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Electronic Pages AbstractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Oral Oncology)
Source: Oral Oncology - November 20, 2009 Category: Cancer & Oncology Tags: Printed Pages (pp. 1005-1078) Source Type: journals

Editorial Board/Aims & ScopeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Oral Oncology)
Source: Oral Oncology - November 20, 2009 Category: Cancer & Oncology Source Type: journals

Impact and other newer factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The impact factor (IF) has now been in use for some years, is well recognized by most readers, and may have some utility – but the disadvantages are also increasingly recognized. The five year Impact Factor, calculated in the same way as the regular IF, but measuring citations over a five year window rather than the two year window period of the regular IF, may reflect more accurately the impact of a journal. It has also been in use for some years. (Source: Oral Oncology)
Source: Oral Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Crispian Scully Tags: Editorial Source Type: journals

Reconstruction of the maxilla and midface – Surgical management, outcome, and prognostic factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Loss of the maxilla due to tumor ablation has both functional and aesthetic consequences. Even small defects become obvious because of missing bone and soft tissue. Reconstruction of the maxilla and midface in these patients presents a challenge to the surgeon although several possibilities are available for this purpose. The long term benefit to patients of the different modalities remains unclear due to wide individual variation.One hundred and twenty-one patients with maxillary oral squamous cell carcinoma were treated with curative intent. One hundred and five patients were surgically reconstructed using local...
Source: Oral Oncology - November 4, 2009 Category: Cancer & Oncology Authors: Thomas Mücke, Denys John Loeffelbein, Bettina Hohlweg-Majert, Marco Rainer Kesting, Klaus-Dietrich Wolff, Frank Hölzle Tags: Original Articles Source Type: journals

The significance of journal metrics for oral oncologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In response to an editorial from May 2008, ‘The real impact of oral oncology’, wherein you highlighted the improved rate of download of journals from your journal, we would like to draw your attention to some recent work carried by us on the theme of bibliometrics in oncology. Using the web service PubReMiner™ we identified the 10 journals which published most prolifically on oral cancer in 2007. We then determined their respective impact factors (IF), eigenfactors (EF), and citation rates using the 2007 edition of Thomson Scientific’s Journal Citation Report (JCR) (). The 10 most prolific journals produced a total...
Source: Oral Oncology - November 4, 2009 Category: Cancer & Oncology Authors: R.W. Glynn, M.J. Kerin, K.J. Sweeney Tags: Letter to the Editor Source Type: journals

Electronic Pages AbstractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Oral Oncology)
Source: Oral Oncology - October 20, 2009 Category: Cancer & Oncology Tags: Printed Pages (pp. 927-1004) Source Type: journals

Editorial Board/Aims & ScopeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Oral Oncology)
Source: Oral Oncology - October 20, 2009 Category: Cancer & Oncology Source Type: journals

Oncolytic virotherapy for oral squamous cell carcinoma using replication-competent virusesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Oncolytic virotherapy utilizes viruses that can selectively destroy cancer cells without harming normal tissues. Clinical trials of oncolytic viruses show that most oncolytic agents are well tolerated and safe. The virotherapeutic agents currently in use have limited potency when administered alone; however, combination therapy using virotherapeutic agents and conventional anticancer agents, such as chemotherapeutics, radiation, and gene therapy, exhibits encouraging levels of efficacy. Advances in recombinant DNA technology have allowed the development of viruses that are tumor-selective and armed with transgenes...
Source: Oral Oncology - October 15, 2009 Category: Cancer & Oncology Authors: Kengo Saito, Hiroshi Shirasawa, Naohisa Isegawa, Masashi Shiiba, Katsuhiro Uzawa, Hideki Tanzawa Tags: Reviews Source Type: journals

Mucositis: The impact, biology and therapeutic opportunities of oral mucositisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis’ pathogenesis until relatively recently. More frustrating for patients and clinicians, no effective treatment existed. Fortunately, the situation is changing; ongoing research is leading to a comprehensive understanding of the biology of mucositis, which has resulted in the development of novel interventions. While the FDA’s approval of palifermin in 2004 was limited to only a ...
Source: Oral Oncology - October 15, 2009 Category: Cancer & Oncology Authors: Stephen T. Sonis Tags: Reviews Source Type: journals

Saliva as a tool for oral cancer diagnosis and prognosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Saliva testing, a non-invasive alternative to serum testing, may be an effective modality for diagnosis and for prognosis prediction of oral cancer, as well as for monitoring post therapy status, by measuring specific salivary macromolecules, examining proteomic or genomic targets such as enzymes, cytokines, growth factors, metalloproteinases, endothelin, telomerase, cytokeratines, mRNA’s and DNA transcripts. Salivary analysis has been shown to be a useful diagnostic tool also for distant malignancies such as breast cancer. In recent years, significant alterations have been demonstrated in the saliva of oral can...
Source: Oral Oncology - October 15, 2009 Category: Cancer & Oncology Authors: Rafael M. Nagler Tags: Reviews Source Type: journals

Christopher John O’Brien 1952–2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the brightest stars in the Head and Neck firmament was extinguished on 4 June 2009 with the untimely death of Professor Chris O’Brien at the age of 57. At the time of his enforced retirement when he was stricken with glioblastoma multiforme in November 2006, Chris was Australia’s leading academic head and neck surgeon with an international reputation for his contributions to the science and practice of head and neck oncology, including seminal papers on the biologic behaviour and management of skin cancers metastatic to the parotid gland and neck. He was Director of the Sydney Cancer Centre and the Sydney Head ...
Source: Oral Oncology - October 15, 2009 Category: Cancer & Oncology Authors: Lester J Peters Tags: Obituary Source Type: journals

Immortalization of ameloblastoma cells via reactivation of telomerase function: Phenotypic and molecular characteristicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we used a retroviral infection method to over-express the human telomerase reverse transcriptase (hTERT) gene to acquire immortality of hTERT+-AM cells. Furthermore, it was revealed both by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot that the pathway of immortalization was loss of p16, not p53 or p21. Also, there was no evidence indicating that the hTERT+-AM cells underwent malignant transformation by the nude mouse tumorigenicity assay. Taken together, this hTERT-immortalized cell line may be a potentially valuable and reliable cell model for further study of the invasive prope...
Source: Oral Oncology - October 15, 2009 Category: Cancer & Oncology Authors: Qian Tao, Biao Lv, Bin Qiao, Chao-qun Zheng, Zhi-feng Chen Tags: Original Articles Source Type: journals

The free vascularized flap and the pectoralis major pedicled flap options: Comparative results of reconstruction of the tongueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Reconstruction after extensive resection of the tongue remains a surgical challenge. Free soft-tissue transfer is now favored for head and neck reconstruction following cancer resection. However, the choice of either free tissue transfer (FTT) or of the pedicled Pectoralis Major Musculocutaneous Flap (PMMF), the workhorse in head and neck reconstruction, remains controversial. The purpose of this study is to assess the post-operative outcomes after radical ablative surgery and reconstruction for patients with a tongue cancer.We conducted a retrospective comparison of two different reconstruction techniques. From J...
Source: Oral Oncology - October 5, 2009 Category: Cancer & Oncology Authors: Y. Mallet, S. El Bedoui, N. Penel, J. Ton Van, C. Fournier, J.L. Lefebvre Tags: Original Articles Source Type: journals

Review of the molecular pathogenesis of the odontogenic keratocystEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The odontogenic keratocyst (keratocystic odontogenic tumour) (OKC) is one of the most prevalent odontogenic tumours. Since its initial description, a number of studies have focused on different aspects of this lesion, attempting to explain its distinctive biological behaviour. In this review the authors address the main genetic and epigenetic alterations reported on this tumour. Although most of the knowledge on this field is not being used in the clinical practice, some perspectives of translational studies are discussed. (Source: Oral Oncology)
Source: Oral Oncology - October 5, 2009 Category: Cancer & Oncology Authors: Carolina Cavaliéri Gomes, Marina Gonçalves Diniz, Ricardo Santiago Gomez Tags: Reviews Source Type: journals

Oncocytoma of the salivary glands: A clinicopathologic and immunohistochemical studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a clinicopathologic and immunohistochemical study of 21 Chinese patients with oncocytoma of salivary gland origin, a rare benign tumour composed exclusively of large epithelial cells with eosinophilic granular cytoplasm (oncocytes). The median age was 60.1years with a male predominance (67%). All the tumours occurred in the parotid except one in the palate. A painless mass was the most common feature, although intermittent pain was complained of in four cases. All the patients were treated by superficial parotidectomy, with no recurrence or metastasis. Histologically, most tumours displayed an encapsulated nodul...
Source: Oral Oncology - October 5, 2009 Category: Cancer & Oncology Authors: Chuan-Xiang Zhou, Yan Gao Tags: Original Articles Source Type: journals

The assessment of diffused light illumination and acetic acid rinse (Microlux/DL™) in the visualisation of oral mucosal lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Oral examination alone cannot always distinguish benign from premalignant and malignant lesions, thereby resulting in delayed patient referral and poorer prognosis. Thus, any non-invasive technology which highlights oral premalignant and malignant lesions in a highly sensitive and specific manner will undoubtedly aid clinicians in early diagnosis and treatment of these conditions. The aim of this study was to assess the efficacy of acetic acid mouthwash and diffused light illumination (Microlux/DL™) as a diagnostic aid in the visualisation of oral mucosal lesions and its ability to highlight malignant and potent...
Source: Oral Oncology - October 5, 2009 Category: Cancer & Oncology Authors: Lidija McIntosh, Michael J. McCullough, Camile S. Farah Tags: Original Articles Source Type: journals

Acetaldehyde production from ethanol and glucose by non-Candidaalbicans yeasts in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Colonization of oral mucosa with a non-C. albicans species such as C. glabrata, capable of producing carcinogenic amounts of ACH from both ethanol and glucose, may contribute to the development of oral cancer. (Source: Oral Oncology)
Source: Oral Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Mikko T. Nieminen, Johanna Uittamo, Mikko Salaspuro, Riina Rautemaa Tags: Short Communication Source Type: journals

Electronic Pages AbstractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Oral Oncology)
Source: Oral Oncology - September 23, 2009 Category: Cancer & Oncology Tags: Printed Pages (pp. 843-925) Source Type: journals

Journal progress in 2008–2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oral Oncology continued to make very good progress in 2008, as shown by key indicators which include:Oral Oncology remains in the top 10 journals of the ‘Dentistry, Oral Surgery and Medicine’ category for Impact Factors. The 2007 Impact Factor of 2.569 relates to the journal in 2005 and 2006 and we are confident of yet a further increase in the impact factor for 2008, due soon. (Source: Oral Oncology)
Source: Oral Oncology - September 23, 2009 Category: Cancer & Oncology Authors: Crispian Scully Tags: Editorial Source Type: journals

Editorial Board/Aims & ScopeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Oral Oncology)
Source: Oral Oncology - September 23, 2009 Category: Cancer & Oncology Source Type: journals

Malignant salivary gland tumors and cyclo-oxygenase-2: A histopathological and immunohistochemical analysis with implications on histogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The classification system for malignant salivary gland tumors (MST) is largely dependent on its histogenesis. The histogenesis is uncertain but the “bicellular theory of origin” has been accepted by most and states that malignant transformation of reserve cells from either the intercalated or excretory duct are responsible for the development of MST. Cyclooxygenase-2 (cox-2), a potential molecular marker for MST, was analyzed on a series (n=56) of MST with the aim of determining the morphological MST subtypes capable of cox-2 overexpression and correlating its expression with histogenesis.Fifty six primary maj...
Source: Oral Oncology - September 3, 2009 Category: Cancer & Oncology Authors: Sharon Akrish, Micha Peled, Ofer Ben-Izhak, Rafi M. Nagler Tags: Original Articles Source Type: journals

Relationship between molecular markers and treatment response in a retrospective cohort of Indian patients with primary carcinoma of the larynxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we evaluate the relationships between p53 over expression/mutations, bcl2 expression and ploidy status in a retrospective cohort of responder and non-responder carcinoma of the larynx patients.Tissue samples from 22 patients with histopathologically confirmed carcinoma of the larynx and matched for age, stage, node status and treatment regimen, were analysed from our tissue biorepository. Differences in the above molecular markers were analysed between the responders and non-responders to conventional treatment. p53 and bcl2 over expression was checked by IHC and p53 mutation by PCR and direct sequencing. DN...
Source: Oral Oncology - September 3, 2009 Category: Cancer & Oncology Authors: R. Sahoo, V. Chittibabu, G. Patil, S. Rao, S. Thakur, G. Dhondalay, A.J. Kulkarni, A. Banerjee, B.S. Ajaikumar, A. Korlimarla, A. Nargund, R.N. Niti, K.S. Gopinath, Shilpa Prabhudesai, R.M. Raghavendra Tags: Original Articles Source Type: journals

The impacts of liver cirrhosis on head and neck cancer patients undergoing microsurgical free tissue transfer: An evaluation of flap outcome and flap-related complicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Several authors have cited liver cirrhosis as a risk factor for surgery but no study performed statistical correlation between flap outcome and severity of liver cirrhosis in patients with head and neck cancer. We performed a retrospective analysis of 3108 patients who underwent free tissue transfer after head and neck cancer ablation between January 2000 and December 2008. Liver cirrhosis was identified in 62 patients. Forty-two patients (67.7%) were classified as having Child’s class A cirrhosis, seventeen (27.4%) as having class B, and three (4.9%) as having class C cirrhosis. The overall complete flap surviv...
Source: Oral Oncology - September 2, 2009 Category: Cancer & Oncology Authors: Huang-Kai Kao, Kai-Ping Chang, Wei-Cheng Ching, Chung-Kan Tsao, Ming-Huei Cheng, Fu-Chan Wei Tags: Original Articles Source Type: journals

Esculetin enhances TRAIL-induced apoptosis through DR5 upregulation in human oral cancer SAS cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we showed that esculetin significantly suppressed the growth of oral cancer SAS cells in a dose-dependent manner. DNA content flow cytometry and TUNEL assay revealed that esculetin induced cell cycle arrest and apoptosis. Western blotting showed esculetin increased DR5 protein expression and activated caspase-8, which differed from previous studies conducted in other cell types. Furthermore, treatment with esculetin significantly increased TRAIL-induced apoptosis in SAS cells and the TRAIL-sensitizing effect was blocked by DR5/Fc chimera protein. Our results indicate that esculetin enhances TRAIL-induced apo...
Source: Oral Oncology - September 1, 2009 Category: Cancer & Oncology Authors: Sang-Heng Kok, Cheng-Chang Yeh, Mei-Ling Chen, Mark Yen-Ping Kuo Tags: Original Articles Source Type: journals

Role of primary surgery for early-stage (T1–2N0) squamous cell carcinoma of the oropharynxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: To evaluate treatment outcomes and the role of primary definitive surgery for T1–2, clinically N0 oropharyngeal squamous cell carcinoma (OPSCC) patients, we performed a retrospective analysis of 46 consecutive cases treated primarily by surgery and/or postoperative radiotherapy at Yonsei University between May 1992 and December 2006. Twelve patients were T1 and 34 were T2. The most common location was the tonsil (54%), followed by the soft palate (19%), the base of the tongue (BOT) (15%) and the posterior wall (12%). Occult lymph node metastasis was noted in 12 cases (26%). Seventeen patients (37%) received adju...
Source: Oral Oncology - September 1, 2009 Category: Cancer & Oncology Authors: Hyang Ae Shin, Young Chang Lim, Ha Min Jeong, Eun Chang Choi Tags: Original Articles Source Type: journals

The association between hypoxia inducible factor-1α gene polymorphisms and increased susceptibility to oral cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The aim of this study was to estimate the relations between hypoxia inducible factor-1α (HIF-1α) gene polymorphisms, C1772T and G1790A, to the susceptibility and clinicopathological status of oral cancer. A total of 521 subjects, including 347 controls and 174 oral cancer patients, were recruited in this study and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze the impact of these two polymorphic variants on oral cancer. A significant association between oral cancer susceptibility and G1790A polymorphism was demonstrated since individuals with heterozygotes, ...
Source: Oral Oncology - September 1, 2009 Category: Cancer & Oncology Authors: Mu-Kuan Chen, Hui-Ling Chiou, Shih-Chi Su, Tsung-Te Chung, Hsien-Chun Tseng, Hsiu-Ting Tsai, Shun-Fa Yang Tags: Original Articles Source Type: journals

The increased impact factor and real impact of Oral OncologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 2008, an Editorial defined the various parameters by which the progress and impact of Oral Oncology could be affirmed to that date. Oral Oncology has since seen continued real progress. (Source: Oral Oncology)
Source: Oral Oncology - August 31, 2009 Category: Cancer & Oncology Authors: Crispian Scully Tags: Editorial Source Type: journals

Endocultivation: 3D printed customized porous scaffolds for heterotopic bone inductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The aim of this study was to evaluate the ability of computer assisted designed (CAD) synthetic hydroxyapatite and tricalciumphosphate blocks to serve as precise scaffolds for intramuscular bone induction in a rat model. A central channel to allow for vessel pedicle or nerve integration was added. Natural bovine hydroxyapatite blocks served as controls to evaluate and compare biocompatibility of the new matrices.Individually designed 3D-printed rounded and porous hydroxyapatite (HA) and tricalcium phosphate (TCP) blocks were placed in pouches in the Musculus latissimus dorsi in 12 Lewis rats bilaterally. Bovine hy...
Source: Oral Oncology - August 31, 2009 Category: Cancer & Oncology Authors: Stephan T. Becker, Hendrik Bolte, Oliver Krapf, Hermann Seitz, Timothy Douglas, Sureshan Sivananthan, Jörg Wiltfang, Eugene Sherry, Patrick H. Warnke Tags: Electronic Pages (pp. e181-e209) Source Type: journals

Electronic Pages AbstractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Oral Oncology)
Source: Oral Oncology - August 31, 2009 Category: Cancer & Oncology Tags: Printed Pages (pp. 743-842) Source Type: journals

Editorial Board/Aims & ScopeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Oral Oncology)
Source: Oral Oncology - August 31, 2009 Category: Cancer & Oncology Source Type: journals

Peroxiredoxin I plays a protective role against cisplatin cytotoxicity through mitogen activated kinase signalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we examined the effects of Prx I on cell sensitivity to cisplatin-induced apoptosis. Mouse embryo fibroblasts (MEFs) derived from Prx I-deficient mice showed increased cisplatin-induced apoptosis compared with wild-type MEFs. Cisplatin treatment also led to increased activation of p38 MAPK and JNK, and reduced ERK phosphorylation in Prx I-deficient MEFs compared with wild-type MEFs. Furthermore, JNK- and ERK-specific inhibitors protected the Prx I-deficient MEFs from cisplatin-induced apoptosis, but Prx I-deficient MEFs remained more sensitive than wild-type MEFs when treated with a p38 MAPK-specific inhibi...
Source: Oral Oncology - August 19, 2009 Category: Cancer & Oncology Authors: Dongmei Ma, Eiji Warabi, Toru Yanagawa, Shintaro Kimura, Harumi Harada, Kenji Yamagata, Tetsuro Ishii Tags: Original Articles Source Type: journals

[18F]FLT-PET and [18F]FDG-PET in the evaluation of radiotherapy for laryngeal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, [18F]-fluoro-3′-deoxy-l-thymidine ([18F]FLT), a proliferation tracer is compared with 2-[18F]-fluoro-2-deoxy-d-glucose ([18F]FDG).Patients with primary laryngeal cancer, scheduled to undergo radiotherapy were included in this study. Patients underwent both [18F]FLT-PET and [18F]FDG-PET shortly before radiotherapy. Ten patients underwent [18F]FLT-PET and [18F]FDG-PET 2–3months after radiotherapy. Scans were analyzed visually for areas of increased tracer uptake. The standardized uptake value (SUV) was measured as a semi-quantitative value of tracer uptake.Fourteen patients, all male, were included in this...
Source: Oral Oncology - August 19, 2009 Category: Cancer & Oncology Authors: Lukas B. Been, Harald J. Hoekstra, Albert J.H. Suurmeijer, Pieter L. Jager, Bernard F.A.M. van der Laan, Philip H. Elsinga Tags: Original Articles Source Type: journals

Perineural invasion in adenoid cystic carcinoma of the salivary glands: A valid prognostic indicator?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Of malignant tumours with a propensity to invade the perineural space, adenoid cystic carcinoma of the salivary glands is perhaps the best known. However, it is not known if microscopic evidence of perineural invasion has true prognostic significance in adenoid cystic carcinoma. A review of the available data, which is the aim of this article, reveals the issue is not straightforward. There is a plethora of conflicting data which, on balance, suggest the answer is indeed in the affirmative, particularly if the nerve involved is above a certain size, or “named”. Even if the data are equivocal, many head and nec...
Source: Oral Oncology - August 18, 2009 Category: Cancer & Oncology Authors: A. William Barrett, Paul M. Speight Tags: Reviews Source Type: journals

Advances in imaging in the work-up of head and neck cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Accurate staging at the time of the diagnosis of head and neck squamous cell carcinoma (HNSCC) is critical for selection of the appropriate treatment strategy. Therefore, optimizing pre-treatment imaging in the diagnostic work-up is of great importance. CT and MRI are the corner stones of diagnostic work-up. Technical improvements will increase the value of these techniques even further. PET and PET-CT became a standard imaging techniques for HNSCC patients. It may be helpful for the detection of occult primary tumours, but its sensitivity for the detection of occult lymph node metastases is too low. Alternatively...
Source: Oral Oncology - August 18, 2009 Category: Cancer & Oncology Authors: Remco de Bree, Jonas A. Castelijns, Otto S. Hoekstra, C. René Leemans Tags: Reviews Source Type: journals

Transcultural tobacco regulation – A debate floundering in political correctnessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is widely accepted that any debate which advocates a harm reduction strategy which, itself incorporates smokeless tobacco within its armament, will divide the tobacco control community. The deep wounds left by the tobacco industry and the wide felt suspicion towards their intentions are such that, their recently announced strategy to promote smokeless tobacco as an alternative to smoking cigarettes, has been met with negative rebuttal. As with any of the tobacco industry’s new ventures, the latter is being dismissed as either a cynical move, by them, to introduce a new section of the population to tobacco or an attemp...
Source: Oral Oncology - August 18, 2009 Category: Cancer & Oncology Authors: Raman Bedi Tags: Electronic Pages (pp. e73-e116) Source Type: journals

Gene hypermethylation in tumor tissue of advanced oral squamous cell carcinoma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Oral squamous cell carcinoma (OSCC) is characterized by high mortality rate and rising incidence. The aim of this study was to examine the methylation of particular tumor suppressor genes promoters in OSCC and to correlate the methylation status with the tumor-host features and patients survival. The genes selected for our investigation are involved in key cellular processes of malignant transformation, including cell cycle control (p16), apoptosis (Death Associated Protein Kinase, DAPK), Wnt signaling (Adenomatous Polyposis Coli, APC), cell–cell adhesion (E-cadherin, E-cad), and DNA repair (O6-methylguanine-DNA...
Source: Oral Oncology - August 10, 2009 Category: Cancer & Oncology Authors: Gordana Šupić, Ružica Kozomara, Mirjana Branković-Magić, Nebojša Jović, Zvonko Magić Tags: Original Articles Source Type: journals

Detection of copy number amplification of cyclin D1 (CCND1) and cortactin (CTTN) in oral carcinoma and oral brushed samples from areca chewersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study identified amplifications of CCND1 and CTTN by quantitative (Q)-PCR analysis in 50% and 45% of OSCC samples, respectively. Co-amplification of both genes was identified in 20% of tumors. Higher CTTN expression was associated with nodal metastasis of the OSCC, while the amplification of CCND1 was identified in 28% of oral brushed samples from areca chewers, who form a high risk group for OSCC. This study confirms the importance of alterations in CCND1 and CTTN with respect to areca-associated OSCC, and demonstrates that there is an early occurrence of amplification of these genes in the risk population. The non-i...
Source: Oral Oncology - August 10, 2009 Category: Cancer & Oncology Authors: Hui-Shen Liu, Hsuan-Hsuan Lu, Mann-Tin Lui, En-Hao Yu, Wilma Shen, Yu-Ping Chen, Kuo-Wei Chang, Hsi-Feng Tu Tags: Original Articles Source Type: journals

Lipopolysaccharides increase the amount of CXCR4, and modulate the morphology and invasive activity of oral cancer cells in a CXCL12-dependent mannerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Recently, it has been reported that bacterial infections play an important role in the development of cancers of the upper aero digestive tract. To examine the influence of bacterial infections on oral cancer, human oral carcinoma T3M-1 cells were treated with lipopolysaccharide (LPS) for 24h as a model of infection. The LPS treatment increased the mRNA expression of CXCR4 and invasiveness in T3M-1 cells stimulated with CXCL12.The Rho family of small guanosine triphosphatases regulates the dynamics of the actin cytoskeleton that underlie cellular functions such as cell shape changes, migration and polarity. In T3M...
Source: Oral Oncology - August 9, 2009 Category: Cancer & Oncology Authors: Tetsuji Takabayashi, Noboru Takahashi, Masayuki Okamoto, Hideshi Yagi, Makoto Sato, Shigeharu Fujieda Tags: Original Articles Source Type: journals

High 2-[18F]fluoro-2-deoxy-d-glucose (18FDG) uptake measured by positron emission tomography is associated with reduced overall survival in patients with oral squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the present analysis was to define the potential value of 2-[18F]fluoro-2-deoxy-d-glucose (18FDG) uptake in the tumor measured by positron emission tomography (PET) in predicting patients’ outcome in the clinical course of OSCC. In this respect, a clinically well-defined cohort of 79 patients with primary OSCC was retrospectively evaluated. 18FDG uptake in the primary tumor site was quantified by calculation of the maximum standardized uptake values (SUVmax). Subsequent statistical analyses found, that 18FDG uptake of the primary tumor was significantly higher in stage T3/T4 vs. T1/T2 (p (Source: Oral Oncology)
Source: Oral Oncology - August 9, 2009 Category: Cancer & Oncology Authors: Christof Hofele, Kolja Freier, Oliver C. Thiele, Uwe Haberkorn, Inga Buchmann Tags: Original Articles Source Type: journals

Long-term quality of life after treatment for locally advanced oropharyngeal carcinoma: Surgery and postoperative radiotherapy versus concurrent chemoradiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The aim of this study was to evaluate the long-term quality of life (QoL) in survivors with oropharyngeal carcinoma (OC) treated with surgery and postoperative radiotherapy (PORT) versus concurrent chemoradiation (CRT) using the European Organization for Research and Treatment of Cancer QoL Questionnaires. The study group consisted of 57 patients. The scores for physical (P=0.043) and social (P=0.036) functioning were significantly more favorable in the chemoradiation group. Surgical patients showed statistically higher problems with fatigue (P=0.047), pain (P=0.027), swallowing (P=0.042), social eating (P=0.038) ...
Source: Oral Oncology - August 9, 2009 Category: Cancer & Oncology Authors: Paolo Boscolo-Rizzo, Marco Stellin, Roberto Fuson, Carlo Marchiori, Alessandro Gava, Maria Cristina Da Mosto Tags: Original Articles Source Type: journals

VX2-induced rabbit buccal carcinoma: A potential cancer model for human buccal mucosa squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our findings indicated that VX2-induced rabbit buccal carcinomas could be a potential cancer model for human buccal mucosa squamous cell carcinoma. (Source: Oral Oncology)
Source: Oral Oncology - August 9, 2009 Category: Cancer & Oncology Authors: Li-Min Lin, Yuk-Kwan Chen, Chi-Hsien Chen, Yu-Wen Chen, Anderson Hsien-Cheng Huang, Wen-Chen Wang Tags: Electronic Pages (pp. e181-e209) Source Type: journals

Isolation and characterization of normal hamster buccal pouch stem/stromal cells – A potential oral cancer stem/stem-like cell modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, normal HBP stem/stromal cells provide a potential avenue for future experimental trials of cancer stem/stem-like cells for treatment of buccal SCC. In vitro, we may detect the sequential changes of normal HBP stem/stromal cells during multistep oral carcinogenesis or the alternations of these cells upon irradiation treatment and/or chemotherapy. (Source: Oral Oncology)
Source: Oral Oncology - August 9, 2009 Category: Cancer & Oncology Authors: Anderson Hsien-Cheng Huang, Yuk-Kwan Chen, Anthony Wing-Sang Chan, Tien-Yu Shieh, Li-Min Lin Tags: Electronic Pages (pp. e181-e209) Source Type: journals

The assessment of the DNA content of oral cytology via virtual microscopy for the early detection of epithelial dysplasia and neoplasia in oral mucosal lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oral squamous cell carcinoma (OSCC) is associated with high morbidity and mortality which is due, at least in part, to late detection. Precancerous and cancerous oral lesions may mimic any number of benign oral lesions and recently oral cytology has been investigated as an adjunct clinical tool in the assessment of these lesions. The purpose of the present study was to compare the usefulness of ploidy analysis after Feulgen stained cytological thin-prep specimens with incisional biopsy and histo-pathological examination. Analyses of the cytological specimens were undertaken utilising virtual microscopy. 100 healthy individ...
Source: Oral Oncology - August 9, 2009 Category: Cancer & Oncology Authors: Michael J. McCullough, Camile S. Farah Tags: Electronic Pages (pp. e73-e116) Source Type: journals

Reversal effect of Raf-1/Mdr-1 siRNAs co-transfection on multidrug resistance in KBv200 cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Multidrug resistance (MDR) is a major barrier for chemotherapy of many cancers. Mdr-1 plays a key role in the development of MDR as extensively verified. However, the role of Raf-1 overexpression in the development of multidrug resistance in human squamous carcinoma (KBv200) cells remains largely unknown. The aim of this study was to investigate the correlation of Raf-1 overexpression with the development of multidrug resistance in KBv200 cells. Furthermore, we explored the reversal effect of Raf-1 siRNA transfection and Raf-1/Mdr-1 siRNAs co-transfection on the multidrug resistance of KBv200 cells and potential m...
Source: Oral Oncology - July 23, 2009 Category: Cancer & Oncology Authors: Yan Dong, Shujuan Shao, Jun Hu, Peiman Yang Tags: Original Articles Source Type: journals

Unmet information needs and preferences in newly diagnosed and surgically treated oral cavity cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study revealed differences in information needs between diagnosed patients and surgically treated oral cavity cancer patients. Results suggest that healthcare professionals should design a protocol to guide development of a comprehensive pre- and postoperative information package to be given to these patients. (Source: Oral Oncology)
Source: Oral Oncology - July 23, 2009 Category: Cancer & Oncology Authors: Shu-Ching Chen, Yeur-Hur Lai, Chun-Ta Liao, Joseph Tung-Chien Chang, Chia-Chin Lin Tags: Original Articles Source Type: journals

CAL 27 is an oral adenosquamous carcinoma cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we verified the identity of CAL 27 cells by using by short tandem repeat analysis. Then, we performed tumor formation assay, HE staining and immunohistochemistry assay to further study the growing characteristics and histopathological diagnosis of CAL 27 xenografts. Our results showed that CAL 27 xenografts grew slowly in vivo with vesicle formation at both the surfaces and deeper areas of the tumors. The CAL 27 xenografts were then diagnosed as oral adenosquamous carcinomas. Thus CAL 27 appears to be an oral adenosquamous carcinoma cell line. (Source: Oral Oncology)
Source: Oral Oncology - July 23, 2009 Category: Cancer & Oncology Authors: Lu Jiang, Ning Ji, Yu Zhou, Jing Li, Xianting Liu, Zhi Wang, Qianming Chen, Xin Zeng Tags: Electronic Pages (pp. e181-e209) Source Type: journals

Desmoplastic ameloblastoma – A reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, these retrospective results confirm the statement that DA is a variation among ameloblastomas. DA present clinicoradiographic and histologic distinct features, when compared with “conventional ameloblastomas”. (Source: Oral Oncology)
Source: Oral Oncology - July 23, 2009 Category: Cancer & Oncology Authors: Zhi-Jun Sun, Yan-Ru Wu, Ning Cheng, Roger A Zwahlen, Yi-Fang Zhao Tags: Reviews Source Type: journals

Intralesional injection of Pingyangmycin for vascular malformations in oral and maxillofacial regions: An evaluation of 297 consecutive patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The purpose of the study was to investigate the indications and treatment results of intralesional injection of Pingyangmycin for vascular malformations in oral and maxillofacial regions. Between June 2002 and July 2007, 297 patients with oral and maxillofacial vascular malformations (except venular malformation and arteriovenous malformation) were treated with percutaneous injection of Pingyangmycin in our department. There were 159 males and 138 females aged from 8months to 72years (mean age 20.6years). The types of the disease included 98 lymphatic malformations (66 microcystic and 32 macrocystic malformations)...
Source: Oral Oncology - July 22, 2009 Category: Cancer & Oncology Authors: Jia Wei Zheng, Xiu Juan Yang, Yan An Wang, Yue He, Wei Min Ye, Zhi Yuan Zhang Tags: Original Articles Source Type: journals

Overexpression and activation of Akt2 protein in oral squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study were (1) to investigate expression of pan-Akt and its phosphorylated form (p-Akt), Akt1, and Akt2 in oral squamous cell carcinoma (OSCC) specimens (n=20) by immunohistochemistry, and (2) to determine mRNA expression of three Akt isoforms, including Akt1, Akt2, and Akt3, as well as their respective proteins, in five oral cancer cell lines and normal human oral keratinocytes (HOKs) by RT-PCR and Western blot assays. The results show that pan-Akt was expressed in 80% of OSCC cases, while Akt1, Akt2, and p-Akt were expressed in all OSCC cases. An intense expression of p-Akt at the invasive fronts o...
Source: Oral Oncology - July 22, 2009 Category: Cancer & Oncology Authors: Anak Iamaroon, Suttichai Krisanaprakornkit Tags: Electronic Pages (pp. e117-e179) Source Type: journals

Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Oral squamous cell carcinoma is the sixth most common cancer in the world and the seventh most common cancer in Vietnam. The RAS and PI3K-AKT signaling pathways play an important role in oral carcinogenesis. Our previous study on PI3K signaling pathway showed the absence of PIK3CA and PTEN gene mutations in Vietnamese oral cancer. We thus hypothesized that the RAS could be more likely activated as an upstream effector. However, the status of RAS mutations in Vietnamese oral cancer had not been studied. In the present study, Fifty six primary tumor DNA samples were screened for mutations of hot spots in exons 1 and...
Source: Oral Oncology - July 22, 2009 Category: Cancer & Oncology Authors: Avaniyapuram Kannan Murugan, Nguyen Thi Hong, Tran Thi Kim Cuc, Nguyen Chan Hung, Arasambattu Kannan Munirajan, Masa-Aki Ikeda, Nobuo Tsuchida Tags: Electronic Pages (pp. e117-e179) Source Type: journals