodies Source Type: organizations

FGF Basic and Cell Proliferation in Endothelial CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We are pleased with the growth of our Fibroblast Growth Factor Proteins.Here's a recent publications referencing use of our FGF basic in Endothelial Cell Cultures.Harun Elmasri, Cagatay Karaaslan, Yaroslav Teper, Elisa Ghelfi, MeiQian Weng, Tan A. Ince, Harry Kozakewich, Joyce Bischoff, and Sule Cataltepe. Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB J, Jul 2009; doi:10.1096/fj.09-134882...VEGF-A 165 (VEGF) and human basic FGF (bFGF) were purchased from R&D Systems (Minneapolis, MN, USA) and Neuromics (Edina, MN, USA), respectively...Featured Reagent...
Source: Neuromics - July 30, 2009 Category: Neuroscience Tags: FGF Basic Recombinant Protein Fibroblast Growth Factor Basic Endothelial Cell Proliferation FGF2 Fibroblast Growth Factor 2 Source Type: organizations

TRPA1 in Craniofacial Muscle PainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Jin Ro and his team reference use of TRP antibodies in their recent study of craniofacial muscle nociception and mechanical hyperalgesia:Jin Y. Ro, Jong-Seok Lee and Youping Zhang. Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia. doi:10.1016/j.pain.2009.04.021.... TRPA1 (1:1500; rat polyclonal, Neuromics)...Featured ReagentsTRPA1-Cat#: RA14135Related Reagents:TRPA1 for WBVR1 N-Terminus (TRPV1)VR1 C-terminus (TRPV1)VR1 C-Terminus (TRPV1) - mouse specificVR1 (TRPV1)-GoatVR like-3 (TRPV3)All TRPV (Vanilloid); TRPM; TRPA and TRPCsPain and Inflammation Antibodies (Source: Neuromics)
Source: Neuromics - July 28, 2009 Category: Neuroscience Tags: Hyperalgesia Craniofacial pain TRPA1 antibody Vaniloid Receptor Antibody TRPV1s Dr. Jin Ro TRPV1 antibody Nociceptive Pain Pain Research Vanilloid Receptor Antibody Source Type: organizations

STEMEZ hN2 Human Neurons-DataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neuromics rolled out STEMEZTM hN2 Human Neurons Discovery Kits several months ago.Applications for these include: cellular model studies, high content screening, developmental studies, RNAi studies and genetic manipulation.Drilling down further, I am pleased to present Electro-physiology and related data generated by Aruna and collaborators: hN2 Cells-Electro Phys Data SupplementhN2-Whole Cell Voltage ClampFigure. hN2 cells can produce inward currents that generate action potentials. (A) Isolated hN2 with significant neurite growth 1 week after plating . This cell was subjected to whole cell voltage clamp utilizing a potas...
Source: Neuromics - July 26, 2009 Category: Neuroscience Tags: Electrophysiology Recordings Aruna Biomedical Whole cell volatge clamp Stem Cells Dr. Steve Stice Human Neurons Source Type: organizations

Stem Cell MarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study the authors demonstrate a between SSCs and RET.ETV5 is expressed beginning in fetal Sertoli cells and can potentially have effects on both neonatal Sertoli and germ cells. In addition, ETV5 has critical effects on neonatal spermatogonial proliferation, which may involve impaired signaling through the RET receptor.Gaurav Tyagi, Kay Carnes, Carla Morrow, Natalia V. Kostereva, Gail C. Ekman, Daryl D. Meling,Chris Hostetler, Michael Griswold, Kenneth M. Murphy, Rex A. Hess, Marie-Claude Hofmann and Paul S. Cooke. Loss of Etv5 Decreases Proliferation and RET Levels in neonatal Mouse Testicular Germ Cells and Cause...
Source: Neuromics - July 23, 2009 Category: Neuroscience Tags: SSCs hESCs Dr. Paul S. Cooke Neural Stem Cell Markers Spermatogenesis Ret nestin antibody Dr. Steve Stice Sertoli Cells Stem Cell Antibodies Source Type: organizations

JoVE: Generation of Single-Cell Suspensions from Mouse Neural Tissue (Video Protocol)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Shared via AddThis (Source: Neuromics)
Source: Neuromics - July 21, 2009 Category: Neuroscience Tags: neuroscience e-18 Primary Mouse Neurons dissocaition Source Type: organizations

stem cells | Science BlogEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Posted using ShareThis (Source: Neuromics)
Source: Neuromics - July 19, 2009 Category: Neuroscience Source Type: organizations

Hes-1 and Develpmental NeurobiologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Developmental Neurobiology is a core area of focus for Neuromics. Our goal is to provide a growing catalog of research proven reagents to Researchers. Their work is key to unlocking root causes of developmental related diseases and defects.We continue to see use of our reagents in publications by leading labs. Here's a new publication by Dr. Paul Trainor and his team at Stower's Institute referencing use of our HES-1 antibody:Angelo Iulianella, Madhulika Sharma, Greg B. Vanden Heuvel, and Paul A. Trainor. Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord. Development 1...
Source: Neuromics - June 26, 2009 Category: Neuroscience Tags: Craniofacial Development Notch Antibodies Developmental Neurobiology Hes-1 Antibody Hairy and Enhancer of Split-1 Antibody Neural Crest Hes1 antibody Dr. Paul Trainor Source Type: organizations

Potent Stem Cell MarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The potency of our Stem Cell Research Reagents is confirmed by the growng list of publication referencing them.Here're the latest:Saishu Yoshida, Takako Kato, Takao Susa, Li-yi Cai, Michie Nakayama, Yukio Kato. PROP1 coexists with SOX2 and induces PIT1-commitment cells. Biochemical and Biophysical Research Communications, Volume 385, Issue 1, 17 July 2009, Pages 11-15... SOX2 (1:500 dilution, Neuromics, Edina, MN, USA)...Saravanan Karumbayaram, Bennett G. Novitchb, Michaela Patterson, Joy A. Umbach, Laura Richter, Anne Lindgren, Anne E. Conway, Amander T. Clark, Steve A. Goldman, Kathrin Plath, Martina Wiedau-pazos, Harley...
Source: Neuromics - June 14, 2009 Category: Neuroscience Tags: nestin protein embryonic stem cells Stem Research Reagents sox2 proteins sox2 antibody PROP1 Protein P2Y2 antibody nestin antibody stem cell proteins Stem Cell Antibodies Source Type: organizations

Detecting Apoptosis in Real TimeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kudos to Drs. Aaron Thomas and Carol Erickson for their novel use of our Magic Red™ Real Time! Apptosis Kits. Here's the related publication:Aaron J. Thomas and Carol A. Erickson. FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanism. Development, Apr 2009; doi:10.1242/dev.031989....Apoptosis was assayed using Magic Red Caspases 3&7 reagent (Neuromics)...Related Reagents:FLIVO™ Polycaspase Live!, in vivo Apoptosis Kits-NewFLICA™ in vitro Caspase KitsFast!-Use Caspase kits to quantitate apoptosis via active caspases in who...
Source: Neuromics - May 7, 2009 Category: Neuroscience Tags: Caspases Magic Red Apoptosis Detection Dr. Aaron Thomas Caspase 7 Magic Red Apoptosis Kit FOXD3 Neural Crest Dr. Carol Erickson Apoptosis Reagents Caspase 3 Source Type: organizations

RAGE and PneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We are working with customers and collaborators to strengthen our product offerings for Immune Response Researchers.An interesting finding on Receptor for Advanced Glycation End Products (RAGE) and response to S. pneumoniae pneumonia infection just crossed our radar. Dr. Marieke A. D. van Zoelen and team published evidence that RAGE plays a detrimental role in the host response to S. pneumoniae pneumonia by facilitating the bacterial growth and dissemination and concurrently enhancing the pulmonary inflammatory and procoagulant response. Data include use of our RAGE-Cat#: GT15030.Here's the publication and related data:Mar...
Source: Neuromics - April 2, 2009 Category: Neuroscience Tags: inflammatory response procoagulant response Immunohistochemistry Dr. Marieke A. D. van Zoelen RAGE immune response Receptor for Advanced Glycation End Products Source Type: organizations

Introducing Human Neuron KitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
hN2 Human Neurons Discovery Kit-NewEnergize you Research!Neuromics has formed an alliance with Aruna Biomedical. This Alliance gives us the capabilities to bring you the reliable, robust and highly scalable hN2TMHuman Neurons Discovery Kits.These kits are designed to reduce basic Neuroscience Research and Drug Discovery timelines. Potential applications include: cellular model studies, high content screening, developmental studies, RNAi studies and genetic manipulation.Approximate Yield=1,000,000 healthy Neurons.hN2 Human Neurons Discovery Kit Details (Source: Neuromics)
Source: Neuromics - March 30, 2009 Category: Neuroscience Tags: sensory neurons Aruna Biomedical Culturing Human Neurons Protocol hN2 Kits Source Type: organizations

Amyloid Beta and E18 Primary Hippocampal NeuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We would like to feature an interesting application of our E18 Rat Primary Hippocampal Neurons.Related Publication:Karunya K. Kandimalla1, Olenych G. Scott, Smita Fulzele1, Michael W. Davidson, Joseph F. Poduslo. Mechanism of Neuronal versus Endothelial Cell Uptake of Alzheimer's Disease Amyloid β Protein. PLoS ONE 4(2): e4627. doi:10.1371/journal.pone.0004627.... Rat primary hippocampal (RPH) neurons were isolated from the hippocampii of 18-day-old embryonic Sprague Dawley rat brains (Neuromics, Edina, MN). The hippocampii were dispersed using a fire polished Pasteur pipette and plated on poly-D-lysine (Sigma-Aldrich, St...
Source: Neuromics - March 14, 2009 Category: Neuroscience Tags: AD Abeta40 Rat Primary Hippocampal Neurons Alzheimer's Disease Amyloid Beta Rat Hippocampi e-18 Primary Rat Neurons Amyloid Beta40 Source Type: organizations

TRPV1 with a TwistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kudos to Dr. Marna Erickson and her team at the University of Minnesota. They recently published excellent work demonstrating a relationship between TRPV1 -EGFR signaling and skin cancer.Ann M. Bode, Yong-Yeon Cho, Duo Zheng, Feng Zhu, Marna E. Ericson, Wei-Ya Ma, Ke Yao, and Zigang Dong. Transient Receptor Potential Type Vanilloid 1 Suppresses Skin Carcinogenesis.Cancer Res., Feb 2009; 69: 905 - 913."TRPV1 interacts with EGFR, leading to EGFR degradation. Notably, the absence of TRPV1 in mice results in a striking increase in skin carcinogenesis. The TRPV1 is the first membrane receptor shown to have a tumor-suppressing e...
Source: Neuromics - February 28, 2009 Category: Neuroscience Tags: Vanillid Receptors Vaniloid Receptor Antibody TRPV1s Skin Cancer Mouse TRPV1 Dr.Marna Ericson EGFR EGFR Antibody Epidermanl Growth Factor VR1-C; TRPV1-C Source Type: organizations

TRPV1 and Retinal Ganglion Cell ApoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The publications referencing our TRPV (Vanilloid); TRPM; TRPA and TRPC Antibodies keep on coming.In this February 2009 publication, Dr. David Calkins and his team at Vanderbilt demontrate that Retinal Ganglian Cells express the TRPV1 channel and that TRPV1 activation contributes to their death with exposure to hydrostatic pressure . We also demonstrated that activation of TRPV1 alone was sufficient to induce apoptosis of RGCs.Rebecca M. Sappington, Tatiana Sidorova, Daniel J. Long, and David J. Calkins. TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca2+ with Exposure to Hydrostatic Pres...
Source: Neuromics - February 22, 2009 Category: Neuroscience Tags: Vanillid Receptors TRPV1-C Antibody Dr. David Calkins Vaniloid Receptor Antibody TRP antibody Retinal Ganglion Cell Apoptosis TRPV1-N Antibody VR1-N Antibody VR1-C; TRPV1-C Source Type: organizations

Neurotrophin Expression in Airway Smooth Muscle CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Y.K. Prakash and his team at Mayo Clinic College of Medicine have published a study of Neurotrophin Signaling in Airway Smooth Muscle (ASM) cells. Here they demonstrate that BDNF/TrkB signaling (but not BDNF/p75NTR) in human ASM cells regulates [Ca2+]i responses to agonist in both normal ASM, as well as with inflammation induced by TNFα. These effects suggest an important role of NT signaling in inflammation-induced changes in ASM contractility.Y.S. Prakash, Michael A Thompson, and Christina M Pabelick. Brain Derived Neurotrophic Factor in TNF Modulation of Ca2+ in Human Airway Smooth Muscle. Am. J. Respir. Cell Mol. ...
Source: Neuromics - February 20, 2009 Category: Neuroscience Tags: Mayo Clinic TrkB Antibody Neurotrophins NT Antibody NT Antibodies Trk Antibody Neurotrophin Antibodies Source Type: organizations

Substance-P PubEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We re-introduced our Substance P Whole Serum Guinea Pig and Substance P Purified-Guinea Pig Antibodies in 2008.The feedback has been positive. Related to this, here's a recent reference:Maureen S. Riedl, Stephen A. Schnell, Aaron C. Overland, Anne-Julie Chabot-Doré, Anna M. Taylor, Alfredo Ribeiro-Da-Silva, Robert P. Elde, George L. Wilcox, Laura S. Stone. Coexpression of 2A-adrenergic and -opioid receptors in substance P-containing terminals in rat dorsal horn. The Journal of Comparative Neurology Volume 513 Issue 4, Pages 385 - 398 Published Online: 29 Jan 2009 Copyright © 2009 Wiley-Liss, Inc., A Wiley Company....guin...
Source: Neuromics - February 12, 2009 Category: Neuroscience Tags: Substance P Antibody NK-1 antibody Neuropeptide Antibodies Substance P Antibodies Dr. Laura Stone Neuropeptides Neurokinin-3 antibody NK-3 Antibody neurokinin-1 antibody Source Type: organizations

Opioid Receptor Antibodies that WorkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have Opioid Receptor Antibodies that work hard for our customers.They are extensively referenced. We feature select publications and are pleased to feature the latest referencing staining of mouse neurons using our Kappa Opioid Receptor....Dominika Labuz, Yvonne Schmidt, Anja Schreiter, Heike L. Rittner, Shaaban A. Mousa and Halina Machelska. Immune cell–derived opioids protect against neuropathic pain in mice. J. Clin. Invest. doi:10.1172/JCI36246. Copyright © 2009, The American Society for Clinical Investigation......κ-opioid receptor (1:800, Neuromics)...All Opioid Receptor Publications-Mu, Kappa and DeltaPublish...
Source: Neuromics - January 23, 2009 Category: Neuroscience Tags: Delta Opioid Receptors Antibodies Kappa Opioid Receptor Antibodies Mu Opioid Receptor Antibodies DOR Antibody Pain Research MOR Antibody KOR Antibody Source Type: organizations

24-OHC-27-OHC and Alzheimer'sEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Othman Ghribi and his team at University of North Dakota have just published interesting results regarding the relationship between 24-hydroxycholesterol (24-OHC) and 27-hydroxycholesterol (27-OHC).27-OHC increased levels of amyloid precursor protein (APP) as well as beta-secretase (BACE1)the enzyme that cleaves APP to yield Abeta, a molecule that causes alzheimer's.24-OHC are associated with increased levels of sAPPalpha, suggesting that 24-OHC favors the processing of APP to the non-amyloidogenic pathway.Futher study of this relationship between 27 and 24-OHC could yield possible targets for decreasing the cleavage o...
Source: Neuromics - January 14, 2009 Category: Neuroscience Tags: BACE-1 Beta Amyloid 24-hydroxycholesterol Dr. Othman Ghribi 27-OHC 24-OHC ABCA1 27-hydroxycholesterol Source Type: organizations

December 2008 Featured PubsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intrathecal Delivery of siRNAAnother publication referencing successful delivery of siRNA using i-FectSuneeta Tumati, Tally Largent Milnes, Henry I. Yamamura, Todd W. Vanderah, William R. Roeske and Eva V. Varga. Intrathecal Raf-1-selective siRNA attenuates sustained morphine-mediated thermal hyperalgesia. doi:10.1016/j.ejphar.2008.10.033...siRNAs stock solutions (100 ?M) were prepared in double distilled RNAse free water and stored in aliquots at ?80 °C. For intrathecal treatment, aliquots of the stock solution (2 ?g of the appropriate siRNA) were mixed (1:5 v/v)with i-Fect transfection reagent (Neuromics, Edina, MN). Af...
Source: Neuromics - January 12, 2009 Category: Neuroscience Tags: mGluR5 siRNA delivery in-vivo Western Blot Gene Silencing Western Blotting Source Type: organizations

Excellent TRPV1-N IHC and WBEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kudos to Dr. Federica MF van Dissel-Emiliani and her team for the excellent Immunohistochemistry and Western Blot results using our TRPV1-N Antibody(Catalog #: RA10110) . The antibody was in their study demonstrating the sensitivity of spermatogenesis to capsaicin.Here's the related publication:Sefika C Mizrak, Bart M Gadella, Hatice Erdost, Aytekin Ozer, Ana MM van Pelt, Federica MF van Dissel-Emiliani. Spermatogonial stem cell sensitivity to capsaicin: An in vitro study. Reproductive Biology and Endocrinology 2008, 6:52 doi:10.1186/1477-7827-6-52.Anti TRPV1 antibody staining: Bouin's fixed, paraffin embedded 5 um-thick r...
Source: Neuromics - November 22, 2008 Category: Neuroscience Tags: TRPV1s Vaniloid Receptor Antibody WB Western Blotting TRPV1-N Antibody IHC Testis Tissue Vanilloid Receptors Immunohistochemistry Spermatogenesis Capsaicin VR1-N Antibody Source Type: organizations

DRG Neurons Now Available.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary Rat DRGs are live neurons isolated from micro-surgically dissected regions of day 18 embryonic Sprague/Dawley rat brain. These cells are prepared fresh each week and shipped in a nutrient rich medium that keeps the cells alive for up to 14 days under refrigeration.Please note: It is important to review Protocol/Datasheet prior to ordering. There is a unique step for making the dissociation enzyme solution. Do not hesitate to call or e-mail me (612-801-1007 or pshuster@neuromics.com) should you have questions.Image: DRGs cultured on Calf Skin Collagen.References:-A dissection and Tissue Culture Manual of the Nervous...
Source: Neuromics - November 13, 2008 Category: Neuroscience Tags: sensory neurons Dorsal Root Ganglia Dorsal Root Ganglion Dorsal Root Ganglia Neurons Culturing DRG Neurons Protocol drgs Source Type: organizations

Power Trio of Pain Research AntibodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I received a call from a customer asking if there were any publications referencing our rabbit Alpha 2a Adrenergic Receptor antibody. The resulting search found an article referencing excellent results using a trio of of our pain research antibodies. The research was conducted by our friend, Dr. Hui-Lin Pan and his team at University of Texas M.D. Anderson Cancer Center.Shao-Rui Chen, Hao-Min Pan, Timothy E. Richardson, and Hui-Lin Pan. Potentiation of Spinal α2-Adrenoceptor Analgesia in Rats Deficient in TRPV1- Expressing Afferent Neurons. Published online 2007 March 24. doi: 10.1016/j.neuropharm.2007.03.009.Images: Doub...
Source: Neuromics - November 4, 2008 Category: Neuroscience Tags: TRPV1s Pain Research Dr. Hui-Lin Pan Alpha 2a Adrenergic Receptor VR1-C; TRPV1-C Source Type: organizations

Purinergic Receptor PubsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Our Purinergic Receptor Antibodies have recently been referenced in several publications.In the first study 5 of our antibodies are used. It investigates the expression of purinergic P2 receptors in oxygen-induced retinal neovascularization.Sylvia Sarman; Jorge Mancini; Ingeborg van der Ploeg; J. Oscar Croxatto; Anders Kvanta; Juan E. Gallo. Involvement of Purinergic P2 Receptors in Experimental Retinal Neovascularization. Current Eye Research. 10.1080/02713680701885470 ....Five eyes (5 animals) from either hyperoxa- or non-hyperoxia-treated mice were enucleated and fixed for 48 hr at 4°C in paraformaldehyde (Sigma-Aldric...
Source: Neuromics - October 16, 2008 Category: Neuroscience Tags: Retina P2X1 P2X3 Retinal neovascularization Purinergic Receptors Antibodies P2X2 P2Y2 Neurotransmission Source Type: organizations

Neuron/Neuron Glial MarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have a comprehensive and growing catalog of Neuron/Glial Marker Antibodies and Proteins.These reagents must work everytime in our customers' applications. Quality is confirmed by pro-active customers follow up and publication referencing the reagents.Here we have several recent publications.We are pleased to first feature Dr. Dr. Juana Maria Pasquini, University of and colleagues from University of Buenos Aires. She and her team use our Olig1,2,3 as a marker to study de-myelinating disease.P.G. Franco, L. Silvestroff, E.F. Soto and J.M. Pasquini. Thyroid hormones promote differentiation of oligodendrocyte progenitor cel...
Source: Neuromics - October 9, 2008 Category: Neuroscience Tags: Olig 1 Neuron Markers GFAP Antibody de-myelinating disease 3 Glial Markers Oligodendrocytes 2 Source Type: organizations

siRNA-mediated gene silencingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Josephine Lai (Professor of Pharmacology, University of Arizona) is pioneer in developing experimental designs and methods for delivering siRNA to the CNS for gene expression analysis.She and her team have documented these in the publication:Modulating Sensory Systems Using RNAi(pdf - 187Kb)© 2007 LaiFor researchers desiring to effectively deliver siRNA to the CNS for gene expression of analysis of specific receptors, this publication offers proven methods. These include:The Choice of siRNAChoosing and Optimizing Transfection Reagents for siRNA Delivery to the Nervous SystemDelivery Systems-Microinjection and Infusion...
Source: Neuromics - October 4, 2008 Category: Neuroscience Tags: siRNA delivery in-vivo siRNA Microinjection Delivering siRNA to the CNS RNAi Gene Silencing Dr. Josephine Lai Source Type: organizations

Skeletal Muscle Derived Stem Cell MarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tetsuro Tamaki, Yoshinori Okada, Yoshiyasu Uchiyama, Kayoko Tono, Maki Masuda, Masahiro Nitta, Akio Hoshi, Akira Akatsuka. Skeletal Muscle–Derived CD34+/45- and CD34-/45- Stem Cells Are Situated Hierarchically Upstream of Pax7+. Cells. Stem Cells and Development. August 1, 2008, 17(4): 653-668. doi:10.1089/scd.2008.0070....anti-nucleostemin (1:200; overnight; Neuromics, Edina, USA) for proliferative capacity...Featured Reagent:Nucleostemin-Cat#:15050Related Reagents:Stem Cell ReagentsNeuron/Glial Markers (Source: Neuromics)
Source: Neuromics - October 1, 2008 Category: Neuroscience Tags: Skeletal Derived Stem Cells Nucleostemin Source Type: organizations

Human Embryonic Stem Cell Differentiation ProtocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Here's a protocol that could be of interest to hESC researchers:Elizabeth S Ng, Richard Davis, Edouard G Stanley & Andrew G Elefanty. A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies. Nature Protocols 3, - 768 - 776 (2008). (Source: Neuromics)
Source: Neuromics - September 23, 2008 Category: Neuroscience Tags: Stem Research Reagents Stem Cell Diffrentiation Protocol Source Type: organizations

PDGFs in Non-small Cell Lung Cancer Tumor and Stromal CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Serving Cancer and Tumorigenesis Researhers is a central component to our business strategy. This means constantly building our catalog of Cancer Antibodies and Cancer Proteins.I personally follow up with every customer that purchases our Cancer Research Reagents. This ensures they work as expected. In most cases, this is validate. If not, we fix the expressed issues.We are now seeing more confirmation by the reagents being referenced in publications. In this publication, our PDGF-C antibody was used as a marker for Non-small Cell Lung Cancer Tumors."In univariate analyses, high tumor cell expression of PDGF-B (p 0.001), P...
Source: Neuromics - September 19, 2008 Category: Neuroscience Tags: PDGF Antibody Platelet-Derived Growth Factor Antibodies Lung Cancer. Stromal Cells Platelet-Derived Growth Factors PDGF-C Antibody Non-small Cell Lung Cancer Tumor Source Type: organizations

Rat Sensory Neurons and NK-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A publication featuring our Neurokinin-1 (NK 1) Receptor just crossed my radar. It is authored by our friend, Dr. Matt Ramer.Matt and his team at University of British Columbia study primary sensory nerve cells (neurons), which are responsible for the transmission of somatic (bodily) sensations such as touch, pain, hot, cold and so on from the periphery (skin, muscles and viscera) to the central nervous system (CNS, spinal cord and brain). His research extends to therapeutic potential of neurotrophins on regeneration in spinal cord injury and deafferentation pain.In the past several years, he has generouly shared NT-3 and ...
Source: Neuromics - September 18, 2008 Category: Neuroscience Tags: Substance P Antibody sensory neurons neurokinin-1 NK-1 antibody Neurotrophins Neuropeptides neurokinin-1 antibody Source Type: organizations

ELISA techniques and protocolsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Power Point of ELISA Methods and Protocols(pps - 1.4M)This teaching guide covers the three major types of ELISA: indirect, competitive, and sandwich. It integrates theory with practice, to help you understand what you are doing, and help you to do it!Courtesy of our friends at Novus Biologicals. (Source: Neuromics)
Source: Neuromics - September 13, 2008 Category: Neuroscience Tags: sandwich ELISA competitive ELISA Indirect ELISA Source Type: organizations

Ischemia, Inflammatory Response and Umbilical Stem CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We would like to send Kudos to Dr. Yan Xu and his colleagues at University of Pittburgh for their findings on inflammatory response in Golbal Ischemia. Their work was recently published:Aaron Hirko, Renee Dallasen, Sachiko Jomura, Yan Xu. Modulation of Inflammatory Responses after Global Ischemia by Transplanted Umbilical-Cord Matrix Stem Cells. Stem Cells First published online August 21, 2008; doi:doi:10.1634/stemcells.2008-0075Secondary to Cardiac Arrest is Brain Damage do to lack of blood flow. This is marked by a delayed loss of Neurons in CA1 hippocampus region of the brain due to inflammatory response.The story time...
Source: Neuromics - September 11, 2008 Category: Neuroscience Tags: Umblical Cells stem-cell-like RUCM cells. Microglia Neuroprotection Astrocyte Marker Cerebral Ischemia GFAP Antibody Astrocytosis Stem Cells Source Type: organizations

Neurotoxicity TestingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We combine our expertise in providing fresh and healthy:E18 and E20 Rat Primary Neuronal Tissue -NEURON CULTURESE18 Rat Primary Neuronal Tissue - ASTROCYTE CULTURESE18 Mouse Neuronal Tissue -NEURON CULTURESE18 Mouse Neuronal Tissue -ASTROCYTE CULTURESAND Apoptosis Research Reagentsto help researchers more effectively study Neurotoxicity.Images: Polycaspase Assay Kit, green was used to assess cell death in primay rat hippocampal neurons.Cells were plated on 25-mm poly-l-lysine-coated coverslips at 300,000 cells per coverslip. Cells were used at 4 or 8 days in vitro. Composite imagae (A) 3 out of 4 cells are apoptotic (green...
Source: Neuromics - September 8, 2008 Category: Neuroscience Tags: Astrocytes Apoptosis Neurotoxicity FLICA e-18 Primary Mouse Neurons Polycasp e-18 Primary Rat Neurons Source Type: organizations