Editorial Board/Aims & Scope
(Source: Oral Oncology)
Source: Oral Oncology - August 14, 2018 Category: Cancer & Oncology Source Type: research
Low level laser therapy reduces oral leukoplakia lesion size: Results from a preliminary study
Dear Editor, (Source: Oral Oncology)
Source: Oral Oncology - August 8, 2018 Category: Cancer & Oncology Authors: Bhagyashree Jagtap, D.Y. Patil Vidyapeeth, Kalyani Bhate, S.N. Santhoshkumar Tags: Letter to the editor Source Type: research
Flavored tobacco to E-cigarette ’s: How the tobacco industry sustains its product flow
Manufacture of tobacco products remains to be a thriving industry, despite evidence indicating significant health hazards posed by tobacco use. The major reason for their enormous success is lobbying by which they influence the tobacco regulatory bodies to waive restrictions and prevent implementation of any additional sanctions [1]. In addition, the tobacco industry has regularly marketed new tobacco products with fresh designs bearing misleading advertisements. E-cigarettes are a prime example of how the tobacco industry has sustained its product flow by marketing it as a safe alternative to conventional cigarettes [2,3]...
Source: Oral Oncology - August 6, 2018 Category: Cancer & Oncology Authors: A. Thirumal Raj, Shankargouda Patil, Archana A. Gupta, G. Suveetha Tags: Letter to the editor Source Type: research
Clinical outcomes with therapies for previously treated recurrent/metastatic head-and-neck squamous cell carcinoma (R/M HNSCC): A systematic literature review
Head and neck squamous cell carcinoma (HNSCC) ranks sixth among the cancers diagnosed worldwide, and is the eighth most common cause of cancer-related death [1]. A substantial proportion (20 –40%) of patients with HNSCC will suffer local and/or regional disease recurrence and distant metastases [2–4]. Treatment efficacy is modest for patients with locally recurrent (or unresectable) and/or metastatic (R/M) HNSCC, and treatment goals are palliative [5]. For a limited number of patien ts with locoregional recurrent disease, salvage surgery and re-irradiation are considered [2]. (Source: Oral Oncology)
Source: Oral Oncology - August 1, 2018 Category: Cancer & Oncology Authors: Mallika Lala, Diana Chirovsky, Jonathan D. Cheng, Kapil Mayawala Tags: Review Source Type: research
Reconstruction Special Edition, Issue 3
Re: (Source: Oral Oncology)
Source: Oral Oncology - August 1, 2018 Category: Cancer & Oncology Authors: Matthew Old Source Type: research
Editorial Board/Aims & Scope
(Source: Oral Oncology)
Source: Oral Oncology - August 1, 2018 Category: Cancer & Oncology Source Type: research
Is there a place for FDG-PET-CT in early oral cancer patients?
With interest we read the article ‘Utility of PET-CT in detecting nodal metastasis in cN0 early stage oral cavity squamous cell carcinoma’ by Zhang et al. [1]. They reported on 96 patients diagnosed with cT1 or T2 oral squamous cell carcinoma (OSCC), a palpably negative neck and treated by resection of the primary tumor and elec tive neck dissection. All patients underwent preoperative CT of the neck with 32 patients having undergone [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET-CT). (Source: Oral Oncology)
Source: Oral Oncology - August 1, 2018 Category: Cancer & Oncology Authors: Remco de Bree, Bart de Keizer Tags: Letter to the editor Source Type: research
Letter to the Editor in response to the article, “The epidemiology of oral human papillomavirus infection in healthy populations: A systematic review and meta-analysis”
Dear Editor, (Source: Oral Oncology)
Source: Oral Oncology - August 1, 2018 Category: Cancer & Oncology Authors: Rama Jayaraj, Chellan Kumarasamy, Shanthi Sabarimurugan, Siddhartha Baxi Tags: Letter to the editor Source Type: research
Age and adenoma size are independent risk factors for the development of carcinoma ex pleomorphic adenoma
The frequency of carcinoma ex pleomorphic adenoma (CXAP) is largely varying in literature. Data for the risk of de novo malignant transformation vary between 1.1% and 6.2% [1 –4]. According to Valstar et al. [1] this variation may reflect referral bias. Moreover, there is some evidence for geographical differences in the prevalence of CXPA [4]. The progression of pleomorphic adenoma (PA) to CXPA is a multistep process. Genomic instability and successive mutations durin g tumor growth involving in particular loss of suppressor genes, as well as epigenetic alterations result in rise of a carcinoma [5,6]. (Source: Oral Oncology)
Source: Oral Oncology - July 30, 2018 Category: Cancer & Oncology Authors: E.S. Egal, F.V. Mariano, A.M. Altemani, K. Metze Tags: Letter to the editor Source Type: research
Letter to the editor: “Sentinel node biopsy in early oral squamous cell carcinomas: Long-term follow-up and nodal failure analysis”
We would like to take the opportunity to comment on the recently published article by Moya-Plana [1] et al. “Sentinel node biopsy in early oral squamous cell carcinomas: Long-term follow-up and nodal failure analysis”. Survival benefits of sentinel node biopsy (SNB) were previously demonstrated over watchful waiting in the management of squamous cell carcinoma of oral cavity (OCSCC) with clinically ne gative neck (cN0) [2–4]. We also know the END could benefit cN0 OCSCC patients compared with watchful waiting [5]. (Source: Oral Oncology)
Source: Oral Oncology - July 30, 2018 Category: Cancer & Oncology Authors: Tao Wang, Longjiang Li Tags: Letter to the editor Source Type: research
Clarithromycin as the empiric antibiotic therapy for medication-related osteonecrosis of the jaw in multiple myeloma patients
Medication-related osteonecrosis of the jaw (MRONJ) is a devastating adverse effect of several medications. In vast majority of cases, the offenders are bisphosphonates and denosumab which are given in metabolic bone diseases, bone metastases, hypercalcemia of malignancy, and multiple myeloma (MM). Most patients diagnosed with MRONJ are treated using antibiotics (about 60%) [1,2] and the courses are frequently long-term (even for over a year) [3]. (Source: Oral Oncology)
Source: Oral Oncology - July 28, 2018 Category: Cancer & Oncology Authors: Yehuda Zadik Tags: Perspectives Source Type: research
Self-reported oral morbidities in long-term oropharyngeal cancer survivors: A cross-sectional survey of 906 survivors
With the rise in incidence of HPV-positive oropharyngeal cancer (OPC), increased treatment response and decreased recurrence rates, there is a growing population of OPC survivors who now go on to live years (often decades) with long-term effects of therapy [1 –3]. Oral morbidities such as mucositis, osteoradionecrosis and xerostomia are common side effects when oral tissues such as mucosa, bone, and salivary glands, are within the volume of tissue irradiated. Furthermore, salivary changes affect the oral flora and overall risk of dental caries further increasing risks of osteoradionecrosis and dental/oral complications [...
Source: Oral Oncology - July 26, 2018 Category: Cancer & Oncology Authors: MD Anderson Head and Neck Cancer Symptom Working Group Source Type: research
ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition
Phosphoinositide 3-kinase (PI3K)/AKT/mTOR signalling regulates critical tumor cell functions, including cellular metabolism, survival, angiogenesis, growth and migration [1]. Hyper-activation of PI3K signalling is frequently observed in head and neck squamous cell carcinomas (HNSCCs), with nearly 80% of tumors containing amplifications or mutations of PIK3CA and numerous additional tumors containing losses of tumor suppressor PTEN or amplifications of EGFR or AKT1/2/3 [2 –4]. Owing to the prevalence of PI3K-pathway aberrations in HNSCC and the dependency of tumor cells on PI3K signalling for survival and growth, targetin...
Source: Oral Oncology - July 26, 2018 Category: Cancer & Oncology Authors: Kara M. Ruicci, Nicole Pinto, Mohammed I. Khan, John Yoo, Kevin Fung, Danielle MacNeil, Joe S. Mymryk, John W. Barrett, Anthony C. Nichols Source Type: research
Staging HPV-related oropharyngeal cancer: Validation of AJCC-8 in a surgical cohort
Over the last two decades, human papillomavirus related (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) has been recognized as a fundamentally different disease than tobacco and alcohol related (HPV −) OPSSC [1–3]. While both diseases are squamous cell carcinomas that arise in the oropharynx, HPV+ disease tends to affect a younger cohort of patients with a different set of risk factors [1–3], and has been shown to have different molecular biology than HPV negative disease [4]. Importantly , patients with HPV+ disease have a substantially improved prognosis [1–3,5]. (Source: Oral Oncology)
Source: Oral Oncology - July 22, 2018 Category: Cancer & Oncology Authors: Mathew Geltzeiler, Marnie Bertolet, William Albergotti, John Gleysteen, Brennan Olson, Michael Persky, Neil Gross, Ryan Li, Peter Andersen, Seungwon Kim, Robert L. Ferris, Umamaheswar Duvvuri, Daniel Clayburgh Source Type: research
Communication of prognosis in head and neck cancer patients; a descriptive qualitative analysis
During the last decade patient centered communication and patient involvement in treatment decisions has become an important approach in clinical care [1]. The shared decision making approach (SDM) is considered to be a central component of treatment decision consultations [2]. Patients need to be well-informed in order to be able to be actively involved in treatment decisions [3]. Prognostic information may be a valuable factor in considering treatment options [4]. Besides content, the communication style within the professional setting is also important, especially since patients tend to remember only 20 –60% of the in...
Source: Oral Oncology - July 22, 2018 Category: Cancer & Oncology Authors: Emilie A.C. Dronkers, Arta Hoesseini, Maarten F. de Boer, Marinella P.J. Offerman Source Type: research
