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(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 28, 2009 Category: Radiology Source Type: journals

Use of pressure-hold test for sterilizing filter membrane integrity in radiopharmaceutical manufacturingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The bubble point test is the de facto standard for postproduction filter membrane integrity test in the radiopharmaceutical community. However, the bubble point test depends on a subjective visual assessment of bubbling rate that can be obscured by significant diffusive gas flows below the manufacturer's prescribed bubble point. To provide a more objective means to assess filter membrane integrity, this study evaluates the pressure-hold test as an alternative to the bubble point test. In our application of the pressure-hold test, the nonsterile side of the sterilizing filter is pressurized to 85% of the predeterm...
Source: Nuclear Medicine and Biology - October 28, 2009 Category: Radiology Authors: Anthony P. Belanger, John F. Byrne, Justin M. Paolino, Timothy R. DeGrado Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 28, 2009 Category: Radiology Source Type: journals

Intracellular reactions affecting 2-amino-4-([11C]methylthio)butyric acid ([11C]methionine) response to carbon ion radiotherapy in C10 glioma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The earlier response of [11C]Met uptake to tumor radiotherapy could be attributable to the decline in the intracellular energy-dependent reactions of tumors due to radiotherapy. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Tomoya Uehara, Misuzu Nakagawa, Nobuhiko Takai, Sachiko Koike, Yoshiya Furusawa, Kouichi Ando, Keiichi Kawai, Hiromichi Akizawa, Toshiaki Irie, Yasushi Arano Source Type: journals

Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Use of chemotherapeutic agents to induce cytotoxic DNA damage and programmed cell death is a key strategy in cancer treatments. However, the efficacy of DNA-targeted agents such as temozolomide is often compromised by intrinsic cellular responses such as DNA base excision repair (BER). Previous studies have shown that BER pathway resulted in formation of abasic or apurinic/apyrimidinic (AP) sites, and blockage of AP sites led to a significant enhancement of drug sensitivity due to reduction of DNA base excision repair. Since a number of chemotherapeutic agents also induce formation of AP sites, monitoring of thes...
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Yanming Wang, Lili Liu, Chunying Wu, Alina Bulgar, Eduardo Somoza, Wenxia Zhu, Stanton L. Gerson Source Type: journals

Trypsinization severely perturbs radioiodide transport via membrane Na/I symporter proteolysis: implications for reporter gene imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Trypsinization leads to serious perturbations in iodide accumulating capacity through tryptic degradation of membrane NIS protein. Hence, NIS-based reporter assays and in vivo cell imaging studies may benefit from better-optimized cell cultivation and harvesting procedures. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Kyung-Ho Jung, Jin-Young Paik, You La Lee, Yong Jin Lee, Jaetae Lee, Kyung-Han Lee Source Type: journals

A restricted access material for rapid analysis of [11C]-labeled radiopharmaceuticals and their metabolites in plasmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The described method is fast and robust and the large sample volumes allow for accurate determination of the radioactive components in plasma even at 90 min after injection of a [11C]-labeled radiopharmaceutical. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Nic Gillings Source Type: journals

Glucose utilization in the brain during acute seizure is a useful biomarker for the evaluation of anticonvulsants: effect of methyl ethyl ketone in lithium-pilocarpine status epilepticus ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Enhancement of glucose utilization in the brain has been well known during acute seizure in various kinds of animal model of epilepsy. This enhancement of glucose utilization might be related to neural damage in these animal models. Recently, we found that methyl ethyl ketone (MEK) had both anticonvulsive and neuroprotective effects in lithium-pilocapine (Li-pilo) status epilepticus (SE) rat. In this article, we measured the uptake of [14C]2-deoxyglucose ([14C]DG) in the Li-pilo SE and Li-pilo SE with MEK rat brain in order to assess whether the glucose utilization was a useful biomarker for the detection of effi...
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Akifumi Yamada, Sotaro Momosaki, Rie Hosoi, Kohji Abe, Masatoshi Yamaguchi, Osamu Inoue Source Type: journals

Evaluation of nigrostriatal damage and its change over weeks in a rat model of Parkinson's disease: small animal positron emission tomography studies with [11C]β-CFTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings not only demonstrate that the neuronal degeneration in this model is relatively slow, but also suggest [11C]β-CFT is a sensitive marker to monitor the degree of nigrostriatal damage and its change over weeks. This marker can be used prospectively to study the progression of the disease, thereby making detection of early phases of PD possible. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Limin Liu, Yong Wang, Bo Li, Jun Jia, Zuoli Sun, Jinming Zhang, Jiahe Tian, Xiaomin Wang Source Type: journals

[18F]Fallypride dopamine D2 receptor studies using delayed microPET scans and a modified Logan plotEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although the BPND estimates are slightly overestimated in a delayed scan mode (i.e., no initial radiotracer uptake measurements) compared to a full scan, this overestimation depends primarily on k3 (≈kon×Bmax) and has been evaluated in this work for a wide range of kon values using simulated TACs. In particular, the sensitivity of DVR′ to changes in kon is similar to that of DVR. This method of delayed scans eliminates the necessity of imaging during the initial uptake of the radiotracer and, thus, can be used to increase the throughput of studies. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Mohammed N. Tantawy, Carrie K. Jones, Ronald M. Baldwin, M. Sib Ansari, P. Jeffrey Conn, Robert M. Kessler, Todd E. Peterson Source Type: journals

Targeting aldehyde dehydrogenase: a potential approach for cell labelingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: To pursue this approach for ALDH1 imaging, radiolabeled aldehydes need to be designed such that, in addition to being good substrates for ALDH1, the cognate products should be sufficiently polar so as to be retained within the cells. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Ganesan Vaidyanathan, Haijing Song, Donna Affleck, Darryl L. McDougald, Robert W. Storms, Michael R. Zalutsky, Bennett B. Chin Source Type: journals

Evaluation of single amino acid chelate derivatives and regioselective radiolabelling of a cyclic peptide for the urokinase plasminogen activator receptorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A series of single amino acid chelate (SAAC) ligands have been evaluated for their ability to incorporate 99mTc into peptides. The lead agent to emerge from this work is the thiazole SAAC derivative 1d which has demonstrated the ability to regioselectively label the widest range of peptides. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Andrea F. Armstrong, Jennifer A. Lemon, Shannon K. Czorny, Gurmit Singh, John F. Valliant Source Type: journals

Design of silicon-based misonidazole analogues and 18F-radiolabellingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We have described an efficient and versatile approach for the synthesis of 18F-labeled, silicon-based misonidazole analogues. PET imaging of one of these compounds revealed that hypoxia could be detected. Controlling the biodistribution of 18F-labeled silicon-based misonidazole analogues will require additional studies. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Pierre Bohn, Abdallah Deyine, Rabah Azzouz, Laetitia Bailly, Catherine Fiol-Petit, Laurent Bischoff, Corinne Fruit, Francis Marsais, Pierre Vera Source Type: journals

Localization of radiolabeled anti-CEA antibody in subcutaneous and intrahepatic colorectal xenografts: influence of tumor size and location within host organ on antibody uptakeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Radioimmunodetection and therapy might be greatly influenced by the size and distribution of intrahepatic tumor deposits. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Jason L.J. Dearling, Aiden A. Flynn, Uzma Qureshi, Stephen Whiting, Geoffrey M. Boxer, Alan Green, Richard H.J. Begent, R. Barbara Pedley Source Type: journals

Validation of the calculation of the clearance rate constant (kmono) of [11C]acetate using parametric kmono image for myocardial oxidative metabolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: The purpose of this study was to validate the calculation of myocardial oxidative metabolism rate using a parametric clearance rate constant (kmono) image.Methods: Fifteen subjects (seven volunteers, eight patients) were studied. Dynamic PET was acquired after intravenous injection of 700 MBq of [11C]acetate. The clearance rate constant of [11C]acetate (kmono) was calculated pixel by pixel to generate the parametric kmono image. The kmono values from this image and those calculated from the dynamic image were compared in the same regions of interest (ROIs).Results: Two different methods showed an ex...
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Raihan Hussain, Takashi Kudo, Testuya Tsujikawa, Masato Kobayashi, Yasuhisa Fujibayashi, Hidehiko Okazawa Source Type: journals

Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: FIMA showed high inhibitory potency and selectivity for COX-2. Radioiodinated FIMA showed specific accumulation into COX-2 induced macrophages, no significant in vivo deiodination and rapid blood clearance. Radioiodinated FIMA deserves further investigation as a SPECT radiopharmaceutical for imaging COX-2 expression. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - October 5, 2009 Category: Radiology Authors: Yuji Kuge, Naoyuki Obokata, Hiroyuki Kimura, Yumiko Katada, Takashi Temma, Yukihiko Sugimoto, Kazuki Aita, Koh-ichi Seki, Nagara Tamaki, Hideo Saji Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - September 2, 2009 Category: Radiology Source Type: journals

Validation of 99mTc-labeled “4+1” fatty acids for myocardial metabolism and flow imaging: Part 2. Subcellular distributionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: Our group has synthesized technetium-labeled fatty acids (FA) that are extracted into the myocardium and sequestered due to heart-type fatty acid binding protein (H-FABP) binding. In this article, we further address the detailed subcellular distribution and potential myocardial metabolism of [99mTc]“4+1” FA.Methods: Experiments were conducted using isolated hearts of Wistar rats, as well as of wild-type and H-FABP−/− mice. Myocardium samples underwent subcellular fractionation [subsarcolemmal mitochondria (SM), intermyofibrillar mitochondria (IM), cytosol with microsomes, and nuclei and crud...
Source: Nuclear Medicine and Biology - September 2, 2009 Category: Radiology Authors: Peter Mirtschink, Sebastian N. Stehr, Martin Walther, Jens Pietzsch, Ralf Bergmann, Hans-Jürgen Pietzsch, Johannes Weichsel, Annette Pexa, Peter Dieterich, Gerd Wunderlich, Bert Binas, Joachim Kropp, Andreas Deussen Source Type: journals

Validation of 99mTc-labeled “4+1” fatty acids for myocardial metabolism and flow imaging: Part 1: myocardial extraction and biodistributionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: 13C, 18F and 123I fatty acids (FA) are used for myocardial imaging. Recently, our group showed that [99mTc]-labeled “4+1” FA are extracted into the rat and guinea pig myocardium. The present study evaluates determinants of myocardial uptake and whole body biodistribution of these FA derivatives.Methods: Studies were performed with isolated perfused hearts of Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with a FAT/CD36 deficiency, as well as with heart type FA binding protein knockout mice (H-FABP)−/− and H-FABP+/+. Eight 4+1-99mTc-FA were applied for 3 min followed by 1-min w...
Source: Nuclear Medicine and Biology - September 2, 2009 Category: Radiology Authors: Peter Mirtschink, Sebastian N. Stehr, Martin Walther, Jens Pietzsch, Ralf Bergmann, Hans-Jürgen Pietzsch, Johannes Weichsel, Annette Pexa, Peter Dieterich, Gerd Wunderlich, Bert Binas, Joachim Kropp, Andreas Deussen Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - September 2, 2009 Category: Radiology Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Source Type: journals

Anti-MUC1 aptamers: radiolabelling with 99mTc and biodistribution in MCF-7 tumour-bearing miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: AptA and AptB have been successfully conjugated in high yield to the ligand MAG2 and labelled with 99mTc. The radiolabelled aptamers showed different tumour uptake and clearance, but will require further development prior to diagnostic use. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Chiara Da Pieve, Alan C. Perkins, Sotiris Missailidis Source Type: journals

Biokinetic and dosimetric studies of 188Re-hyaluronic acid: a new radiopharmaceutical for treatment of hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 188Re-HA complex showed good stability, pharmacokinetic and dosimetric characteristics that confirm its potential as a new agent for HCC radiation therapy. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Laura Meléndez-Alafort, Anna Nadali, Elena Zangoni, Alessandra Banzato, Maria Rondina, Antonio Rosato, Ulderico Mazzi Source Type: journals

Sentinel lymph node accumulation of Lymphoseek and Tc-99m-sulfur colloid using a “2-day” protocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Lymphoseek is a receptor-binding radiopharmaceutical specifically designed for sentinel lymph node (SLN) mapping. We conducted a clinical trial which measured the injection site clearance and sentinel lymph node accumulation after a single intradermal injection of Lymphoseek or unfiltered [99mTc]sulfur colloid (TcSC) using a “2-day” protocol for SLN mapping of breast cancer. Eleven patients with breast cancer participated in this study. Five patients received an intradermal administration of 1.0 nmol of 99mTc-labeled Lymphoseek; SLN mapping was performed on four subjects within 19 to 27 h. Six subjects receiv...
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Anne M. Wallace, Carl K. Hoh, Karl K. Limmer, Denise D. Darrah, Gery Schulteis, David R. Vera Source Type: journals

Comparison of 18F-FDG, 18F-FET and 18F-FLT for differentiation between tumor and inflammation in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: The goal of this study was to compare the glucose analog, 2-[18F]fluoro-2-deoxy-d-glucose ([18F]-FDG), the amino acid analog, o-(2-[18F]fluoroethyl)-l-tyrosine ([18F]-FET) and nucleoside analog, 3′-[18F]fluoro-3′-deoxythymidine ([18F]-FLT) with regard to their feasibility for differentiating tumors from inflammation.Methods: In Fisher rat models bearing both 9L tumor and inflammation, the biodistributions and positron emission tomography (PET) images of [18F]-FDG, [18F]-FET and [18F]-FLT at 60 min post injection were compared. Pretreatment with thymidine phosphorylase before injection of [18F]-F...
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Tae Sup Lee, Soon Hyuk Ahn, Byung Seok Moon, Kwon Soo Chun, Joo Hyun Kang, Gi Jeong Cheon, Chang Woon Choi, Sang Moo Lim Source Type: journals

Evaluation of an anti-p185HER2 (scFv-CH2-CH3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-d-GEEEKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: A 105-kDa double mutant single-chain Fv-Fc fragment (scFv-Fc DM) derived from the anti-p185HER2 hu4D5v8 antibody (trastuzumab; Herceptin) has been described recently. The goal of this study was to investigate whether improved tumor targeting could be achieved with this fragment through the use of residualizing radioiodination methods.Methods: The scFv-Fc DM fragment was radioiodinated using N-succinimidyl 4-guanidinomethyl 3-[131I]iodobenzoate ([131I]SGMIB) and Nɛ-(3-[131I]iodobenzoyl)-Lys5-Nα- maleimido-Gly1-GEEEK ([131I]IB-Mal-d-GEEEK), two residualizing radioiodination agents that have been use...
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Ganesan Vaidyanathan, Emmanuelle Jestin, Tove Olafsen, Anna M. Wu, Michael R. Zalutsky Source Type: journals

Treatment of HER2-positive breast carcinomatous meningitis with intrathecal administration of α-particle-emitting 211At-labeled trastuzumabEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Intrathecal 211At-labeled trastuzumab shows promise as a treatment for patients with HER2-positive breast CM. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Abraham Boskovitz, Roger E. McLendon, Tatsunori Okamura, John H. Sampson, Darell D. Bigner, Michael R. Zalutsky Source Type: journals

Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: [18F]WC-IV-3 uptake appears to correlate with increased caspase-3 enzyme activity, but the dynamic range of uptake of these two tracers appears to be less than that seen with [18F]WC-II-89. Studies are ongoing to verify these results in other animal models of apoptosis. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Delphine L. Chen, Dong Zhou, Wenhua Chu, Phillip E. Herrbrich, Lynne A. Jones, Justin M. Rothfuss, Jacquelyn T. Engle, Marco Geraci, Michael J. Welch, Robert H. Mach Source Type: journals

Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: At present, P-glycoprotein (P-gp) function can be studied using positron emission tomography (PET) together with a labelled P-gp substrate such as (R)-[11C]verapamil. Such a tracer is, however, less suitable for investigating P-gp (over)expression. Laniquidar is a third-generation P-gp inhibitor, which has been used in clinic trials for modulating multidrug resistance transporters. The purpose of the present study was to develop the radiosynthesis of [11C]laniquidar and to assess its suitability as a tracer of P-gp expression.The radiosynthesis of [11C]laniquidar was performed by methylation of the carboxylic aci...
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Gert Luurtsema, Robert C. Schuit, Rob P. Klok, Joost Verbeek, Josée E. Leysen, Adriaan A. Lammertsma, Albert D. Windhorst Source Type: journals

Synthesis, 68Ga labeling and preliminary evaluation of DOTA peptide binding vascular adhesion protein-1: a potential PET imaging agent for diagnosing osteomyelitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results represent a proof-of-concept that infection-induced VAP-1 can be targeted by [68Ga]DOTA peptide. [68Ga]DOTAVAP-P1 is just the first candidate peptide and an essential opening for developing VAP-1-specific imaging agents. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Tiina Ujula, Satu Salomäki, Pauliina Virsu, Petteri Lankinen, Tatu J. Mäkinen, Anu Autio, Gennady G. Yegutkin, Juhani Knuuti, Sirpa Jalkanen, Anne Roivainen Source Type: journals

Multipoint analysis of reduced 125I-meta-iodobenzylguanidine uptake and norepinephrine turnover in the hearts of mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine-induced parkinsonismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Thus, MPTP causes rapid reductions in cardiac 125I-MIBG uptake and Bmax of NET, followed by partial recovery of 125I-MIBG uptake. Changes in cardiac 125I-MIBG uptake and NE turnover were closely related in postganglionic cardiac sympathetic nerve terminals in mice with MPTP-induced parkinsonism. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Nobuyoshi Fukumitsu, Masahiko Suzuki, Takahiro Fukuda, Yasushi Kiyono Source Type: journals

Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: [18F]-FPECMO showed significant potential for the detection of mGluR5 in vitro; however, its in vivo characteristics are not optimal for a clear-cut visualization of the mGluR5 in rats. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Christophe Lucatelli, Michael Honer, Jean-Frédéric Salazar, Tobias L. Ross, P. August Schubiger, Simon M. Ametamey Source Type: journals

Dual-isotope single-photon emission computed tomography for dopamine and serotonin transporters in normal and parkinsonian monkey brainsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that dual-isotope SPECT using [99mTc]TRODAT-1 and [123I]ADAM can simultaneously evaluate changes in dopaminergic and serotonergic systems in a PD model. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: I-Hsun Li, Wen-Sheng Huang, Chin-Bin Yeh, Mei-Hsiu Liao, Chia-Chieh Chen, Lie-Hang Shen, Jiang-Chuan Liu, Kuo-Hsing Ma Source Type: journals

Comparative study on DOTA-derivatized bombesin analog labeled with 90Y and 177Lu: in vitro and in vivo evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our studies demonstrated that DOTA-BN[2–14]NH2 can be labeled with 90Y (NCA) and 177Lu (CA) with high radiochemical yields. The in vitro and in vivo comparison between 90Y-DOTA-BN[2–14]NH2 and 177Lu-DOTA-BN[2–14]NH2 indicated that the change of radiometal in the complex from Y to Lu influence the binding affinity to the GRP receptors with preference to the 177Lu-labeled derivative. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Eftychia Koumarianou, Renata Mikołajczak, Dariusz Pawlak, Xhristos Zikos, Pinelopi Bouziotis, Piotr Garnuszek, Urszula Karczmarczyk, Michał Maurin, Spyridon C. Archimandritis Source Type: journals

Chelating ion-exchange methods for the preparation of no-carrier-added 64CuEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We could efficiently separate 64Cu by using short ion-exchange columns. The chelating ion-exchange method provides a high quality of 64Cu that is sufficient for the synthesis of 64Cu-labeled antibodies and medical applications. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Shigeki Watanabe, Satoshi Watanabe, Jixin Liang, Hirofumi Hanaoka, Keigo Endo, Noriko S. Ishioka Source Type: journals

True radiotracers: Cu-64 targeting vectors based upon bombesin peptideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The failure of current therapies to prolong survival and/or quality of life is a driving force for design and development of novel and innovative diagnostic/therapeutic strategies for patients with cancer . Selective targeting of cognate receptors that are expressed in very high numbers on human tumor cancer cells using radiolabeled targeting vectors (i.e., peptides, small proteins, antibodies or antibody fragments) is one such approach and continues to be the focus of many researchers around the world . For example, the successes of OctreoScan for selective targeting and molecular imaging of somatostatin receptor-positive...
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Authors: Timothy J. Hoffman, Charles J. Smith Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 31, 2009 Category: Radiology Source Type: journals

Protective effects of hesperidin against genotoxicity induced by 99mTc-MIBI in human cultured lymphocyte cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study has important implications for patients undergoing nuclear medicine procedures. The results indicate a protective role for hesperidin against the genetic damage and side effects induced by radiopharmaceutical administration. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 29, 2009 Category: Radiology Authors: Seyed Jalal Hosseinimehr, Amirhossein Ahmadi, Davood Beiki, Emran Habibi, Aziz Mahmoudzadeh Source Type: journals

In vivo characterization of a reporter gene system for imaging hypoxia-induced gene expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We have confirmed hypoxia-specific expression of the HSV1-tkeGFP fusion gene in the R3327-AT/HRE tumor model and demonstrated the utility of this model for the evaluation of radiolabeled hypoxia tracers. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 29, 2009 Category: Radiology Authors: Sean Carlin, Andrei Pugachev, Xiaorong Sun, Sean Burke, Filip Claus, Joseph O'Donoghue, C. Clifton Ling, John L. Humm Source Type: journals

In vivo monitoring of intranuclear p27kip1 protein expression in breast cancer cells during trastuzumab (Herceptin) therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: [111In]-Anti-p27kip1-tat may be useful for monitoring changes in the expression of the intranuclear protein, p27kip1. Up-regulation of p27kip1 resulted in increased retention of [111In]-anti-p27kip1-tat in cells treated with trastuzumab. Modest, but statistically significantly higher, retention was also observed in tumours in mice treated with trastuzumab. Since responsiveness to trastuzumab correlated to up-regulation of p27kip1, it may be possible to use [111In]-anti-p27kip1-tat to guide treatment with Herceptin and other drugs which alter p27kip1 expression. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 29, 2009 Category: Radiology Authors: Bart Cornelissen, Veerle Kersemans, Kristin McLarty, Lara Tran, Katherine A. Vallis, Raymond M. Reilly Source Type: journals

Comparison of 18F-FET and 18F-FDG PET in brain tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 18F-FET PET is superior to 18F-FDG for biopsy guidance and treatment planning of cerebral gliomas. The uptake of 18F-FDG is associated with prognosis, but the predictive value is limited and a histological evaluation of tumor tissue remains necessary. Therefore, amino acids like 18F-FET are the preferred PET tracers for the clinical management of cerebral gliomas. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 29, 2009 Category: Radiology Authors: Dirk Pauleit, Gabriele Stoffels, Ansgar Bachofner, Frank W. Floeth, Michael Sabel, Hans Herzog, Lutz Tellmann, Paul Jansen, Guido Reifenberger, Kurt Hamacher, Heinz H. Coenen, Karl-Josef Langen Source Type: journals

Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PETEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ACSS2 plays an important role in the uptake of radiolabeled acetate in tumor cells, which is different from that in the myocardium, which mainly involves ACSS1. The uptake of radiolabeled acetate in tumors increased under hypoxia along with up-regulation of ACSS2 expression. This suggests a possible mechanism for acetate PET for tumors. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 29, 2009 Category: Radiology Authors: Yukie Yoshii, Atsuo Waki, Takako Furukawa, Yasushi Kiyono, Tetsuya Mori, Hiroshi Yoshii, Takashi Kudo, Hidehiko Okazawa, Michael J. Welch, Yasuhisa Fujibayashi Source Type: journals

177Lu- labeled MOv18 as compared to 131I- or 90Y-labeled MOv18 has the better therapeutic effect in eradication of alpha folate receptor-expressing tumor xenograftsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: 177Lu-MOv18 at the maximal tolerated dose is the immunoradioconjugate with the best therapeutic window in experimental conditions of small tumor volume. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 29, 2009 Category: Radiology Authors: Alberto Zacchetti, Angela Coliva, Elena Luison, Ettore Seregni, Emilio Bombardieri, Augusto Giussani, Mariangela Figini, Silvana Canevari Source Type: journals

Standardized methods for the production of high specific-activity zirconium-89Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Zirconium-89 is an attractive metallo-radionuclide for use in immuno-PET due to favorable decay characteristics. Standardized methods for the routine production and isolation of high-purity and high-specific-activity 89Zr using a small cyclotron are reported. Optimized cyclotron conditions reveal high average yields of 1.52±0.11 mCi/μA·h at a proton beam energy of 15 MeV and current of 15 μA using a solid, commercially available 89Y-foil target (0.1 mm, 100% natural abundance). 89Zr was isolated in high radionuclidic and radiochemical purity (>99.99%) as [89Zr]Zr-oxalate by using a solid-phase hydroxamate res...
Source: Nuclear Medicine and Biology - July 29, 2009 Category: Radiology Authors: Jason P. Holland, Yiauchung Sheh, Jason S. Lewis Source Type: journals

Improved work-up procedure for the production of [18F]flumazenil and first results of its use with a high-resolution research tomograph in human strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: [18F]FZ is a potentially useful GABA receptor-binding PET ligand. A modified procedure for its preparation in reproducibly high radiochemical yields has been described and the [18F]FZ thus produced has been used successfully in a pilot clinical study. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 29, 2009 Category: Radiology Authors: Gassan Massaweh, Esther Schirrmacher, Christian la Fougere, Miriam Kovacevic, Carmen Wängler, Dean Jolly, Paul Gravel, Andrew J. Reader, Alexander Thiel, Ralf Schirrmacher Source Type: journals

Reproducibility of the kinetic analysis of 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography in mouse tumor modelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objectives: We assessed the reproducibility of the kinetic analysis of 3′-deoxy-3′-[18F]fluorothymidine (FLT) positron emission tomography (PET) in A431 human epidermoid carcinoma and murine Lewis lung carcinoma (LLC) tumor models.Methods: We injected 7.4 MBq of FLT (n=10 for each group) and acquired 2-h dynamic PET images. A second scan was performed 1 day later. We calculated standardized uptake value (SUV), kinetic rate constants, volume of distribution of phosphorylated FLT (Vdm), net influx constant (KFLT-CA) and influx constant by Patlak graphical analysis (KFLT-PA). The percent difference between measu...
Source: Nuclear Medicine and Biology - July 29, 2009 Category: Radiology Authors: Seung Jin Choi, Seog Young Kim, Su Jin Kim, Jae Sung Lee, Sang Ju Lee, Soo Ah Park, Seung Jin Lee, Sung-Cheol Yun, Ki Chun Im, Seung Jun Oh, Sang-We Kim, Jae Seung Kim, Jin Sook Ryu, Dae Hyuk Moon Source Type: journals

Quantitative micro-SPECT/CT for detecting focused ultrasound-induced blood–brain barrier opening in the ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data demonstrate the usefulness of 99mTc-DTPA micro-SPECT/CT for detecting focused ultrasound-induced BBB disruption in the rat. This method may be used in vivo in combination with quantitative analysis for evaluating the amount of BBB opening. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 9, 2009 Category: Radiology Authors: Kun-Ju Lin, Hao-Li Liu, Po-Hong Hsu, Yi-Hsiu Chung, Wen-Cheng Huang, Jin-Chung Chen, Shiaw-Pyng Wey, Tzu-Chen Yen, Ing-Tsung Hsiao Source Type: journals

Imaging of peripheral-type benzodiazepine receptor in tumor: in vitro binding and in vivo biodistribution of N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: [11C]DAC was taken up into PBR-expressing NFSa. [11C]DAC is a promising PET ligand that can be used for imaging PBR in tumor-bearing mice. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 9, 2009 Category: Radiology Authors: Tomoteru Yamasaki, Katsushi Kumata, Kazuhiko Yanamoto, Akiko Hatori, Makoto Takei, Yukio Nakamura, Sachiko Koike, Koichi Ando, Kazutoshi Suzuki, Ming-Rong Zhang Source Type: journals

Bifunctional phage-based pretargeted imaging of human prostate carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study demonstrates the use of multivalent bifunctional phage in a three-step pretargeting system for prostate cancer radioimaging. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 9, 2009 Category: Radiology Authors: Jessica R. Newton-Northup, Said D. Figueroa, Thomas P. Quinn, Susan L. Deutscher Source Type: journals

In-depth evaluation of the cycloaddition–retro-Diels–Alder reaction for in vivo targeting with [111In]-DTPA-RGD conjugatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The tandem crDA reaction using methyl-substituted oxanorbornadiene is a versatile method for a single-step ligation that proceeds independently of pH and also proceeds in serum and blood. Currently, we are further looking into enhancement of reaction kinetics and exploitation of tandem crDA in vivo. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 9, 2009 Category: Radiology Authors: Peter Laverman, Silvie A. Meeuwissen, Sander S. van Berkel, Wim J.G. Oyen, Floris L. van Delft, Floris P.J.T. Rutjes, Otto C. Boerman Source Type: journals