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Treatment of osteoporosis: recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion With early recognition and proper management, including immediate and permanent withdrawal of the culprit agent, accompanied by hospitalization and rehydration and systemic corticosteroids if necessary, the prognosis is good. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00198-009-1097-5Authors P. Musette, Charles Nicolle University Hospital Department of Dermatology and INSERM Unit 905 Rouen FranceM. L. Brandi, University of Florence Department of Internal Medicine Florence ItalyP. Cacoub, AH-HP, Hôpital Pitié Salpétrière, and Université Pierre et Marie Curie Department of In...
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: a prospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Alendronate was effective in suppressing bone resorption and subsequent BMD decrease at the lumbar spine in patients with high-dose GC treatment. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1110-zAuthors H. Kaji, Kobe University Graduate School of Medicine Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine 7-5-2 Kusunoki-cho, Chuo-ku Kobe 650-0017 JapanY. Kuroki, Kobe Century Memorial Hospital Internal Medicine Kobe JapanY. Murakawa, Shimane University Faculty of Medicine Internal Medicine 3 Izumo JapanI. Funakawa, National Hyo...
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Measurement uncertainty for the analysis of serum 25-hydroxyvitamin DEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00198-009-1099-3Authors H. C. M. Stepman, Ghent University Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences Harelbekestraat 72 9000 Ghent BelgiumL. M. Thienpont, Ghent University Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences Harelbekestraat 72 9000 Ghent Belgium Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Measurement uncertainty for the analysis of serum 25-hydroxyvitamin D: response to Stepman and ThienpontEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00198-009-1098-4Authors E. Cavalier, University Hospital of Liège Department of Clinical Chemistry, University of Liège Domaine du Sart-Tilman 4000 Liège BelgiumP. Delanaye, University Hospital of Liège Department of Nephrology, Dialysis and Hypertension, University of Liège Liège BelgiumC. Cormier, Hôpital Cochin Department of Rheumatology Paris FranceJ. C. Souberbielle, Hôpital Necker-Enfants Malades Laboratoire d’Explorations Fonctionnelles Paris France Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (S...
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Cross-sectional geometry of weight-bearing tibia in female athletes subjected to different exercise loadingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions High-impact, odd-impact, and repetitive low-impact exercise loadings were associated with thicker cortex at the distal tibia. At the tibial shaft, impact loading was not only associated with thicker cortex, but also a larger cross-sectional area. High-magnitude exercise loading did not show such associations at either site but was comparable to repetitive non-impact loading and reference data. Collectively, the relevance of high strain rate together with moderate-to-high strain magnitude as major determinants of osteogenic loading of the weight-bearing tibia is implicated. Content Type Jou...
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Compromised bone strength index in the hemiparetic distal tibia epiphysis among chronic stroke patients: the association with cardiovascular function, muscle atrophy, mobility, and spasticityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Cardiovascular function, muscle atrophy, mobility, and spasticity are independently associated with BSI of the distal tibia epiphysis among chronic stroke patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1038-3Authors M. Y. C. Pang, Hong Kong Polytechnic University Department of Rehabilitation Sciences Hung Hom Hong Kong ChinaM. C. Ashe, University of British Columbia Department of Physical Therapy Vancouver BC CanadaJ. J. Eng, University of British Columbia Department of Physical Therapy Vancouver BC Canada Journal Osteoporosis InternationalOnlin...
Source: Osteoporosis International - October 30, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Immune changes in post-menopausal osteoporosis: the Immunos studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results suggest that, regardless of age and estrogen status, postmenopausal OP is associated with immune changes, highlighting a possible role of IFN-γ in the pathophysiology of OP and reporting, for the first time, changes in several B lymphocyte populations. These alterations may reflect the frailty observed after fracture, providing new insight into the mechanisms of morbidity and mortality associated with OP fractures. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1018-7Authors V. Breuil, CHU de Nice, Hôpital l’Archet Service de Rhumatologie Route...
Source: Osteoporosis International - October 30, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Osteonecrosis of the jaw in patients receiving oral bisphosphonatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory LetterDOI 10.1007/s00198-009-1089-5Authors Athanassios Kyrgidis, Theagenio Cancer Hospital Department of Oral and Maxillofacial Surgery Thessaloniki GreeceKonstantinos Vahtsevanos, Theagenio Cancer Hospital Department of Oral and Maxillofacial Surgery Thessaloniki Greece Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - October 28, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Alveolar bone density measurement in risk assessment for bisphosphonate-related osteonecrosis of the jaw: response to comments by TaguchiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory LetterDOI 10.1007/s00198-009-1093-9Authors Y. Takaishi, Takaishi Dental Clinic 3-32, Hojo-guchi Himeji 670-0935 JapanT. Ikeo, Osaka Dental University Department of Biochemistry Osaka JapanM. Nakajima, Osaka Dental University Department of Oral and Maxillofacial Surgery Osaka JapanT. Miki, Osaka City University Department of Geriatric Medicine Osaka JapanT. Fujita, Katsuragi Hospital Osaka Japan Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - October 26, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Automated 3D trabecular bone structure analysis of the proximal femur—prediction of biomechanical strength by CT and DXAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion A combination of bone mass (DXA) and structure parameters of the trabecular bone (linear and nonlinear, global and local) most accurately predicted absolute and relative femoral bone strength. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1090-zAuthors T. Baum, Technische Universität München Institut für Röntgendiagnostik, Klinikum Rechts der Isar Ismaninger Str. 22 81675 Munich GermanyJ. Carballido-Gamio, University of California, San Francisco Musculoskeletal and Quantitative Imaging Research, Department of Radiology 185 Berry Street, Suite 350 San Francis...
Source: Osteoporosis International - October 26, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Does standardized BMD still remove differences between Hologic and GE-Lunar state-of-the-art DXA systems?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The sBMD values were shown to be equivalent within 1.0% for hip but were significantly different for spine on the two systems. Biases may persist in pooled sBMD data from different manufacturers, and further study is necessary to determine the cause. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1062-3Authors B. Fan, University of California San Francisco Department of Radiology and Biomedical Imaging San Francisco CA USAY. Lu, University of California San Francisco Department of Radiology and Biomedical Imaging San Francisco CA USAH. Genant, University of Cali...
Source: Osteoporosis International - October 26, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Orbital inflammatory disease secondary to a single-dose administration of zoledronic acid for treatment of postmenopausal osteoporosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 60-year-old woman received a single 5-mg dose of zoledronic acid (Aclasta®) for treatment of postmenopausal osteoporosis. One day after receiving the drug, she acutely developed a painful periorbital swelling, chemosis, and hyperemia in the right eye. The condition worsened despite initial treatment with topical steroids. An orbital CT scan showed right eye proptosis, eyelid edema, and intraorbital fat stranding. A diagnosis of orbital inflammatory disease was made, and the patient was treated with high-dose oral steroids (prednisone 80 mg/day) tapered along 6 weeks. The symptoms and th...
Source: Osteoporosis International - October 26, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

PTH improves titanium implant fixation more than pamidronate or renutrition in osteopenic rats chronically fed a low protein dietEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions PTH reversed the deleterious effects of long-term protein undernutrition on mechanical fixation and bone microarchitecture and improved implant osseointegration more than pamidronate or renutrition, likely through changes to structure model index. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1031-xAuthors R. Dayer, Geneva University Hospitals and Faculty of Medicine Division of Bone Diseases (WHO Collaborating Center for Osteoporosis Prevention), Department of Rehabilitation and Geriatrics 1211 Geneva 14 SwitzerlandT. C. Brennan, Geneva University Hospitals an...
Source: Osteoporosis International - October 26, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Burden of hip fracture on inpatient care: a before and after population-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Osteoporotic HF represents a pronounced excess expenditure in hospital, which is mostly linked to rehabilitation care. Considering that utilization of inpatient acute care was quite similar before and after the index stay, HF might result from a patient's pre-fracture poor health status, rather than predispose to a worsening of such pre-existing conditions. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1087-7Authors A. Duclos, Hospices Civils de Lyon Pôle Information Médicale Évaluation Recherche Lyon 69003 FranceS. Couray-Targe, Hospices Civils de Lyon Pô...
Source: Osteoporosis International - October 26, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Use of bisphosphonates and raloxifene and risk of deep venous thromboembolism and pulmonary embolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Bisphosphonates seem associated with an increased risk of DVT/PE. However, the association does not seem to be causal. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1091-yAuthors P. Vestergaard, Aarhus University Hospital Department of Endocrinology and Metabolism C Tage Hansens Gade 2 8000 Arhus C DenmarkK. Schwartz, University of Copenhagen Department of Oral and Maxillofacial Surgery, Institute of Odontology, Faculty of Health Sciences Norre alle 20 2200 Copenhagen N DenmarkE. M. Pinholt, University of Copenhagen Department of Oral and Maxillofacial Surgery, I...
Source: Osteoporosis International - October 26, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Alveolar density measurement and bisphosphonate-related osteonecrosis of the jawsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory LetterDOI 10.1007/s00198-009-1094-8Authors A. Taguchi, Matsumoto Dental University Department of Oral and Maxillofacial Radiology, School of Dentistry 1780 Gobara, Hirooka Shiojiri 399-0781 Japan Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - October 26, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Successful treatment of sternal fracture nonunion with teriparatideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Based on the success of teriparatide in animal studies to accelerate fracture healing, there is growing interest in using this drug in humans for the same purpose. We report a case of what we believe to be the first successful use of teriparatide in the healing of a sternal nonunion fracture. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00198-009-1061-4Authors S. Chintamaneni, Stony Brook University Medical Center Rheumatology New York USAK. Finzel, Radiology, ProHealth Care Associates New York USAB. L. Gruber, NY College of Osteopathic Medicine (NYCOM) New York USA J...
Source: Osteoporosis International - October 26, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Daidzein administration positively affects thyroid C cells and bone structure in orchidectomized middle-aged ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These findings indicate that daidzein treatment stimulates thyroid C cells, increase trabecular bone mass, and decrease bone turnover in Orx middle-aged rats, which is the model of male osteoporosis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1092-xAuthors B. Filipović, Institute for Biological Research Belgrade SerbiaB. Šošić-Jurjević, Institute for Biological Research Belgrade SerbiaV. Ajdžanović, Institute for Biological Research Belgrade SerbiaD. Brkić, Johnson and Johnson S.E. Inc. Belgrade SerbiaM. Manojlović-Stojanoski, Institute for Biologic...
Source: Osteoporosis International - October 26, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Chronic obstructive pulmonary disease or asthma was associated with lower BMD at the spine and hip and increased risk of vertebral and nonvertebral fractures independent of age, clinic site, BMI, and smoking. A history of COPD or asthma may be a useful clinical risk factor to identify patients with osteoporosis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1076-xAuthors T.-T. Dam, Columbia University Department of Medicine, College of Physicians and Surgeons New York New York USAS. Harrison, Research Institute, California Pacific Medical Center San Francisco C...
Source: Osteoporosis International - October 9, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Respiratory complications associated with IV zoledronic acid infusion in the treatment of postmenopausal osteoporosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory LetterDOI 10.1007/s00198-009-1088-6Authors H. Taggart, Osteoporosis Clinic Belfast City Hospital Lisburn Road Belfast BT9 7AB UKJ. Cheng, Osteoporosis Clinic Belfast City Hospital Lisburn Road Belfast BT9 7AB UKP. Archbold, Osteoporosis Clinic Belfast City Hospital Lisburn Road Belfast BT9 7AB UK Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - October 8, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Relationship between 3-month changes in biochemical markers of bone remodelling and changes in bone mineral density and fracture incidence in patients treated with strontium ranelate for 3 yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Short-term changes in biochemical markers of bone formation are associated with future BMD changes in patients treated with strontium ranelate, suggesting a bone-forming activity of this treatment, but are not appropriate to monitor the efficacy of strontium ranelate at the individual level. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1078-8Authors O. Bruyère, University of Liège Department of Public Health, Epidemiology and Health Economics, CHU Sart-Tilman Bât B23 4000 Liège BelgiumJ. Collette, University of Liège Department of Public Health, Epidemio...
Source: Osteoporosis International - October 8, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Low-energy distal radius fractures in middle-aged and elderly men and women—the burden of osteoporosis and fracture riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Every second to every third fracture patient met the present BMD criteria for osteoporosis treatment. Because a large proportion of distal radius fracture patients did not have osteoporosis, treatment decisions should not be based on fracture risk assessment without bone densitometry. Thus, all distal radius fracture patients ≥50 years should be referred to bone densitometry, and if indicated, offered medical treatment. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1068-xAuthors J. Øyen, University of Bergen Department of Surgical Sciences, Faculty of...
Source: Osteoporosis International - October 8, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Suppressive effects of 1,4-dihydroxy-2-naphthoic acid administration on bone resorptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results show that DHNA has some effects for improving bone mass reduction caused by FK506. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1075-yAuthors M. Matsubara, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Oral and Maxillofacial Reconstructive Surgery 2-5-1 Sikata-cho Okayama City 7008525 JapanE. Yamachika, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Oral and Maxillofacial Reconstructive Surgery 2-5-1 Sikata-cho Okayama City 7008525 JapanH. Tsu...
Source: Osteoporosis International - October 8, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Detecting early bone changes using in vivo micro-CT in ovariectomized, zoledronic acid-treated, and sham-operated ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Treatment with zoledronic acid as late as 2 weeks after ovariectomy still facilitates the full reversal of cancellous bone loss in the rat tibia. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1082-zAuthors E. Perilli, SA Pathology and Hanson Institute Bone and Joint Research Laboratory, Surgical Pathology Frome Road Adelaide 5000 AustraliaV. Le, SA Pathology and Hanson Institute Bone and Joint Research Laboratory, Surgical Pathology Frome Road Adelaide 5000 AustraliaB. Ma, SA Pathology and Hanson Institute Bone and Joint Research Laboratory, Surgical Patho...
Source: Osteoporosis International - October 7, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Hip fractures in Italy: 2000–2005 extension studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Hip fractures of the elderly are increasing and represent a major health problem in industrialized countries such as Italy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1084-xAuthors P. Piscitelli, University of Florence Florence ItalyF. Gimigliano, Second University of Naples Naples ItalyS. Gatto, Second University of Naples Naples ItalyA. Marinelli, Second University of Naples Naples ItalyA. Gimigliano, Second University of Naples Naples ItalyP. Marinelli, Second University of Naples Naples ItalyG. Chitano, ISBEM Research Institute via Reali di Bulgaria 72023...
Source: Osteoporosis International - October 7, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Hip protectors: recommendations for biomechanical testing—an international consensus statement (part I)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Introduction Hip protectors represent a promising strategy for preventing fall-related hip fractures. However, clinical trials have yielded conflicting results due, in part, to lack of agreement on techniques for measuring and optimizing the biomechanical performance of hip protectors as a prerequisite to clinical trials. Methods In November 2007, the International Hip Protector Research Group met in Copenhagen to address barriers to the clinical effectiveness of hip protectors. This paper represents an evidence-based consensus statement from the group on recommended methods for ev...
Source: Osteoporosis International - October 6, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research DatabaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study shows a greater association of VTE in osteoporotic compared to non-osteoporotic patients, but does not show any greater association in treated patients with strontium ranelate or alendronate compared to untreated osteoporotic patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1050-7Authors G. Breart, Hôpital Tenon INSERM U 953 4 rue de la Chine 75020 Paris FranceC. Cooper, University of Southampton MRC Epidemiology Resource Centre Southampton UKO. Meyer, AP-HP Hôpital Bichat 46 rue Henri Huchard 75018 Paris FranceC. Speirs, Epsom Hospital John ...
Source: Osteoporosis International - October 6, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Hip protectors: recommendations for conducting clinical trials—an international consensus statement (part II)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Introduction While hip protectors are effective in some clinical trials, many, including all in community settings, have been unable to demonstrate effectiveness. This is due partly to differences in the design and analysis. The aim of this report is to develop recommendations for subsequent clinical research. Methods In November of 2007, the International Hip Protector Research Group met to address barriers to the clinical effectiveness of hip protectors. This paper represents a consensus statement from the group on recommended methods for conducting future clinical trials of hip...
Source: Osteoporosis International - October 6, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss: a 24-month randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Strength/weight training exercises may prevent loss of BMD in postmenopausal BCS at risk for bone loss. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1083-yAuthors N. L. Waltman, University of Nebraska Medical Center College of Nursing Lincoln Division 1230 “O” Street, Ste. 131 Lincoln NE 685880220 USAJ. J. Twiss, University of Nebraska Medical Center College of Nursing Omaha Division Omaha NE USAC. D. Ott, University of Nebraska Medical Center College of Nursing Kearney Division Kearney NE USAG. J. Gross, University of Nebraska Medical Center College of Nurs...
Source: Osteoporosis International - October 3, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

The differences of femoral neck geometric parameters: effects of age, gender and raceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In conclusion, the differences of FNGPs according to gender and ethnicity provide important implications in the different prevalence of osteoporotic fracture among different gender and ethnic groups. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1057-0Authors F. Zhang, Hunan Normal University Laboratory of Molecular and Statistical Genetics, College of Life Sciences Changsha Hunan 410081 People’s Republic of ChinaL.-J. Tan, Hunan Normal University Laboratory of Molecular and Statistical Genetics, College of Life Sciences Changsha Hunan 410081 People’s Republ...
Source: Osteoporosis International - October 3, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Calcium supplement and bone lossEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory LetterDOI 10.1007/s00198-009-1073-0Authors T. V. Nguyen, Garvan Institute of Medical Research Osteoporosis and Bone Biology Program 384 Victoria Street Sydney New South Wales Australia Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - October 3, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: results of the HORIZON Pivotal Fracture TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Once-yearly ZOL increased hip and spine BMD vs placebo, assessed by QCT vs DXA. Changes in trabecular bone resulted in increased indices of compressive strength. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1077-9Authors R. Eastell, University of Sheffield Academic Unit of Bone Metabolism Sheffield UKT. Lang, University of California Department of Radiology San Francisco USAS. Boonen, Katholieke Universiteit Leuven Leuven University Centre for Metabolic Bone Diseases and Division of Geriatric Medicine Leuven BelgiumS. Cummings, University of California CPMC Re...
Source: Osteoporosis International - October 3, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Population-based Canadian hip fracture rates with international comparisonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Overall hip fracture rates for Canadian women were found to be substantially lower than those for the USA and Germany. This study underscores the importance of assessing country-specific fracture patterns prior to adopting an existing FRAX tool. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1080-1Authors W. D. Leslie, University of Manitoba Faculty of Medicine, Department of Medicine (C5121) 409 Tache Avenue Winnipeg Manitoba R2H 2A6 CanadaS. O’Donnell, Public Health Agency of Canada Ottawa CanadaC. Lagacé, Public Health Agency of Canada Ottawa CanadaP. Wals...
Source: Osteoporosis International - October 3, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Calcium supplementation for older men and women?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory LetterDOI 10.1007/s00198-009-1072-1Authors M. J. Bolland, University of Auckland Department of Medicine Private Bag 92019 Auckland 1020 New ZealandA. B. Grey, University of Auckland Department of Medicine Private Bag 92019 Auckland 1020 New ZealandI. R. Reid, University of Auckland Department of Medicine Private Bag 92019 Auckland 1020 New Zealand Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - October 3, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

“The effect of calcium supplementation on bone loss in 32 controlled trials in postmenopausal women”: response to commentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory LetterDOI 10.1007/s00198-009-1074-zAuthors B. E. C. Nordin, Royal Adelaide Hospital Endocrine & Metabolic Unit Adelaide South Australia AustraliaP. Keane, Library, Royal Adelaide Hospital Adelaide South Australia AustraliaA. Metcalfe, The University of Adelaide School of Mathematical Sciences Adelaide South Australia Australia Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - October 3, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Effects of arzoxifene on bone, lipid markers, and safety parameters in postmenopausal women with low bone massEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Arzoxifene suppressed bone turnover and increased BMD. Within the limitations of this study, the endometrial safety profile of arzoxifene appeared similar to that of raloxifene. While no clear dose effect was evident, arzoxifene 20 and 40 mg/day appeared the optimal doses for reducing bone turnover. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1060-5Authors R. W. Downs, Virginia Commonwealth University Program for Osteoporosis and Bone Health, Division of Endocrinology and Metabolism 1101 E Marshall Street, 7-015 P.O. Box 980111 Richmond VA 23298-0111 U...
Source: Osteoporosis International - October 1, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Predictors of oral bisphosphonate prescriptions in post-menopausal women with osteoporosis in a real-world setting in the USAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Certain patient characteristics are predictors of physicians prescribing oral bisphosphonates. However, many patients remain untreated. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1079-7Authors C. Asche, University of Utah School of Medicine Salt Lake UT USAR. Nelson, University of Utah School of Medicine Salt Lake UT USAC. McAdam-Marx, University of Utah School of Medicine Salt Lake UT USAM. Jhaveri, Sanofi-Aventis Bridgewater NJ USAX. Ye, University of Utah School of Medicine Salt Lake UT USA Journal Osteoporosis InternationalOnline ISSN 1433-2965Prin...
Source: Osteoporosis International - October 1, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

BMD T-score discriminates trochanteric fractures from unfractured controls, whereas geometry discriminates cervical fracture cases from unfractured controls of similar BMDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The study suggests that the risk of trochanteric fractures could be discriminated based on a BMD T-score <−2.5 criterion, whereas cervical fracture cases would remain under-diagnosed if solely using this criterion. Instead, geometrical risk factors are able to discriminate cervical fracture cases even among individuals with T-score >−2.5. For cervical and trochanteric fractures combined, BMD and geometric measures independently contributed to hip fracture discrimination. Our data support changing from T-score <−2.5 to a more comprehensive assessment of hip fracture etiology, in whi...
Source: Osteoporosis International - September 29, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Sarcopenia: etiology, clinical consequences, intervention, and assessmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aging process is associated with loss of muscle mass and strength and decline in physical functioning. The term sarcopenia is primarily defined as low level of muscle mass resulting from age-related muscle loss, but its definition is often broadened to include the underlying cellular processes involved in skeletal muscle loss as well as their clinical manifestations. The underlying cellular changes involve weakening of factors promoting muscle anabolism and increased expression of inflammatory factors and other agents which contribute to skeletal muscle catabolism. At the cellular level, these m...
Source: Osteoporosis International - September 24, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Low-energy distal radius fractures in middle-aged and elderly women—seasonal variations, prevalence of osteoporosis, and associates with fracturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our study highlights that environmental factor, as well as osteoporosis are associated with distal radius fractures in middle-aged and elderly women. Osteoporosis is also frequently found in outdoor patients, thus, all female distal radius fracture patients ≥50 years should be referred for osteoporosis assessment. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1065-0Authors J. Øyen, University of Bergen Department of Surgical Sciences, Faculty of Medicine and Dentistry Bergen NorwayG. E. Rohde, Sørlandet Hospital Department of Rheumatology Kristiansand...
Source: Osteoporosis International - September 23, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Independent from muscle power and balance performance, a creatinine clearance below 65 ml/min is a significant and independent risk factor for falls and fall-related fractures in elderly men and women diagnosed with osteoporosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In this study, we found a significant gender-independent correlation between decreasing CrCl and lower performance in balance and muscle power tests. Reduced muscle power and balance may therefore be involved in the low creatinine clearance associated increased risk for falls and fall-related fractures. Furthermore, we found that a CrCl <65 ml/min., independent from the performance in muscle power, muscle function, and balance tests, is a significant risk factor for falls and fractures. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1064-1Authors L. Du...
Source: Osteoporosis International - September 22, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Prior nonhip limb fracture predicts subsequent hip fracture in institutionalized elderly peopleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A fracture history at upper or nonhip lower limbs, in combination with other known risk factors, is useful for the prediction of future hip fracture in institutional settings. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1081-0Authors K. Nakamura, Niigata University Graduate School of Medical and Dental Sciences Department of Community Preventive Medicine 1-757 Asahimachi-dori, Chuo-ku Niigata 951-8510 JapanS. Takahashi, Niigata University School of Medicine 1-757 Asahimachi-dori, Chuo-ku Niigata 951-8510 JapanM. Oyama, Niigata University Graduate School of Me...
Source: Osteoporosis International - September 22, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Micro-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We observed the difference in microstructure between postmenopausal women with OA and OP, which might relate to the opposite bone defects in OA and OP. BV/TV might play an important role in mechanical properties of the subchondral bone in either OA or OP. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1071-2Authors Z.-M. Zhang, Shanghai Jiaotong University School of Medicine Department of Orthopedic Surgery, Xinhua Hospital 1665 Kongjiang Road Shanghai 200092 ChinaZ.-C. Li, Shanghai Jiaotong University School of Medicine Department of Orthopedic Surgery, Xinhua...
Source: Osteoporosis International - September 22, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Erratum to: Bone mineral: update on chemical composition and structureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00198-009-1063-2Authors C. Rey, University of Toulouse, CIRIMAT, ENSIACET 118 Route de Narbonne 31077 Toulouse Cedex 04 FranceC. Combes, University of Toulouse, CIRIMAT, ENSIACET 118 Route de Narbonne 31077 Toulouse Cedex 04 FranceC. Drouet, University of Toulouse, CIRIMAT, ENSIACET 118 Route de Narbonne 31077 Toulouse Cedex 04 FranceM. J. Glimcher, Harvard Medical School and Children’s Hospital Boston Laboratory for the Study of Skeletal Disorders and Rehabilitation, Department of Orthopaedic Surgery 300 Longwood Ave Boston MA 02115 USA Journal Osteopor...
Source: Osteoporosis International - September 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Collagen cross-linking, a major post-translational modification of collagen, plays important roles in the biological and biomechanical features of bone. Collagen cross-links can be divided into lysyl hydroxylase and lysyl oxidase-mediated enzymatic immature divalent cross-links, mature trivalent pyridinoline and pyrrole cross-links, and glycation- or oxidation-induced non-enzymatic cross-links (advanced glycation end products) such as glucosepane and pentosidine. These types of cross-links differ in the mechanism of formation and in function. Material properties of newly synthesized collagen matrix ...
Source: Osteoporosis International - September 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Adjustment for body mass index and calcitrophic hormone levels improves the diagnostic accuracy of the spot urine calcium-to-creatinine ratioEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We conclude that the SUCCR underestimates urine calcium loss and does not reliably diagnose hypercalciuria. A formula derived from multivariate regression incorporating other readily measurable variables greatly improved the SUCCR’s accuracy. Future studies must verify this correction before clinical implementation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1058-zAuthors A. N. Jones, University of Wisconsin School of Medicine and Public Health Department of Medicine 600 Highland Avenue Madison WI 53792 USAR. D. Blank, University of Wisconsin School of Me...
Source: Osteoporosis International - September 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Bisphosphonates and BMU birth rate: response to comments by OttEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory LetterDOI 10.1007/s00198-009-1027-6Authors E. Seeman, University of Melbourne Department of Endocrinology, Austin Health Melbourne Australia Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - September 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Assessing interest in an osteoporosis website: a survey among women eligible for osteoporosis screeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These data suggest that middle-aged women are moderately receptive to the concept of web-based care for certain components of osteoporosis management and education. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1054-3Authors Y. Rozenfeld, Providence Health & Services Portland OR USAT. Johnson, Providence Health & Services Portland OR USAC. Klug, Providence Health & Services Portland OR USA Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)
Source: Osteoporosis International - September 15, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Is there a U-shaped association between physical activity and falling in older persons?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The hypothesized U-shaped relationship between physical activity and falling could not be confirmed. At higher levels of physical activity, the risk of recurrent falling decreased, while no association was found with fall risk. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1053-4Authors G. M. E. E. Peeters, VU University Medical Center Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research Amsterdam the NetherlandsN. M. van Schoor, VU University Medical Center Department of Epidemiology and Biostatistics, EMGO Institute for He...
Source: Osteoporosis International - September 15, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Hip structural geometry and incidence of hip fracture in postmenopausal women: what does it add to conventional bone mineral density?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Two hip geometry parameters, intertrochanter outer diameter and buckling ratio, predict incident hip fracture after accounting for clinical risk factors and aBMD. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1056-1Authors A. Z. LaCroix, Fred Hutchinson Cancer Research Center WHI Clinical Coordinating Center Seattle WA USAT. J. Beck, The Johns Hopkins University Department of Radiology Baltimore MD USAJ. A. Cauley, University of Pittsburgh Department of Epidemiology Pittsburgh PA USAC. E. Lewis, University of Alabama Division of Preventive Medicine Birmingham A...
Source: Osteoporosis International - September 15, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals