Osteoporosis
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New cause of osteoporosis: Mutation in a miroRNA
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Many biological processes are controlled by small molecules known as microRNAs. Researchers have now identified a previously unknown microRNA (miR-2861) as crucial to bone maintenance in mice and humans; significantly, expression of functional miR-2861 was absent in two related adolescents with primary osteoporosis. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 20, 2009 Category: Science Source Type: news
Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScoresEmail this article to a colleague.
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Conclusions These new algorithms can predict risk of fracture in primary care populations in the UK without laboratory measurements and are therefore suitable for use in both clinical settings and for self assessment (www.qfracture.org). QFractureScores could be used to identify patients at high risk of fracture who might benefit from interventions to reduce their risk. (Source: BMJ Online First)
Source: BMJ Online First - November 20, 2009 Category: Journals (General) Authors: Hippisley-Cox, J., Coupland, C. Tags: Liver disease, Smoking and tobacco, Epidemiologic studies, General practice / family medicine, Immunology (including allergy), Drugs: cardiovascular system, Menopause (including HRT), Asthma, Connective tissue disease, Degenerative joint disease, Drugs: m Source Type: journals
New osteoporosis risk scores highly effectiveEmail this article to a colleague.
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Algorithms effectively predict osteoporotic risk and hip fractureRelated items from OnMedicaBooklet cuts antibiotic use for respiratory infectionsLarge rise in women having cervical screeningPolyclinics will destroy patient trust, warns studyPatient care improves in ScotlandGPs not prescribing enough beta blockers (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 20, 2009 Category: UK Health Source Type: news
Paper round: FridayEmail this article to a colleague.
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Stem cell therapy for eyes, epilepsy as an art form, and moreRelated items from OnMedicaSwine flu prompts warning over critical care beds shortagesNICE draft guidance rejects use of cancer liver drugDaily alcohol consumption can lower heart diseaseGPs fail to consider their own end-of-life careNew osteoporosis risk scores highly effective (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 20, 2009 Category: UK Health Source Type: news
Evaluation and management of osteoporosis and fragility fractures in the elderlyEmail this article to a colleague.
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Aging Health , December 2009, Vol. 5, No. 6, Pages 833-850. (Source: Future Medicine: Aging Health)
Source: Future Medicine: Aging Health - November 19, 2009 Category: Geriatrics Tags: article Source Type: journals
Peak BMD may explain Indian osteoporosis rateEmail this article to a colleague.
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Research suggests that peak bone mineral density in Indian men and women is lower than expected, which may explain why osteoporosis is more common in India than in Western populations. (Source: MedWire News - Bone Health)
Source: MedWire News - Bone Health - November 19, 2009 Category: Orthopaedics Source Type: news
Secondary prevention of osteoporosis post minimal trauma fracture in an Australian regional and rural populationEmail this article to a colleague.
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Conclusion: Overall, fracture risk identification and initiation of secondary prevention in this regional and rural population was low and this is consistent with findings in recent metropolitan studies. Effective regional and rural strategies are required that ensure identification and effective communication of risk to patients and their GPs. (Source: Australian Journal of Rural Health)
Source: Australian Journal of Rural Health - November 19, 2009 Category: Rural Health Authors: Cecily M. Barrack, Ellen E. McGirr, Jeffrey D. Fuller, Nicola M. Foster, Dan P. Ewald Tags: Original Articles Source Type: journals
Bone Health of 40-Something HIV-Positive Men Similar to That of Uninfected Men Decades OlderEmail this article to a colleague.
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The prevalence of osteoporosis among HIV-positive men in their 40s is similar to that of uninfected men in their 70s. Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - November 18, 2009 Category: Internal Medicine Tags: HIV/AIDS Source Type: info
Osteoporosis in Older PersonsEmail this article to a colleague.
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Pathophysiology and Therapeutic Approach Osteoporosis in Older Persons - Pathophysiology and Therapeutic Approach has the most up-to-date information about the pathophysiology and new therapeutic alternatives. Until recently most effort concerning osteoporosis research was directed mainly at the mechanisms of a type of osteoporosis known as post-menopausal osteoporosis. It was only just recently that a new syndrome, ... (Source: Springer Medicine titles)
Source: Springer Medicine titles - November 17, 2009 Category: Databases & Libraries Tags: Rheumatology Source Type: organizations
Measurement uncertainty for the analysis of serum 25-hydroxyvitamin DEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00198-009-1099-3Authors
H. C. M. Stepman, Ghent University Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences Harelbekestraat 72 9000 Ghent BelgiumL. M. Thienpont, Ghent University Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences Harelbekestraat 72 9000 Ghent Belgium
Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals
Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: a prospective studyEmail this article to a colleague.
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Conclusion Alendronate was effective in suppressing bone resorption and subsequent BMD decrease at the lumbar spine in patients with
high-dose GC treatment.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1110-zAuthors
H. Kaji, Kobe University Graduate School of Medicine Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine 7-5-2 Kusunoki-cho, Chuo-ku Kobe 650-0017 JapanY. Kuroki, Kobe Century Memorial Hospital Internal Medicine Kobe JapanY. Murakawa, Shimane University Faculty of Medicine Internal Medicine 3 Izumo JapanI. Funakawa, National Hyo...
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals
Treatment of osteoporosis: recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivityEmail this article to a colleague.
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Conclusion With early recognition and proper management, including immediate and permanent withdrawal of the culprit agent, accompanied
by hospitalization and rehydration and systemic corticosteroids if necessary, the prognosis is good.
Content Type Journal ArticleCategory ReviewDOI 10.1007/s00198-009-1097-5Authors
P. Musette, Charles Nicolle University Hospital Department of Dermatology and INSERM Unit 905 Rouen FranceM. L. Brandi, University of Florence Department of Internal Medicine Florence ItalyP. Cacoub, AH-HP, Hôpital Pitié Salpétrière, and Université Pierre et Marie Curie Department of In...
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals
Cross-sectional geometry of weight-bearing tibia in female athletes subjected to different exercise loadingsEmail this article to a colleague.
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Conclusions High-impact, odd-impact, and repetitive low-impact exercise loadings were associated with thicker cortex at the distal tibia.
At the tibial shaft, impact loading was not only associated with thicker cortex, but also a larger cross-sectional area. High-magnitude
exercise loading did not show such associations at either site but was comparable to repetitive non-impact loading and reference
data. Collectively, the relevance of high strain rate together with moderate-to-high strain magnitude as major determinants
of osteogenic loading of the weight-bearing tibia is implicated.
Content Type Jou...
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals
Measurement uncertainty for the analysis of serum 25-hydroxyvitamin D: response to Stepman and ThienpontEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00198-009-1098-4Authors
E. Cavalier, University Hospital of Liège Department of Clinical Chemistry, University of Liège Domaine du Sart-Tilman 4000 Liège BelgiumP. Delanaye, University Hospital of Liège Department of Nephrology, Dialysis and Hypertension, University of Liège Liège BelgiumC. Cormier, Hôpital Cochin Department of Rheumatology Paris FranceJ. C. Souberbielle, Hôpital Necker-Enfants Malades Laboratoire d’Explorations Fonctionnelles Paris France
Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (S...
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals
Survivorship: adult cancer survivors.Email this article to a colleague.
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During the next decade, a rapid increase in the number of new cancer diagnoses in the population as well as a growing number of cancer survivors can be expected. Cancer is anticipated to exceed cardiovascular disease as the primary cause of mortality in the United States population. Despite efforts in tobacco control, the aging of the population and obesity epidemic will contribute toward the increasing incidence of cancer. Although oncology specialists will continue to play a critical role in the diagnosis and initial treatment of patients with cancer, primary care providers will need to play an expanding role in the ...
Source: Primary Care - November 17, 2009 Category: Primary Care Authors: Ganz PA Tags: Prim Care Source Type: journals
MicroRNA mutation causes rare form of primary osteoporosisEmail this article to a colleague.
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Chinese scientists have identified a micro RNA mutation that plays a key role in primary osteoporosis by promoting osteoblast differentiation. (Source: MedWire News - Bone Health)
Source: MedWire News - Bone Health - November 17, 2009 Category: Orthopaedics Source Type: news
Mutation In A MiroRNA: New Cause Of OsteoporosisEmail this article to a colleague.
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Many biological processes are controlled by small molecules known as microRNAs, which work by suppressing the expression of specific sets of genes. Xiang-Hang Luo and colleagues, at Second Xiangya Hospital of Central South University, People's Republic of China, have now identified a previously unknown microRNA (miR-2861) as crucial to bone maintenance in mice and humans. (Source: Genetics News From Medical News Today)
Source: Genetics News From Medical News Today - November 17, 2009 Category: Genetics & Stem Cells Tags: Bones / Orthopaedics Source Type: news
Mutation In A MiroRNA: New Cause Of OsteoporosisEmail this article to a colleague.
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Many biological processes are controlled by small molecules known as microRNAs, which work by suppressing the expression of specific sets of genes. Xiang-Hang Luo and colleagues, at Second Xiangya Hospital of Central South University, People's Republic of China, have now identified a previously unknown microRNA (miR-2861) as crucial to bone maintenance in mice and humans. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 17, 2009 Category: Consumer Health News Tags: Bones / Orthopaedics Source Type: news
Soy What?Email this article to a colleague.
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Scientists have long suspected that the soy foods in Asian diets may help explain why people in places like Japan, China, and Singapore have lower rates of breast cancer, prostate cancer, osteoporosis, and heart disease. And thousands of studies over the past two decades- most of them carried out in the West- have tried to figure out whether soybeans are beneficial and, if so, which parts of the soybean are responsible. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news
Low Vitamin D Levels May Raise Heart RiskEmail this article to a colleague.
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Some men with low levels of vitamin D in their blood are at particularly high risk of developing heart disease and weakened bones that can lead to osteoporosis, researchers report. (Source: WebMD Health)
Source: WebMD Health - November 16, 2009 Category: Consumer Health News Source Type: news
JCI online early table of contents: Nov. 16, 2009Email this article to a colleague.
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(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Nov. 16 2009, in the JCI, including: New cause of osteoporosis: mutation in a miroRNA; Watching Lyme disease-causing microbes move in ticks; MIFfed about protection for the heart; Th22 immune cell subset: a therapeutic target in chronic inflammatory skin disorders?; Loop the loop: speeding up a serious blood vessel condition; and others. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 16, 2009 Category: Cancer & Oncology Source Type: news
Cervical cancer effectively treated with ER-alpha blockersEmail this article to a colleague.
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Cervical cancer could one day be effectively treated with fulvestrant and raloxifene, two drugs currently used to treat breast cancer and osteoporosis, show results of an animal study. (Source: MedWire News - Ob/Gyn)
Source: MedWire News - Ob/Gyn - November 16, 2009 Category: OBGYN Source Type: news
Postmenopausal osteoporosis possible risk factor for coronary artery diseaseEmail this article to a colleague.
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Postmenopausal women with osteoporosis are more likely to have arterial stiffness than women with osteopenia or normal bone mineral density, study findings show. (Source: MedWire News - Ob/Gyn)
Source: MedWire News - Ob/Gyn - November 16, 2009 Category: OBGYN Source Type: news
Baseline Glucocorticoid Dose and Bone Mineral Density Response with Teriparatide or Alendronate Therapy in Patients with Glucocorticoid-induced Osteoporosis.Email this article to a colleague.
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CONCLUSION: Teriparatide and alendronate increased LS and hip BMD across a range of baseline glucocorticoid doses. LS BMD increases with teriparatide were greater in the low-dose category than in the high-dose category. Overall LS BMD increases were significantly greater with teriparatide compared with alendronate, which may reflect the respective anabolic and antiresorptive mechanisms of action. Clinical Trial Registry Number: NCT00051558.
PMID: 19918047 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 16, 2009 Category: Rheumatology Authors: Devogelaer JP, Adler RA, Recknor C, See K, Warner MR, Wong M, Krohn K Tags: J Rheumatol Source Type: journals
Assessment of risk factors for osteoporosis and fractures in children with meningomyelocele.Email this article to a colleague.
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Conclusions: Low-energetic fractures in MMC children may result from metabolic disturbances that are a consequence of excessive renal calcium loss or excessive fatty tissue content.
PMID: 19919941 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - November 16, 2009 Category: Biomedical Science Authors: Okurowska-Zawada B, Konstantynowicz J, Kułak W, Kaczmarski M, Piotrowska-Jastrzębska J, Sienkiewicz D, Paszko-Patej G Tags: Adv Med Sci Source Type: journals
The endometrium--from estrogens alone to TSECs.Email this article to a colleague.
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This article reviews publications dating back more than a century describing investigations of the endometrium, including those examining the relationship between endometrial hyperplasia and carcinoma, the influence of estrogens on the endometrium, and strategies for protecting the endometrium from unopposed estrogen stimulation. Endometrial hyperplasia and carcinoma studies date from before 1900. The influence of endogenous estrogens on the endometrium became evident with observations of endometrial hyperplasia and/or carcinoma in women with estrogen-secreting tumors or polycystic ovarian disease. Later, observational stu...
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Pickar JH Tags: Climacteric Source Type: journals
High-Impact Activity May Be Good for Old BonesEmail this article to a colleague.
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Sampling of senior athletes finds better density with some sports
Source: HealthDay
Related MedlinePlus Topics: Exercise for Seniors, Osteoporosis, Seniors' Health (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 14, 2009 Category: Consumer Health News Source Type: consumer
Biology and Clinical Significance of Tartrate-Resistant Acid Phosphatases: New Perspectives on an Old EnzymeEmail this article to a colleague.
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Abstract Type 5 tartrate-resistant acid phosphatase (TRAP) has been a clinically relevant biomarker for about 50 years. It has always
been a reliable and specific cytochemical marker for hairy cell leukemia and for differentiated cells of monocytic lineage.
Only recently has the test for serum TRAP activity been accepted as sensitive and specific enough for clinical use as a marker
of osteoclasts and bone resorption. This has come about through steady advances in knowledge about TRAP enzymology, structure,
function, and molecular regulation and a consequent appreciation that TRAP isoforms 5a and 5b have...
Source: Calcified Tissue International - November 14, 2009 Category: Orthopaedics Tags: Calcified Tissue International Source Type: journals
Bone healthEmail this article to a colleague.
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Strictly star's moves target osteoporosis patients (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 14, 2009 Category: Consumer Health News Tags: Health Source Type: news
Preferential reduction of bone mineral density at the femur reflects impairment of physical activity in patients with low-activity rheumatoid arthritisEmail this article to a colleague.
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Abstract Bone mineral density (BMD) and factors influencing BMD in rheumatoid arthritis (RA) under good or moderate control were examined
to assess management of osteoporosis in RA. BMD of the lumbar spine, femur, and distal radius was measured in 105 female patients
with well-controlled RA. Laboratory and clinical variables associated with disease activity were measured in the same subjects,
and correlations between these variables and BMD were evaluated. The RA patients showed a greater decrease in BMD of the femoral
neck than of the lumbar spine. Age, Health Assessment Questionnaire (HAQ) score, and Larse...
Source: Modern Rheumatology - November 13, 2009 Category: Rheumatology Tags: Modern Rheumatology Source Type: journals
Microarchitecture of the Radial Head and Its Changes in AgingEmail this article to a colleague.
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Abstract Fractures of the radial head are common; however, it remains to be determined whether the radial head has to be considered
as a typical location for fractures associated with osteoporosis. To investigate whether the human radial head shows structural
changes during aging, we analyzed 30 left and 30 right human radial heads taken from 30 individuals. The specimens taken from
the left side were analyzed by peripheral quantitative computed tomography (pQCT) and micro-CT. The specimens taken from the
right elbow joint were analyzed by radiography and histomorphometry. In these specimens pQCT revealed a ...
Source: Calcified Tissue International - November 13, 2009 Category: Orthopaedics Tags: Calcified Tissue International Source Type: journals
Prevalence and Predictors of Osteoporosis Risk in Orthopaedic Patients.Email this article to a colleague.
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CONCLUSIONS: Low bone mineral density is common among orthopaedic outpatients. Age, female gender, smoking, wrist fractures, and spinal deformities are independent risk factors for osteoporosis. We present a probability model designed to assist orthopaedic surgeons in identifying high-risk patients and initiating adequate preventative measures. LEVEL OF EVIDENCE: Level I, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.
PMID: 19911243 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - November 13, 2009 Category: Orthopaedics Authors: Rozental TD, Shah J, Chacko AT, Zurakowski D Tags: Clin Orthop Relat Res Source Type: journals
People entering their 60s may have more disabilities today than in prior generationsEmail this article to a colleague.
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In a development that could have significant ramifications for the nation's health care system, Baby Boomers may well be entering their 60s suffering far more disabilities than their counterparts did in previous generations, according to a new UCLA study. The findings, researchers say, may be due in part to changing American demographics.
In the study, which will be published in the January 2010 issue of the American Journal of Public Health, researchers from the division of geriatrics at the David Geffen School of Medicine at UCLA found that the cohort of individuals b...
Source: UCLA Newsroom: Health Sciences - November 12, 2009 Category: Universities & Medical Training Source Type: organizations
Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis modelEmail this article to a colleague.
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Recent studies support the notion that there is an intricate relationship between hematopoiesis and bone homeostasis in normal steady states. Using mice undergoing chronic inflammatory arthritis, we investigated the relationship between hematopoiesis and bone homeostasis in pathologic conditions. We demonstrate that mice undergoing chronic inflammatory arthritis displayed osteoporosis resulting from a severe defect in osteoblast function. Despite the defective osteoblast function, however, the hematopoietic stem cells from these mice exhibited normal properties in either long-term repopulation or cell cycling. Therefore, t...
Source: Blood - November 12, 2009 Category: Hematology Authors: Ma, Y. D., Park, C., Zhao, H., Oduro, K. A., Tu, X., Long, F., Allen, P. M., Teitelbaum, S. L., Choi, K. Tags: Hematopoiesis and Stem Cells Source Type: journals
Muscle activity unaltered by jaw osteoporosisEmail this article to a colleague.
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Osteoporosis of the jaw does not significantly alter muscle activity when chewing, suggest the results of an electromyographic study. (Source: MedWire News - Bone Health)
Source: MedWire News - Bone Health - November 12, 2009 Category: Orthopaedics Source Type: news
Prenatal and Nutritional Influences on Skeletal Development: Lessons from Animal StudiesEmail this article to a colleague.
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Abstract It is now well established that the onset of adult diseases such as heart disease, stroke, type 2 diabetes and hypertension
are linked to an adverse uterine growth environment, in particular through maternal nutrition, during development of the individual.
The geographical distribution of the incidence rate of heart disease is similar to that of osteoporosis. This may indicate
a link between maternal nutrition during pregnancy and the subsequent risk of developing osteoporosis in the offspring. This
review summarises what we know to date, from animal models, about maternal nutrition and the subseque...
Source: Clinical Reviews in Bone and Mineral Metabolism - November 12, 2009 Category: Internal Medicine Tags: Clinical Reviews in Bone and Mineral Metabolism Source Type: journals
Does Percutaneous Vertebroplasty Work for Osteoporosis-Related Vertebral Compression Fractures?Email this article to a colleague.
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There have been limited evidence-based data demonstrating the efficacy of percutaneous vertebroplasty for osteoporotic vertebral fractures. Medscape Orthopaedics & Sports Medicine (Source: Medscape Ob/Gyn & Women's Health Headlines)
Source: Medscape Ob/Gyn & Women's Health Headlines - November 11, 2009 Category: OBGYN Tags: Orthopaedics Source Type: info
GP osteoporosis funding set to run until 2011Email this article to a colleague.
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The Government plans to extend funding for GPs to identify and treat patients with osteoporosis. (Source: Pulse)
Source: Pulse - November 11, 2009 Category: Primary Care Tags: News Source Type: news
Zosano Pharma, Inc. Announces Publication Of Positive Phase 2 Study Of Its ZP-PTH Patch For Osteoporosis TherapyEmail this article to a colleague.
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Zosano Pharma, Inc., a privately held pharmaceutical company developing products using a novel transdermal delivery technology, announced publication in the current issue of the Journal of Clinical Endocrinology and Metabolism of results from a positive phase 2 study of its rapid-delivery transdermal patch (ZP-PTH) for the treatment of postmenopausal osteoporosis. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 11, 2009 Category: Consumer Health News Tags: Bones / Orthopaedics Source Type: news
Zosano Pharma, Inc. Announces Publication Of Positive Phase 2 Study Of Its ZP-PTH Patch For Osteoporosis TherapyEmail this article to a colleague.
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Zosano Pharma, Inc., a privately held pharmaceutical company developing products using a novel transdermal delivery technology, announced publication in the current issue of the Journal of Clinical Endocrinology and Metabolism of results from a positive phase 2 study of its rapid-delivery transdermal patch (ZP-PTH) for the treatment of postmenopausal osteoporosis. The study by authors Felicia Cosman, Nancy E. Lane, Michael A. Bolognese, Jose R. Zanchetta, Pedro A. (Source: Bones / Orthopaedics News From Medical News Today)
Source: Bones / Orthopaedics News From Medical News Today - November 11, 2009 Category: Orthopaedics Tags: Bones / Orthopaedics Source Type: news
Alpha Blockers Stop and Prevent Cervical Cancer in MiceEmail this article to a colleague.
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Two FDA-approved drugs, one used to treat breast cancer and the other to treat osteoporosis, may eventually be used to stop cervical cancer in its tracks. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - November 11, 2009 Category: Consumer Health News Source Type: news
Depression 'increases osteoporosis risk'Email this article to a colleague.
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New research has discovered a link between depression and the onset of osteoporosis. (Source: Arthritis Research Campaign)
Source: Arthritis Research Campaign - November 11, 2009 Category: Rheumatology Authors: Arthritis Research Campaign (mailto:info at arc.org.uk) Source Type: news
New osteoporosis trans-dermal drug patch moves a step closerEmail this article to a colleague.
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A novel treatment for postmenopausal osteoporosis, delivered via a trans-dermal patch, has successfully completed the second stage of its trial (Source: Arthritis Research Campaign)
Source: Arthritis Research Campaign - November 11, 2009 Category: Rheumatology Authors: Arthritis Research Campaign (mailto:info at arc.org.uk) Source Type: news
Tissue-Selective Regulation of Aromatase Expression by Calcitriol: Implications for Breast Cancer Therapy.Email this article to a colleague.
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Aromatase, the enzyme that catalyzes estrogen synthesis, is critical for the progression of estrogen receptor-positive breast cancer (BCa) in postmenopausal women. We show that calcitriol, the hormonally active form of vitamin D, regulates the expression of aromatase in a tissue-selective manner. Calcitriol significantly decreased aromatase expression in human BCa cells and adipocytes and caused substantial increases in human osteosarcoma cells (a bone cell model exhibiting osteoblast phenotype in culture) and modest increases in ovarian cancer cells. Calcitriol administration to immunocompromised mice bearing human BC...
Source: Endocrinology - November 11, 2009 Category: Endocrinology Authors: Krishnan AV, Swami S, Peng L, Wang J, Moreno J, Feldman D Tags: Endocrinology Source Type: journals
Update: A 55-Year-Old Woman With Osteopenia [Clinical Crossroads Update]Email this article to a colleague.
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(Source: JAMA)
Source: JAMA - November 10, 2009 Category: Journals (General) Authors: Mattson-DiCecca, A. A., Reynolds, E. E., Cummings, J. R. Tags: Aging/ Geriatrics, Exercise, Rheumatology, Osteoporosis, Women's Health, Menopause, Women's Health, Other, Drug Therapy, Drug Therapy, Other Clinical Crossroads Update Source Type: journals
Early tests on cervical cancer drugsEmail this article to a colleague.
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Conclusion
This small study has shown that the oestrogen receptor blockers fulvestrant and raloxifene can treat cervical cancers in genetically engineered mice with this disease. Although these results suggest that the drugs may be worth investigating further for potential use in human cervical cancer, they may not represent the effects that the drugs would have in humans. As the researchers note, “Although our transgenic mouse model for HPV-associated cervical cancer recapitulates most aspects of human cervical cancer, it is obvious that further study is needed to determine whether this proposed model is relevant to h...
Source: NHS News Feed - November 10, 2009 Category: Consumer Health News Tags: Cancer Medical practice Source Type: news
FDA-approved Drugs Eliminate, Prevent Cervical Cancer In MiceEmail this article to a colleague.
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Researchers have eliminated cervical cancer in mice with two FDA-approved drugs currently used to treat breast cancer and osteoporosis. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 10, 2009 Category: Science Source Type: news
Link Between Depression And OsteoporosisEmail this article to a colleague.
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Research carried out among thousands of people has shown a clear connection between depression and a loss of bone mass, leading to osteoporosis and fractures. This was revealed by Hebrew University of Jerusalem researchers, Prof. Raz Yirmiya, head of the Brain and Behavior Laboratory, and Prof. Itai Bab, head of the Bone Laboratory. They further revealed that the relationship between depression and bone loss is particularly strong among young women. (Source: Depression News From Medical News Today)
Source: Depression News From Medical News Today - November 10, 2009 Category: Psychiatry Tags: Depression Source Type: news
Link Between Depression And OsteoporosisEmail this article to a colleague.
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Research carried out among thousands of people has shown a clear connection between depression and a loss of bone mass, leading to osteoporosis and fractures. This was revealed by Hebrew University of Jerusalem researchers, Prof. Raz Yirmiya, head of the Brain and Behavior Laboratory, and Prof. Itai Bab, head of the Bone Laboratory. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 10, 2009 Category: Consumer Health News Tags: Depression Source Type: news
Cervical cancer wiped out by pioneering use of 'amazing' osteoporosis drugs (Daily Mail, 10 November 2009)Email this article to a colleague.
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Two drugs, fulvestrant and raloxifene, used to treat breast cancer and osteoporosis respectively, have shown promise in the treatment of cervical cancer, according to initial studies in mice.
Full article (Source: Society for Endocrinology)
Source: Society for Endocrinology - November 10, 2009 Category: Endocrinology Source Type: organizations
