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Safety Notables: Information from the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 13, Issue 6, Page 1388-1394, November 20, 2009. (Source: Organic Process Research)
Source: Organic Process Research - November 20, 2009 Category: Chemistry Tags: article Source Type: journals

Why Do Organic Compounds Crystallise Well or Badly or Ever so Slowly? Why Is Crystallisation Nevertheless Such a Good Purification Technique?†Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 13, Issue 6, Page 1231-1240, November 20, 2009. (Source: Organic Process Research)
Source: Organic Process Research - November 20, 2009 Category: Chemistry Tags: article Source Type: journals

Process Development and Pilot-Scale Synthesis of New Cyclization Conditions of Substituted Phenylacetamides to Tetrahydroisoquinoline-2-ones Using Eaton’s ReagentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 17, 2009 Category: Chemistry Tags: article Source Type: journals

Book Review: Dynamic Stereochemistry of Chiral Compounds - Principles and ApplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 17, 2009 Category: Chemistry Tags: book review Source Type: journals

The Development of a New Manufacturing Route to the Novel Anticonvulsant, SB-406725AEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 16, 2009 Category: Chemistry Tags: article Source Type: journals

Development of a Multikilogram Synthesis of a Chiral Epoxide Precursor to a CCR1 Antagonist. Use of in Situ Monitoring for Informed Optimisation via Fragile IntermediatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 11, 2009 Category: Chemistry Tags: article Source Type: journals

Application of Quality by Design Principles to Support Development of a Control Strategy for the Control of Genotoxic Impurities in the Manufacturing Process of a Drug SubstanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 6, 2009 Category: Chemistry Tags: article Source Type: journals

Investigation of Synthetic Routes to a Key Benzopyran Intermediate of a 5HT4 AgonistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 6, 2009 Category: Chemistry Tags: article Source Type: journals

Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel - A Practical Application of a New DiscoveryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 4, 2009 Category: Chemistry Tags: article Source Type: journals

The Challenges of Developing an API Crystallization Process for a Complex Polymorphic and Highly Solvating System. Part IEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 4, 2009 Category: Chemistry Tags: article Source Type: journals

Turning DSC Charts of Polymorphs into Phase Diagrams: A Tutorial Paper†Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 4, 2009 Category: Chemistry Tags: article Source Type: journals

Special Polymorphism and Crystallisation Feature SectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 3, 2009 Category: Chemistry Tags: article Source Type: journals

Special Safety Feature SectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 3, 2009 Category: Chemistry Tags: article Source Type: journals

Some Items of Interest to Process R&D Chemists and EngineersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 3, 2009 Category: Chemistry Tags: article Source Type: journals

Seeded Batch Cooling Crystallization with Temperature Cycling for the Control of Size Uniformity and Polymorphic Purity of Sulfathiazole CrystalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 3, 2009 Category: Chemistry Tags: article Source Type: journals

An Efficient Synthesis of a Cyclic Ether Key Intermediate for 9-Membered Masked Enediyne Using an Automated SynthesizerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 2, 2009 Category: Chemistry Tags: article Source Type: journals

Development of Manufacturing Processes for a New Family of 2,6-Dihaloaryl 1,2,4-Triazole InsecticidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 2, 2009 Category: Chemistry Tags: article Source Type: journals

Book Review of Catalysis of Organic ReactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 2, 2009 Category: Chemistry Tags: book review Source Type: journals

An Improved Synthetic Route for Preparative Process of VardenafilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 2, 2009 Category: Chemistry Tags: article Source Type: journals

Development of a Scalable Synthetic Process for DG-051B, A First-in-Class Inhibitior of LTA4HEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - November 2, 2009 Category: Chemistry Tags: article Source Type: journals

Book Review of Flash Chemistry: Fast Organic Synthesis in MicrosystemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 30, 2009 Category: Chemistry Tags: book review Source Type: journals

A Practical Approach for Using Solubility to Design Cooling CrystallisationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 30, 2009 Category: Chemistry Tags: article Source Type: journals

Some Thoughts on Generic API ManufactureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 30, 2009 Category: Chemistry Tags: article Source Type: journals

Book Review of Green CatalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 30, 2009 Category: Chemistry Tags: book review Source Type: journals

The Discovery and Development of a Safe, Practical Synthesis of ABT-869Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 28, 2009 Category: Chemistry Tags: article Source Type: journals

A Review of U.S. Patents in the Field of Organic Process Development Published During June and July 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 28, 2009 Category: Chemistry Tags: article Source Type: journals

Crystallization Behavior of Polymorphic Mixtures of MPPOEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 28, 2009 Category: Chemistry Tags: article Source Type: journals

Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled CrystallizerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 27, 2009 Category: Chemistry Tags: article Source Type: journals

Practical Enantioselective Synthesis of a 3-Aryl-3-trifluoromethyl-2-aminopropanol DerivativeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 27, 2009 Category: Chemistry Tags: article Source Type: journals

Green N-Methylation of Electron Deficient Pyrroles with DimethylcarbonateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 26, 2009 Category: Chemistry Tags: article Source Type: journals

Removal of Heavy Metals from Organic Reaction Mixtures: Preparation and Application of Functionalized Resins(1)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 20, 2009 Category: Chemistry Tags: article Source Type: journals

Preparation of Saxagliptin, a Novel DPP-IV InhibitorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 16, 2009 Category: Chemistry Tags: article Source Type: journals

A Continuously Operated Bimembrane Reactor Process for the Biocatalytic Production of (2R,5R)-HexanediolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 16, 2009 Category: Chemistry Tags: article Source Type: journals

Development of a Scalable Synthesis of Dipeptidyl Peptidase-4 Inhibitor ABT-279Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 15, 2009 Category: Chemistry Tags: article Source Type: journals

Short and Efficient Process for the Synthesis of trans-4-Aminocyclohexanecarboxylic Acid DerivativesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 15, 2009 Category: Chemistry Tags: article Source Type: journals

New and Improved Manufacturing Process for ValsartanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 13, 2009 Category: Chemistry Tags: article Source Type: journals

Solvent Effects on the Crystallization and Preferential Nucleation of Carbamazepine Anhydrous Polymorphs: A Molecular Recognition PerspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 7, 2009 Category: Chemistry Tags: article Source Type: journals

A Practical Solid Form Screen Approach To Identify a Pharmaceutical Glutaric Acid Cocrystal for DevelopmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 6, 2009 Category: Chemistry Tags: article Source Type: journals

Evaluation and Establishment of a Cleaning Protocol for the Production of Vanisal Sodium and Aspirin Using a Continuous Oscillatory Baffled ReactorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 6, 2009 Category: Chemistry Tags: article Source Type: journals

Synthesis of the NK1 Receptor Antagonist GW597599. Part 3: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine Urea, A Happy EndEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 2, 2009 Category: Chemistry Tags: article Source Type: journals

A Novel Chiral Resolving Reagent, Bis((S)-Mandelic acid)-3-nitrophthalate, for Amlodipine Racemate Resolution: Scalable Synthesis and Resolution ProcessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 2, 2009 Category: Chemistry Tags: article Source Type: journals

Polymorphism in Processes of Crystallization in Solution: A Practical ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 1, 2009 Category: Chemistry Tags: article Source Type: journals

An Efficient Kilogram-Scale Synthesis of N,N′-Bis(4,6-disubstituted 1,3,5-triazin-2-yl)-4-aminophenetylamineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 1, 2009 Category: Chemistry Tags: article Source Type: journals

A Novel Crystallization Methodology To Ensure Isolation of the Most Stable Crystal FormEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 1, 2009 Category: Chemistry Tags: article Source Type: journals

A Rapid Method for Screening Crystallization Conditions and Phases of an Active Pharmaceutical IngredientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - September 29, 2009 Category: Chemistry Tags: article Source Type: journals

An Improved Process for Pioglitazone and Its Pharmaceutically Acceptable Salt†Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - September 29, 2009 Category: Chemistry Tags: article Source Type: journals

Scalable Process for the Premix of Esomeprazole†Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - September 25, 2009 Category: Chemistry Tags: article Source Type: journals

An Efficient Laboratory Automation Concept for Process ChemistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - September 23, 2009 Category: Chemistry Tags: article Source Type: journals

A Scalable Zinc Activation Procedure Using DIBAL-H in a Reformatsky ReactionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - September 23, 2009 Category: Chemistry Tags: article Source Type: journals

Process Development and Scale Up of a Glycine AntagonistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - September 23, 2009 Category: Chemistry Tags: article Source Type: journals