Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study.
To examine associations between serum oxylipins, which regulate tissue repair and pain signalling, and knee pain/radiographic osteoarthritis (OA) at baseline and knee pain at 3 year follow-up. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 20, 2024 Category: Rheumatology Authors: James Turnbull, Rakesh R. Jha, Peter R.W. Gowler, Rose Ferrands-Bentley, Dong-Hyun Kim, David A. Barrett, Aliya Sarmanova, Gwen S. Fernandes, Michael Doherty, Weiya Zhang, David A. Walsh, Ana M. Valdes, Victoria Chapman Source Type: research
Association between hip muscle strength/function and hip cartilage defects in sub-elite football players with hip/groin pain.
To explore associations between hip muscle strength and cartilage defects (presence and severity) on magnetic resonance imaging (MRI) in young adults with hip/groin pain participating in sub-elite football. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 20, 2024 Category: Rheumatology Authors: SL Coburn, KM Crossley, JL Kemp, F Gassert, J Luitjens, SJ Warden, AG Culvenor, MJ Scholes, MG King, P Lawrenson, T Link, JJ Heerey Source Type: research
Mild Exercise Expedites Joint Clearance and Slows Joint Degradation in a Joint Instability Model of Osteoarthritis in Male Rats
In this study, we hypothesized that exercise could slow progression of preclinical PTOA in part by enhancing knee joint clearance. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 17, 2024 Category: Rheumatology Authors: Jarred M Kaiser, Fabrice C Bernard, Krishna Pucha, Sarvgna K Raval, Tracy Eng, Travis Fulton, Shannon E Anderson, Kyle D Allen, J Brandon Dixon, Nick J Willett Source Type: research
Osteochondral fluid transport in an ex vivo system
The objectives of this study were to (1) test for diffusion of 3kDa molecular tracers from bone-to-cartilage and (2) assess potential differences in bone-to-cartilage fluid transport between different loading conditions. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 15, 2024 Category: Rheumatology Authors: Brady David Hislop, Ara K. Mercer, Alexandria G. Whitley, Erik P. Myers, Marie Mackin, Chelsea M. Heveran, Ronald K. June Tags: Brief Report Source Type: research
Adiposity and cartilage lesions following ACL reconstruction
To determine if global, central, or peripheral adiposity is associated with prevalent and worsening cartilage lesions following anterior cruciate ligament reconstruction (ACLR). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 14, 2024 Category: Rheumatology Authors: Harvi F. Hart, Kay M. Crossley, Brooke E. Patterson, Ali Guermazi, Trevor B. Birmingham, Chris Koskoletos, Am élie Michaud, Alysha De Livera, Adam G. Culvenor Source Type: research
Primary Title: Assessing the Efficacy of the Stop OsteoARthritis (SOAR) program: A randomized delayed-controlled trial in persons at increased risk of early onset post-traumatic knee osteoarthritis,
Assess the efficacy of an 8-week virtual, physiotherapist (PT)-guided knee health program (SOAR) to improve knee extensor strength in individuals at risk of post-traumatic knee osteoarthritis (PTOA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 12, 2024 Category: Rheumatology Authors: Justin M. Losciale, Linda K. Truong, Kexin Zhang, Trish Silvester-Lee, Maxi Miciak, Andrea Pajkic, Y. Le Christina, Hui Xie, Alison M. Hoens, Amber D. Mosewich, Michael A. Hunt, Linda C. Li, Ewa M. Roos, Jackie L. Whittaker Source Type: research
Elevated Nutrient Availability Enhances Chondrocyte Metabolism and Biosynthesis in Tissue-Engineered Cartilage
This study aimed to explore the effect of further increases in media availability on ECM synthesis and chondrocyte metabolism. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 12, 2024 Category: Rheumatology Authors: Roberto Tarantino, Halie Mei Jensen, Stephen D. Waldman Source Type: research
Transient Receptor Potential Vanilloid 4 Regulates Extracellular Matrix Composition and Mediates Load-Induced Intervertebral Disc Degeneration in a Mouse Model
Transient receptor potential vanilloid 4 (TRPV4) is a multi-modally activated cation channel that mediates mechanotransduction pathways by which musculoskeletal tissues respond to mechanical load and regulate tissue health. Using conditional Trpv4 knockout mice, we investigated the role of Trpv4 in regulating intervertebral disc (IVD) health and injury-induced IVD degeneration. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 9, 2024 Category: Rheumatology Authors: Min Kyu, Mark Kim, Matthew Lawrence, Diana Quinonez, Courtney Brooks, Rithwik Ramachandran, Cheryle A. S éguin Source Type: research
Pioneering a Chick Embryo Model to Explore the Intrauterine Etiology of Developmental Dysplasia of the Hip in Oligohydramnios Conditions
To explore the impact of oligohydramnios on fetal movement and hip development, given its association with Developmental Dysplasia of the Hip (DDH) but unclear mechanisms. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 6, 2024 Category: Rheumatology Authors: Shaoting Luo, Yufan Chen, Weizheng Zhou, Federico Canavese, Lianyong Li Source Type: research
Sex Differences in Osteoarthritis Prevalence, Pain Perception, Physical Function and Therapeutics
Women have a higher prevalence of osteoarthritis (OA) and worse clinical courses than men. However, the underlying factors and therapeutic outcomes of these sex-specific differences are incompletely researched. This review examines the current state of knowledge regarding sex differences in OA prevalence, risk factors, pain severity, functional outcomes, and use and response to therapeutics. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 6, 2024 Category: Rheumatology Authors: Neil A. Segal, Jeannine M. Nilges, Win Min Oo Source Type: research
Exploring the Association of Gender Role Expectations of Pain and Measures of Pain Sensitization in People with Knee Osteoarthritis: A Cross-Sectional Study
First, we explored the association between Gender Role Expectations of Pain (GREP), and psychophysical measures of sensitization in people with knee osteoarthritis (OA). Second, we explored whether the association differed by level of GREP items (high vs low scores). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 2, 2024 Category: Rheumatology Authors: Y V Raghava Neelapala, Saurab Sharma, Lisa Carlesso Source Type: research
Post-traumatic and OA-related lesions in the knee at baseline and 2 years after traumatic meniscal injury: Secondary analysis of a randomized controlled trial
To assess the presence of early degenerative changes on Magnetic Resonance Imaging (MRI) 24 months after a traumatic meniscal tear and to compare these changes in patients treated with arthroscopic partial meniscectomy or physical therapy plus optional delayed arthroscopic partial meniscectomy. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 1, 2024 Category: Rheumatology Authors: Sabine J.A. van der Graaff, Edwin H.G. Oei, Max Reijman, Lars Steenbekkers, Marienke van Middelkoop, Rianne A. van der Heijden, Duncan E. Meuffels, STARR Study Group Tags: Clinical Trial Source Type: research
Posttraumatic and OA-related lesions in the knee at baseline and 2 years after traumatic meniscal injury: secondary analysis of a randomized controlled trial
To assess the presence of early degenerative changes on magnetic resonance imaging (MRI) 24 months after a traumatic meniscal tear and to compare these changes in patients treated with arthroscopic partial meniscectomy or physical therapy plus optional delayed arthroscopic partial meniscectomy. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 1, 2024 Category: Rheumatology Authors: Sabine J.A. van der Graaff, Edwin H.G. Oei, Max Reijman, Lars Steenbekkers, Marienke van Middelkoop, Rianne A. van der Heijden, Duncan E. Meuffels, STARR Study Group Source Type: research
Posttraumatic and OA-related lesions in the knee at baseline and 2 years after traumatic meniscal injury: secondary analysis of a randomized controlled trial
To assess the presence of early degenerative changes on Magnetic Resonance Imaging (MRI) 24 months after a traumatic meniscal tear and to compare these changes in patients treated with arthroscopic partial meniscectomy or physical therapy plus optional delayed arthroscopic partial meniscectomy. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 1, 2024 Category: Rheumatology Authors: Sabine J.A. van der Graaff, Edwin H.G. Oei, Max Reijman, Lars Steenbekkers, Marienke van Middelkoop, Rianne A. van der Heijden, STARR Study Group, Duncan E. Meuffels, Susanne M. Eijgenraam, Eline M. van Es, Dirk Jan Hofstee, Kiem Gie Auw Yang, Julia C.A. Tags: Clinical Trial Source Type: research
Studies on postoperative outcome prognostic factors reveal intrinsic nature of osteoarthritis as a systemic disease: comment on Osteoarthritis and Cartilage 2023;24(1):98 –107
Dear Editor, (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 28, 2024 Category: Rheumatology Authors: E.V. Tchetina, E.A. Taskina Tags: Letter to the Editor Source Type: research
