New England Journal of Medicine
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CME: Case 36-2009: A 23-Year-Old Man with Cough, Hoarseness, and Abnormalities on Chest Imaging
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Source Type: journals
CME: Inflammatory Bowel DiseaseEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Source Type: journals
CME: A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney DiseaseEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Source Type: journals
Cost Expansion versus Cost Control -- Lessons from the Canadian SystemEmail this article to a colleague.
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The health care reform effort in the United States is driven by the desires for cost control and expanded coverage. However, as Daniel Callahan recently wrote, "cost controls that are ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Liao, J., Choi, K. Tags: OTHER POINTS OF VIEW Source Type: journals
Alpha1-Antitrypsin DeficiencyEmail this article to a colleague.
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To the Editor: In their Clinical Practice article (June 25 issue),1 Silverman and Sandhaus mention two small trials of augmentation ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Gotzsche, P. C., Johansen, H. K., Taylor, N. J., Shawcross, D. L., Silverman, E. K., Sandhaus, R. A. Tags: CORRESPONDENCE Source Type: journals
Apixaban or Enoxaparin for ThromboprophylaxisEmail this article to a colleague.
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To the Editor: Lassen and colleagues (Aug. 6 issue)1 state that apixaban and enoxaparin had similar efficacy, based on the ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Gomez-Outes, A., Suarez-Gea, M. L., Pozo-Hernandez, C., Lassen, M. R., Raskob, G. E., Gallus, A. Tags: CORRESPONDENCE Source Type: journals
Trials of Vertebroplasty for Vertebral FracturesEmail this article to a colleague.
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To the Editor: In the August 6 issue, Kallmes et al.1 report on the Investigational Vertebroplasty Safety and Efficacy Trial ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Clark, W., Lyon, S., Burnes, J., Baerlocher, M. O., Munk, P. L., Liu, D. M., Lotz, J. C., Grey, A., Bolland, M., Buchbinder, R., Osborne, R., Staples, M., Kallmes, D. F., Heagerty, P. J., Jarvik, J. G., Weinstein, J. N. Tags: CORRESPONDENCE Source Type: journals
The Hedgehog Pathway and Pancreatic CancerEmail this article to a colleague.
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Treatment of a mouse model of aggressive pancreatic cancer with an inhibitor of the hedgehog pathway enhanced tumor sensitivity to gemcitabine and resulted in the stabilization of disease. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Hidalgo, M., Maitra, A. Tags: CLINICAL IMPLICATIONS OF BASIC RESEARCH Source Type: journals
Interleukin-10 in Inflammatory Bowel DiseaseEmail this article to a colleague.
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In this issue of the Journal, Glocker et al.1 provide the first substantial support for a functional role for the immunosuppressive cytokine interleukin-10 in the pathogenesis of inflammatory bowel disease ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Kelsall, B. Tags: EDITORIALS Source Type: journals
Treatment of Anemia in Chronic Kidney Disease -- Strategies Based on EvidenceEmail this article to a colleague.
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Anemia associated with chronic kidney disease and end-stage renal disease is due, in large part, to reduced production of renal erythropoietin and abnormalities in extracellular-fluid volume homeostasis.1 Moreover, anemia and ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Marsden, P. A. Tags: EDITORIALS Source Type: journals
Case 36-2009 -- A 23-Year-Old Man with Cough, Hoarseness, and Abnormalities on Chest ImagingEmail this article to a colleague.
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A 23-year-old man was transferred to this hospital because of cough, hoarseness, fever, and abnormalities on chest imaging. One month before admission, a nonproductive cough developed, followed by hoarseness, dyspnea on exertion, and fever. Imaging studies at another facility showed pulmonary and mediastinal masses and a lesion in the pelvis. Positron-emission tomographic scans obtained at this hospital showed 18F-fluorodeoxyglucose-avid lesions. A diagnostic procedure was performed. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Choy, E., Digumarthy, S. R., Koplin, S. A. Tags: CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL Source Type: journals
Gouty TophiEmail this article to a colleague.
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A 77-year-old man presented with a 5-day history of painful swelling of his right elbow, which was also red, warm, and tender. When pressure was applied, a toothpastelike, white, chalky ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Wiesner, T., Fried, I. Tags: IMAGES IN CLINICAL MEDICINE Source Type: journals
Air in the Portal and Mesenteric VeinsEmail this article to a colleague.
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A 73-year-old man with history of smoking, hypertension, chronic obstructive pulmonary disease, and type 2 diabetes mellitus presented with respiratory distress. The trachea was intubated, and the patient was admitted ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: de Mendoza-Asensi, D., Planas, K. Tags: IMAGES IN CLINICAL MEDICINE Source Type: journals
Mechanisms of Disease: Inflammatory Bowel DiseaseEmail this article to a colleague.
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This review gives an account of recent advances in our knowledge of the intestinal immune system and how it becomes perturbed in Crohn's disease and ulcerative colitis. The importance of genetic factors in these diseases has been increasingly recognized, and this article emphasizes their roles. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Abraham, C., Cho, J. H. Tags: REVIEW ARTICLES Source Type: journals
A Novel Protective Prion Protein Variant that Colocalizes with Kuru ExposureEmail this article to a colleague.
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In this report, further investigation involving kuru-exposed survivors in Papua New Guinea shows that certain polymorphisms in PRNP codon 127 lead to genetic resistance to kuru. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Mead, S., Whitfield, J., Poulter, M., Shah, P., Uphill, J., Campbell, T., Al-Dujaily, H., Hummerich, H., Beck, J., Mein, C. A., Verzilli, C., Whittaker, J., Alpers, M. P., Collinge, J. Tags: ORIGINAL ARTICLES Source Type: journals
Combined Immunodeficiency Associated with DOCK8 MutationsEmail this article to a colleague.
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This article describes a group of 11 patients between the ages of 6 and 21 years who had recurrent sinopulmonary infections, extensive cutaneous viral infections, severe allergies, and elevated serum levels of IgE; some of the patients also had asthma or reactive airway disease or susceptibility to cancer. All patients had loss-of-function mutations in the DOCK8 gene. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Zhang, Q., Davis, J. C., Lamborn, I. T., Freeman, A. F., Jing, H., Favreau, A. J., Matthews, H. F., Davis, J., Turner, M. L., Uzel, G., Holland, S. M., Su, H. C. Tags: ORIGINAL ARTICLES Source Type: journals
Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 ReceptorEmail this article to a colleague.
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Genetic analyses showed that mutations affecting the interleukin-10 receptor are associated with early-onset colitis. Further molecular analyses showed that the mutations abrogated interleukin-10 signaling. Treatment of one of the affected children by means of allogeneic hematopoietic stem-cell transplantation was successful. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Glocker, E.-O., Kotlarz, D., Boztug, K., Gertz, E. M., Schaffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Allroth, A., Murugan, D., Hatscher, N., Pfeifer, D., Sykora, K.-W., Sauer, M., Kreipe, H., Lacher, M., Nustede, R., Woellner, C., Baumann, U., Tags: ORIGINAL ARTICLES Source Type: journals
A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney DiseaseEmail this article to a colleague.
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Anemia is associated with an increased risk of cardiovascular and renal events among patients with type 2 diabetes and chronic kidney disease. This placebo-controlled trial randomly assigned such patients to receive darbepoetin alfa or placebo. The two composite end points were death or cardiovascular disease and death or end-stage renal disease. Darbepoetin alfa did not reduce either outcome and was associated with an increased risk of stroke. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Pfeffer, M. A., Burdmann, E. A., Chen, C.-Y., Cooper, M. E., de Zeeuw, D., Eckardt, K.-U., Feyzi, J. M., Ivanovich, P., Kewalramani, R., Levey, A. S., Lewis, E. F., McGill, J. B., McMurray, J. J.V., Parfrey, P., Parving, H.-H., Remuzzi, G., Singh, A. K., Tags: ORIGINAL ARTICLES Source Type: journals
Mandatory Vaccination of Health Care WorkersEmail this article to a colleague.
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Mandatory vaccination of health care workers raises important questions about the limits of a state's power to compel individuals to engage in particular activities in order to protect the public. ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Stewart, A. M. Tags: PERSPECTIVE Source Type: journals
Massachusetts Health Care Reform -- Near-Universal Coverage at What Cost?Email this article to a colleague.
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Massachusetts has long been known for its academic medical centers, biomedical research, high-quality health care, and perhaps not unrelatedly, high health care costs. In 2006, the state captured national attention ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Weissman, J. S., Bigby, J. Tags: PERSPECTIVE Source Type: journals
Medicaid and National Health Care ReformEmail this article to a colleague.
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Defined by a history of both achievement and controversy, Medicaid has once again become central to the U.S. health policy debate, this time figuring as a key to national health ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Rosenbaum, S. Tags: PERSPECTIVE Source Type: journals
The American Public and the Next Phase of the Health Care Reform DebateEmail this article to a colleague.
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Congressional leaders and President Barack Obama are moving ahead to develop a single piece of major health care legislation, which will be debated, voted on by both houses of Congress, ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Blendon, R. J., Benson, J. M. Tags: PERSPECTIVE Source Type: journals
Compromises and Controversies -- Moving Forward on ReformEmail this article to a colleague.
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Accelerating progress toward the Democrats' goal of enacting health care reform legislation, House Speaker Nancy Pelosi (D-CA) unveiled a bill on October 29 that would establish a mandate for most ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Iglehart, J. K. Tags: PERSPECTIVE Source Type: journals
Not "Socialized Medicine" -- An Israeli View of Health Care ReformEmail this article to a colleague.
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In 2007, the United States spent about 15% of its gross domestic product (GDP) on health care, whereas Israel's health care spending was about 8% of its GDP (see graph, ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Chernichovsky, D. Tags: PERSPECTIVE Source Type: journals
Antiviral Treatment for Patients Hospitalized with 2009 Pandemic Influenza A (H1N1)Email this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Uyeki, T. Tags: OTHER POINTS OF VIEW Source Type: journals
Eliminating a Viable Primary Care Workforce -- A Primary Care PerspectiveEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Sterling, M. L. Tags: OTHER POINTS OF VIEW Source Type: journals
Health Care Reform -- A Republican ViewEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Grassley, C. Tags: PERSPECTIVE Source Type: journals
Lobbying, Campaign Contributions, and Health Care ReformEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Steinbrook, R. Tags: PERSPECTIVE Source Type: journals
Industry Influence on Comparative-Effectiveness Research Funded through Health Care ReformEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Selker, H. P., Wood, A. J.J. Tags: PERSPECTIVE Source Type: journals
The Consequences of "No"Email this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Kellermann, A. L., Lewin, L. S. Tags: PERSPECTIVE Source Type: journals
The Supreme Court, Process Patents, and Medical InnovationEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Kesselheim, A. S. Tags: PERSPECTIVE Source Type: journals
Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in HumansEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Blyth, C. C., Iredell, J. R., Dwyer, D. E. Tags: CORRESPONDENCE Source Type: journals
Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist DeviceEmail this article to a colleague.
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Background Patients with advanced heart failure have improved survival rates and quality of life when treated with implanted pulsatile-flow left ventricular assist devices as compared with medical therapy. New continuous-flow ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 17, 2009 Category: Internal Medicine Authors: Slaughter, M. S., Rogers, J. G., Milano, C. A., Russell, S. D., Conte, J. V., Feldman, D., Sun, B., Tatooles, A. J., Delgado, R. M., Long, J. W., Wozniak, T. C., Ghumman, W., Farrar, D. J., Frazier, O. H., the HeartMate II Investigators Tags: ORIGINAL ARTICLES Source Type: journals
Platelet Inhibition with Cangrelor in Patients Undergoing PCIEmail this article to a colleague.
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Background Cangrelor, a nonthienopyridine adenosine triphosphate analogue, is an intravenous blocker of the adenosine diphosphate receptor P2Y12. This agent might have a role in the treatment of patients who require ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 17, 2009 Category: Internal Medicine Authors: Harrington, R. A., Stone, G. W., McNulty, S., White, H. D., Lincoff, A. M., Gibson, C. M., Pollack, C. V., Montalescot, G., Mahaffey, K. W., Kleiman, N. S., Goodman, S. G., Amine, M., Angiolillo, D. J., Becker, R. C., Chew, D. P., French, W. J., Leisch, F Tags: ORIGINAL ARTICLES Source Type: journals
Ferric Carboxymaltose in Patients with Heart Failure and Iron DeficiencyEmail this article to a colleague.
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This study aimed to determine whether treatment with intravenous iron (ferric carboxymaltose) would improve symptoms in patients who had heart failure, reduced left ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 17, 2009 Category: Internal Medicine Authors: Anker, S. D., Comin Colet, J., Filippatos, G., Willenheimer, R., Dickstein, K., Drexler, H., Luscher, T. F., Bart, B., Banasiak, W., Niegowska, J., Kirwan, B.-A., Mori, C., von Eisenhart Rothe, B., Pocock, S. J., Poole-Wilson, P. A., Ponikowski, P., the F Tags: ORIGINAL ARTICLES Source Type: journals
Rise of the Machines -- Left Ventricular Assist Devices as Permanent Therapy for Advanced Heart FailureEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 17, 2009 Category: Internal Medicine Authors: Fang, J. C. Tags: EDITORIALS Source Type: journals
Anemia and Iron Deficiency -- New Therapeutic Targets in Heart Failure?Email this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 17, 2009 Category: Internal Medicine Authors: Dec, G. W. Tags: EDITORIALS Source Type: journals
Long-Term Outcome Associated with Early Repolarization on ElectrocardiographyEmail this article to a colleague.
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Background Early repolarization, which is characterized by an elevation of the QRS-ST junction (J point) in leads other than V1 through V3 on 12-lead electrocardiography, has been associated with vulnerability ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 16, 2009 Category: Internal Medicine Authors: Tikkanen, J. T., Anttonen, O., Junttila, M. J., Aro, A. L., Kerola, T., Rissanen, H. A., Reunanen, A., Huikuri, H. V. Tags: ORIGINAL ARTICLES Source Type: journals
Intravenous Platelet Blockade with Cangrelor during PCIEmail this article to a colleague.
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Background Intravenous cangrelor, a rapid-acting, reversible adenosine diphosphate (ADP) receptor antagonist, might reduce ischemic events during percutaneous coronary intervention (PCI). Methods In this double-blind, placebo-controlled study, we randomly assigned 5362 ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 15, 2009 Category: Internal Medicine Authors: Bhatt, D. L., Lincoff, A. M., Gibson, C. M., Stone, G. W., McNulty, S., Montalescot, G., Kleiman, N. S., Goodman, S. G., White, H. D., Mahaffey, K. W., Pollack, C. V., Manoukian, S. V., Widimsky, P., Chew, D. P., Cura, F., Manukov, I., Tousek, F., Jafar, Tags: ORIGINAL ARTICLES Source Type: journals
Extended-Release Niacin or Ezetimibe and Carotid Intima-Media ThicknessEmail this article to a colleague.
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Background Treatment added to statin monotherapy to further modify the lipid profile may include combination therapy to either raise the high-density lipoprotein (HDL) cholesterol level or further lower the low-density ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 15, 2009 Category: Internal Medicine Authors: Taylor, A. J., Villines, T. C., Stanek, E. J., Devine, P. J., Griffen, L., Miller, M., Weissman, N. J., Turco, M. Tags: ORIGINAL ARTICLES Source Type: journals
Biventricular Pacing in Patients with Bradycardia and Normal Ejection FractionEmail this article to a colleague.
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In this study, we examined whether biventricular pacing is superior to ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 15, 2009 Category: Internal Medicine Authors: Yu, C.-M., Chan, J. Y.-S., Zhang, Q., Omar, R., Yip, G. W.-K., Hussin, A., Fang, F., Lam, K. H., Chan, H. C.-K., Fung, J. W.-H. Tags: ORIGINAL ARTICLES Source Type: journals
Cangrelor -- A Champion Lost in Translation?Email this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 15, 2009 Category: Internal Medicine Authors: Kastrati, A., Ndrepepa, G. Tags: EDITORIALS Source Type: journals
Deleterious Effects of Right Ventricular PacingEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 15, 2009 Category: Internal Medicine Authors: Lindsay, B. D. Tags: EDITORIALS Source Type: journals
Statin Therapy with Ezetimibe or Niacin in High-Risk PatientsEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 15, 2009 Category: Internal Medicine Authors: Kastelein, J. J.P., Bots, M. L. Tags: EDITORIALS Source Type: journals
The HALTS Trial -- Halting Atherosclerosis or Halted Too Early?Email this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 15, 2009 Category: Internal Medicine Authors: Blumenthal, R. S., Michos, E. D. Tags: EDITORIALS Source Type: journals
CME: Case 35-2009: A 60-Year-Old Male Renal-Transplant Recipient with Renal Insufficiency, Diabetic Ketoacidosis, and Mental-Status ChangesEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 11, 2009 Category: Internal Medicine Source Type: journals
CME: Renal-Artery StenosisEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 11, 2009 Category: Internal Medicine Source Type: journals
CME: Critical Care Services and 2009 H1N1 Influenza in Australia and New ZealandEmail this article to a colleague.
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(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 11, 2009 Category: Internal Medicine Source Type: journals
Five-Year Risk of Colorectal Neoplasia after Negative Screening ColonoscopyEmail this article to a colleague.
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. In the References (page 1224), reference 24 should have read: "Brenner H, Hoffmeister M, Stegmaier C, Brenner G, Altenhofen L, ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 11, 2009 Category: Internal Medicine Tags: CORRECTIONS Source Type: journals
A Randomized Trial of Arthroscopic Surgery for Osteoarthritis of the KneeEmail this article to a colleague.
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. In the legend for Figure 2 (page 1102), the third sentence should have read, "Error bars indicate the ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 11, 2009 Category: Internal Medicine Tags: CORRECTIONS Source Type: journals
