Association Between STAT4 rs7574865 Polymorphism and Rheumatoid Arthritis: Debate Unresolved.
Conclusion: STAT4 rs7574865 TT genotype showed a potential impact on ACPA positivity in Syrian RA patients. However, STAT4 rs7574865 effect on RA onset and severity is minor compared to other genetic factors such as HLA-DRB1 shared epitope alleles.
PMID: 30505369 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - December 7, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Losartan, but not Enalapril and Valsartan, Inhibits the Expression of IFN- γ, IL-6, IL-17F and IL-22 in PBMCs from Rheumatoid Arthritis Patients.
Conclusion: PBMCs from RA patients are responsive in inhibiting proinflammatory cytokines using Losartan better than Enalapril and Valsartan and it could be a better antihypertensive choice for patients with RA and systemic arterial hypertension treatment.
PMID: 30288187 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - October 7, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
SLE and Serum Complement: Causative, Concomitant or Coincidental?
Authors: Sandhu V, Quan M
PMID: 30288188 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - October 7, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus.
Conclusion: MPV decreases in patients with active SLE and is inversely correlated with SLEDAI.
PMID: 30258502 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - September 29, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Plasma Saturated and Monounsaturated Fatty Acids in Beh çet's Disease.
Conclusion: Unfavourable plasma SFA and MUFA profile were reported in BD patients. POA, which is associated with higher plasma hsCRP level, may play a role in the pathogenesis of BD.
PMID: 30258503 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - September 29, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Tocilizumab in Large Vessel Vasculitis - Different Routes of Administration.
Conclusion: Tocilizumab is efficacious in patients with large vessel vasculitis in a real-life situation. Safety appears to be acceptable, but infectious complications have to be considered. Intravenous tocilizumab may be used in patients who relapse under subcutaneous application.
PMID: 30258504 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - September 29, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
MicroRNA155 Expression in Relation to BDCAF Scored Beh çet's Disease in an Egyptian Patients' Sample.
Conclusion: Increased miRNA155 may be used as a biomarker of BD remission and thus in the disease follow up. There could be a prospect of treating the disease via microRNA 155 effect enhancement.
PMID: 30197703 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - September 11, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Immune Regulatory Genes Are Major Genetic Factors to Behcet Disease: Systematic Review.
Authors: Deng Y, Zhu W, Zhou X
PMID: 30197704 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - September 11, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Comparison of Vitamin D Serum Values between Rheumatoid Arthritis and Lupus Populations: An Observational Study.
Authors: Maryam S, Atabati E, Yalda R
PMID: 30197705 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - September 11, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Pamidronate Treatment of Osteonecrosis of the Hip in Young Male.
Conclusion: We reported a case of aseptic osteonecrosis of the hip which was successfully treated pamidronate at dosage of 45 mg.
PMID: 30197706 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - September 11, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Correlation Between Tumor Necrosis Factor- α Levels, Free Fatty Acid Levels, and Soluble Vascular Cell Adhesion Molecule-1 Levels in Rheumatoid Arthritis Patients.
Conclusions: (1) There was no correlation between TNF-α levels and VCAM-1 levels in RA patients; (2) There was no correlation between TNF-α levels and FFA levels in RA patients; (3) There was a negative correlation between FFA levels and VCAM-1 levels in RA patients.
PMID: 30123370 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - August 21, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.
Authors: Zhu W, Deng Y, Zhou X
Abstract
Gout is a common form of inflammatory arthritis caused by hyperuricemia and the deposition of Monosodium Urate (MSU) crystals. It is also considered as a complex disorder in which multiple genetic factors have been identified in association with its susceptibility and/or clinical outcomes. Major genes that were associated with gout include URAT1, GLUT9, OAT4, NPT1 (SLC17A1), NPT4 (SLC17A3), NPT5 (SLC17A4), MCT9, ABCG2, ABCC4, KCNQ1, PDZK1, NIPAL1, IL1β, IL-8, IL-12B, IL-23R, TNFA, MCP-1/CCL2, NLRP3, PPARGC1B, TLR4, CD14, CARD8, P2X7R, EGF, A1CF, HNF4G and TRIM46, LR...
Source: Open Rheumatology Journal - August 21, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Sj ögren's, Renal Tubular Acidosis and Osteomalacia - An Asian Indian Series.
Sjögren's, Renal Tubular Acidosis and Osteomalacia - An Asian Indian Series.
Open Rheumatol J. 2018;12:114
Authors: Sandhya P, Danda D, Rajaratnam S, Thomas N
PMID: 30123372 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - August 21, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Immune Regulatory Genes Are Major Genetic Factors to Behcet Disease: Systematic Review.
Authors: Deng Y, Zhu W, Zhou X
Abstract
Behcet's disease (BD) is a chronic refractory multi-system autoimmune disorder that occurs in a genetically susceptible host. Multiple genetic factors have been identified that may contribute to the pathogenesis of BD. The major genes with polymorphisms associated with BD include HLA-B and -A, CIITA, ERAP1, MICA, IL10, IL12A, IL12RB2, IL23R, MEFV, IRF8, TNFAIP3, REL, TLR4, NOD1,2, CCR1,CCR3, GIMAP1,2,4, KLRC4, STAT4, NCOA5, FOXP3, PSORS1C1, FUT2, UBAC2, SUMO4, ADO-EGR2, CEBPB-PTPN1, and JPKL-CNTN5. These genes encode proteins involved mainly in immune regulation and ...
Source: Open Rheumatology Journal - August 5, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Comparison of Vitamin D Serum Values between Rheumatoid Arthritis and Lupus Populations: An Observational Study.
Conclusion: VitD serum values were lower in lupus patients than RA ones. Since VitD deficiency is very common in Iran, physiologic doses of VitD supplementation in patients lead to higher serum levels of VitD. Lower VitD values in lupus patients compared with RA ones may stem from intestinal malabsorption, higher doses of corticosteroid therapy, renal involvement and proteinuria, different polymorphisms of VitD receptors, and more sun protection strategies in lupus patients.
PMID: 29854015 [PubMed] (Source: Open Rheumatology Journal)
Source: Open Rheumatology Journal - June 5, 2018 Category: Rheumatology Tags: Open Rheumatol J Source Type: research
