Correlating transcription and protein expression profiles of immune biomarkers following lipopolysaccharide exposure in lung epithelial cells
by Daniel E. Jacobsen, Makaela M. Montoya, Trent R. Llewellyn, Kaitlyn Martinez, Kristen M. Wilding, Kiersten D. Lenz, Carrie A. Manore, Jessica Z. Kubicek-Sutherland, Harshini Mukundan
Universal and early recognition of pathogens occurs through recognition of evolutionarily conserved pathogen associated molecular patterns (PAMPs) by innate immune receptors and the consequent secretion of cytokines and chemokines. The intrinsic complexity of innate immune signaling and associated signal transduction challenges our ability to obtain physiologically relevant, reproducible and accurate data from experimental systems. One of ...
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Daniel E. Jacobsen Source Type: research
Frequency, complications, and mortality of inhalation injury in burn patients: A systematic review and meta-analysis protocol
DiscussionDespite the extensive experience managing IIs in burn patients, they still represent an important cause of morbidity and mortality. Diagnosis and accurate measurement of its damage are complex, and therapies are essentially based on supportive measures. Considering the challenge, their impact, and their potential severity, IIs represent a promising area for research, needing further studies to understand and contribute to its better evolution.The protocol of this review is registered on the International prospective register of systematic reviews platform of the Center for Revisions and Disclosure of the Universi...
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Juliana Elvira Herdy Guerra Avila Source Type: research
Risk factors of central catheter bloodstream infections in intensive care units: A systematic review and meta-analysis
ConclusionsEffective interventions targeting the above modifiable factors may reduce the risk of developing CRBSI in ICU and improve the clinical outcome of patients. Further prospective studies are needed to confirm these findings. (Source: PLoS One)
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Huayong Huang Source Type: research
Demand forecasting for platelet usage: From univariate time series to multivariable models
This study is the first to utilize different methods from statistical time series models to data-driven regression and machine learning techniques for platelet transfusion using clinical predictors and with different amounts of data. We find that the multivariable approaches have the highest accuracy in general, however, if sufficient data are available, a simpler time series approach appears to be sufficient. We also comment on the approach to choose predictors for the multivariable models. (Source: PLoS One)
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Maryam Motamedi Source Type: research
Development and validation of a race-agnostic computable phenotype for kidney health in adult hospitalized patients
by Tezcan Ozrazgat-Baslanti, Yuanfang Ren, Esra Adiyeke, Rubab Islam, Haleh Hashemighouchani, Matthew Ruppert, Shunshun Miao, Tyler Loftus, Crystal Johnson-Mann, R. W. M. A. Madushani, Elizabeth A. Shenkman, William Hogan, Mark S. Segal, Gloria Lipori, Azra Bihorac, Charles Hobson
Standard race adjustments for estimating glomerular filtration rate (GFR) and reference creatinine can yield a lower acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence among African American patients than non–race adjusted estimates. We developed two race-agnostic computable p henotypes that assess kidney health among 139,15...
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Tezcan Ozrazgat-Baslanti Source Type: research
Khat consumption and undernutrition among adult population in Ethiopia: A systematic review and meta-analysis
ConclusionThere is evidence of an association between khat chewing and an increased risk of undernutrition among adults in Ethiopia, which highlights the need for public health interventions to address the potential adverse effects of khat chewing on nutritional status. (Source: PLoS One)
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Abdu Oumer Source Type: research
Activities of daily living, self-efficacy and motor skill related fitness and the interrelation in children with moderate and severe Developmental Coordination Disorder
ConclusionsChildren with DCD participate and enjoy physical activity less than their peers. This combination of lower participation, lower predilection to physical activity and lowered motor skill-related fitness is a concern for the present and future health status of children with DCD. (Source: PLoS One)
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Fai çal Farhat Source Type: research
Correlation between maternal and umbilical cord 25-hydroxy-vitamin D levels over a range of values. A prospective observational study from the United Arab Emirates
by Magnus Jutell, Shakura Bhat, Maria Lindstrom Bagge, Per-Erik Isberg, Nana Wiberg
Worldwide vitamin D insufficiency is remarkably prevalent in both children and adults, including pregnant women. The total amount of the vitamin is best measured by 25-hydroxy-vitamin D (25(OH)D), which is a measurement of total serum cholecalciferol 25(OH)D3 and ergocalciferol 25(OH)D2. There is a known correlation between maternal and umbilical cord blood (UCB) 25(OH)D; however, whether specific maternal demographics or comorbidities influence the correlation remains uncertain. This prospective observational study was designed to study i...
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Magnus Jutell Source Type: research
Correlation analysis of serum TLR4 protein levels and < i > TLR4 gene < /i > polymorphisms in gouty arthritis patients
by Lu Liu, Shuang He, Lin Jia, Hua Yao, Dan Zhou, Xiaobin Guo, Lei Miao
ObjectiveThe Toll-like receptor (TLR) 4-mediated nuclear factor kappa B (NF- κB) signaling pathway regulates the production of inflammatory factors and plays a key role in the pathogenesis of gouty arthritis. The aim of the present study was to investigate the link amongTLR4 gene polymorphisms at various loci, protein expression, and gouty arthritis susceptibility. MethodsBetween 2016 and 2021, a case-control study was used to collect a total of 1207 study subjects, including 317 male patients with gouty arthritis (gout group) and 890 healthy males (c...
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Lu Liu Source Type: research
Gaussian accelerated molecular dynamics simulations facilitate prediction of the permeability of cyclic peptides
In this study, we have used Gaussian accelerated molecular dynamics (GaMD) simulations to characterize the effect of solvent on the free energy landscape of lariat peptides, a subset of CPs that have recently shown potential for drug development (Kellyet al.,JACS 2021). Differences in the free energy of lariat peptides as a function of solvent can be used to predict permeability of these molecules, and our results show that permeability is most greatly influenced by N-methylation and exposure to solvent. Our approach lays the groundwork for using GaMD as a way to virtually screen large libraries of CPs and drive forward de...
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Nicolas Frazee Source Type: research
Causal relationships of Helicobacter pylori and related gastrointestinal diseases on Type 2 diabetes: Univariable and Multivariable Mendelian randomization
ConclusionOur study found that H. pylori IgG antibody, H. pylori GroEL antibody, gastroduodenal ulcer and chronic gastritis are all related to t T2DM, and blood glucose level and obesity mediate the development of H. pylori GroEL antibody and gastroduodenal ulcer on T2DM, respectively. These findings may inform new prevention and intervention strategies for T2DM. (Source: PLoS One)
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Mei Sun Source Type: research
Identifying areas of Australia with high out-of-hospital cardiac arrest incidence and low bystander cardiopulmonary resuscitation rates: A retrospective, observational study
ConclusionsWe have identified high-risk LGAs, characterised by high incidence and low bystander CPR rates, which are predominantly in regional and remote areas of Australia. Strategies for reducing OHCA and improving bystander response may be best targeted at these regions. (Source: PLoS One)
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Tan Doan Source Type: research
Comparing closure compliance and ease of use for consumer product packs designed to reduce access to children
by Annalise Richmond, David C. Schwebel, Clara Ng Pak Leung, Elke Vallez, Heidi Lesage, Raf Degeyter, Zhiwu Liang, Gerard Stijntjes
Child impeding packs are difficult for children to open so protect them from unintended access to hazardous contents inside the pack. However, if packs are difficult for adults to open, in normal usage scenarios, this may result in a higher occurrence of packs being left open. This research explor es differences in ease of usage and closure compliance between two types of child impeding packs of liquid laundry detergent capsules. The two packs, “Pinch& Lift ” and “Press& Lift ”, had d...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Annalise Richmond Source Type: research
Assessing the causal associations of different types of statins use and knee/hip osteoarthritis: A Mendelian randomization study
This study comprehensively evaluated the causal relationship between different types of statins use and knee/hip osteoarthritis (OA) using a two-sample and multivariate Mendelian randomization (MR) method. MethodsMR analysis was conducted using publicly available summary statistics data from genome-wide association studies (GWAS) to assess the causal associations between total statins use (including specific types) and knee/hip OA. The primary analysis utilized the inverse variance-weighted (IVW) method, with sensitivity analysis conducted to assess robustness. Multivariable MR (MVMR) analysis adjusted for low-density lipo...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Xin Chen Source Type: research
Serum brain-derived neurotrophic factor levels in type 2 diabetes mellitus patients and its association with cognitive impairment: A meta-analysis
by Wan-li He, Fei-xia Chang, Tao Wang, Bi-xia Sun, Rui-rong Chen, Lian-ping Zhao
ObjectiveTo compare the serum levels of brain-derived neurotrophic factor (BDNF) in type 2 diabetes mellitus (T2DM) patients with healthy controls (HC) and evaluate the BDNF levels in T2DM patients with/without cognitive impairment. MethodsPubMed, EMBASE, and the Cochrane Library databases were searched for the published English literature on BDNF in T2DM patients from inception to December 2022. The BDNF data in the T2DM and HC groups were extracted, and the study quality was evaluated using the Agency for Healthcare Research and Quality. A m...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Wan-li He Source Type: research
