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The Link between Dengue Incidence and El Niño Southern OscillationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pejman Rohani discusses a new study that examined the dynamic relationship between climate variables and dengue incidence in Thailand, Mexico, and Puerto Rico. (Source: PLoS Medicine)
Source: PLoS Medicine - November 17, 2009 Category: Internal Medicine Authors: Pejman Rohani Source Type: journals

Multiyear Climate Variability and Dengue—El Niño Southern Oscillation, Weather, and Dengue Incidence in Puerto Rico, Mexico, and Thailand: A Longitudinal Data AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Michael Johansson and colleagues use wavelet analysis to show that there is limited evidence for a multiyear relationship between climate and dengue incidence in Puerto Rico, Mexico, and Thailand. (Source: PLoS Medicine)
Source: PLoS Medicine - November 17, 2009 Category: Internal Medicine Authors: Michael A. Johansson et al. Source Type: journals

How Can We Support the Use of Systematic Reviews in Policymaking?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
John Lavis discusses how health policymakers and their stakeholders need research evidence, and the best ways evidence can be synthesized and packaged to optimize its use. (Source: PLoS Medicine)
Source: PLoS Medicine - November 17, 2009 Category: Internal Medicine Authors: John N. Lavis Source Type: journals

The Unintended Consequences of Clinical Trials RegulationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alex McMahon and colleagues critique the International Conference on Harmonisation (ICH) guidance on good clinical practice (GCP), arguing that it is having a disastrous effect on noncommerical randomized clinical trials in Europe. (Source: PLoS Medicine)
Source: PLoS Medicine - November 17, 2009 Category: Internal Medicine Authors: Alex D. McMahon et al. Source Type: journals

Hip Fracture Incidence in Relation to Age, Menopausal Status, and Age at Menopause: Prospective AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Using data from the UK Million Women Study, Emily Banks and colleagues investigate the relationships between the incidence of hip fracture and a woman's age, menopausal status, and age at menopause. (Source: PLoS Medicine)
Source: PLoS Medicine - November 10, 2009 Category: Internal Medicine Authors: Emily Banks et al. Source Type: journals

Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers from the Medical Research Council Cognitive Function and Ageing Neuropathology Study carry out an analysis of brain pathologies contributing to dementia, within a cohort of elderly individuals in the UK who agreed to brain donation. (Source: PLoS Medicine)
Source: PLoS Medicine - November 10, 2009 Category: Internal Medicine Authors: Fiona E. Matthews et al. Source Type: journals

Development and Implementation of a National Programme for the Management of Severe and Very Severe Pneumonia in Children in MalawiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Penelope Enarson and colleagues describe the development, scale-up, and achievements of a national pneumonia program in Malawi, which is based on a successful anti-tuberculosis service delivery model. (Source: PLoS Medicine)
Source: PLoS Medicine - November 10, 2009 Category: Internal Medicine Authors: Penelope Marjorie Enarson et al. Source Type: journals

Packages of Care for Dementia in Low- and Middle-Income CountriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the fifth in a series of six articles on packages of care for mental disorders in low- and middle-income countries, Martin Prince and colleagues discuss the treatment of dementia. (Source: PLoS Medicine)
Source: PLoS Medicine - November 3, 2009 Category: Internal Medicine Authors: Martin J. Prince et al. Source Type: journals

Impact Monitoring of the National Scale Up of Zinc Treatment for Childhood Diarrhea in Bangladesh: Repeat Ecologic SurveysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Charles Larson and colleagues find that 23 months into a national campaign to scale up zinc treatment for diarrhea in children under age 5 years, only 10% of children with diarrhea in rural areas and 20%–25% in urban/municipal areas were getting the treatment. (Source: PLoS Medicine)
Source: PLoS Medicine - November 3, 2009 Category: Internal Medicine Authors: Charles P. Larson et al. Source Type: journals

Mandatory Disclosure of Pharmaceutical Industry-Funded Events for Health ProfessionalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
David Henry and colleagues examine compliance with new disclosure requirements of Medicines Australia, the pharmaceutical industry representative body, and argue that they fall short and instead more comprehensive reporting standards are needed. (Source: PLoS Medicine)
Source: PLoS Medicine - November 3, 2009 Category: Internal Medicine Authors: Jane Robertson et al. Source Type: journals

Lost but Not Forgotten—The Economics of Improving Patient Retention in AIDS Treatment ProgramsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gregory Bisson and Jeffrey Stringer discuss the implications of a new study showing how loss to follow-up affects the effectiveness of a public sector HIV program in Côte d'Ivoire. (Source: PLoS Medicine)
Source: PLoS Medicine - October 27, 2009 Category: Internal Medicine Authors: Gregory P. Bisson et al. Source Type: journals

Cost-Effectiveness of Preventing Loss to Follow-up in HIV Treatment Programs: A Côte d'Ivoire AppraisalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Based on data from West Africa, Elena Losina and colleagues predict that interventions to reduce dropout rates from HIV treatment programs (such as eliminating copayments) will be cost-effective. (Source: PLoS Medicine)
Source: PLoS Medicine - October 27, 2009 Category: Internal Medicine Authors: Elena Losina et al. Source Type: journals

Efficacy of Short-Course AZT Plus 3TC to Reduce Nevirapine Resistance in the Prevention of Mother-to-Child HIV Transmission: A Randomized Clinical TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neil Martinson and colleagues report a randomized trial of adding short-course zidovudine+lamivudine to reduce drug resistance from single-dose nevirapine used to prevent mother-to-child transmission of HIV. (Source: PLoS Medicine)
Source: PLoS Medicine - October 27, 2009 Category: Internal Medicine Authors: James A. McIntyre et al. Source Type: journals

A Prospective Nested Case-Control Study of Dengue in Infants: Rethinking and Refining the Antibody-Dependent Enhancement Dengue Hemorrhagic Fever ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Analyses of a prospective case-control study of infant dengue by Daniel Libraty and colleagues casts doubt on the antibody-dependent enhancement model for dengue hemorrhagic fever. (Source: PLoS Medicine)
Source: PLoS Medicine - October 27, 2009 Category: Internal Medicine Authors: Daniel H. Libraty et al. Source Type: journals

Packages of Care for Alcohol Use Disorders in Low- And Middle-Income CountriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the fourth in a series of six articles on packages of care for mental disorders in low- and middle-income countries, Vivek Benegal and colleagues discuss the treatment of alcohol use disorders. (Source: PLoS Medicine)
Source: PLoS Medicine - October 27, 2009 Category: Internal Medicine Authors: Vivek Benegal et al. Source Type: journals

Antiretroviral Strategies to Prevent Mother-to-Child Transmission of HIV: Striking a Balance between Efficacy, Feasibility, and ResistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dara Lehman and colleagues discuss a randomized trial that found that adding up to a week of twice-daily zidovudine+lamivudine to single-dose nevirapine reduces the risk of resistance in mothers and infants. (Source: PLoS Medicine)
Source: PLoS Medicine - October 27, 2009 Category: Internal Medicine Authors: Dara A. Lehman et al. Source Type: journals

PLoS Medicine Issue Image | Vol. 6(10) October 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Five years of access and activism. In April 2009, PLoS Medicine announced a "refocusing of the journal's priorities." Going forward, said the editors, the journal would prioritize papers addressing those diseases with the greatest global burden. It would also aim to be as broad a journal as possible, publishing papers that explored not just biological causes of illness, but also social, environmental, and political determinants of health. In this month's Editorial, as the journal marks its official five year anniversary, the editors look back over the last six months to assess the impact of the refocused scope. Image Credi...
Source: PLoS Medicine - October 27, 2009 Category: Internal Medicine Authors: PLoS Source Type: journals

Molecular Genomic Approaches to Infectious Diseases in Resource-Limited SettingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Josefina Coloma and Eva Harris discuss advances in genomics in resource-limited settings and argue that access to training and capacity building in bioinformatics and data mining will be crucial for the future (Source: PLoS Medicine)
Source: PLoS Medicine - October 26, 2009 Category: Internal Medicine Authors: Josefina Coloma et al. Source Type: journals

Five Years of Access and ActivismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PLoS Medicine announced a “refocusing of the journal's priorities” in April 2009, and the editors now look back over the last six months to assess the impact of the refocused scope. (Source: PLoS Medicine)
Source: PLoS Medicine - October 20, 2009 Category: Internal Medicine Authors: PLoS Source Type: journals

Potential Role of Decoy B7-H4 in the Pathogenesis of Rheumatoid Arthritis: A Mouse Model Informed by Clinical DataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Finding an association between soluble B7-H4 and rheumatoid arthritis severity, Lieping Chen and colleagues use a mouse model to show that the soluble form blocks the inhibitory function of cell-surface B7-H4. (Source: PLoS Medicine)
Source: PLoS Medicine - October 20, 2009 Category: Internal Medicine Authors: Takeshi Azuma et al. Source Type: journals

Packages of Care for Schizophrenia in Low- and Middle-Income CountriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the third in a series of six articles on packages of care for mental disorders in low- and middle-income countries, Jair Mari and colleagues discuss the treatment of schizophrenia. (Source: PLoS Medicine)
Source: PLoS Medicine - October 20, 2009 Category: Internal Medicine Authors: Jair de Jesus Mari et al. Source Type: journals

Five Years of Access and ActivismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PLoS Medicine announced a “refocusing of the journal's priorities” in April 2009, and the editors now look back over the last six months to assess the impact of the refocused scope. (Source: PLoS Medicine)
Source: PLoS Medicine - October 19, 2009 Category: Internal Medicine Authors: PLoS Source Type: journals

Potential Role of Decoy B7-H4 in the Pathogenesis of Rheumatoid Arthritis: A Mouse Model Informed by Clinical DataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Finding an association between soluble B7-H4 and rheumatoid arthritis severity, Lieping Chen and colleagues use a mouse model to show that the soluble form blocks the inhibitory function of cell-surface B7-H4. (Source: PLoS Medicine)
Source: PLoS Medicine - October 19, 2009 Category: Internal Medicine Authors: Takeshi Azuma et al. Source Type: journals

Packages of Care for Schizophrenia in Low- and Middle-Income CountriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the third in a series of six articles on packages of care for mental disorders in low- and middle-income countries, Jair Mari and colleagues discuss the treatment of schizophrenia. (Source: PLoS Medicine)
Source: PLoS Medicine - October 19, 2009 Category: Internal Medicine Authors: Jair de Jesus Mari et al. Source Type: journals

Medico-Legal Findings, Legal Case Progression, and Outcomes in South African Rape Cases: Retrospective ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rachel Jewkes and colleagues examine the processing of rape cases by South African police and courts and show an association between documentation of ano-genital injuries, trials commencing, and convictions in rape cases. (Source: PLoS Medicine)
Source: PLoS Medicine - October 12, 2009 Category: Internal Medicine Authors: Rachel Jewkes et al. Source Type: journals

Task Shifting for Scale-up of HIV Care: Evaluation of Nurse-Centered Antiretroviral Treatment at Rural Health Centers in RwandaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fabienne Shumbusho and colleagues evaluate a task-shifting model of nurse-centered antiretroviral treatment prescribing in rural primary health centers in Rwanda and find that nurses can effectively and safely prescribe ART when given adequate training, mentoring, and support. (Source: PLoS Medicine)
Source: PLoS Medicine - October 12, 2009 Category: Internal Medicine Authors: Fabienne Shumbusho et al. Source Type: journals

Packages of Care for Epilepsy in Low- and Middle-Income CountriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the second in a series of six articles on packages of care for mental health disorders in low- and middle-income countries, Caroline Mbuba and Charles Newton discuss treatment for epilepsy. (Source: PLoS Medicine)
Source: PLoS Medicine - October 12, 2009 Category: Internal Medicine Authors: Caroline K. Mbuba et al. Source Type: journals

The Comparative Oncology Trials Consortium: Using Spontaneously Occurring Cancers in Dogs to Inform the Cancer Drug Development PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chand Khanna and colleagues describe the work of the Comparative Oncology Trials Consortium (COTC), which provides infrastructure and resources to integrate naturally occurring dog cancer models into the development of new human cancer drugs, devices, and imaging techniques. (Source: PLoS Medicine)
Source: PLoS Medicine - October 12, 2009 Category: Internal Medicine Authors: Ira Gordon et al. Source Type: journals

Facilitating the Recruitment of Minority Ethnic People into Research: Qualitative Case Study of South Asians and AsthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aziz Sheikh and colleagues report on a qualitative study in the US and the UK to investigate ways to bolster recruitment of South Asians into asthma studies, including making inclusion of diverse populations mandatory. (Source: PLoS Medicine)
Source: PLoS Medicine - October 12, 2009 Category: Internal Medicine Authors: Aziz Sheikh et al. Source Type: journals

Packages of Care for Mental, Neurological, and Substance Use Disorders in Low- and Middle-Income Countries: PLoS Medicine SeriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a Perspective article, Vikram Patel and Graham Thornicroft introduce a new series in PLoS Medicine on mental health disorders in low- and middle-income countries that reviews the evidence for packages of care for ADHD, alcohol misuse disorders, dementia, depression, epilepsy, and schizophrenia. (Source: PLoS Medicine)
Source: PLoS Medicine - October 5, 2009 Category: Internal Medicine Authors: Vikram Patel et al. Source Type: journals

Packages of Care for Depression in Low- and Middle-Income CountriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the first in a series of six articles on packages of care for mental disorders in low- and middle-income countries, Neerja Chowdary and colleagues discuss the treatment of depression. (Source: PLoS Medicine)
Source: PLoS Medicine - October 5, 2009 Category: Internal Medicine Authors: Vikram Patel et al. Source Type: journals

Cholinesterase Inhibitors and Hospitalization for Bradycardia: A Population-Based StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Laura Park-Wyllie and colleagues examined the health records of more than 1.4 million older adults and show that initiation of cholinesterase inhibitor therapy is associated with a more than doubling of the risk of hospitalization for bradycardia. (Source: PLoS Medicine)
Source: PLoS Medicine - September 28, 2009 Category: Internal Medicine Authors: Laura Y. Park-Wyllie et al. Source Type: journals