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1241 records returned

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing HeartEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The directionality of local blood flow in the zebrafish embryonic heart is essential for proper heart valve formation. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 17, 2009 Category: Biology Authors: Julien Vermot et al. Source Type: journals

Role of CBP and SATB-1 in Aging, Dietary Restriction, and Insulin-Like SignalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Increased transcriptional complex activity, or pharmacological mimics of increased complex activity, predict lifespan in mice and mediate the protective effects of dietary restriction during aging. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 17, 2009 Category: Biology Authors: Minhua Zhang et al. Source Type: journals

The Multicopy Gene Sly Represses the Sex Chromosomes in the Male Mouse Germline after MeiosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Small-interfering RNAs have been used to disrupt the function of the more than 100 copies of the Sly gene on the mouse Y chromosome, leading to defective sex chromosome repression during spermatid differentiation and, as a consequence, sperm malformations and near-sterility. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 17, 2009 Category: Biology Authors: Julie Cocquet et al. Source Type: journals

Sly Represses Gene Expression in Sex ChromosomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 17, 2009 Category: Biology Authors: Caitlin Sedwick Source Type: journals

Article-Level Metrics and the Evolution of Scientific ImpactEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors discuss the value of article-level metrics in determining an article's scientific impact. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 17, 2009 Category: Biology Authors: Cameron Neylon et al. Source Type: journals

Explaining the Linguistic Diversity of Sahul Using Population ModelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Areal and genealogical links between the diverse ancient languages of Australia and New Guinea are investigated using a phylogenetic clustering method adopted from population genetics. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 17, 2009 Category: Biology Authors: Ger Reesink et al. Source Type: journals

Cadherin-2 Controls Directional Chain Migration of Cerebellar Granule NeuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Imaging cerebellar granule neurons in zebrafish embryos reveals a further role for Cadherin-2 in neurogenesis: regulating cohesive and directional granule cell migration via intra-membranous Cadherin-2 relocalisation and centrosome stabilization. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 10, 2009 Category: Biology Authors: Sandra Rieger et al. Source Type: journals

Migrating Brain Cells Stick TogetherEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 10, 2009 Category: Biology Authors: Mason Inman Source Type: journals

Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A specific microRNA reduces the synthesis of hundreds of proteins via concordant effects on the abundance and translation of the mRNAs that encode them. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 10, 2009 Category: Biology Authors: David G. Hendrickson et al. Source Type: journals

University Public-Access Mandates Are Good for ScienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new and better order to make scholarship available for free to all is emerging through deposit mandates like those adopted by Harvard, MIT, and Kansas. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 10, 2009 Category: Biology Authors: David Shulenburger Source Type: journals

Identification and Functional Characterization of N-Terminally Acetylated Proteins in Drosophila melanogasterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new study reveals a functional rule for N-terminal acetylation in higher eukaryotes called the (X)PX rule and describes a generic method that prevents this modification to allow the study of N-terminal acetylation in any given protein. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 3, 2009 Category: Biology Authors: Sandra Goetze et al. Source Type: journals

An aPKC-Exocyst Complex Controls Paxillin Phosphorylation and Migration through Localised JNK1 ActivationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The exocyst/aPKC complex controls the spatiotemporal activation of the kinases JNK and ERK at the leading edge of migrating cells and thereby controls the dynamic behaviour of the adhesion protein paxillin during cell migration. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 3, 2009 Category: Biology Authors: Carine Rosse et al. Source Type: journals

A Simple Rule for Proteins to FollowEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - November 3, 2009 Category: Biology Authors: By Caitlin Sedwick Source Type: journals

Species-Specific Heterochromatin Prevents Mitotic Chromosome Segregation to Cause Hybrid Lethality in DrosophilaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Early embryonic lethality of interspecies hybrids in Drosophila can be caused by defects in mitotic segregation of paternal X chromatids carrying a critical domain of heterochromatic DNA. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: Patrick M. Ferree et al. Source Type: journals

Heterochromatin: A Rapidly Evolving Species BarrierEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent work has shown that changes in the sequence composition of heterochromatin, or in the factors that maintain that heterochromatin, may play an important role in speciation. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: Stacie E. Hughes et al. Source Type: journals

Neurons Help Bridge the Brain's Communication GapEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: Rachel Jones Source Type: journals

Transient Neuronal Populations Are Required to Guide Callosal Axons: A Role for Semaphorin 3CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurons, glia, and callosal axons operate as a “ménage à trois” in the development of the corpus callosum. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: Mathieu Niquille et al. Source Type: journals

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein SerotonylationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Non-neuronal, peripheral serotonin deficiency causes diabetes mellitus and identifies an intracellular role for serotonin in the regulation of insulin secretion. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: Nils Paulmann et al. Source Type: journals

Recognition of Lyso-Phospholipids by Human Natural Killer T LymphocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
By identifying the lipid LPC as an endogenous antigen, recognized by the invariant subset of human NKT cells, this study establishes a novel link between these immunoregulatory cells and an inflammatory lipid mediator. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: Lisa M. Fox et al. Source Type: journals

Serotonin's Role in the Pancreas Revealed at LastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: Richard Robinson Source Type: journals

Linking Inflammation to Natural Killer T Cell ActivationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immune activation is often associated with inflammation, but inflammation's role in the expansion of antigen-specific immune responses remains unclear. This primer focuses on recent findings that show how specific natural killer T cells are activated by inflammatory messengers, thus illuminating the cellular and molecular links between immunity and inflammation. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: Mariolina Salio et al. Source Type: journals

Global Conformational Dynamics of a Y-Family DNA Polymerase during CatalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
High-resolution analysis of protein, and DNA conformational changes during DNA polymerization, established relationships between the enzymatic function and conformational dynamics of individual domains for a DNA polymerase. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: Cuiling Xu et al. Source Type: journals

Light Directs Zebrafish period2 Expression via Conserved D and E BoxesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A highly conserved promoter module in a vertebrate clock gene confers light-regulated gene expression. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: Gad Vatine et al. Source Type: journals

PLoS Biology Issue Image | Vol. 7(10) October 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Worker females guarding the nest entrance of a honeybee colony. Each colony has thousands of female workers, one queen, and a few hundred males (drones). This strong sex bias relies on an unusual sex determination system. Gempe et al. (e1000222) show key functions for the regulation of two genes: csd, which establishes the decision between males and females by allelic combination, and fem, which memorizes the sexual decision by a positive regulatory feedback loop that operates throughout development.Image Credit: Björn Schmitt, Heinrich-Heine-Universität Düsseldorf (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 27, 2009 Category: Biology Authors: PLoS Source Type: journals

Genomics of Emerging Infectious Disease: A PLoS CollectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 26, 2009 Category: Biology Authors: Jonathan A. Eisen et al. Source Type: journals

Can an Infectious Disease Genomics Project Predict and Prevent the Next Pandemic?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Infectious diseases need a globally coordinated genomic-based movement linking sequencing efforts to development of response tools to mitigate the impact of existing and emerging threats. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 26, 2009 Category: Biology Authors: Rajesh Gupta et al. Source Type: journals

The Role of Genomics in the Identification, Prediction, and Prevention of Biological ThreatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author Summary In all likelihood, it is only a matter of time before our public health system will face a major biological threat, whether intentionally dispersed or originating from a known or newly emerging infectious disease. It is necessary not only to increase our reactive “biodefense,” but also to be proactive and increase our preparedness. To achieve this goal, it is essential that the scientific and public health communities fully embrace the genomic revolution, and that novel bioinformatic and computing tools necessary to make great strides in our understanding of these novel and emerging threats be developed...
Source: PLoS Biology: Archived Table of Contents - October 26, 2009 Category: Biology Authors: W. Florian Fricke et al. Source Type: journals

Sex Determination in Honeybees: Two Separate Mechanisms Induce and Maintain the Female PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sex determination in honeybees is realized by the csd and the fem gene that establish and maintain, throughout development, sexual fates via the control of alternative splicing. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 20, 2009 Category: Biology Authors: Tanja Gempe et al. Source Type: journals

Daughter-Specific Transcription Factors Regulate Cell Size Control in Budding YeastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The asymmetric localization of cell fate determinants results in asymmetric cell cycle control in budding yeast. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - October 20, 2009 Category: Biology Authors: Stefano Di Talia et al. Source Type: journals