Refracture and mortality risk in the elderly with osteoporotic fractures: the AGES-Reykjavik study
ConclusionThe risk of refracture significantly increases in the first six years following the initial fracture. Elderly women, who experience fractures at a younger age, should be closely monitored to address their long-term elevated refracture risk. Elderly men, especially those with hip and vertebral fractures, face substantial mortality risk and require prioritized monitoring and treatment. (Source: Osteoporosis International)
Source: Osteoporosis International - April 24, 2024 Category: Orthopaedics Source Type: research
Treatment patterns in women with postmenopausal osteoporosis using abaloparatide: a real-world observational study
ConclusionMost patients completed treatment with abaloparatide as prescribed, and over half continued with an antiresorptive agent. This favorable conduct may be the result of regular follow-up visits and accessibility to both medication and patient support services. (Source: Osteoporosis International)
Source: Osteoporosis International - April 24, 2024 Category: Orthopaedics Source Type: research
Secondary fracture prevention in primary care: a narrative review
AbstractThe global burden of osteoporosis continues to rise with an ageing population. Untreated osteoporotic fractures not only heighten the risk of subsequent fractures but are associated with excess mortality. Although primary care guidelines consistently stress the importance of secondary fracture prevention, fewer than 20% of patients are appropriately treated for osteoporosis following an initial osteoporotic fracture. This worldwide phenomenon is known as the osteoporosis care gap. This literature review examines the barriers to secondary fracture prevention in primary care and evaluates the effectiveness of targete...
Source: Osteoporosis International - April 23, 2024 Category: Orthopaedics Source Type: research
Bone mineral density, turnover, and microarchitecture assessed by second-generation high-resolution peripheral quantitative computed tomography in patients with Sheehan ’s syndrome
ConclusionLow areal BMD (aBMD) is highly prevalent in SS as compared to age- and BMI-matched controls. However, there were no significant differences in bone microarchitectural measurements, except for tibial cortical vBMD, which was lower in adequately treated SS patients. (Source: Osteoporosis International)
Source: Osteoporosis International - April 19, 2024 Category: Orthopaedics Source Type: research
The yield of routine laboratory examination in osteoporosis evaluation in primary care
ConclusionsWe identified a low prevalence of laboratory abnormalities in a primary care population of older women and the majority of these findings had no medical consequences. (Source: Osteoporosis International)
Source: Osteoporosis International - April 19, 2024 Category: Orthopaedics Source Type: research
Correction: Hypophosphatasia diagnosis: current state of the art and proposed diagnostic criteria for children and adults
(Source: Osteoporosis International)
Source: Osteoporosis International - April 19, 2024 Category: Orthopaedics Source Type: research
Clinical features, treatment, and follow-up of OPPG and high-bone-mass disorders: LRP5 is a key regulator of bone mass
ConclusionThis study deepened the understanding of the clinical characteristics, treatment, and follow-up of OPPG and LRP5-HBM; expanded the pathogenic gene spectrum of OPPG; and confirmed that bisphosphonates were effective for OPPG. Additionally, it was found that Ala242Thr mutation could not protect LRP5-HBM patients from age-related bone loss. This phenomenon deserves further study. (Source: Osteoporosis International)
Source: Osteoporosis International - April 16, 2024 Category: Orthopaedics Source Type: research
Family/caregiver influence on osteoporosis management for older people: an integrative review
This study applied an integrative literature review methodology to key literature findings on family/caregiver influence on osteoporosis management for older people. Key findings include caregivers’ tendency to overprotect persons who experience hip fracture by limiting mobil ization, thus impeding recovery, caregivers’ risks for their own fragility fractures due to the demands of their caregiving role, risks of poor bone health in caregivers, and caregivers’ experience of significant burden for which facilitators have been identified. Family caregivers of older peop le with osteoporosis have unique needs and require...
Source: Osteoporosis International - April 15, 2024 Category: Orthopaedics Source Type: research
The cost-effectiveness of osteoporosis medications for preventing periprosthetic fractures following femoral neck fracture indicated hip arthroplasty: a break-even analysis
ConclusionThe utilization of lower cost osteoporosis medications such as oral bisphosphonates and estrogen hormonal therapy as PPF prophylaxis in this patient population would be economically viable if they reduce the PPF rate by 1.8% and 1.5%, respectively. For IV bisphosphonates and newer agents to be economically viable as PPF prophylaxis in the USA, their costs need to be significantly reduced. (Source: Osteoporosis International)
Source: Osteoporosis International - April 15, 2024 Category: Orthopaedics Source Type: research
Delayed and significant hypercalcaemia due to teriparatide therapy: a case report and review
We report the case of a female who developed significant delayed hypercalcaemia after teriparatide treatment for osteoporosis and review other cases in the literature to date.Case reportA 72-year-old female on teriparatide for the treatment of osteoporosis was found to have hypercalcaemia (3.30 mmol/l) on routine testing approximately 3 months after starting therapy. Serum calcium pretreatment was normal at 2.39 mmol/l. She was admitted to the hospital for investigations which identified a serum 25-hydroxyvitamin D of 94 nmol/l, a low parathyroid hormone of 6.0 pg/ml, and normal test results for 1,25 dihydroxyvitamin D (11...
Source: Osteoporosis International - April 13, 2024 Category: Orthopaedics Source Type: research
Higher prevalence of thyroid-specific autoantibodies (TPOAb and TgAb) is related to a higher prevalence of fractures in females: results from NHANES 2007 –2010
ConclusionHigher prevalence of thyroid-specific autoantibodies may lead to decreased BMD. In females, higher prevalence of TgAb and TPOAb significantly associated with fractures and TPOAb especially relating to the fractures of hip and spine. Males patients with vitamin D deficiency or insufficiency associated a higher possibility of fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - April 12, 2024 Category: Orthopaedics Source Type: research
