Pathology, Research and PracticeThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5 6 7

339 records returned

Clear cell meningioma with anaplastic features: Case report and review of literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present two cases of CCMs with anaplastic features in the intracranial and intraspinal region. The first case is a 65-year-old male who gradually developed changes in behavior over a period of 1 year. The second case is a 35-year-old female who presented with a 7-month history of posterior cervicothoracic pain and dysuria for 1 week. Magnetic resonance imaging revealed an intracranial lesion in the right frontal lobe in the male patient, and an intradural extramedullary lesion at C7 in the female patient. On histological examination, both tumors partly exhibited unusual anaplastic appearances with nuclear pleomorphism, ...
Source: Pathology, Research and Practice - October 24, 2009 Category: Pathology Authors: Tong-Tong W, Li-Juan B, Zhi L, Yang L, Bo-Ning L, Quan H Tags: Pathol Res Pract Source Type: journals

Rapid spontaneous malignant progression of supratentorial tanycytic ependymoma with sarcomatous features - "Ependymosarcoma"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on an example of this paradigm, involving tanycytic ependymoma as the host tumor in a 40-year-old female who underwent two tumor extirpation procedures at one-year interval. She first presented with severe headaches, and was seen by imaging to harbor a moderately enhancing mass 2.5cm in diameter at the rostral septum pellucidum accompanied by occlusive hydrocephalus. Microscopically, the tumor consisted of solid, wavy fascicles of elongated cells that were occasionally interrupted by vague perivascular pseudorosettes. Mitotic activity was absent, and less than 1% of nuclei immunoreacted for MIB-1. A histological ...
Source: Pathology, Research and Practice - October 21, 2009 Category: Pathology Authors: Vajtai I, Kuhlen D, Kappeler A, Mariani L, Zimmermann A, Paulus W Tags: Pathol Res Pract Source Type: journals

Expression of vascular endothelial growth factor (VEGF), hypoxia inducible factor 1 alpha (HIF-1alpha), and transforming growth factors beta1 (TGFbeta1) and beta3 (TGFbeta3) in gestational trophoblastic disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to investigate the relationship between the expression of vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF-beta1 and TGF-beta3), and hypoxia inducible factor 1 alpha (HIF-1alpha) in gestational trophoblastic diseases to highlight the possible histogenesis. Twenty-one partial hydatidiform moles (PHM), 19 complete hydatidiform moles (CHM), 13 choriocarcinomas, and 20 nonhydropic spontaneous abortions (control group) were evaluated with immunohistochemistry using VEGF, HIF-1alpha, TGFbeta1, and TGFbeta3. The extent of immunohistochemical positivity (0%=0, 1-24%=1, 2...
Source: Pathology, Research and Practice - October 13, 2009 Category: Pathology Authors: Bolat F, Haberal N, Tunali N, Aslan E, Bal N, Tuncer I Tags: Pathol Res Pract Source Type: journals

Comparison of molecular markers expression in vacuum-assisted biopsies and surgical specimens of human breast carcinomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined whether vacuum-assisted breast biopsy (VABB) specimens provide an accurate immunohistochemical assessment of estrogen receptors (ER), progesterone receptors (PR), c-erbB-2, and p53 proteins. Thirty-seven consecutive cases with a VABB diagnosis of ductal carcinoma in situ (DCIS) were included. The immunohistochemical expression of ER and PR, c-erbB-2, and p-53 was assessed in VABB and in surgical specimens with pathological concordance. The "clinically relevant concordance rate" (CRCR) was calculated. The CRCRs were 77.8%, 77.8%, and 89% for ER, PR, and c-erbB-2, respectively. Concerning both ER a...
Source: Pathology, Research and Practice - October 13, 2009 Category: Pathology Authors: Zagouri F, Sergentanis TN, Nonni A, Papadimitriou CA, Michalopoulos NV, Giannakopoulou G, Bletsa G, Patsouris E, Zografos GC Tags: Pathol Res Pract Source Type: journals

Peripheral T-cell lymphoma developing at ileocolonic anastomosis site after colectomy for adenocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 69-year-old man underwent right hemicolectomy for colon cancer in the transverse colon in 2005. Two years after surgery, he was admitted with abdominal pain. Colonoscopy revealed a submucosal tumor of approximately 4cm in size at the ileocolonic anastomosis site. In the biopsied samples from the anastomosis site, there was diffuse proliferation of large lymphoid cells, which were immunohistochemically positive for CD3 and CD4, but negative for CD8 and CD20. Clonality analysis of T-cell receptor-beta gene rearrangement revealed a single band, indicating monoclonal proliferation of the T- lymphocytes. Epstein-Barr viru...
Source: Pathology, Research and Practice - October 13, 2009 Category: Pathology Authors: Ikeda JI, Yamauchi A, Hoshida Y, Okamura S, Hashimoto K, Aozasa K, Morii E Tags: Pathol Res Pract Source Type: journals

HER2-testing in 538 consecutive breast cancer cases using FISH and immunohistochemistry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HER2 is amplified and overexpressed in up to 20% of all breast carcinomas, and accurate assessment of the HER2-status is essential for the appropriate use of anti-HER2 therapies, including trastuzumab. Here, we have evaluated the accuracy of two commercially available and commonly used HER2 antibodies (antibody A0485 and HercepTest), followed by FISH-test, in 538 consecutive breast cancers, to identify a reliable procedure for the determination of HER2-status. Immunohistochemical (IHC) analysis revealed that 282 cases (52.2%) were positive (2+/3+) for antibody A0485, while only 179 cases (33.3%) were positive (2+/3+) f...
Source: Pathology, Research and Practice - October 8, 2009 Category: Pathology Authors: Kovács A, Stenman G Tags: Pathol Res Pract Source Type: journals

The number of Foxp3-positive regulatory T cells is increased in Helicobacter pylori gastritis and gastric cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was based on the analysis of gastric biopsy specimens from 126 cases of H. pylori-associated gastritis, 16 cases of H. pylori-negative gastritis, 17 cases of gastric dysplasia, and 25 cases of gastric adenocarcinoma. The number of Tregs was elevated in H. pylori-associated gastritis, where it was positively correlated with the grade of chronic inflammation and the number of lymphoid follicles. It was significantly elevated in adenocarcinomas compared to chronic gastritis and gastric dysplasia. In summary, the number of Tregs is increased in H. pylori-associated gastritis and gastric cancer. PMID: 19819643 [P...
Source: Pathology, Research and Practice - October 8, 2009 Category: Pathology Authors: Jang TJ Tags: Pathol Res Pract Source Type: journals

Expression of the GLUT1 glucose transporter and p53 in carcinomas of the pancreatobiliary tract.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Only few studies have evaluated the usefulness of the GLUT1 and p53 status of pancreatobiliary tract carcinomas in revealing tumorigenesis. We studied GLUT1 and p53 immunoexpression in a total of 355 cases of the pancreatobiliary carcinoma to determine the biological significance of GLUT1 and p53 expression. Positive expression of GLUT1 was identified in 38 out of 67 (57.7%) ampulla of Vater (AV) carcinomas, in 27 out of 52 (51.8%) pancreatic (PA) carcinomas, in 38 out of 121 (31.4%) extrahepatic bile duct (EBD) carcinomas, and in 53 out of 115 (46.5%) gallbladder (GB) carcinomas. GLUT1 expression in pancreatobiliary c...
Source: Pathology, Research and Practice - October 8, 2009 Category: Pathology Authors: Sung JY, Kim GY, Lim SJ, Park YK, Kim YW Tags: Pathol Res Pract Source Type: journals

Micropapillary urothelial carcinoma: Clinico-pathologic review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Micropapillary carcinoma is a rare distinct variant of high grade urothelial carcinoma, which has specific morphological characteristics and is almost always associated with muscularis propria and vascular invasion. No currently defined imaging techniques can reliably diagnose some types of deeply invasive urothelial carcinoma of urinary bladder, in particular its micropapillary variant. Therefore, the pathological findings are crucial in making the diagnosis. Micropapillary carcinoma (MPC) is a tumor with an aggressive clinical course, an advanced stage of disease at the time of presentation, and usually a poor outcom...
Source: Pathology, Research and Practice - September 17, 2009 Category: Pathology Authors: Perepletchikov AM, Parwani AV Tags: Pathol Res Pract Source Type: journals

Synchronous squamous cell carcinoma of the kidney, squamous cell carcinoma of the ureter, and sarcomatoid carcinoma of the urinary bladder: A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The author presents a unique case of a synchronous triple carcinoma of kidney, ureter, and urinary bladder. A 73-year-old man was admitted to our hospital because of hematuria and lumbago. Endoscopy and imaging modalities revealed a bladder tumor, a left ureter tumor, and a left kidney tumor. No other tumors were found in the body by imaging modalities. Cystectomy and left nephroureterectomy were performed. The bladder tumor was a large polypoid tumor consisting of pleomorphic sarcomatoid carcinoma (80%) and high-grade papillary urothelial carcinoma (20%), both invading the deep muscle layer. There were gradual merges ...
Source: Pathology, Research and Practice - September 16, 2009 Category: Pathology Authors: Terada T Tags: Pathol Res Pract Source Type: journals

An unusual self-limited clonal Mott cell proliferation with lymphoplasmacytic lymphoma-like features in a child with the Wiskott-Aldrich syndrome and Von Recklinghausen's neurofibromatosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a self-limited lymphoproliferation with features of lymphoplasmacytic lymphoma arising in a patient with the Wiskott-Aldrich syndrome. The patient also had stigmata of von Recklinghausen's neurofibromatosis. The tumor was composed of CD138+, IgGkappa+, CD20-, PAX-5- Mott cells and CD5-, CD10-, CD19+, CD20+, CD43- small lymphoid B-cells that partially expressed CD23. The lymphadenopathy spontaneously resolved after a period of less than a year, and the patient had remained free of detectable lymphoproliferation for almost 4 years. He then developed Burkitt's lymphoma of the left parapharyngeal space. It...
Source: Pathology, Research and Practice - August 24, 2009 Category: Pathology Authors: Rampisela D, Donner LR Tags: Pathol Res Pract Source Type: journals

Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mutation analysis of the KRAS oncogene is now established as a predictive biomarker in colorectal cancer (CRC). Large prospective clinical trials have shown that only CRCs with wild-type KRAS respond to anti-epidermal growth factor receptor (EGFR) treatment. Therefore, mutation analysis is mandatory before treatment, and reliable benchmarks for the frequency and types of KRAS mutations have to be established for routinely testing large numbers of metastatic CRCs. A thousand and eighteen cases (879 primary tumors and 139 metastases) of metastatic colorectal cancer were analyzed for the KRAS mutational status of codons 1...
Source: Pathology, Research and Practice - August 10, 2009 Category: Pathology Authors: Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A Tags: Pathol Res Pract Source Type: journals

Pulmonary hypertensive necrotizing arteritis: An unusual case of unilateral involvement in an infant with congenital heart disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, in pulmonary valve atresia, the lungs may be supplied via aortopulmonary collaterals. Necrotizing pulmonary arteritis is a severe lesion seen in irreversible pulmonary hypertension. PMID: 19679401 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - August 10, 2009 Category: Pathology Authors: Steiner I, Bološová V, Fejtová S Tags: Pathol Res Pract Source Type: journals

Solid-pseudopapillary neoplasm of the pancreas with massive central calcification in an old man.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Solid-pseudopapillary neoplasm (SPN) is a rare pancreatic tumor primarily affecting women in their twenties. It is characterized by a well-demarcated or encapsulated mass, indolent behavior and favorable prognosis. Capsular or punctate calcification is occasionally observed. Reported herein is a case of SPN of the pancreas with massive calcification in a 76-year-old Japanese man. Macroscopically, the pancreatic tumor appeared to be a simple calcified nodule, but histological examination revealed that it was an epithelioid tumor with massive calcification. The tumor cells, forming nests and cords, had eosinophilic cytop...
Source: Pathology, Research and Practice - August 9, 2009 Category: Pathology Authors: Matsuda I, Hao H, Zozumi M, Koishi K, Matsumoto T, Kaibe N, Fujiwara Y, Sasako M, Hirota S Tags: Pathol Res Pract Source Type: journals

Expression profiling of integrins in lung cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Integrins are heterodimeric transmembrane receptors consisting of 18 alpha and 8 beta subunits. Heterodimer composition of alpha and beta subunits has a potential for determining tumor subtypes of human lung cancer. The purpose of this study was to investigate the expression profile of integrins in lung cancer cells. Expression profiling of integrins in a panel of lung cancer cell line, including A549 (adenocarcinoma, ADC), Calu-1 (squamous carcinoma, SCC), H1650 (bronchioloalveolar carcinoma, BAC) and DMS-53 (small cell lung cancer, SCLC), was analyzed by cDNA microarrays, restriction analysis of gene expression (RAGE...
Source: Pathology, Research and Practice - August 9, 2009 Category: Pathology Authors: Guo L, Zhang F, Cai Y, Liu T Tags: Pathol Res Pract Source Type: journals

Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sertoli-Leydig cell tumor (SLCT) is a rare tumor involving the ovary. Approximately 20% of SLCT are associated with heterologous elements that are either of endodermal or mesodermal origin. The gastrointestinal-type epithelium is the most commonly described endodermal heterologous element. SLCT with benign and borderline mucinous neoplasm has been reported in the literature. However, SLCT with mucinous adenocarcinoma as heterologous element has been rarely documented. Herein, we describe a rare case of intermediately differentiated Sertoli-Leydig cell tumor with mucinous adenocarcinoma as the heterologous element in a ...
Source: Pathology, Research and Practice - August 9, 2009 Category: Pathology Authors: Virk R, Lu D Tags: Pathol Res Pract Source Type: journals

Assessment of the role of histopathology and DNA image analysis in the diagnosis of molar and non-molar abortion: A study of 89 cases in the center of Tunisia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study retrospectively evaluated the histopathological criteria commonly used in the literature on the diagnosis of hydatidiform mole, in correlation with the diagnosis rendered previously. The molar and non-molar cases seen in the first-trimester of pregnancy were separately reviewed by two pathologists. The correlation between the consensual histological diagnosis and the ploidy status was then evaluated. We retrospectively studied 89 specimens of abortus conception, including 35 complete hydatidiform moles (CHM), 12 partial hydatidiform moles (PHM), and 42 hydropic abortions (HA). The final histopathological diagnos...
Source: Pathology, Research and Practice - August 5, 2009 Category: Pathology Authors: Landolsi H, Missaoui N, Yacoubi MT, Trabelsi A, Rammeh-Rommani S, Hidar S, Gribaa M, Hmissa S, Mokni M Tags: Pathol Res Pract Source Type: journals

An intracapsular carcinoma ex pleomorphic adenoma with lung metastases composed exclusively of benign elements: Histological evidence of a continuum between metastasizing pleomorphic adenoma and carcinoma ex pleomorphic adenoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the case of a 62-year-old female with an intracapsular ca ex PA of the buccal mucosa with subsequent metastases to the lung. The metastatic deposits resembled benign PA with no histological evidence of malignancy. This pattern of spread is described with mPA, an entity that caused controversy in the past regarding its exact classification as a benign or malignant tumor. The possibility that ca ex PA originates from a mPA, with intracapsular ca ex PA representing an intermediate lesion in a histological continuum, is discussed. PMID: 19665316 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - August 5, 2009 Category: Pathology Authors: Weissferdt A, Langman G Tags: Pathol Res Pract Source Type: journals

No parietal cell hypertrophy of the metaplastic corpus mucosa in the distal esophagus under PPI treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When biopsies obtained from short tongues of columnar epithelium in the distal esophagus show only corpus or cardia-corpus transitional mucosa, it remains uncertain whether we are dealing with columnar epithelium metaplasia or a sampling error. In 50 patients with gastro-esophageal reflux disease receiving proton pump inhibitor (PPI) with such tongues of columnar epithelium, we noted that under this treatment, PPI-typical hypertrophy of the parietal cells in the corpus can be found, but not in the corpus or cardia/corpus transitional mucosa in biopsy material obtained from tongues of columnar epithelium in the distal e...
Source: Pathology, Research and Practice - August 4, 2009 Category: Pathology Authors: Stolte M Tags: Pathol Res Pract Source Type: journals

Primary vulvar Ewing's sarcoma/primitive neuroectodermal tumor in a post-menopausal woman: A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the case of a 52-year-old woman who was admitted to our hospital for the local excision of a 4cm vulvar mass, originally thought to be a Bartholin's gland cyst. It was subsequently found to consist of small round cells positive for anti-CD99 antibody, thus suggesting a diagnosis of ES/pPNET. The demonstration of EWSR1 gene translocations by means of fluorescent in situ hybridization excluded small-cell carcinoma, squamous cell carcinoma of the small type, Merkel cell carcinoma, and lymphoblastic lymphoma. After surgery, the patient received six cycles of polychemotherapy and radiotherapy; she is still alive and...
Source: Pathology, Research and Practice - August 2, 2009 Category: Pathology Authors: Boldorini R, Riboni F, Cristina S, Allegrini S, Valentini S, Muscarà M, Ruspa G Tags: Pathol Res Pract Source Type: journals

Focal adhesion kinase (FAK) expression in normal and neoplastic lymphoid tissues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Focal adhesion kinase (FAK) is a protein tyrosine kinase essential for intracellular regulatory events, such as cell growth, differentiation, migration and tumor metastasis. The aim of this study was to analyze the expression of FAK protein in a series of normal and neoplastic lymphoid tissues. An anti-FAK antibody was used to study the protein expression in paraffin-embedded samples of normal and neoplastic, hematolymphoid and non-hematolymphoid tissues by immunohistochemistry. In normal hematolymphoid tissue, the strongest expression of FAK was detected in germinal center and marginal-zone B cells; positive staining ...
Source: Pathology, Research and Practice - July 30, 2009 Category: Pathology Authors: Ozkal S, Paterson JC, Tedoldi S, Hansmann ML, Kargi A, Manek S, Mason DY, Marafioti T Tags: Pathol Res Pract Source Type: journals

Histological patterns and associated PSA levels for prostatic adenocarcinoma following brachytherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Changes in morphologic patterns over a time course following radiation and their corresponding PSA levels were investigated. A total of 60 patients with prostatic adenocarcinoma treated with brachytherapy between 1993 and 2003, who had at least one positive post-radiation biopsy, were evaluated for their morphologic patterns as well as the associated PSA levels. A total of 86 positive post-radiation biopsies were performed. There were 17 patients with more than 1 positive post-radiation biopsy and 43 patients with single positive biopsy. Among the 17 with more than 1 positive biopsy, the morphologic patterns of treatme...
Source: Pathology, Research and Practice - July 28, 2009 Category: Pathology Authors: Xiao GQ, Huan Y, Stone N, Stock R, Unger PD Tags: Pathol Res Pract Source Type: journals

Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The differential diagnosis between benign salivary oncocytoma (ONC) and low-grade malignant acinic cell carcinoma (ACC) can be difficult due to a significant histomorphological overlap of the structural and cytological presentation of both tumor types. To the best of our knowledge a comprehensive study comparing (immuno-)histological markers in cases of difficult differential diagnosis between ONC and ACC has not yet been performed. We investigated a panel of different immunohistochemical (CK5/6, CK14, CK7, CK18, p63 and Ki67) and histochemical (PAS, alpha-amylase) markers in 12 cases of ONC and 19 cases of ACC. The st...
Source: Pathology, Research and Practice - July 28, 2009 Category: Pathology Authors: Weiler C, Reu S, Zengel P, Kirchner T, Ihrler S Tags: Pathol Res Pract Source Type: journals

True thymic hyperplasia associated with thymic hemorrhage in an adult patient.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A case of true thymic hyperplasia (TTH) associated with thymic hemorrhage (TH) was observed in a 22-year-old male patient who presented with persistent cough and thoracic pain due to an anterior mediastinal mass. The diagnosis of TTH was supported by the observation that the mediastinal mass was essentially composed of histologically normal thymic lobules with preserved cortico-medullary differentiation. The TTH tissue presented multiple areas of hemorrhage associated with the presence of large, tortuous, abnormal vessels in the thymic stroma. Foci of spindle cell proliferations resembling an epitheliod hemangioma were...
Source: Pathology, Research and Practice - July 26, 2009 Category: Pathology Authors: Pilozzi E, Del Prete F, De Dominicis C, Angelo Rendina E, P Ruco L Tags: Pathol Res Pract Source Type: journals

NK-cell lymphoma with nodal presentation and expression of cutaneous lymphocyte-associated antigen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present 2 non-nasal NK-cell lymphomas with nodal presentation. Both tumors showed the phenotype of CD3+ (cytoplasmic), CD5-, CD7-, CD16+, CD56+, cytotoxic molecules+, EBV+ (by in situ hybridization), and CLA+. They were polyclonal for T-cell receptor gamma chain gene rearrangement, indicating an NK cell lineage. The aggressive course in these two patients suggested that in nasal and nasal-type NK-cell lymphomas, CLA expression might be an indicator of poor prognosis. More studies are needed to elucidate the prognostic impact of CLA expression in T cell and NK-cell lymphomas. PMID: 19628338 [PubMed - as supplied by p...
Source: Pathology, Research and Practice - July 20, 2009 Category: Pathology Authors: Chang ST, Liao YL, Lin SH, Chuang SS Tags: Pathol Res Pract Source Type: journals

siRNA targeting Survivin inhibits growth and induces apoptosis in human renal clear cell carcinoma 786-O cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the inhibitory effect of small interfering RNA (siRNA) targeting Survivin gene on cell proliferation and apoptosis in human renal clear cell carcinoma 786-O cells. qRT-PCR, immunocytochemistry, and Western Blot were used to detect Survivin gene expression in 786-O cells. Cell proliferation was determined by BrdU assay and PCNA expression. Cell apoptosis was analyzed through detection of caspase-3 activity, and the effect of Survivin-siRNA on Bcl-2 gene expression was also examined. Forty-eight hours after transfection, Survivin expression was markedly inhibited at the mRNA and protein level. Downregulat...
Source: Pathology, Research and Practice - July 20, 2009 Category: Pathology Authors: Zhang Y, Chen ZD, Du CJ, Xu G, Luo W Tags: Pathol Res Pract Source Type: journals

Methotrexate-associated lymphoproliferative disorders mimicking angioimmunoblastic T-cell lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe three cases of RA patients who developed MTX-associated LPDs resembling AITL. They developed systemic lymph node swelling after initiation of MTX. The affected lymph nodes showed the histological finding of AITL: polymorphous infiltrates, mainly T-cells and arborizing high endothelial venules. Two cases showed a predominance of CD4-positive cells in proliferative T-cells, whereas the third case showed CD8-positive cells. CD10 was negative in all cases. RNA in situ hybridization of Epstein-Barr virus (EBV) demonstrated EBV-positive B-cells to be scattered in two cases, but not in one case. The ly...
Source: Pathology, Research and Practice - July 20, 2009 Category: Pathology Authors: Hatanaka K, Nakamura N, Kojima M, Ando K, Irie S, Bunno M, Nakamine H, Uekusa T Tags: Pathol Res Pract Source Type: journals

Hepatocyte growth factor suppresses tumor cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 protein expression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we aimed at determining whether HGF is a potent inhibitor of cell apoptosis in NPC, and tried to find out which antiapoptotic or proapoptotic protein is involved in this process. A hundred and forty-seven cases of NPC and CNE-1, CNE-2 NPC cell line were collected. Expression of HGF, Bcl-2 and Bax in tumor tissues was investigated by immunohistochemical staining, and the apoptotic index was evaluated using the Terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) method in all of the NPC cases. NPC cells were treated with HGF (25ng/ml), followed by an assay for cell viability and apoptos...
Source: Pathology, Research and Practice - July 19, 2009 Category: Pathology Authors: Li-Juan B, Bing L, Zhi L, Yang L, Ying-Jie L Tags: Pathol Res Pract Source Type: journals

Tumor-to-tumor metastasis: Warthin tumor as a recipient of lung carcinoma and of renal carcinoma - Report of two cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of a 65-year-old man with duplicity of colonic and lung adenocarcinomas who presented with swelling of the left parotid gland, and of a 75-year-old man who presented with swelling of the right parotid gland. Microscopical and immunohistochemical examination showed metastasis of lung carcinoma and of renal carcinoma, respectively, to Warthin tumor as the first clinical manifestation of the malignancy in the latter case. To the best of our knowledge, such a phenomenon has not been reported so far. PMID: 19625134 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 19, 2009 Category: Pathology Authors: Laco J, Celakovsky P, Kalfert D, Hornychova H, Rybnikar T, Ryska A Tags: Pathol Res Pract Source Type: journals

Expression and localization of aquaporin-1 in human cirrhotic liver.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the expression and localization of aquaporin-1 (AQP-1) in hepatitis B virus (HBV)-associated cirrhotic human liver tissues. The expression of AQP-1 at the protein and mRNA levels was analyzed by immunohistochemistry, quantitative real-time polymerase chain reaction (qPCR) and Western blotting in normal and HBV-associated cirrhotic human liver tissues. The correlation with the expression of CK19, CK7 and AQP-1 was also compared. AQP-1 staining was strongly and uniformly positive in mature bile ducts, isolated hepatic progenitor cells (HPCs) and ductular reactions. Scattered intermediate hepatocyte-like c...
Source: Pathology, Research and Practice - July 17, 2009 Category: Pathology Authors: Xian ZH, Cong WM, Wang YH, Wang B, Wu MC Tags: Pathol Res Pract Source Type: journals

Rare growth of a psammomatous meningioma in a mature ovarian Teratoma: A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of psammomatous meningioma in which meningothelial cells and psammoma bodies were both abundant and diffuse, allowing for the diagnosis of a meningioma. PMID: 19616897 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 16, 2009 Category: Pathology Authors: Mandal S, Dhingra K, Gupta P, Khurana N Tags: Pathol Res Pract Source Type: journals

Comparative immunohistochemical analysis of aurora-A and aurora-B expression in human glioblastomas. Associations with proliferative activity and clinicopathological features.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present study, we carried out a comparative immunohistochemical analysis of aurora-A and aurora-B expression in 40 patients with primary glioblastomas, and attempted to identify any associations with Ki-67 index and the patients' clinical features. The impact of various treatment modalities and proliferative activity on patient outcome was also assessed. Immunohistochemistry was carried out using formalin-fixed and paraffin-embedded tissue sections. Aurora-A expression was higher in tumors with high Ki-67 expression (p=0.01) and was positively, though marginally, related to aurora-B expression (p=0.085). Aurora-...
Source: Pathology, Research and Practice - July 16, 2009 Category: Pathology Authors: Samaras V, Stamatelli A, Samaras E, Arnaoutoglou C, Arnaoutoglou M, Stergiou I, Konstantopoulou P, Varsos V, Karameris A, Barbatis C Tags: Pathol Res Pract Source Type: journals

Extensive extranodal metastases of basal-like breast cancer with predominant myoepithelial spindle cell differentiation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A differentiation towards myoepithelial cells has been demonstrated in several types of lesions in the breast. These include multifocal myoepitheliomatosis, the rare mixed tumor or pleomorphic adenoma, adenoid cystic carcinoma, adenomyoepithelioma and myoepithelial carcinoma (malignant myoepithelioma). Myoepithelial carcinoma is the only lesion purely composed of myoepithelial cells. All these tumors are benign and/or of low-grade malignancy, with the exception of malignant myoepithelioma. In contrast to the statement of the current World Health Organization (WHO), recent studies have reported that regional and distant...
Source: Pathology, Research and Practice - July 16, 2009 Category: Pathology Authors: Trepp R, Padberg BC, Varga Z, Cathomas R, Inauen R, Reinhart WH Tags: Pathol Res Pract Source Type: journals

Non-specific histopathological changes in kidney with renal tubular dysgenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Absence of proximal convoluted tubules (APCT) is a specific pathomorphological change found in kidney with renal tubular dysgenesis (RTD). Non-specific structural abnormalities in the kidney with this disorder have rarely been reported. The aim of this study was to detect non-specific histopathological changes (NSHC) in RTD kidney, to evaluate their incidence, and to establish a possible relationship to various etiological-pathogenic variants of RTD. Kidneys of 12 patients with RTD diagnosed in 9 Israeli hospitals were studied. Paraffin sections were examined using histological, histochemical, and immunohistochemical s...
Source: Pathology, Research and Practice - July 16, 2009 Category: Pathology Authors: Moldavsky M Tags: Pathol Res Pract Source Type: journals

Clinicopathological study of tuberculous brain abscess.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, 21 cases of tuberculous abscesses encountered over a period of 13 years (1995-2007) were reviewed to study the clinical, radiological, and histopathological spectrum of the disease. The presence of palisading epithelioid cells and sheets of foamy histiocytes, enclosing a neutrophillic exudate rich in fibrin with nuclear debris, were clues as to suspicion of a tuberculous abscess. The demonstration of acid fast bacilli in the wall of the abscess or necrotic contents by microscopy or culture is essential to confirm the diagnosis of tuberculous abscess. A high index of clinical suspicion is necessary particular...
Source: Pathology, Research and Practice - July 13, 2009 Category: Pathology Authors: Chakraborti S, Mahadevan A, Govindan A, Nagarathna S, Santosh V, Yasha TC, Indira Devi B, Chandramouli BA, Kovoor JM, Chandramuki A, Shankar SK Tags: Pathol Res Pract Source Type: journals

Synchronous renal cell carcinoma and clear cell hepatocellular carcinoma mimicking metastatic disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of synchronous double primary clear cell tumor in the liver and the kidney of a 70-year-old male. The renal mass was a renal cell carcinoma of mixed clear and granular cell types, and the hepatic mass was a hepatocellular carcinoma with extensive clear cell change that mimicked a metastatic renal cell carcinoma. A simple battery of immunohistochemical stains composed of hepatocyte antigen, and CD10 was performed to make a definite diagnosis. PMID: 19608351 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 13, 2009 Category: Pathology Authors: Hou TC, Wu CC, Yang CR, Wang J Tags: Pathol Res Pract Source Type: journals

Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study is the first to demonstrate overexpression of FABP-7 in triple-negative breast cancers [ER(-), PgR(-)/HER2(-)], especially in basal-like breast cancer, and to give a probable interpretation of the high histological grade and poor prognosis of basal-like breast cancer. PMID: 19608352 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 13, 2009 Category: Pathology Authors: Tang XY, Umemura S, Tsukamoto H, Kumaki N, Tokuda Y, Osamura RY Tags: Pathol Res Pract Source Type: journals

Sclerosing stromal tumor of the ovary in a 4-year-old girl with characteristics of an ovarian signet-ring stromal tumor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a right OSST with prominent characteristics of signet-ring stromal tumor in a 4-year-old girl with symptoms of premature thelarche. We describe the clinical, histopathological, and immunohistochemical findings and review the literature. To our knowledge, the 4-year-old patient presented here is the youngest case of OSST reported in premenarchal children. The presence of non-mucin/non-lipid obvious signet-ring-like cells in this case suggests a possible relationship between OSST and signet-ring stromal tumor of the ovary. PMID: 19604650 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 12, 2009 Category: Pathology Authors: He Y, Yang KX, Jiang W, Wang DQ, Li L Tags: Pathol Res Pract Source Type: journals

Mature mediastinal teratoma with subtotal unidirectional pancreatic differentiation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 17-year-old male who presented with progressive dyspnea due to a large mediastinal tumor with accompanying pericardial effusion. Percutaneous core needle biopsies showed differentiated pancreatic tissue with chronic inflammation and cystic transformation. On this basis, heterotopic pancreatic tissue of the mediastinum, a lesion occasionally reported in the literature, was suspected and the lesion was excised. The histopathological workup of the surgically excised lesion, in the first place, supported the primary diagnosis. However, after extensive sampling of the lesion, the diagnosis had to be chan...
Source: Pathology, Research and Practice - July 9, 2009 Category: Pathology Authors: Weichert W, Koch M, Schmidt B, Krüll M, Badakhshi H, Neudecker J, Rogalla P, Rückert JC Tags: Pathol Res Pract Source Type: journals

Epithelioid angiomatous nodule of head and neck.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epithelioid vascular proliferations comprise a wide morphologic spectrum, ranging from reactive hyperplasia via benign tumor to malignant conditions. Epithelioid angiomatous nodule (EAN) is a recently recognized benign vascular proliferation with distinct clinical and pathological features. We review the literature and present six additional EANs in the head and neck examined by immunohistochemistry. This series comprised an equal number of males (n=3) and females (n=3) aged 13-45 years (mean 25.8 years). The sites of origin included the tongue (n=2), skin of the lip (n=2), periorbital and temporal skin (n=1), and nose...
Source: Pathology, Research and Practice - July 8, 2009 Category: Pathology Authors: Sun ZJ, Cai Y, Zhao YF, Hu X, Zhang W, Chen XM, Lai FM Tags: Pathol Res Pract Source Type: journals

Expression of xenobiotic and steroid hormone metabolizing enzymes in hepatocellular tumors of the non-cirrhotic liver.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, HCA and HCC revealed changes in the expression of certain metabolic enzymes as compared with the non-neoplastic liver tissue or FNH. Therefore, reduced expression of GST alpha and CYP3A4 may indicate specific metabolic defects in the tumor tissue characterizing subgroups of HCA and HCC. PMID: 19596526 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 8, 2009 Category: Pathology Authors: Haas S, Merkelbach-Bruse S, Justenhoven C, Brauch H, Fischer HP Tags: Pathol Res Pract Source Type: journals

Angiogenesis in chronic hepatitis C is associated with inflammatory activity grade and fibrosis stage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Data regarding the assessment of angiogenesis in liver tissue in chronic hepatitis C (CHC) are rare. The study was performed to explain the association between the histopathological features and the number of new blood vessels in lobules and portal tracts in CHC. The second aim of the study was to define the localization of sprouting and pattern of formation of new vessels by estimating CD 34 antigen expression in the liver. The study involved 74 patients with CHC, infected with viral genotype 1b before antiviral therapy. The number of new-formatted blood vessels was positively associated with fibrosis stage and inflam...
Source: Pathology, Research and Practice - July 7, 2009 Category: Pathology Authors: Gabriel A, Kukla M, Wilk M, Liszka L, Petelenz M, Musialik J Tags: Pathol Res Pract Source Type: journals

The expression of p63 and p53 in keratoacanthoma and intraepidermal and invasive neoplasms of the skin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
p53 is a well-known tumor suppressor gene, and its mutation is a common event in intraepidermal and invasive neoplasms of the skin. p63 is a homologue of the tumor suppressor gene p53, which is expressed in human basal squamous epithelium, and despite its homology to p53, it is considered to act as an oncogene. We evaluated p63 and p53 expression in usual skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), keratoacanthoma (KA), and intraepidermal neoplasms, including Bowen's disease (BD), actinic keratosis (AK), malignant melanoma in situ (MM in situ), and Paget's disease (PD) to clarify ...
Source: Pathology, Research and Practice - July 2, 2009 Category: Pathology Authors: Sakiz D, Turkmenoglu TT, Kabukcuoglu F Tags: Pathol Res Pract Source Type: journals

Spontaneous hepatic hemorrhage secondary to prolonged use of oral contraceptives.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of spontaneous hepatic hemorrhage secondary to prolonged ingestion of combined OCPs followed by multiple pulmonary emboli without underlying thrombophilia. PMID: 19577854 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 2, 2009 Category: Pathology Authors: Jaffar R, Pechet L, Whalen GF, Banner BF Tags: Pathol Res Pract Source Type: journals

Primary embryonal spindle cell cardiac rhabdomyosarcoma: Case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary cardiac tumors are rare. Of all primary heart neoplasms, sarcomas account for around 10%, and of these, rhabdomyosarcomas (RMS) constitute a minority. A case of primary left atrial RMS, reminiscent of leiomyosarcoma, is reported herein. Histologically, the tumor was composed of tightly-packed spindle-shaped cells arranged in long fascicles. At immunohistochemistry, the tumor cells stained strongly and diffusely with vimentin, muscle-specific actin, desmin and myogenin, and focally with fast-myosin and sarcomeric actin. WT-1 showed diffuse and intense cytoplasmic staining. Staining for calponin was weak. Stainin...
Source: Pathology, Research and Practice - July 1, 2009 Category: Pathology Authors: Fraternali Orcioni G, Louis Ravetti J, Gaggero G, Bocca B, Bisceglia M Tags: Pathol Res Pract Source Type: journals

Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: A report of two cases and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the cases of two patients in their fifties who presented with a growing abdominal mass and died of metastatic disease within less than a year. Histological assessment revealed large cell neuroendocrine carcinoma admixed with mucinous adenocarcinoma and teratoma. Different hypotheses regarding the origin of large cell neuroendocrine carcinoma of the ovary are discussed. The immunohistochemical pattern of staining for cytokeratin 7 and cytokeratin 20 suggests that the composite epithelial tumors originated from the pre-existing teratoma. PMID: 19577382 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 1, 2009 Category: Pathology Authors: Chênevert J, Bessette P, Plante M, Têtu B, Dubé V Tags: Pathol Res Pract Source Type: journals

Is D2-40 a useful marker for distinguishing malignant mesothelioma from pulmonary adenocarcinoma and benign mesothelial proliferations?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since pulmonary adenocarcinomas, malignant mesotheliomas (MM), and sometimes benign mesothelial proliferations show a great histomorphological resemblance to each other, an immunohistochemical panel is usually necessary for differential diagnosis. D2-40 is an available monoclonal antibody, which is already in use as a lymphatic endothelial marker. It has also been suggested to be useful in identifying the mesothelial differentiation. The aim of this study is to compare D2-40 immunostaining in MM, pulmonary adenocarcinoma, and benign mesothelial proliferations. In this retrospective study, D2-40 immunostaining was inves...
Source: Pathology, Research and Practice - June 29, 2009 Category: Pathology Authors: Deniz H, Kibar Y, Güldür ME, Bakır K Tags: Pathol Res Pract Source Type: journals

Atypical E-cadherin expression in cell clusters overlying focally disrupted mammary myoepithelial cell layers: implications for tumor cell motility and invasion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study attempted to determine if these cells would show aberrant E-cadherin expression, which imparts greater propensity for cell motility and invasion. Consecutive sections from breast tumors with a high frequency of FMCLD were double-immunostained for E-cadherin and a panel of related markers. The E-cadherin mRNA levels in cells overlying FMCLD and adjacent cells within the same duct were compared using real-time PCR. Nearly all the cell clusters overlying FMCLD were strongly immunoreactive for E-cadherin, whereas their adjacent counterparts within the same duct were largely negative. Cell clusters overlying FMCLD we...
Source: Pathology, Research and Practice - June 27, 2009 Category: Pathology Authors: Zhang X, Hashemi SS, Yousefi M, Gao C, Sheng J, Ni J, Wang W, Mason J, Man YG Tags: Pathol Res Pract Source Type: journals

Squamous cell carcinoma arising in a ciliated hepatic foregut cyst: case report and literature review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of squamous cell carcinoma arising in a ciliated hepatic foregut cyst (CHFC) in the left lobe of the liver in a 60-year-old woman. Gross examination revealed an irregular, partially encapsulated, smooth tumor mass with multiple cystic areas, 3-5mm in size. Microscopically, the lining of the microcysts was composed of ciliated columnar epithelium with scattered goblet cells. Multiple foci of squamous metaplasia of the columnar epithelium were observed, which showed areas with dysplastic changes and other areas with carcinomatous transformation. Our case also showed an inconspicuous or absent smooth muscle l...
Source: Pathology, Research and Practice - June 27, 2009 Category: Pathology Authors: Zhang X, Wang Z, Dong Y Tags: Pathol Res Pract Source Type: journals

Extraneural metastases of anaplastic oligodendroglial tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on an anaplastic oligodendroglioma and an anaplastic oligoastrocytoma that metastasized to cervical lymph nodes and bones. Both patients were women aged 54 and 30 years, and the metastases appeared following craniotomy. In the first patient, metastases to cervical lymph nodes developed one year after surgery, and, despite adjuvant therapy, recurred in the same location several times. Fine needle aspiration biopsy (FNAB) of the cervical lymph node prior to neck dissection suggested a possible metastatic primitive neuroepithelial tumor. In the second case, metastases to the sacrum and femur developed after surgery ...
Source: Pathology, Research and Practice - June 27, 2009 Category: Pathology Authors: Volavsek M, Lamovec J, Popović M Tags: Pathol Res Pract Source Type: journals