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Extrarenal teratoid Wilms' tumor: Two cases in unusual locations, one associated with elevated serum AFPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Teratoid Wilms' tumor is an unusual morphological entity characterized by a classic triphasic malignancy with predominantly heterologous tissue. The authors describe two cases of teratoid Wilms' tumor with an extrarenal site: one in a 13-year-old girl with vaginal spotting (patient 1) and another in a 1-day-old girl with a sacrococcygeal mass (patient 2). The tumors were located in the vagina and coccyx, respectively. Under the initial clinical diagnosis of sarcoma botryoides in patient 1 and teratoma in patient 2, the masses were removed. Microscopically, both tumors were composed of typical triphasic Wilms' tumor tissue ...
Source: Pathology International - November 13, 2009 Category: Pathology Authors: Joon Seon Song, In Koo Kim, Yong Man Kim, Shin-Kwang Khang, Kyu-Rae Kim, Yonghee Lee Source Type: journals

Chromosomal abnormalities of clear cell renal cell carcinoma: Frequent gain of chromosome 7Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gain of chromosome 7 is well known to be a characteristic abnormality of papillary renal cell carcinoma (RCC). The purpose of the present study was to perform cytogenetic analysis of G-band karyotype in 16 clear cell RCC obtained from nephrectomy. The age of patients ranged from 50 to 79 years and the tumor size in largest dimension ranged from 1.8 to 6.2 cm. As a result, the structural abnormality of chromosome 3 was most frequently observed (eight clones). Loss of chromosome 3 and gain of chromosome 7 followed (four clones). Among four clones showing gain of chromosome 7, two were associated with the abnormality of chrom...
Source: Pathology International - November 12, 2009 Category: Pathology Authors: Naoto Kuroda, Masato Tamura, Tomoyuki Shiotsu, Shoichiro Nakamura, Takahiro Taguchi, Akira Tominaga, Ondrej Hes, Michal Michal, Chiaki Kawada, Taro Shuin, Gang-Hong Lee Source Type: journals

Epithelial–mesenchymal transition in human lungs with usual interstitial pneumonia: Quantitative immunohistochemistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fibroblastic foci, a major histological feature of usual interstitial pneumonia (UIP), play a critical role in the development of UIP. The mechanisms involved in the formation of these foci, however, including cellular origin, remain unclear. Recent in vitro and animal studies suggested epithelial[ndash]mesenchymal transition (EMT) of alveolar epithelial cells during pulmonary fibrogenesis. The aim of the present study was to investigate the presence of EMT in patients with UIP on quantitative immunohistochemistry using pathological tissue sections. The study subjects were 13 patients with UIP pattern among 52 patients wit...
Source: Pathology International - November 12, 2009 Category: Pathology Authors: Taishi Harada, Kazuki Nabeshima, Makoto Hamasaki, Noriko Uesugi, Kentaro Watanabe, Hiroshi Iwasaki Source Type: journals

Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype: Their possible involvement in pathological processesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although numerous macrophages are found in the lesions of Langerhans cell histiocytosis (LCH), their activation phenotypes and their roles in the disease process have not been clarified. Paraffin-embedded LCH samples were examined on immunohistochemistry and it was found that CD163 can be used to distinguish infiltrated macrophages from neoplastic Langerhans cells (LC). The number of CD163-positve macrophages was positively correlated with the number of multinucleated giant cells (MGC), indicating that most MGC are derived from infiltrated macrophages. A significant number of CD163-positive macrophages were positive for in...
Source: Pathology International - November 12, 2009 Category: Pathology Authors: Koji Ohnishi, Yoshihiro Komohara, Naomi Sakashita, Ken-ichi Iyama, Toshihiko Murayama, Motohiro Takeya Source Type: journals

Minimal deviation mucinous adenocarcinoma ('adenoma malignum') of the uterine corpusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary mucinous adenocarcinomas of the uterine corpus are typically low grade and frequently associated with endometrial hyperplasia and/or ordinary endometrioid adenocarcinoma, but may appear as a heterogeneous group of neoplasms. A case is described of a 56-year-old postmenopausal woman who presented with mucinous vaginal discharge. Imaging demonstrated thickened myometrium due to adenomyosis. Serum CA19-9 levels were elevated to 486 U/mL. Microscopic examination of hysterectomy specimens indicated highly differentiated mucinous adenocarcinoma diffusely infiltrating the portion of adenomyosis of the corpus. In some area...
Source: Pathology International - November 12, 2009 Category: Pathology Authors: Kaoru Abiko, Tsukasa Baba, Madoka Ogawa, Yoshiki Mikami, Takashi Koyama, Masaki Mandai, Ikuo Konishi Source Type: journals

Intraductal oncocytic papillary carcinoma of the pancreas showing numerous hyaline globules in the lumenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two cases of intraductal oncocytic papillary carcinoma (IOPC) treated surgically were analyzed on light microscopy and immunohistochemistry: that of a 61-year-old man and that of a 55-year-old man. There were no clinical symptoms in either case. Pancreatic abnormalities were discovered incidentally on CT. Various clinical examinations were carried out, and the preoperative diagnosis was intraductal papillary mucinous carcinoma (IPMC) in both cases. Surgery was performed. Macroscopic observation of tissue cross-sections indicated multilocular cystic mass containing polypoid lesions encapsulated by the dilated pancreatic duc...
Source: Pathology International - November 12, 2009 Category: Pathology Authors: Takuma Tajiri, Tomoko Inagaki, Nobuyuki Ohike, Mutsuko Omatsu, Hisashi Kasugai, Toshiaki Kunimura, Akira Shiokawa, Toshiyuki Mitsuya, Toshio Morohoshi Source Type: journals

Concurrent xanthogranulomatous orchiepididymitis and seminoma in the same testisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Xanthogranulomatous orchiepididymitis (XGO) is a rare inflammatory and destructive disease of the testis that may simulate testicular malignancy. To the authors' knowledge only 19 cases of XGO have been previously reported. Herein is reported the case of a 52-year-old man with XGO who presented with a left testicular mass and pyogenic discharge from the scrotum. Ultrasound examination indicated heterogeneous testicular areas suggestive of neoplasia. Testicular tumor markers were normal. Orchidectomy was performed and histopathology showed XGO and a concurrent, occult typical seminoma. As far as the authors know the coincid...
Source: Pathology International - November 12, 2009 Category: Pathology Authors: J. Fernando Val-Bernal, Pilar González-Márquez, Enrique Ramos-Barseló, José Antonio Portillo Source Type: journals

Clinicopathological features of syphilitic gastritis in Korean patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Syphilitic gastritis is difficult to diagnose without a history of syphilis, because endoscopic and microscopic findings can simulate gastric cancer or lymphoma. Herein are reported two cases of syphilitic gastritis and analysis of the clinicopathological characteristics of 11 cases in Korean subjects, including nine previously reported ones. The two present patients were 25- and 32-year-old men with epigastric pain. The gastroduodenoscopy features were similar: multiple erosive or ulcerative lesions in whole gastric mucosa. Microscopically, gastric mucosa contained severe chronic active gastritis involving submucosa with ...
Source: Pathology International - October 30, 2009 Category: Pathology Authors: Kyungeun Kim, Eun Ju Kim, Mi-Jung Kim, Ho June Song, Yoon-Seon Lee, Kee Wook Jung, Eunsil Yu Source Type: journals

Age-related EBV-associated B-cell lymphoproliferative disorders: Diagnostic approach to a newly recognized clinicopathological entityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
EBV is prevalent among healthy individuals, and is implicated in numerous reactive and neoplastic processes in the immune system. The authors originally identified a series of senile or age-related EBV-associated B-cell lymphoproliferative disorders (LPD) bearing a resemblance to immunodeficiency-associated ones, which may be associated with immune senescence in the elderly and which are now incorporated into the 2008 World Health Organization lymphoma classification as EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly. This newly described disease is pathologically characterized by a proliferation of atypi...
Source: Pathology International - October 30, 2009 Category: Pathology Authors: Yoshie Shimoyama, Naoko Asano, Masaru Kojima, Satoko Morishima, Kazuhito Yamamoto, Takashi Oyama, Tomohiro Kinoshita, Shigeo Nakamura Source Type: journals

Sclerosing angiomatoid nodular transformation of the spleen (SANT): Clinicopathological study of 10 cases with or without abdominal disseminated calcifying fibrous tumors, and the presence of a significant number of IgG4+ plasma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, SANT can occur either as a solitary or as multiple tumors. Frequent association with abdominal disseminated CFT simulating carcinomatosis was observed. A statistically significant number of IgG4+ plasma cells was found in all of the cases of SANT and the associated CFT. Whether they are related to the IgG4-related sclerosing disease or not is debatable and warrants further investigation. (Source: Pathology International)
Source: Pathology International - October 30, 2009 Category: Pathology Authors: Tseng-tong Kuo, Tse-Ching Chen, Li-yu Lee Source Type: journals

Unique vascular tumor primary arising in the liver and exhibiting histopathological features consistent with so-called polymorphous hemangioendotheliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reported herein is an unusual vascular tumor primary arising in the liver and exhibiting unique histopathological features. A 47-year-old woman underwent left hepatectomy because of a large hepatic mass. On histology the tumor had a composite pattern, consisting of angiomatous, retiform and solid areas, formed by oval to cuboidal to spindle cells, that expressed only endothelial markers (CD31 and factor VIII-related antigen). These findings led to the diagnosis of a low-grade vascular neoplasm with morphological features consistent with so-called polymorphous hemangioendothelioma. The tumor was completely resected. At 24 m...
Source: Pathology International - October 30, 2009 Category: Pathology Authors: Lorenzo Cobianchi, Marco Lucioni, Renato Rosso, Sandro Zonta, Giacomo Fiandrino, Mario Alessiani, Marco Doni, Alberta Ferrari, Umberto Magrini, Marco Paulli, Paolo Dionigi Source Type: journals

Expression of ERCC1 and class IIIβ tubulin for predicting effect of carboplatin/paclitaxel in patients with advanced inoperable non-small cell lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It was recently reported that expression of excision repair cross-complementation group 1 (ERCC1), a DNA repair protein, predicts sensitivity to platinum-based chemotherapy drugs. Microtubule inhibitors such as paclitaxel demonstrate anticancer effects by inhibiting spindle fibers during mitosis; and class III[beta] tubulin (III[beta] tubulin), a microtubule component, is thought to be resistant to microtubule inhibitors. The purpose of the present study was to examine the correlation between prognosis and expression of these proteins using biopsy tissues obtained from 40 patients with advanced inoperable non-small cell lu...
Source: Pathology International - October 28, 2009 Category: Pathology Authors: Satoshi Ikeda, Kazuhiko Takabe, Keiko Suzuki Source Type: journals

Area of residual tumor beyond the muscular layer is a useful predictor of outcome in rectal cancer patients who receive preoperative chemoradiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of the present study was to determine whether the amount and the location of residual tumor are associated with outcome in surgically treated rectal cancer patients who receive preoperative chemoradiation therapy. Forty-three rectal cancer patients who underwent sphincter-saving operations after preoperative chemoradiation therapy were enrolled in the study. The total area of residual tumors was measured using morphometry software, and then the area of the residual tumors located within and beyond the muscular layer was also determined. Associations between clinicopathological features were evaluated. The resul...
Source: Pathology International - October 28, 2009 Category: Pathology Authors: Motohiro Kojima, Genichiro Ishii, Yuki Yamane, Yuji Nishizawa, Norio Saito, Atsushi Ochiai Source Type: journals

Comparison of tissue microarray and full section in immunohistochemistry of gastrointestinal stromal tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the present study was to compare the efficiency of tissue microarray (TMA) results using immunohistochemistry markers applied to a variety of core sizes and full sections of gastrointestinal stromal tumors (GIST) using performance measures such as core loss rate and concordance rate. Six primary antibody markers (c-Kit, CD34, smooth muscle actin (SMA), S-100, p53, and Ki-67) were used with the TMA technique to analyze 0.6 mm, 2 mm, and 3 mm punch cores of GIST samples from 67 patients. No statistical association was found between core size and loss rate (P= 0.512). TMA results for the 0.6 mm, 2 mm, and 3 mm core...
Source: Pathology International - October 28, 2009 Category: Pathology Authors: Mi Jung Kwon, Eun Sook Nam, Seong Jin Cho, Hye Rim Park, Hyung Sik Shin, Jun Ho Park, Chan Heun Park, Won Jae Lee Source Type: journals

Plasmablastic lymphoma of the retroperitoneum in an HIV-negative patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herein is reported a case of plasmablastic lymphoma (PBL) of the retroperitoneum in an HIV-negative patient. This is the first reported case of PBL at this location and of PBL from Japan in the English-language literature. A 76-year-old Japanese man was admitted to hospital with a chief complaint of right inguinal lymph node swelling. Lymph node biopsy indicated large tumor cells with both diffuse and cohesive growth patterns, and conspicuous tumor cell proliferation in lymph node sinuses. The initial pathological diagnosis was metastatic carcinoma. The patient died approximately 1 month after admission, and autopsy showed...
Source: Pathology International - October 13, 2009 Category: Pathology Authors: Yoshihisa Takahashi, Ippo Saiga, Jun-ichi Fukushima, Nobuhiko Seki, Naoya Sugimoto, Akiko Hori, Kenji Eguchi, Toshio Fukusato Source Type: journals

Collision tumor of the stomach: Gastric adenocarcinoma intermixed with gastrointestinal stromal tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The synchronous occurrence of tumors of different histological types in the stomach is uncommon. This rare association is usually detected incidentally at gastroscopy, surgery or histopathology. It is still not known whether such association represents an incidental coexistence or indicates a similar pathogenesis in the simultaneous development of tumors of different histological types in the same organ. A 73-year-old woman complained of discomfort after eating a Chinese dumpling, and had tarry stools three times. Gastroscopy showed a tumor at the juncture of the gastric fundus and corpus. The tumor was composed of gastric...
Source: Pathology International - October 11, 2009 Category: Pathology Authors: Rui Bi, Weiqi Sheng, Jian Wang Source Type: journals

Pleural malignant mesothelioma with invasive micropapillary component and its association with pulmonary metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The micropapillary pattern (characterized by papillary structure with tufts lacking a central fibrovascular core) is a predictor of aggressive carcinoma. The purpose of the present study was to review 34 pleural malignant mesotheliomas (21 epithelioid, five sarcomatoid, seven biphasic and one lymphohistiocytoid), with special reference to the presence of invasive micropapillary component. Two invasive micropapillary pattern-positive tumors were identified. The invasive micropapillary pattern was seen to have a focal distribution in 15[ndash]20% of the tumor tissues. The majority of the invasive micropapillary clusters expr...
Source: Pathology International - October 10, 2009 Category: Pathology Authors: Ai Mogi, Kazuki Nabeshima, Makoto Hamasaki, Noriko Uesugi, Kazuo Tamura, Akinori Iwasaki, Takayuki Shirakusa, Hiroshi Iwasaki Source Type: journals

Characterization of endoglin and Ki-67 expression in endothelial cells from benign and malignant lesions of the uterine cervixEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Activation of endothelial cells is often associated with the cellular proliferation in vitro. CD105 is a more specific marker of activated endothelial cells from tumor vessels and Ki-67 is used to assess the proliferation status of both tumor and endothelial cells. The aim of the present study was to evaluate the status of endothelial cells using CD105 and Ki-67 immunohistochemistry in benign and malignant lesions of the uterine cervix. Double stain for CD105/Ki-67 in benign and malignant lesions of the uterine cervix showed that these two markers had divergent expression on endothelial cells from associated tumor blood ve...
Source: Pathology International - September 24, 2009 Category: Pathology Authors: Anca M. Cimpean, Lilian Saptefrati, Raluca Ceausu, Marius Raica Tags: Rapid Communication Source Type: journals

AnnouncementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pathology International)
Source: Pathology International - September 23, 2009 Category: Pathology Tags: Announcement Source Type: journals

Perivascular epithelioid cell tumor of the nasal cavity with TFE3 expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pathology International)
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Naoto Kuroda, Masakazu Goda, Dmitry V. Kazakov, Ondrej Hes, Michal Michal, Gang-Hong Lee Tags: Letters to the Editor Source Type: journals

Hypercalcemic-type ovarian small cell carcinoma with unique CD34 expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pathology International)
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Yukinori Inadome, Toshikatsu Shibata, Keiko Suzuki, Mikiko Tsugata, Koji Shimabukuro, Masayuki Noguchi Tags: Letters to the Editor Source Type: journals

Mucinous cystadenoma of the pancreas with huge mural hematomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 60-year-old woman was referred for evaluation of a cystic mass in the pancreatic body that extended to the tail. Transabdominal ultrasonography demonstrated an oval cystic mass 24 cm in diameter, filled with debris. On the cyst wall there was a wide-based, smooth-surfaced, heterogeneous high-echoic protrusion that was 5 cm in diameter. On CT the protrusion showed internal enhancement. Endoscopic pancreatography showed no intraductal mucin or communication with the cyst. A distal pancreatectomy was performed under the diagnosis of mucinous cystadenocarcinoma. Grossly there was a brownish, hemispherical protrusion into the...
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Takeshi Hisa, Hiroki Ohkubo, Satoshi Shiozawa, Hiroki Ishigame, Mizuho Ueda, Masato Takamatsu, Masayuki Furutake Tags: Case Reports Source Type: journals

Heparin-induced thrombocytopenia with multiple organized thrombi accompanied by unusual cholesterin deposition: Autopsy case after long-term follow upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heparin-induced thrombocytopenia (HIT) is characterized by a reduction in the platelet count and systemic thromboembolism during heparin therapy. Herein is reported a case of HIT with characteristic thrombus formation. A 68-year-old man who had been treated for hypertension for 27 years suffered a brain infarction and was treated with heparin. After this treatment, other new infarctions occurred in multiple organs. Because serum antibodies against heparin/PF4 complex were detected, he was diagnosed as having HIT, and warfarin and argatroban were administered instead of heparin. He died, however, 119 days after the first on...
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Masaaki Ichinoe, Tetuo Mikami, Sachiko Ujiie, Kosuke Suzuki, Isao Okayasu Tags: Case Reports Source Type: journals

Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary tumor thrombotic microangiopathy (PTTM) is characterized by fibrocellular intimal proliferation and thrombus formation in small pulmonary arteries and arterioles in patients with metastatic carcinoma. Osteopontin (OPN) is a multifunctional cytokine and adhesive protein, and has been demonstrated to be implicated in fibrosis, neointima formation, arterial occlusion by thrombus, and tumor metastases in cooperation with platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). Herein is described an autopsy case of gastric adenocarcinoma with severe pulmonary hypertension due to PTTM. Hist...
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Fumiyuki Takahashi, Toshio Kumasaka, Tetsutaro Nagaoka, Midori Wakiya, Hiroaki Fujii, Kazue Shimizu, Koji Uchida, Yoshiteru Morio, Kuniaki Seyama, Okio Hino, Kazuhisa Takahashi, Yoshinosuke Fukuchi Tags: Case Reports Source Type: journals

Small cell carcinoma with skeletal muscle differentiation of urinary bladderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reported herein is a case of small cell carcinoma (SCC) with skeletal muscle differentiation of urinary bladder in a 76-year-old woman presenting macrohematuria. Ultrasonography and CT detected a mass at the anterior wall of the urinary bladder, and total cystectomy followed. The tumor consisted of solid growth of small round cells with high nucleocytoplasmic ratio admixed with rhabdoid cells with eosinophilic cytoplasmic inclusions, invading the perivesical tissue. On immunohistochemistry the tumor cells were diffusely positive for neural markers and CD99, and sporadically for skeletal muscle markers. Fluorescence in situ...
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Nobuhisa Yajima, Hiroki Mizukami, Ryuichi Wada, Fumitada Saito, Soroku Yagihashi Tags: Case Reports Source Type: journals

Small invasive ductal adenocarcinoma of the pancreas associated with lymphoplasmacytic sclerosing pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An asymptomatic 59-year-old man underwent pancreatoduodenectomy for a pancreatic mass that was discovered during a health check-up. Histopathology indicated typical features of lymphoplasmacytic sclerosing pancreatitis (LPSP) or autoimmune pancreatitis along with the presence of abundant IgG4-positive plasma cells throughout the mass. A small invasive ductal adenocarcinoma was observed in the center of the area affected by LPSP. The present case suggests that LPSP may be closely related to carcinogenesis of the pancreas. (Source: Pathology International)
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Utaroh Motosugi, Tomoaki Ichikawa, Hiroshi Yamaguchi, Tadao Nakazawa, Ryohei Katoh, Jun Itakura, Hideki Fujii, Tadashi Sato, Tsutomu Araki, Michio Shimizu Tags: Case Reports Source Type: journals

Atypical cell clusters expressing both neuronal and oligodendrocytic markers: Novel histological pattern of glioneuronal tumors?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glioneuronal tumors are a group of brain tumors that consist of both neuronal and glial cells. The spectrum of glioneuronal tumors is currently expanding, and many atypical glioneuronal tumors require further characterization. Two patients are described who had an atypical glioneuronal tumor with peculiar pathological features. One patient was a 7-year-old girl with a tumor in the right cerebellar hemisphere. This patient had no recurrence after total resection. The other was a 37-year-old man with a tumor in the spinal cord. He suffered incessant recurrence and received operative treatment four times. Although the clinica...
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Ji Hoon Phi, Sung-Hye Park, Chun Kee Chung, Kyu-Chang Wang, Byung-Kyu Cho, Seung-Ki Kim Tags: Case Reports Source Type: journals

Decreased protein and gene expression of hepatic cholesterol 7a-hydroxylase associated with dilated endoplasmic reticulum in chronic hypothyroid ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic hypothyroidism is associated with an increased risk for cardiovascular disease attributed, in part, to increased serum cholesterol and atherosclerosis. Decreased hepatic activity of cholesterol 7a-hydroxylase (CYP7A1) is thought to contribute to hypercholesterolemia in hypothyroidism. The endoplasmic reticulum (ER) has been shown to be a central organelle, and it is the location of CYP7A1 in hepatocyte. The aim of the present study was to determine whether the expression of CYP7A1 mRNA and protein could be decreased and whether ER could undergo morphological changes in a rodent model of chronic hypothyroidism induc...
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Xinli Zhou, Yong Han, Jia Liu, Ling Gao, Jiajun Zhao Tags: Original Articles Source Type: journals

Lung cysts in Birt-Hogg-Dubé syndrome: Histopathological characteristics and aberrant sequence repeatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Birt-Hogg-Dubé (BHD) syndrome is a rare disorder inherited in an autosomal dominant manner. The affected patients are predisposed to cutaneous fibrofolliculomas, renal cell tumors and lung cysts with recurrent pneumothorax. Contrary to neoplastic events in the skin and the kidney, the lung cysts have frequently been confused with non-neoplastic changes such as blebs or bullae. Herein is reported a case of multiple lung cysts associated with BHD syndrome. Detailed histopathological characteristics of the lesion are also given. The lung cysts were closely associated with the peripheral interlobular septum, visceral pleura o...
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Shunsuke Koga, Mitsuko Furuya, Yoko Takahashi, Reiko Tanaka, Atsushi Yamaguchi, Kazuhiro Yasufuku, Kenzo Hiroshima, Masatoshi Kurihara, Ichiro Yoshino, Ichiro Aoki, Yukio Nakatani Tags: Original Articles Source Type: journals

Diagnostic findings of ultrasound-guided fine-needle aspiration cytology for gastrointestinal stromal tumors: Proposal of a combined cytology with newly defined features and histology diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recently, endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) has been applied for diagnosis of gastrointestinal submucosal tumors. There have been no definite criteria, however, for the adequate cytological diagnosis of gastrointestinal stromal tumor (GIST) in practice. To facilitate this a novel method is proposed that combines cytology and histology. For 49 cases of submucosal tumor of gastrointestinal tract, EUS-FNA was performed. The aspirated materials were processed for cytology and histology. Both cytological and histological findings were examined on immunocytochemical and immunohistochemical staini...
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Satoko Yoshida, Kazuya Yamashita, Masashi Yokozawa, Mitsuhiro Kida, Miyoko Takezawa, Tetuo Mikami, Isao Okayasu Tags: Original Articles Source Type: journals

Mucosal remodeling in long-standing ulcerative colitis with colorectal neoplasia: Significant alterations of NCAM+ or α-SMA+ subepithelial myofibroblasts and interstitial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Evidence has been provided in ulcerative colitis (UC) that early genomic instability of both epithelial and stromal cells is important for colorectal tumorigenesis, as well as remodeling and morphological alterations of mucosal crypts. To clarify roles of stromal cells in tumor development in UC, the present study focused on heterogeneous phenotypes of subepithelial myofibroblasts and interstitial cells, in association with mucosal remodeling. To clarify the relationship of alterations to tumorigenesis, mucosa of resected rectae from patients with UC (n= 49) and sporadic cancer (n= 10) were analyzed on immunohistochemistry...
Source: Pathology International - September 23, 2009 Category: Pathology Authors: Isao Okayasu, Tsutomu Yoshida, Tetuo Mikami, Kiyomi Hana, Masashi Yokozawa, Kayo Araki, Jun Mitsuhashi, Masaomi Kikuchi, Eijiro Adachi, Miwa Sada Tags: Original Articles Source Type: journals

Peribiliary cyst of common bile duct: possible cause of refractory jaundiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pathology International)
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Hiroyuki Takahashi, Shigeharu Miwa, Kazuhiro Nomoto, Shinichi Hayashi, Koichi Tsuneyama, Yasuo Takano Tags: Letters to the Editor Source Type: journals

Renal angiomyoadenomatous tumor: fluorescence in situ hybridizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pathology International)
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Naoto Kuroda, Michal Michal, Ondrej Hes, Takahiro Taguchi, Akira Tominaga, Kohichi Mizobuchi, Chisato Ohe, Noriko Sakaida, Yoshiko Uemura, Taro Shuin, Gang-Hong Lee Tags: Letters to the Editor Source Type: journals

Renal cell carcinoma with extensive clear cell change sharing characteristics of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pathology International)
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Naoto Kuroda, Masato Tamura, Ondrej Hes, Michal Michal, Chiaki Kawada, Taro Shuin, Gang-Hong Lee Tags: Letters to the Editor Source Type: journals

Sclerosing encapsulating peritonitis (abdominal cocoon) associated with liver cirrhosis and diffuse large B-cell lymphoma: Autopsy caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A case of sclerosing encapsulating peritonitis (SEP) associated with liver cirrhosis (LC) and complicated by diffuse large B-cell lymphoma (DLBCL) is reported herein. A 49-year-old Japanese man had undergone peritoneo-venous shunt against refractory ascites due to hepatitis C virus-positive uncompensated LC for 2 years. After he received a diagnosis of DLBCL of the left neck lymph node 3 months before his death, palliative care was given because of his poor general condition. He developed severe abdominal distention and pain over 1 week and was found to have marked ascites and whole bowel lumped together on abdominal CT. A...
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Sohsuke Yamada, Akihide Tanimoto, Yasumasa Matsuki, Yuji Hisada, Yasuyuki Sasaguri Tags: Case Reports Source Type: journals

Metaplastic breast carcinoma with melanocytic differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metaplastic carcinoma of the breast is a rare heterogeneous malignancy, accounting for (Source: Pathology International)
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Antonia Bendic, Maja Bozic, Merica G. Durdov Tags: Case Reports Source Type: journals

Multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IgG4-related sclerosing disease is recognized as a distinct clinicopathological entity. It is well known that this disease can occur in the salivary, lacrimal and pituitary glands, in the head and neck region. The nasal cavity is an extremely rare site of involvement of IgG4-related sclerosing disease. Herein is reported a case of multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septum. A 73-year-old Japanese man presented with nasal obstruction and tumors of the right maxillary sinus and parotid gland were detected, after which resections of these tumors were performed. One year aft...
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Mitsuaki Ishida, Machiko Hotta, Ryoji Kushima, Masayuki Shibayama, Takeshi Shimizu, Hidetoshi Okabe Tags: Case Reports Source Type: journals

Spontaneous regression of primary breast lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Described herein is a case of primary breast lymphoma (PBL) that underwent spontaneous regression (SR). A 71-year-old woman visited hospital because of the rapid growth of a tumor in her left breast. On imaging, including magnetic resonance imaging (MRI), a discrete solid nodule was detected, which suggested malignant tumor. Histology of the following core needle biopsy (CNB) specimen indicated diffuse large B-cell lymphoma (DLBCL). The patient had no past history of lymphoma and there was no evidence of systemic lymph nodes enlargement. After CNB, however, the patient noticed that her breast nodule gradually decreased in ...
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Masafumi Oya, Minako Hirahashi, Miho Ochi, Mitsunori Hashimoto, Koichi Ohshima, Masahiro Kikuchi, Masazumi Tsuneyoshi Tags: Case Reports Source Type: journals

Medullary thyroid carcinoma with poor differentiation and atypical radiographic pattern of metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A diagnosis of sporadic medullary thyroid carcinoma (MTC) is complicated. On first diagnosis it may present with distant metastasis. There has been inconsistency regarding metastatic MTC tissue expression of calcitonin, its tumor marker. Adding to the difficulty is the fact that the radiographic pattern of pulmonary metastasis from MTC may vary substantially among patients. Herein is reported the case of a 73-year-old man who presented with two ill-defined pulmonary opacities, clinically resembling primary lung carcinoma. MTC was diagnosed on histopathology of tissue obtained from a total thyroidectomy. The pulmonary biops...
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Wei-Wen Hung, Chuan-Sheng Wang, Kun-Bow Tsai, Fu Ou-Yang, Shyi-Jang Shin, Pi-Jung Hsiao Tags: Case Reports Source Type: journals

Simple cysts of testis with immunohistochemical evidence of mesothelial originEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Simple cysts of the testis are an uncommon lesion found in adults as well as infants. Only a few histological and immunohistochemical studies for this lesion have been reported because the lesion have rarely undergone surgical excision or histological confirmation. Herein is reported an autopsy case of simple cysts of the right testis found incidentally in an 84-year-old man who died of hepatocellular carcinoma. The cysts were multilocular, 12 × 8 mm in size, separated from the tunica albuginea and filled with transparent and colorless serous fluid. Histology and immunohistochemistry showed that the cystic lesion had flat...
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Satoshi Kuwamoto, Keisuke Okuno, Masako Kato, Kazuhiko Hayashi Tags: Case Reports Source Type: journals

Perivascular epithelioid cell tumor (PEComa) of the pancreas: Immunoelectron microscopy and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A perivascular epithelioid tumor (PEComa) is a rare tumor probably arising from the perivascular epithelioid cells. Only three cases of pancreatic PEComa have been reported in the English-language literature. The present report describes an extremely rare case of pancreatic PEComa. A 47-year-old Japanese woman complained of lower abdominal pain and a well-demarcated solid tumor was found in the pancreatic head. There was no history of tuberous sclerosis complexes. Pylorus-preserving pancreaticoduodenectomy was thus performed. There was a well-demarcated, solid tumor measuring 17 mm in the pancreatic head. The tumor was com...
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Kenichi Hirabayashi, Naoya Nakamura, Hiroshi Kajiwara, Sadaaki Hori, Yoshiaki Kawaguchi, Tomohiro Yamashita, Shoichi Dowaki, Toshihide Imaizumi, Robert Y. Osamura Tags: Case Reports Source Type: journals

Primary urothelial carcinoma of the upper tract: Important clinicopathological factors predicting bladder recurrence after surgical resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, male patients and those with high-grade and papillary UUT-UC, and who received LNU had higher risks of urinary bladder recurrence. Accordingly, for these patients, more intensive follow up coupled with postoperative intravesical adjuvant therapy to prevent urinary bladder recurrence should also be considered. (Source: Pathology International)
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Wen-Wei Huang, Hsuan-Ying Huang, Alex C. Liao, Yow-Ling Shiue, Hsiu-Lun Tai, Chun-Mao Lin, Yu-Hui Wang, Ching-Nan Lin, Kun-Hung Shen, Chien-Feng Li Tags: Original Articles Source Type: journals

Immunohistochemistry of IgG4 can help subclassify Hashimoto's autoimmune thyroiditisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, immunostaining of IgG4 can help subclassify Hashimoto's thyroiditis; and IgG4 thyroiditis may have a close relationship with IgG4-related sclerosing disease. (Source: Pathology International)
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Yaqiong Li, Yanhua Bai, Zhiyan Liu, Takashi Ozaki, Emiko Taniguchi, Ichiro Mori, Koji Nagayama, Hirotoshi Nakamura, Kennichi Kakudo Tags: Original Articles Source Type: journals

Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Macrophage polarization is divided into M1 and M2 type based on membrane receptors, cytokines, and chemokines. M1 expresses CD80, interleukin (IL)-6, IL-12, and chemokine receptor (CCR)7, while M2 expresses CD163, IL10, and chemokine ligand (CCL)22. The aim of the present study was to identify the properties of infiltrating tissue macrophages in histiocytic necrotizing lymphadenitis (HNL). Twenty patients with HNL were studied, and immunohistochemistry for CD68 (KP1), CD163, CCL22, CCR7, and CD123 was done, along with myeloperoxidase (MPO). To evaluate the phenotypes of tissue macrophages in HNL, the number of cells staine...
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Yuko Nomura, Masanori Takeuchi, Shiro Yoshida, Yasuo Sugita, Daisuke Niino, Yoshizo Kimura, Kei Shimizu, Ryosuke Aoki, Nobuko Suefuji, Shinichi Hirose, Masahiro Kikuchi, Koichi Ohshima Tags: Original Articles Source Type: journals

Increased cytoplasmic S100A6 expression is associated with pulmonary adenocarcinoma progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
S100A6 is a calcium-binding protein implicated in many cellular processes and frequently upregulated in cancer. Recently it was reported that S100A6 is one of the genes having higher expression in adenocarcinoma mixed subtype with a bronchioloalveolar carcinoma (BAC) component than in pure BAC. To clarify the association of S100A6 expression with stepwise progression of lung adenocarcinoma, S100A6 protein expression was examined on immunohistochemistry in 92 formalin-fixed and paraffin-embedded lung adenocarcinomas. Both the nucleus and cytoplasm of the tumor cells were stained, and the nuclear and cytoplasmic expression o...
Source: Pathology International - August 12, 2009 Category: Pathology Authors: Aya Ishii, Meguri Suzuki, Kaishi Satomi, Hiromi Kobayashi, Shingo Sakashita, Junko Kano, Yihua Pei, Yuko Minami, Shigemi Ishikawa, Masayuki Noguchi Tags: Original Articles Source Type: journals

Molecular pathology of early stage chemically induced hepatocarcinogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the early stage of chemically induced hepatocarcinogenesis, rare hepatocytes are transformed into preneoplastic hepatocytes, which progressively evolve into cells with increasing neoplastic phenotypes. Preneoplastic hepatocytes have gene expression different from normal hepatocytes, presumably from the outset. Some of these gene products are related to the growth and survival of the preneoplastic hepatocytes themselves, while others seem to involve the interaction of preneoplastic hepatocytes with non-parenchymal cell components (paracrine mechanism). Carcinogen treatment, in contrast, usually causes chronic liver injur...
Source: Pathology International - July 31, 2009 Category: Pathology Authors: Katsuhiro Ogawa Tags: Review Article Source Type: journals

Pathology of soft-tissue tumors: Daily diagnosis, molecular cytogenetics and experimental approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews problems in diagnostic pathology and molecular cytogenetics of soft-tissue tumors. Also discussed are the origin of soft-tissue sarcomas and the molecular basis of effective target therapy for sarcomas. Molecular cytogenetic analysis of tumor-specific chromosomal translocations and associated fusion gene transcripts offers a useful adjunct to the diagnosis of soft-tissue tumors, but recent studies have indicated a growing number of fusion gene variations in each tumor type. In pleomorphic sarcoma/malignant fibrous histiocytoma, the alternative lengthening of telomeres (ALT) mechanism may result in form...
Source: Pathology International - July 15, 2009 Category: Pathology Authors: Hiroshi Iwasaki, Kazuki Nabeshima, Jun Nishio, Shiro Jimi, Mikiko Aoki, Kaori Koga, Makoto Hamasaki, Hiroyuki Hayashi, Ai Mogi Tags: Review Article Source Type: journals

Primary small cell neuroendocrine carcinoma of the female urethraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pathology International)
Source: Pathology International - July 13, 2009 Category: Pathology Authors: Koo Han Yoo, Gou Young Kim, Tae Gu Kim, Gyeong Eun Min, Hyung-Lae Lee Tags: Letters to the Editor Source Type: journals

Secondary aortoduodenal fistula caused on the suture line of the wrappingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pathology International)
Source: Pathology International - July 13, 2009 Category: Pathology Authors: Sayaka Tanaka, Natsuhiko Kameda, Yuki Kubo, Naoko Obatake, Tomoko Wakasa, Masahiko Ohsawa, Kenichi Wakasa Tags: Letters to the Editor Source Type: journals

Clear cell carcinoma of the lower urinary tract in a male patient. Presentation and update on histogenesis and managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pathology International)
Source: Pathology International - July 13, 2009 Category: Pathology Authors: Stavros I. Tyritzis, Ioannis Anastasiou, Andreas Petrolekas, Aristoteles Alevizopoulos, Dionysios Mitropoulos, Constantinos A. Constantinides Tags: Letters to the Editor Source Type: journals