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ADAS-COG and mental deterioration battery: different instruments for different aspects of cognitive decline in Alzheimer's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results supports the use of the MDB in the screening phase of AD patients and of ADAS-Cog to follow the progression of cognitive decline over time.
Source: Neuroscience Research Communications - October 4, 2006 Category: Neuroscience Authors: Laura Serra, Roberta Perri, Giovanni Augusto Carlesimo, Lucia Fadda, Sebastiano Lorusso, Alessandro Padovani, Carla Pettenati, Maia Vegliante, Carlo Caltagirone Source Type: journals

Alzheimer's disease and immune activation: A translational perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alzheimer's Disease (AD) is a neurodegenerative disorder characterised by abnormal fibrillar deposits of amyloid beta peptides (A[bgr]), which are suggested to play a pivotal role in driving disease pathogenesis. Although the aetiology of AD is still unknown, a perturbation of the immune system has been widely demonstrated in both animal experimental models and patients. The most studied aspect of immune reaction in AD is inflammation, which has been described to be implied in its pathogenic processes. Moreover, a growing body of evidence, indicating that the triggering of the specific A[bgr] immune response can be effecti...
Source: Neuroscience Research Communications - October 4, 2006 Category: Neuroscience Authors: Paola Bossù, Antonio Ciaramella, M. Luisa Moro, Gianfranco Spalletta, Carlo Caltagirone Source Type: journals

Oxidative stress in Alzheimer's disease: a selective status reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Age has a powerful effect on enhanced susceptibility to cardiovascular diseases, stroke, cognitive impairment and neurodegenerative diseases and a condition of increased oxidative stress status seems to be the link factor. In this paper we briefly reviewed the more recently reports on the role of oxidative stress in aging and age-related diseases with a specific focus on mild cognitive impairment and Alzheimer's disease. The role of antioxidant therapy and/or supplementation and the importance of an antioxidant rich diet are then discussed.
Source: Neuroscience Research Communications - October 4, 2006 Category: Neuroscience Authors: Patrizia Mecocci, Francesca Mangialasche, M. Cristina Polidori Source Type: journals

Phosphorylation of the amyloid precursor protein (APP): Is this a mechanism in favor or against Alzheimer's disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review discusses the phosphorylation of the Amyloid Precursor Protein (APP) and the possible role of this phosphorylation in Alzheimer's disease (AD). AD is a neurodegenerative disorder characterized by the deposition of [bgr]-amyloid plaques in the brain parenchyma and neurofibrillary tangles comprised of hyperphosphorylated tau. APP plays a primary role in the pathogenesis of AD, because its processing generates the amyloid beta peptide (A[bgr]), the core of the amyloid plaque. APP has a large N-terminal extracellular domain and a short intracellular C-terminal domain that can be phosphorylated by various protein ki...
Source: Neuroscience Research Communications - October 4, 2006 Category: Neuroscience Authors: Lucia Pastorino, Kun Ping Lu Source Type: journals

Advance on the diagnostic potential of biological markers in the early detection of Alzheimer DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Here we summarise current knowledge about biological markers available for early Alzheimer Disease detection. In fact delineating disease process from "normal ageing" may be difficult in the very early stages; in later stages of the disease distinguishing Dementia of Alzheimer Type from a number of neurodegenerative diseases associated with dementia may also be troublesome.
Source: Neuroscience Research Communications - October 4, 2006 Category: Neuroscience Authors: Barbara Borroni, Monica DiLuca, Flaminio Cattabeni, Alessandro Padovani Source Type: journals

The potential role played by artificial adaptive systems in enhancing our understanding of Alzheimer disease: The experience gained within Italian Interdisciplinary network on Alzheimer diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The author describes a refiguration of medical thought which originate from non linear dynamics and chaos theory. The coupling of computer science and these new theoretical bases allows the creation of "intelligent" agents (Artificial Adaptive Systems AAS) able to adapt themselves dynamically to problem of high complexity like Alzheimer Disease. ASS are able to reproduce the dynamical interactio of multiple factors simultaneously, allowing the study of complexity; they can also draw conclusions on individual basis and not as average trends. In the last years of co-operation between ITINAD, Bracco Medical Department and Sem...
Source: Neuroscience Research Communications - October 4, 2006 Category: Neuroscience Authors: Enzo Grossi, Massimo Buscema Source Type: journals

Behavioural and psychological symptoms of dementia: clinical aspectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Non cognitive symptoms are almost always present in dementia with important consequences for patients and caregivers quality of life. Behavioural and Psychological Symptoms of Dementia (BPSD) are heterogeneous and varied in relation to the stage of the demetia and to the aetiology. Treatment of behavioral and psychological symptoms of dementia represent an important challenge, and non pharmacological and pharmacological approach needs. Antidepressant and neuroleptics are the most frequently used drugs in the treatment of BPSD, even if the number of well designed controlled studies are limited. A variety of different forms ...
Source: Neuroscience Research Communications - November 1, 2004 Category: Neuroscience Authors: Angelo Bianchetti, Marco Trabucchi Source Type: journals