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Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 7, 2009 Category: Nutrition Source Type: journals

Extent of glycemic control in type 2 diabetes mellitus: Close, but no cigarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In June 2008, two large randomized controlled trials were published on the probably most important, yet unanswered question for the care of patients with type 2 diabetes mellitus: Is a rather tight glycemic control beneficial regarding cardiovascular outcomes and all-cause mortality? Since then, a subsequent, smaller randomized controlled trial and the first and second meta-analysis on this subject were published. These two meta-analyses and also the systematic review by Mannucci et al. in this issue included a similar set of studies. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 16, 2009 Category: Nutrition Authors: Christian Lerch, Bernd Richter Tags: Editorial Comment Source Type: journals

The association between intensive glycemic control and vascular complications in type 2 diabetes mellitus: A meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and Aim: In patients with type 2 diabetes mellitus, the relationship between lowering glycated hemoglobin (HbA1c) and macrovascular complications is not clear and therefore lowering the level of HbA1c is controversial.Methods and Results: We searched for all randomized controlled trials comparing the effects of intensive and standard glycemic control on vascular events in patients with type 2 diabetes mellitus. The primary endpoint was combined macrovascular complications, including cardiac events, stroke and peripheral vascular disease. Fixed and random effect models were used to analyze the results.E...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 12, 2009 Category: Nutrition Authors: J. Ma, W. Yang, N. Fang, W. Zhu, M. Wei Tags: Original Articles Source Type: journals

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(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 4, 2009 Category: Nutrition Source Type: journals

Independent relationship of serum uric acid levels with leukocytes and coronary atherosclerotic burdenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and Aim: Epidemiological studies have shown that increased serum uric acid (SUA) level is associated with coronary artery disease (CAD). Leukocytes have been shown to play an important role in the atherosclerotic process. The aim of the study was to investigate whether there is any relationship among SUA, leukocyte counts and coronary atherosclerotic burden in patients who are suspected of having CAD.Method and results: We enrolled 690 eligible patients who had undergone coronary angiography between October 2005 and June 2006 in a consecutive manner. The relationship of SUA with total and differential ...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 25, 2009 Category: Nutrition Authors: S.A. Kocaman, A. Sahinarslan, M. Cemri, T. Timurkaynak, B. Boyaci, A. Cengel Tags: Original Articles Source Type: journals

Lipids, atherosclerosis and CVD risk: Is CRP an innocent bystander?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data suggest that elevated CRP per se does not cause CVD; however, inflammation per se possibly contributes to CVD. Elevated CRP levels more likely is a marker for the extent of atherosclerosis or for the inflammatory activity and vulnerability of atherosclerotic plaques, and thus simply an innocent bystander in CVD. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 19, 2009 Category: Nutrition Authors: B.G. Nordestgaard, J. Zacho Tags: Viewpoint Source Type: journals

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(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 28, 2009 Category: Nutrition Source Type: journals

Serum adiponectin is decreased in patients with familial combined hyperlipidemia and normolipaemic relatives and is influenced by lipid-lowering treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and aims: Hypoadiponectinemia has been reported in patients with familial combined hyperlipidemia (FCHL) presenting increased waist circumference and insulin resistance. However, no studies have evaluated this association in non-obese FCHL patients. Moreover, it is unclear whether correction of lipoprotein abnormalities may influence adiponectin levels in FCHL.Methods and Results: We have compared serum levels of adiponectin in 199 non-obese FCHL patients (BMI 25.96±3.7), 116 normolipaemic (NL) non-affected relatives (BMI 24.4±4.0) and 192 controls (BMI 28.0±7.4). In a subgroup of FCHL patients, cha...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 27, 2009 Category: Nutrition Authors: M. Arca, V.M. Cambuli, A. Montali, F. Sentinelli, E. Filippi, F. Campagna, F. Quagliarini, R. Antonini, S. Romeo, M.G. Baroni Tags: Original Articles Source Type: journals

How to improve cardiovascular diseases prevention in Europe?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is well known that cardiovascular diseases (CVD) are the major health problem and the leading cause of death worldwide, both for women and for men. In Europe CVD cause not only nearly half of all deaths (48%), but are also the main cause of the disease burden (23% illness and death) . Therefore they contribute substantially to the escalating costs of healthcare . In most of the high-income countries the incidence of CVD has been decreasing over the last decades but the incidence in low- and middle-income countries has been rising continuously . The burden of CVD in these countries is set to rise further due to unfavoura...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 23, 2009 Category: Nutrition Authors: Ž. Reiner Tags: Editorial Source Type: journals

Effects of red wine on endothelial function: Postprandial studies vs clinical trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Analysis of all data about the acute effects of red wine constituents on endothelial function, is inconclusive and it is obvious that new studies are necessary in order to elucidate this matter. Undoubtedly, one should be very careful in suggesting red wine consumption in high-risk populations, as its acute postprandial effect is not yet clear. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 2, 2009 Category: Nutrition Authors: K. Karatzi, E. Karatzis, C. Papamichael, J. Lekakis, A. Zampelas Tags: Review Source Type: journals

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(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 25, 2009 Category: Nutrition Source Type: journals

Diabetes related autoimmunity in gestational diabetes mellitus: Is it important?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Some GDM women show autoantibody positivity during and after pregnancy and pancreatic autoantibodies can appear for the first time in some patients after delivery. Autoantibody positivity is often accompanied by a high frequency of DR3 and DR4 alleles, which are classically related to the development of type 1 diabetes and, although not all studies agree on this point, by an immunological imbalance expressed by the behaviour of the lymphocyte subpopulation, which can be seen as diabetic anomalies overlapping with the immunological changes that occur during pregnancy. It is worth emphasizing that such patients may...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 22, 2009 Category: Nutrition Authors: A. Lapolla, M.G. Dalfrà, D. Fedele Tags: Reviews Source Type: journals

Carbonated beverages and gastrointestinal system: Between myth and realityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion there is now sufficient scientific evidence to understand the physiological impact of carbonated beverages on the gastrointestinal system, while providing a basis for further investigation on the related pathophysiological aspects. However, more studies are needed, particularly intervention trials, to support any claim on the possible beneficial effects of carbonated beverages on the gastrointestinal system, and clarify how they affect digestion. More epidemiological and mechanistic studies are also needed to evaluate the possible drawbacks of their consumption in terms of risk of tooth erosion and gastric di...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 8, 2009 Category: Nutrition Authors: R. Cuomo, G. Sarnelli, M.F. Savarese, M. Buyckx Tags: Viewpoint Source Type: journals

Cerebrovascular disease in diabetes mellitus: The role of carotid intima-media thicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and purpose: Cerebrovascular disease in diabetes appears to be less considered than coronary and peripheral disease, the reason being the intrinsic difficulty in finding available diagnostic tools for its early identification. Among these, carotid artery intima-media thickness (cIMT) represents the simplest measurable parameter for pre-atherosclerotic lesions in extra-cranic arteries.Methods: The role of cIMT as a surrogate marker of cerebral atherosclerosis and predictor of stroke, its relationship to microangiopathy and chronic inflammation, along with its role as an outcome parameter in anti-hypergl...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 8, 2009 Category: Nutrition Authors: S. Vigili de Kreutzenberg, A. Tiengo, A. Avogaro Tags: Reviews Source Type: journals

Corrigendum to “Metabolic syndrome and left ventricular hypertrophy in the prediction of cardiovascular events: The Strong Heart Study” [Nutr Metab Cardiovasc Dis 19 (2009) 98–104]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unfortunately, when this article was originally published had two errors in the row “LV mass index”. The correct table is printed correctly below. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 7, 2009 Category: Nutrition Authors: G. de Simone, R.B. Devereux, M. Chinali, M.J. Roman, E.T. Lee, H.E. Resnick, B.V. Howard Tags: Corrigendum Source Type: journals

Increased arterial stiffness is associated with reduced plasma levels of β-carotene in treated hypertensive patients with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several observational studies have demonstrated that the coexistence of hypertension and type 2 diabetes mellitus (T2DM) is associated with twice the increased cardiovascular risk as hypertensive patients without T2DM . Among potential mechanisms linking T2DM and cardiovascular risk, increased central aortic stiffness has been recognized as a predictor of cardiovascular morbidity and mortality in T2DM and other conditions . Meanwhile, an imbalance of the oxidative system has been considered an important contributor to cardiovascular events in T2DM , which may be, in turn, associated with increased arterial stiffness . (Sou...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 7, 2009 Category: Nutrition Authors: H.K. Chung, B. Kang, J.H. Lee, J.Y. Shim, S. Park, S.-H. Lee, Y.K. Park, E. Park, N. Chung, M.-J. Shin Tags: Letters to the Editors Source Type: journals

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(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 1, 2009 Category: Nutrition Source Type: journals

Small artery remodeling in diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Alterations in the microcirculation represent a common pathological finding, and microangiopathy is one of the most important mechanisms involved in the development of organ damage as well as of clinical events in patients with diabetes mellitus. Renin-angiotensin system blockade seems to be effective in preventing and/or regressing alterations in the microvascular structure. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - May 31, 2009 Category: Nutrition Authors: D. Rizzoni, E. Agabiti Rosei Tags: Review Source Type: journals

Metabolic syndrome and Mediterranean dietary pattern in a sample of young, male, Greek navy recruitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Mediterranean Diet (MD) is very beneficial, because of cardiovascular and other effects. The dietary habits of the population nowadays, however, have considerably changed. As there are only few data about the frequency of the metabolic syndrome (MS) in young Greeks, and their adherence to the MD, we studied the prevalence of the MS in a representative sample of young Navy recruits, while investigating adherence to the MD. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - May 27, 2009 Category: Nutrition Authors: J. Doupis, C. Dimosthenopoulos, K. Diamanti, D. Perrea, N. Katsilambros, K. Makrilakis Tags: Letters to the Editors Source Type: journals

Glucose toxicity: The leading actor in the pathogenesis and clinical history of type 2 diabetes – mechanisms and potentials for treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The acquaintance of the role of glucose toxicity should strongly influence the usual therapeutic choices and glycaemic targets where the reduced or absent risk of hypoglycaemia, durability of action, and data on prolonged safety should be the preferred characteristics of the drug of choice in the treatment of type 2 diabetes mellitus. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - May 12, 2009 Category: Nutrition Authors: A. Giaccari, G. Sorice, G. Muscogiuri Tags: Review Source Type: journals

Prevention of cardiovascular disease through glycemic control in type 2 diabetes: A meta-analysis of randomized clinical trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Intensified hypoglycaemic treatment in type 2 diabetic patients leads to a significant reduction of the incidence of myocardial infarction, while it does not affect the incidence of stroke and cardiovascular mortality. Hypoglycemia induced by intensified treatment could be associated with increased cardiovascular mortality. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - May 12, 2009 Category: Nutrition Authors: E. Mannucci, M. Monami, C. Lamanna, F. Gori, N. Marchionni Tags: Original Articles Source Type: journals

High protein diets and weight controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This overview will be predominantly confined to studies that examined high protein, low fat diets of sufficient duration to lead to weight outcomes rather than short term satiety studies. Atkins style diets with very low carbohydrate intakes will be referred to only in passing as the restrictive nature of the diet makes it very difficult to determine the role of protein per se and the major effect is almost certainly due to carbohydrate restriction. The studies will be divided into ad libitum studies where the potential full effect of enhanced satiety from protein may be seen and energy controlled studies in the metabolic...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 15, 2009 Category: Nutrition Authors: P. Clifton Tags: Editorial Source Type: journals

Clustered metabolic abnormalities blunt regression of hypertensive left ventricular hypertrophy: the LIFE studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined whether clusters of two or more metabolic abnormalities (MetAb, including obesity, high plasma glucose without diabetes, low HDL-cholesterol) in addition to hypertension were associated to levels of ECG LVH reduction comparable to that obtained in hypertensive subjects without or with only one additional metabolic abnormality (no-MetAb).Methods and results: We studied 5558 non-diabetic participants without MetAb (2920 women) and 1235 with MetAb (751 women) from the LIFE-study cohort. MetAb was defined by reported LIFE criteria, using partition values from the ATPIII recommendations. Time-trends of Cornell volta...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 13, 2009 Category: Nutrition Authors: G. de Simone, P.M. Okin, E. Gerdts, M.H. Olsen, K. Wachtell, D.A. Hille, B. Dahlöf, S.E. Kjeldsen, R.B. Devereux Tags: Original Articles Source Type: journals

Chronic stress and obesity in adolescents: Scientific evidence and methodological issues for epidemiological researchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This review provides basic evidence for the positive association between chronic stress and obesity, but also points out the need for more research in adolescents to further elucidate the role of chronic stress in the aetiology of obesity in this crucial life period. Good, well-standardized epidemiological surveys could be of great benefit in this research area. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 12, 2009 Category: Nutrition Authors: T. De Vriendt, L.A. Moreno, S. De Henauw Tags: Review Source Type: journals

Macrophage infiltrates with high levels of Toll-like receptor 4 expression in white adipose tissues of male ChineseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to characterize macrophage infiltrates and the associated TLR4 expression in different locations of white adipose tissues (WAT) of male Chinese and determine their correlations to adipocyte hypertrophy and hyperplasia.Methods and results: A total of 30 men, who were lean, overweight or with type 2 diabetes (T2D), were recruited. Their abdominal omental WAT (oWAT) and subcutaneous WAT (scWAT) were obtained. The contents of macrophages in oWAT and scWAT were quantified using anti-CD68 staining. The levels of TLR4 expression were analyzed by western blot assays and the adipocyte size was quantified, followed ...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 9, 2009 Category: Nutrition Authors: H.-M. Zhang, L.-L. Chen, L. Wang, S. Xu, X. Wang, L.-L. Yi, D. Chen, Z.-H. Wu, J.-Y. Zhang, Y.-F. Liao, J. Shang Tags: Original Articles Source Type: journals

Consumption of cod and weight loss in young overweight and obese adults on an energy reduced diet for 8-weeksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and aims: In a cross-European study it was recently shown that consumption of cod increases weight loss in men and also has other positive health effects. The aim of this study was to investigate whether cod consumption increases weight loss and improves cardiovascular risk factors in a dose dependent manner during an 8-week energy restriction diet in young overweight and obese healthy adults.Methods and results: In this dietary intervention 126 subjects (20–40years, BMI 27.5–32.5kg/m2) comprised the group given energy-restricted diets (−30%); they were prescribed an identical macronutrient compo...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 9, 2009 Category: Nutrition Authors: A. Ramel, M.T. Jonsdottir, I. Thorsdottir Tags: Original Articles Source Type: journals

Association of human cathelicidin (hCAP-18/LL-37) gene expression with cardiovascular disease risk factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest that LL-37 gene expression may be closely associated with cardiovascular risk factors independently of BMI and WC. However, functional studies are required to confirm these data. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 6, 2009 Category: Nutrition Authors: H. Benachour, M. Zaiou, A. Samara, B. Herbeth, M. Pfister, D. Lambert, G. Siest, S. Visvikis-Siest Tags: Original Articles Source Type: journals

Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data suggest that progressive reduction in IGF-1 levels may be involved in obesity-related changes in both insulin sensitivity and secretion. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 6, 2009 Category: Nutrition Authors: E. Succurro, F. Andreozzi, M.A. Marini, R. Lauro, M.L. Hribal, F. Perticone, G. Sesti Tags: Original Articles Source Type: journals

Prenatal exposure to maternal low protein diet suppresses replicative potential of myocardial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Maternal LP diet suppresses myocardial replicative potential and this likely contributes to reduced cell numbers at birth. This suppression is lifted by a protein-replete diet which stimulates post-natal replication of myocardial cells and likely results in a catching-up in cell numbers. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 6, 2009 Category: Nutrition Authors: N. Aroutiounova, R. Fandrich, E. Kardami, P.S. Tappia Tags: Original Articles Source Type: journals

Platelet dysfunction in central obesityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Central obesity is a relevant risk factor for major cardiovascular events due to the atherosclerotic involvement of coronary, cerebral and lower limb arterial vessels.A major role in the increased cardiovascular risk is played by platelets, which show an increased activation and a reduced sensitivity to the physiological and pharmacological antiaggregating agents. This review focuses on platelet dysfunction in central obesity.The mechanisms involved are related to: i) the reduced sensitivity to insulin and other substances acting via intracellular cyclic nucleotides, such as nitrates and prostacyclin; ii) the alt...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 5, 2009 Category: Nutrition Authors: G. Anfossi, I. Russo, M. Trovati Tags: Review Source Type: journals

Prenatal exposure to maternal low protein diet suppresses replicative potential of myocardial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Maternal LP diet suppresses myocardial replicative potential and this likely contributes to reduced cell numbers at birth. This suppression is lifted by a protein-replete diet which stimulates post-natal replication of myocardial cells and likely results in a catching-up in cell numbers. PMID: 19346111 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 3, 2009 Category: Nutrition Authors: Aroutiounova N, Fandrich R, Kardami E, Tappia PS Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Association of human cathelicidin (hCAP-18/LL-37) gene expression with cardiovascular disease risk factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our results suggest that LL-37 gene expression may be closely associated with cardiovascular risk factors independently of BMI and WC. However, functional studies are required to confirm these data. PMID: 19346112 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 3, 2009 Category: Nutrition Authors: Benachour H, Zaiou M, Samara A, Herbeth B, Pfister ML, Lambert D, Siest G, Visvikis-Siest S Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Sesame supplementation does not improve cardiovascular disease risk markers in overweight men and women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Supplementation with 25g/d of sesame can significantly increase the exposure to mammalian lignans. However, this did not cause any improvement in markers of cardiovascular disease risk in overweight or obese men and women. PMID: 19346113 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 3, 2009 Category: Nutrition Authors: Wu JH, Hodgson JM, Puddey IB, Belski R, Burke V, Croft KD Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Dietary and supplementary betaine: Effects on betaine and homocysteine concentrations in males.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Supplemental or dietary betaine similarly increase circulating betaine concentrations and attenuate the post-methionine load rise in homocysteine concentrations. PMID: 19346114 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 3, 2009 Category: Nutrition Authors: Atkinson W, Slow S, Elmslie J, Lever M, Chambers ST, George PM Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Fibrinogen kinetics and protein turnover in hypertension: Effects of insulin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In essential hypertension fibrinogen production is increased, is not further stimulated by insulin, and is inversely related to insulin sensitivity at high-physiological insulin concentrations. Amino acid disposal and basal as well as insulin-responsive protein degradation rates are instead normal. PMID: 19346115 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 3, 2009 Category: Nutrition Authors: Kiwanuka E, Coracina A, Vettore M, Semplicini A, Zaramella M, Millioni R, Puricelli L, Baiocchi MR, Tessari P Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These data suggest that progressive reduction in IGF-1 levels may be involved in obesity-related changes in both insulin sensitivity and secretion. PMID: 19346116 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 3, 2009 Category: Nutrition Authors: Succurro E, Andreozzi F, Marini MA, Lauro R, Hribal ML, Perticone F, Sesti G Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Platelet dysfunction in central obesity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Central obesity is a relevant risk factor for major cardiovascular events due to the atherosclerotic involvement of coronary, cerebral and lower limb arterial vessels. A major role in the increased cardiovascular risk is played by platelets, which show an increased activation and a reduced sensitivity to the physiological and pharmacological antiaggregating agents. This review focuses on platelet dysfunction in central obesity. The mechanisms involved are related to: i) the reduced sensitivity to insulin and other substances acting via intracellular cyclic nucleotides, such as nitrates and prostacyclin; ii) the altered...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 3, 2009 Category: Nutrition Authors: Anfossi G, Russo I, Trovati M Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Age- and gender-specific awareness, treatment, and control of cardiovascular risk factors and subclinical vascular lesions in a founder population: The SardiNIA StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aim: We investigated the gender-specific control of cardiovascular (CV) risk factors and subclinical vascular lesions in a founder population in Italy.Methods and Results: 6148 subjects were enrolled (aged 14–102years) from four towns. Hypertension (HT), diabetes mellitus (DM) and dyslipidemia (LIP) were defined in accordance with guidelines. A self-reported diagnosis defined awareness of these conditions, and the current use of specific medications as treatment.Prevalence was HT 29.2%, DM 4.8%, LIP 44.1% and was higher in men than in women. Disease prevalence increased with age for every CV risk factor. Men we...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 26, 2009 Category: Nutrition Authors: A. Scuteri, S.S. Najjar, M. Orru', G. Albai, J. Strait, K.V. Tarasov, M.G. Piras, A. Cao, D. Schlessinger, M. Uda, E.G. Lakatta Tags: Original Articles Source Type: journals

Age- and gender-specific awareness, treatment, and control of cardiovascular risk factors and subclinical vascular lesions in a founder population: The SardiNIA Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A large number of subjects at high CV risk are not treated and the management of subclinical vascular lesions is far from optimal. PMID: 19321325 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 25, 2009 Category: Nutrition Authors: Scuteri A, Najjar SS, Orru' M, Albai G, Strait J, Tarasov KV, Piras MG, Cao A, Schlessinger D, Uda M, Lakatta EG Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Dietary patterns, cardiovascular risk factors and C-reactive protein in a healthy Italian populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In a large healthy Italian population, non-predefined dietary patterns including foods considered to be rather unhealthy, were associated with higher levels of cardiovascular risk factors, CRP and individual global CVD risk, whereas a “prudent–healthy” pattern was associated with lower levels. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 20, 2009 Category: Nutrition Authors: F. Centritto, L. Iacoviello, R. di Giuseppe, A. De Curtis, S. Costanzo, F. Zito, S. Grioni, S. Sieri, M.B. Donati, G. de Gaetano, A. Di Castelnuovo, on behalf of Moli-sani Investigators Tags: Original Articles Source Type: journals

Dietary patterns, cardiovascular risk factors and C-reactive protein in a healthy Italian population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In a large healthy Italian population, non-predefined dietary patterns including foods considered to be rather unhealthy, were associated with higher levels of cardiovascular risk factors, CRP and individual global CVD risk, whereas a "prudent-healthy" pattern was associated with lower levels. PMID: 19303267 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 18, 2009 Category: Nutrition Authors: Centritto F, Iacoviello L, di Giuseppe R, De Curtis A, Costanzo S, Zito F, Grioni S, Sieri S, Donati MB, de Gaetano G, Di Castelnuovo A, Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Impact of diabetes on treatment-induced changes in left ventricular structure and function in hypertensive patients with left ventricular hypertrophy. The LIFE study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Among hypertensive patients with LVH, diabetes is associated with more residual LVH and less improvement in systolic LV function by echocardiography over 4.8 years of antihypertensive treatment. PMID: 19303268 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 18, 2009 Category: Nutrition Authors: Gerdts E, Okin PM, Omvik P, Wachtell K, Dahlöf B, Hildebrandt P, Nieminen MS, Devereux RB Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and aims: Patients with chronic obstructive pulmonary disease (COPD) are at increased atherothrombotic risk. Preliminary findings have suggested that COPD patients may have increased plasma total homocysteine (tHcy), a cardiovascular risk factor often caused by a poor B vitamin status, but plasma levels of such vitamins were not measured. The aim of this study was to investigate hyperhomocysteinaemia in COPD and to determine whether it may be secondary to poor plasma concentrations of B vitamins.Methods and results: We performed a case–control, cross-sectional study of 42 patients with COPD and 29 co...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 12, 2009 Category: Nutrition Authors: F.L. Fimognari, L. Loffredo, S. Di Simone, F. Sampietro, R. Pastorelli, M. Monaldo, F. Violi, A. D'Angelo Tags: Original Articles Source Type: journals

Non-alcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in essential hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Non-alcoholic fatty liver disease was associated with insulin resistance and abnormalities of left ventricular diastolic function in a cohort of patients with essential hypertension, suggesting a concomitant increase of metabolic and cardiac risk in this condition. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 12, 2009 Category: Nutrition Authors: F. Fallo, A. Dalla Pozza, N. Sonino, M. Lupia, F. Tona, G. Federspil, M. Ermani, C. Catena, G. Soardo, L. Di Piazza, S. Bernardi, M. Bertolotto, B. Pinamonti, B. Fabris, L.A. Sechi Tags: Original Articles Source Type: journals

Effect of diet-induced weight loss on plasma apelin and cytokine levels in individuals with the metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and aims: Adipose tissue is an active endocrine organ that secretes signaling molecules involved in the regulation of insulin sensitivity, food intake and inflammation. Apelin is a peptide secreted by adipose tissue that has been shown to modulate cardiovascular tone in animals. The aim of this study was to measure abdominal fat, blood pressure and circulating apelin, adiponectin, leptin, ghrelin, TNF-α and IL-6 levels in patients with the metabolic syndrome after a diet-induced weight loss.Methods and results: 35 obese individuals with the metabolic syndrome underwent an 8-week very-low-calorie diet ...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 12, 2009 Category: Nutrition Authors: M.V. Heinonen, D.E. Laaksonen, T. Karhu, L. Karhunen, T. Laitinen, S. Kainulainen, A. Rissanen, L. Niskanen, K.H. Herzig Tags: Original Articles Source Type: journals

Non-alcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in essential hypertension.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Non-alcoholic fatty liver disease was associated with insulin resistance and abnormalities of left ventricular diastolic function in a cohort of patients with essential hypertension, suggesting a concomitant increase of metabolic and cardiac risk in this condition. PMID: 19278843 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 10, 2009 Category: Nutrition Authors: Fallo F, Pozza AD, Sonino N, Lupia M, Tona F, Federspil G, Ermani M, Catena C, Soardo G, Di Piazza L, Bernardi S, Bertolotto M, Pinamonti B, Fabris B, Sechi LA Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: COPD patients have a poor B vitamin status and, as a consequence, increased tHcy. These abnormalities may contribute to the COPD-related atherothrombotic risk. PMID: 19282159 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 10, 2009 Category: Nutrition Authors: Fimognari FL, Loffredo L, Di Simone S, Sampietro F, Pastorelli R, Monaldo M, Violi F, Angelo AD Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Possible implications for health of the different definitions of dietary fibre.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is impressive evidence from epidemiological and experimental studies that dietary fibre derived form vegetables, fruit and wholegrain cereals protects against and may be useful in the treatment of a wide range of diseases. However, while there is some evidence of benefit of extracted and synthetic fibres in terms of lowering levels of cardiovascular risk factors, improving measures of glycaemic control and gastrointestinal function, epidemiological confirmation of clinical benefit and long term safety are lacking. An appropriate definition of dietary fibre is essential, given that claiming a food is high in dieta...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 10, 2009 Category: Nutrition Authors: Mann JI, Cummings JH Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Back to the ancient diet: A matter of urgency for Southern Mediterranean countries.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19282161 [PubMed - as supplied by publisher] (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 10, 2009 Category: Nutrition Authors: Panagiotakos DB, Matalas AL Tags: Nutr Metab Cardiovasc Dis Source Type: journals