Brain invasion by chronic lymphocytic leukemia
(CLL) is very rare, and only a handful of cases have been reported. We here report a case of 61 ‐year‐old woman who had been treated for CLL for 14 years presenting with a progressive mental disturbance. Magnetic resonance imaging (MRI) showed discontinuous ring‐enhancing lesions compatible with the “open ring” sign, which was considered a demyelinating disorder, in both the frontal lobes. However, on histological examination of the biopsied specimen, infiltration of small lymphocytes positive for CD5, CD20, and CD23, indicating brain invasion by CLL, was seen. The leukemia cells occupied the Virchow–Robin spa...
Source: Neuropathology - November 25, 2018 Category: Neurology Authors: Ryohei Otani,
Takeo Uzuka,
Hadzki Matsuda,
Fumi Higuchi,
Phyo Kim,
Keisuke Ueki Tags: Case Report Source Type: research
Intracranial vascular calcification with extensive white matter changes in an autopsy case of pseudopseudohypoparathyroidism
We herein report an autopsy case of a 69 ‐year‐old man with pseudopseudohypoparathyroidism. The patient suffered from mental retardation and spastic tetraparesis and had all the features of Albright's hereditary osteodystrophy with a normal response to parathyroid hormone in the Ellsworth–Howard test. Computed tomography demonstrated symmetrical massive brain calcification involving the bilateral basal ganglia, thalami, dentate nuclei and cerebral gray/white matter junctions, which was consistent with Fahr's syndrome. Magnetic resonance imaging revealed extensive white matter changes sparing the corpus callosum. Seve...
Source: Neuropathology - November 14, 2018 Category: Neurology Authors: Tamaki Iwase,
Mari Yoshida,
Yoshio Hashizume,
Ikuru Yazawa,
Seishiro Takahashi,
Takashi Ando,
Toshimasa Ikeda,
Kazuya Nokura Tags: Case Report Source Type: research
Autopsied centenarian case of Alzheimer's disease combined with hippocampal sclerosis, TDP ‐43, and α‐synuclein pathologies
A Japanese woman showed slowly progressive memory disturbance starting at the age of 84 years, and disorientation gradually appeared. Head computed tomography revealed severe hippocampal atrophy, whereas the atrophy of the frontal lobe was considerably mild for her age. Behavioral and psychological symptoms of dementia were relatively inconspicuous during the disease course. Apolipo protein E gene analysis showedε3/ε4 heterozygosity. She died at the age of 100 years and she was clinically diagnosed as having Alzheimer's disease (AD). Autopsy revealed numerous neurofibrillary tangles, particularly in the hippocampal...
Source: Neuropathology - November 9, 2018 Category: Neurology Authors: Yasushi Iwasaki,
Akira Deguchi,
Keiko Mori,
Masumi Ito,
Yoshinari Kawai,
Akio Akagi,
Maya Mimuro,
Hiroaki Miyahara,
Mari Yoshida Tags: Case Report Source Type: research
Hydroxychloroquine ‐induced autophagic vacuolar myopathy with mitochondrial abnormalities
We report four patients who were receiving HCQ as part of treatment for connective tissue disorder and who presented with myopathy. The muscle biopsy in these patients was consistent with findings of HCQ toxicity. HCQ muscle toxicity is usually self ‐limiting after discontinuation of the drug. It also usually tends to be under‐reported due to presence of various confounding factors. This warrants close monitoring and consideration of muscle biopsy as part of initial work up of patients who present with myopathy while receiving HCQ. (Source: Neuropathology)
Source: Neuropathology - November 8, 2018 Category: Neurology Authors: Shaweta Khosa,
Negar Khanlou,
Gurveer S. Khosa,
Shri K. Mishra Tags: Case Report Source Type: research
Nuclear abnormalities in vascular myocytes in cerebral autosomal ‐dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
Cerebral autosomal ‐dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a stroke and dementia syndrome with degeneration and loss of vascular smooth muscle cells (VSMCs). The disease is due to mutations inNOTCH3 playing an important role in VSMC differentiation, proliferation and apoptosis. Searching for a possible cause of VSMC dysfunction in CADASIL, we investigated morphology and proliferative activity the affected myocytes. In material from autopsy brains and skin ‐muscle biopsies of patients with CADASIL diagnosis, assessment of VSMCs in arterial vessels at the level of light and e...
Source: Neuropathology - November 6, 2018 Category: Neurology Authors: Dorota Dziewulska,
Ewelina Nycz,
Cecylia Rajczewska ‐Oleszkiewicz,
Jacek Bojakowski,
Dorota Sulejczak Tags: Original Article Source Type: research
Distinct microglia profile in Creutzfeldt –Jakob disease and Alzheimer's disease is independent of disease kinetics
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - October 15, 2018 Category: Neurology Authors: Katarina Krbot,
Peter Hermann,
Magdalena Krbot Skori ć,
Inga Zerr,
Diego Sepulveda‐Falla,
Stefan Goebel,
Jakob Matschke,
Susanne Krasemann,
Markus Glatzel Source Type: research
Cover Image
Neuropathology,Volume 38, Issue 5, Page 455-455, October 2018. (Source: Neuropathology)
Source: Neuropathology - October 4, 2018 Category: Neurology Source Type: research
Issue Information
Neuropathology,Volume 38, Issue 5, Page 456-456, October 2018. (Source: Neuropathology)
Source: Neuropathology - October 4, 2018 Category: Neurology Source Type: research
Brainstem astroblastoma with MN1 translocation
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - September 20, 2018 Category: Neurology Authors: Sun Ah
Shin
,
Bokyung
Ahn
,
Seung ‐Ki
Kim
,
Hyoung Jin
Kang
,
Sumihito
Nobusawa
,
Takashi
Komori
,
Sung‐Hye
Park Source Type: research
Autopsy case of V180I genetic Creutzfeldt ‐Jakob disease presenting with early disease pathology
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - September 14, 2018 Category: Neurology Authors: Yasushi
Iwasaki
,
Hiroko
Kato
,
Tetsuo
Ando
,
Akio
Akagi
,
Maya
Mimuro
,
Hiroaki
Miyahara
,
Tetsuyuki
Kitamoto
,
Mari
Yoshida Source Type: research
First descriptions of tuberous sclerosis by D ésiré‐Magloire Bourneville (1840–1909)
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - September 14, 2018 Category: Neurology Authors: Francesco
Brigo
,
Simona
Lattanzi
,
Eugen
Trinka
,
Raffaele
Nardone
,
Nicola L.
Bragazzi
,
Martino
Ruggieri
,
Mariano
Martini
,
Olivier
Walusinski Source Type: research
Dynactin is involved in Lewy body pathology
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - September 14, 2018 Category: Neurology Authors: Chang
Shen
,
Hiroyuki
Honda
,
Satoshi O
Suzuki
,
Norihisa
Maeda
,
Masahiro
Shijo
,
Hideomi
Hamasaki
,
Naokazu
Sasagasako
,
Naoki
Fujii
,
Toru
Iwaki Source Type: research
Expanding the spectrum of pediatric NTRK ‐rearranged fibroblastic tumors to the central nervous system: A case report with RBPMS‐NTRK3 fusion
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - September 6, 2018 Category: Neurology Authors: Matthew
Torre
,
Nicholas
Jessop
,
Jason L.
Hornick
,
Sanda
Alexandrescu Source Type: research
Xanthomatous meningioma: A metaplastic or degenerative phenomenon?
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - September 6, 2018 Category: Neurology Authors: Yin Ping
Wong
,
Geok Chin
Tan
,
Ramesh
Kumar Source Type: research
Novel ‐graded traumatic brain injury model in rats induced by closed head impacts
Neuropathology, EarlyView. (Source: Neuropathology)
Source: Neuropathology - September 6, 2018 Category: Neurology Authors: Hao
Wang
,
Xiyan
Zhu
,
Zhikang
Liao
,
Hongyi
Xiang
,
Mingliang
Ren
,
Minhui
Xu
,
Hui
Zhao Source Type: research
