In vitro inflammation and toxicity assessment of pre- and post-incinerated organomodified nanoclays to macrophages using high-throughput screening approaches
Organomodified nanoclays (ONC), two-dimensional montmorillonite with organic coatings, are increasingly used to improve nanocomposite properties. However, little is known about pulmonary health risks along the... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 21, 2024 Category: Toxicology Authors: Todd A. Stueckle, Jake Jensen, Jayme P. Coyle, Raymond Derk, Alixandra Wagner, Cerasela Zoica Dinu, Tiffany G. Kornberg, Sherri A. Friend, Alan Dozier, Sushant Agarwal, Rakesh K. Gupta and Liying W. Rojanasakul Tags: Research Source Type: research

Epithelial MAPK signaling directs endothelial NRF2 signaling and IL-8 secretion in a tri-culture model of the alveolar-microvascular interface following diesel exhaust particulate (DEP) exposure
Particulate matter 2.5 (PM2.5) deposition in the lung ’s alveolar capillary region (ACR) is significantly associated with respiratory disease development, yet the molecular mechanisms are not completely understood... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 11, 2024 Category: Toxicology Authors: Eva C. M. Vitucci, Alysha E. Simmons, Elizabeth M. Martin and Shaun D. McCullough Tags: Research Source Type: research

Monitoring redox stress in human airway epithelial cells exposed to woodsmoke at an air –liquid interface
Wildland fires contribute significantly to the ambient air pollution burden worldwide, causing a range of adverse health effects in exposed populations. The toxicity of woodsmoke, a complex mixture of gases, v... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 8, 2024 Category: Toxicology Authors: Aiman Abzhanova, Jon Berntsen, Edward R. Pennington, Lisa Dailey, Syed Masood, Ingrid George, Nina Warren, Joseph Martin, Michael D. Hays, Andrew J. Ghio, Jason P. Weinstein, Yong Ho Kim, Earl Puckett and James M. Samet Tags: Research Source Type: research

Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment
Chronic inflammation and fibrosis are characteristics of silicosis, and the inflammatory mediators involved in silicosis have not been fully elucidated. Recently, macrophage-derived exosomes have been reported... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 7, 2024 Category: Toxicology Authors: Xiaofeng Qin, Zhiyuan Niu, Hui Chen and Yongbin Hu Tags: Research Source Type: research

Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage
With rapid increase in the global use of various plastics, microplastics (MPs) and nanoplastics (NPs) pollution and their adverse health effects have attracted global attention. MPs have been detected out in h... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 7, 2024 Category: Toxicology Authors: Shukun Wan, Xiaoqing Wang, Weina Chen, Manli Wang, Jingsong Zhao, Zhongyan Xu, Rong Wang, Chenyang Mi, Zhaodian Zheng and Huidong Zhang Tags: Research Source Type: research

Correction: Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life
(Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 6, 2024 Category: Toxicology Authors: Caroline Carl é, Delphine Boucher, Luisa Morelli, Camille Larue, Ekaterina Ovtchinnikova, Louise Battut, Kawthar Boumessid, Melvin Airaud, Muriel Quaranta-Nicaise, Jean-Luc Ravanat, Gilles Dietrich, Sandrine Menard, Gérard Eberl, Nicolas Barnich, Emmanu Tags: Correction Source Type: research

Results from omic approaches in rat or mouse models exposed to inhaled crystalline silica: a systematic review
Crystalline silica (cSiO2) is a mineral found in rocks; workers from the construction or denim industries are particularly exposed to cSiO2 through inhalation. cSiO2 inhalation increases the risk of silicosis and... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - March 1, 2024 Category: Toxicology Authors: Laura Morin, Val érie Lecureur and Alain Lescoat Tags: Review Source Type: research

Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury
Zinc oxide nanoparticles (ZnONPs) are common materials used in skin-related cosmetics and sunscreen products due to their whitening and strong UV light absorption properties. Although the protective effects of... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 28, 2024 Category: Toxicology Authors: Bour-Jr Wang, Yu-Ying Chen, Hui-Hsuan Chang, Rong-Jane Chen, Ying-Jan Wang and Yu-Hsuan Lee Tags: Research Source Type: research

Differential pulmonary toxicity and autoantibody formation in genetically distinct mouse strains following combined exposure to silica and diesel exhaust particles
Inhalation of airborne particulate matter, such as silica and diesel exhaust particles, poses serious long-term respiratory and systemic health risks. Silica exposure can lead to silicosis and systemic autoimm... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 27, 2024 Category: Toxicology Authors: Lisa MF Janssen, Frauke Lemaire, Nora Fopke Marain, Steven Ronsmans, Natasja Heylen, Arno Vanstapel, Greetje Vande Velde, Jeroen AJ Vanoirbeek, Kenneth Michael Pollard, Manosij Ghosh and Peter HM Hoet Tags: Research Source Type: research

Effective density of inhaled environmental and engineered nanoparticles and its impact on the lung deposition and dosimetry
Airborne environmental and engineered nanoparticles (NPs) are inhaled and deposited in the respiratory system. The inhaled dose of such NPs and their deposition location in the lung determines their impact on ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 17, 2024 Category: Toxicology Authors: Denisa Lizonova, Amogh Nagarkar, Philip Demokritou and Georgios A. Kelesidis Tags: Research Source Type: research

Particulate matter from car exhaust alters function of human iPSC-derived microglia
Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive fun... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 15, 2024 Category: Toxicology Authors: Henna J äntti, Steffi Jonk, Mireia Gómez Budia, Sohvi Ohtonen, Ilkka Fagerlund, Mohammad Feroze Fazaludeen, Päivi Aakko-Saksa, Alice Pebay, Šárka Lehtonen, Jari Koistinaho, Katja M. Kanninen, Pasi I. Jalava, Tarja Malm and Paula Korhonen Tags: Research Source Type: research

Influence of polyethylene terephthalate (PET) microplastic on selected active substances in the intramural neurons of the porcine duodenum
Currently, society and industry generate huge amounts of plastics worldwide. The ubiquity of microplastics is obvious, but its impact on the animal and human organism remains not fully understood. The digestiv... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 6, 2024 Category: Toxicology Authors: Ismena Ga łęcka, Natalia Szyryńska and Jarosław Całka Tags: Research Source Type: research

The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages
Micro- and nanoplastics (MNPs) represent one of the most widespread environmental pollutants of the twenty-first century to which all humans are orally exposed. Upon ingestion, MNPs pass harsh biochemical cond... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - February 4, 2024 Category: Toxicology Authors: Hugo Brouwer, Mojtaba Porbahaie, Sjef Boeren, Mathias Busch and Hans Bouwmeester Tags: Research Source Type: research

Comparison of PET tracing and biodistribution between 64Cu-labeled micro-and nano-polystyrene in a murine inhalation model
In this study, we traced the biodistribution of ... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 31, 2024 Category: Toxicology Authors: Joycie Shanmugiah, Javeria Zaheer, Changkeun Im, Choong Mo Kang and Jin Su Kim Tags: Research Source Type: research

Malignant peritoneal mesotheliomas of rats induced by multiwalled carbon nanotubes and amosite asbestos: transcriptome and epigenetic profiles
Malignant mesothelioma is an aggressive cancer that often originates in the pleural and peritoneal mesothelium. Exposure to asbestos is a frequent cause. However, studies in rodents have shown that certain mul... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - January 31, 2024 Category: Toxicology Authors: Stella Marie Reamon-Buettner, Susanne Rittinghausen, Annika Klauke, Andreas Hiemisch and Christina Ziemann Tags: Research Source Type: research