Pathology Oncology ResearchThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5 6 7

307 records returned

Comparison of Beta-catenin with TGF-beta1, HIF-1alpha and Patients' Disease-free Survival in Human Colorectal Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Beta-catenin accumulation is suppressed by TGF-beta1 (transforming growth factor beta1) in intestinal epithelium suggesting negative feedback between these two factors. Besides that, beta-catenin interacts with HIF-1alpha (hypoxia-inducible factor-1alpha) at the promoter region of HIF-1 target genes. Our study was aimed at comparison of beta-catenin with HIF-1alpha, TGF-beta1, Ki67 and survival of sporadic colorectal cancer patients. Expressions of beta-catenin, TGF-beta1, HIF-1alpha, Ki67 were evaluated in triads of specimens of each primary tumor of 72 sporadic colorectal cancers with immunohistochemistry due to limi...
Source: Pathology Oncology Research - November 8, 2009 Category: Pathology Authors: Wincewicz A, Koda M, Sulkowski S, Kanczuga-Koda L, Sulkowska M Tags: Pathol Oncol Res Source Type: journals

Immunohistochemical Detection of Phospho-Akt, Phospho-BAD, HER2 and Oestrogen Receptors alpha and beta in Malaysian Breast Cancer Patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study does not support the simple model of linear HER2/PI3K/Akt pathway in breast cancer. PMID: 19882362 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - November 1, 2009 Category: Pathology Authors: Seow HF, Yip WK, Loh HW, Ithnin H, Por P, Rohaizak M Tags: Pathol Oncol Res Source Type: journals

SDF1-3'A Gene Polymorphism is Associated with Laryngeal Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The SDF1-3' G801A (rs 1801157) polymorphism is associated with increased risk of various types of cancers, including those of the neck and head. Using PCR-RFLPs, we investigated the distribution of SDF1-3' G801A genotypes in patients with laryngeal cancer (n = 118) and controls (n = 250) in Poland. We found that patients with SDF1-3' A/A and G/A genotypes exhibit a 1.863-fold increased risk of laryngeal cancer (95% CI = 1.177-2.949, p = 0.0086). However, there was no significant increase in risk for the homozygous SDF1-3' A/A genotype OR = 3.235 (95% CI = 0.5330-19.633, p = 0.3329). We also did not observe a significan...
Source: Pathology Oncology Research - October 15, 2009 Category: Pathology Authors: Kruszyna L, Lianeri M, Rydzanicz M, Szyfter K, Jagodziński PP Tags: Pathol Oncol Res Source Type: journals

Pim-2 Activates API-5 to Inhibit the Apoptosis of Hepatocellular Carcinoma Cells Through NF-kappaB Pathway.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pim-2 is proved to be relevant to the tumorigenesis of hepatocellular carcinoma (HCC), but the mechanism is unclear. We studied the relationship among Pim-2, NF-kappaB and API-5. In our experiment, expression level of the three factors and phosphorylation level of API-5, as well as NF-kappaB activity, were detected in HCC tissues and the nontumorous controls. Then Pim-2 gene was transfected into nontumorous liver cells L02, and Pim-2 SiRNA was transfected into hepatoblastoma cell line HepG2. Parthenolide was added as NF-kappaB inhibitor. The same detections as above were repeated in the cells, along with the apoptosis ...
Source: Pathology Oncology Research - October 11, 2009 Category: Pathology Authors: Ren K, Zhang W, Shi Y, Gong J Tags: Pathol Oncol Res Source Type: journals

Serum Vascular Endothelial Growth Factors A, C and D in Human Breast Tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Available evidence suggests that vascular endothelial growth factor (VEGF) a potent regulator of vasculogenesis and tumor angiogenesis may be a predictor of recurrence in breast cancer patients. We sought to determine whether VEGF serum levels (VEGF-A, VEGF-C and VEGF-D) in 377 patients with malignant and benign breast tumors differ and whether there is association between vascular growth factors, clinicopathologic features and prognosis. There was no significant difference in investigated circulating angiogenic markers between patients with malignant and non malignant lesions. We found strong correlation between VEGF-...
Source: Pathology Oncology Research - October 10, 2009 Category: Pathology Authors: Gisterek I, Matkowski R, Lacko A, Sedlaczek P, Szewczyk K, Biecek P, Halon A, Staszek U, Szelachowska J, Pudelko M, Bebenek M, Harlozinska-Szmyrka A, Kornafel J Tags: Pathol Oncol Res Source Type: journals

Impact of Tumor Angiogenesis in Peritoneal Mesothelioma After Radical Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peritoneal mesothelioma is one of the peritoneal surface malignancies where long-term survival is a reality after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Tumor angiogenesis has been shown to be of prognostic significance on survival in mesothelioma. We investigated the impact of survival of patients with peritoneal mesothelioma following CRS and HIPEC to determine the impact of tumor angiogenesis on survival after this radical surgical treatment. Paraffin sections of 23 patients who were treated with CRS and HIPEC were retrieved for immunohistochemical analysis. The immunostai...
Source: Pathology Oncology Research - September 30, 2009 Category: Pathology Authors: Chua TC, Yao P, Akther J, Morris DL Tags: Pathol Oncol Res Source Type: journals

Chemo-radiotherapy in Locally Advanced Squamous Cell Oesophageal Cancer-are Upper Third Tumours more Responsive?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Before neoadjuvant therapy was widely applied, the prognosis of oesophageal cancer had been considered dependent on the location of the tumor, i.e. upper third cancers had had the worst prognosis. The aim of this retrolective study was to prove the efficiency of the neoadjuvant treatment, and to compare the response of esophageal cancer in different locations. Between January 1998 and September 2005, 102 patients with locally advanced squamous cell oesophageal cancer received preoperative chemo-radiotherapy. In 40 cases the tumor was located in the upper third and in 62 cases in the middle third of the oesophagus. Afte...
Source: Pathology Oncology Research - September 16, 2009 Category: Pathology Authors: Papp A, Cseke L, Farkas R, Pavlovics G, Horvath G, Varga G, Szigeti A, Bellyei S, Marton S, Poto L, Kalmar K, Vereczkei A, Pozsgai E, Horvath OP Tags: Pathol Oncol Res Source Type: journals

The Role of VE-cadherin in Osteosarcoma Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Osteosarcoma cells can generate vasculogenic-like, patterned networks to obtain nutrients and oxygen, which mimic some function of endotheial-like cells and facilitate tumor malignant progress. These cells also express vascular endothelial-cadherin (VE-cadherin), which is generally accepted as a strictly endothelial-specific transmembrane protein. However, its role is still relatively obscure in osteosarcoma cells. So we inhibit the VE-cadherin gene expression with siRNA in osteosarcoma cells (MG63), and culture those cells in three-dimensional medium, containing Type I collagen or Matrigel, to observe the role of VE-c...
Source: Pathology Oncology Research - September 16, 2009 Category: Pathology Authors: Zhang LZ, Mei J, Qian ZK, Cai XS, Jiang Y, Huang WD Tags: Pathol Oncol Res Source Type: journals

IFN Gamma Gene Polymorphism May Contribute to the Susceptibility to CLL.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The pathogenesis of B-cell chronic lymphocytic leukemia (B-CLL) has been linked with the production and activity of certain growth factors. However a significant proportion of CLL patients display immune abnormalities suggestive of aberrant cytokine secretion and/or response. In contrast to B lymphocytes, T cells of B-CLL patients characterise with the increased production of interferon-gamma (IFN-gamma) and this cytokine has been indicated to prevent malignant cells from entering apoptosis including the slowly expanding population of CD5+ B cells that characterizes chronic lymphocytic leukemia. The aim of the present ...
Source: Pathology Oncology Research - September 14, 2009 Category: Pathology Authors: Urbanowicz I, Mazur G, Stacherzak-Pawlik J, Bogunia-Kubik K, Wróbel T, Woźniak M, Kuliczkowski K Tags: Pathol Oncol Res Source Type: journals

Association Between Histological Type of Tumour Growth and Patient Survival in T2-T3 Lymph Node-Negative Rectal Cancer Treated with Sphincter-Preserving Total Mesorectal Excision.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For rectal cancer patients without nodal metastases the identification of unfavourable factors can be helpful for the better selection for adjuvant therapy and multimodality treatment. The aim of this study was to evaluate the impact of clinico-histological parameters on prognosis in node-negative rectal cancer patients. One hundred and thirty-nine consecutive node negative rectal cancer patients with complete five-year follow-up were studied prospectively. All of them underwent curative anterior resection with total mesorectal excision technique. Seventy-eight patients with tumour penetration beyond the bowel wall rec...
Source: Pathology Oncology Research - September 14, 2009 Category: Pathology Authors: Szynglarewicz B, Matkowski R, Halon A, Lacko A, Stepien M, Forgacz J, Pudelko M, Kornafel J Tags: Pathol Oncol Res Source Type: journals

Effect of Liver Steatosis on Therapeutic Response in Chronic Hepatitis C Virus Genotype 1 Infected Patients in Hungary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatic steatosis seems a frequent histological alteration seen in chronic hepatitis C virus infected patients. There is still a lot to learn about the exact mechanism of effect of liver steatosis and its influence on the progression of liver diseases. Our study involved 96 chronic hepatitis C genotype 1 infected Hungarian patients who received pegylated interferon and ribavirin treatment for the first time. Degree of steatosis, viral and host factors influencing its development and its effect on the efficiency of antiviral treatment were determined. In 61 (64%) of patients the liver tissue showed varying degree of ste...
Source: Pathology Oncology Research - September 14, 2009 Category: Pathology Authors: Werling K, Schaff Z, Dinya E, Tulassay Z Tags: Pathol Oncol Res Source Type: journals

Is Predisposition for Nephroblastoma Linked to Polymorphisms of the WTX Gene?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inactivation of Wilms tumor X (WTX) gene has been linked to the pathogenesis of a varying percentage of nephroblastomas. In contrast, germline mutations of WTX were identified to cause bone dysplasia, but not to induce the development of nephroblastomas. In our study we investigated whether tumor promotion of nephroblastoma by inactivation of WTX gene is linked to certain single nucleotide polymorphisms (SNPs). Therefore 8 SNPs-distributed over the whole length of the WTX gene-were investigated by high resolution melting curve analysis (HRMA) and sequencing of genomic DNA from nephroblastoma patients (NB) and controls....
Source: Pathology Oncology Research - September 12, 2009 Category: Pathology Authors: Guertl B, Leuschner I, Guelly C, Ebner B, Kronberger C, Hoefler G Tags: Pathol Oncol Res Source Type: journals

Neoadjuvant Chemotherapy: Does It Have Benefits for the Surgeon in the Treatment of Advanced Squamous Cell Cancer of the Oral Cavity?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this clinicopathological study was to evaluate the effects and efficiency of combined neoadjuvant chemotherapy related to surgical margin. 100 consecutively treated squamous cell cancer patients receiving a combined neoadjuvant therapy were selected (Bleomycin-Vincristin-Methotrexate (BVM) or BVM + Mitolactol or BVM + Cisplatin). After three courses of chemotherapy, the patients were operated on. The largest diameter of the primary tumors was compared before and after chemotherapy. In the surgical specimen, the involvement of surgical margin was assessed. The largest diameter before chemotherapy was: T2 ...
Source: Pathology Oncology Research - September 11, 2009 Category: Pathology Authors: Olasz L, Szalma J, Orsi E, Tornóczky T, Markó T, Nyárády Z Tags: Pathol Oncol Res Source Type: journals

Expression and Prognostic Value of PRL-3 in Human Intrahepatic Cholangiocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we assessed the expression levels of PRL-3 by immunohistochemistry in 102 primary ICC samples, 62 matched lymph node metastases (LNM) and 102 adjacent normal liver tissues. Then we investigated the relationship between PRL-3 expression and clinicopathologic factors. Survival analysis was performed to determine the prognostic significance of PRL-3 expression in ICC. Immunochemistry results suggested PRL-3 expression was negative or weak in non-neoplastic intrahepatic bile ducts of adjacent liver tissue. In primary lesion and LNM high PRL-3 expression was frequently detected. Furthermore, the rate of high PRL-...
Source: Pathology Oncology Research - September 8, 2009 Category: Pathology Authors: Xu Y, Zhu M, Zhang S, Liu H, Li T, Qin C Tags: Pathol Oncol Res Source Type: journals

Clusterin as a Diagnostic and Prognostic Marker for Transitional Cell Carcinoma of the Bladder.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the feasibility of profiling and measuring the concentration of clusterin in urine and serum for individuals with transitional cell carcinoma (TCC) of the bladder and comparing it with nontumor controls. In addition, we analyzed the correlation of expression of clusterin in specimens of TCC to various clinicopathologic parameters and prognosis of bladder cancer. Blood and urine samples were used from 68 patients with TCC of the bladder and from 61 patients with benign urological diseases. Enzyme-linked immunosorbent assays (ELISA) were performed for clusterin from serum and urine. Quantitation of cluste...
Source: Pathology Oncology Research - September 8, 2009 Category: Pathology Authors: Hazzaa SM, Elashry OM, Afifi IK Tags: Pathol Oncol Res Source Type: journals

The Effect of LMWH (Nadroparin) on Tumor Progression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent clinical studies on patients with malignancies, who were treated with UHF and LMWHs raised the possibility, that these agents may possess an inhibitory effect on tumor progression. Further studies supported that this effect is independent from the anticoagulant and antithrombotic action. In this retrospective study oncological patients with an increased risk for thromboembolism were choosen, who received prophylactic treatment with an LMWH (nadroparin) at least for 6 months. Comparing with the control group, in some subgroups (T3 and T4, as well as M1) the LMWH-treated patients showed a significantly increased s...
Source: Pathology Oncology Research - September 7, 2009 Category: Pathology Authors: Nagy Z, Turcsik V, Blaskó G Tags: Pathol Oncol Res Source Type: journals

Proximal-Type Epithelioid Sarcoma in the Groin Presenting as a Diagnostic Dilemma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of proximal-type epithelioid sarcoma that presented as an inguinal mass in a 47-year-old man. Histologically, the tumor consisted of diffuse sheets of epithelioid cells with scattered rhabdoid morphology. By immunohistochemistry, the neoplastic cells expressed cytokeratin, epithelial membrane antigen, vimentin, CD34, CD99 and showed complete loss of nuclear INI1 protein expression. Fluorescence in situ hybridization was considered borderline for 22q deletion. We present this case to emphasize the importance of diagnosing this uncommon tumor and the role of INI1 immunohistochemistry in establishing the diag...
Source: Pathology Oncology Research - September 7, 2009 Category: Pathology Authors: Mannan AA, Rifaat AA, Kahvic M, Kapila K, Mallik M, Grover VK, Bharati C, Perry A Tags: Pathol Oncol Res Source Type: journals

Chromosomal Integration of the HHV-6 Genome as a Possible Cause of Persistent HHV-6 Detection in a Patient with Langerhans Cell Histiocytosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19731091 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - September 3, 2009 Category: Pathology Authors: Strenger V, Urban C Tags: Pathol Oncol Res Source Type: journals

Primitive Testicular Leiomyosarcoma : An Immunohistochemical and Ultrastructural Study with a Review of the Literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe one further case in a 77-years old man with full histological and ultrastructural evaluation. A short term follow-up of one year signals no recurrence of the disease. PMID: 19731088 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - September 2, 2009 Category: Pathology Authors: Raspollini MR, Stomaci N, Ringressi A, Franchi A Tags: Pathol Oncol Res Source Type: journals

A Histochemical Approach to the Diagnosis of Visceral Pleural Infiltration by Non-small Cell Lung Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings support the consequent application of the recently proposed, pragmatic approach of the international staging committee for lung cancer (IASLC) to define an internationally accepted and standardized staging system for VPI. PMID: 19731089 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - September 2, 2009 Category: Pathology Authors: Warth A, Muley T, Herpel E, Pfannschmidt J, Hoffmann H, Dienemann H, Schirmacher P, Schnabel PA Tags: Pathol Oncol Res Source Type: journals

Oxidant/Antioxidant Status, Lipids and Hormonal Profile in Overweight Women with Breast Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, breast cancer is associated with lipid alterations and enhanced oxidative stress linked to high leptin levels in overweight. PMID: 19731090 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - September 2, 2009 Category: Pathology Authors: Badid N, Baba Ahmed FZ, Merzouk H, Belbraouet S, Mokhtari N, Merzouk SA, Benhabib R, Hamzaoui D, Narce M Tags: Pathol Oncol Res Source Type: journals

Ependymoma in Adults: Surgery, Reoperation and Radiotherapy for Survival.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In our experience the use of radiotherapy in adult, intracranial WHO Grade II ependymoma patients had no significant effect on prognosis. Radical surgery and eventual reoperation seems to be more favorable. PMID: 19728165 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 29, 2009 Category: Pathology Authors: Vitanovics D, Bálint K, Hanzély Z, Banczerowski P, Afra D Tags: Pathol Oncol Res Source Type: journals

PPI-Delayed Diagnosis of Gastrinoma: Oncologic Victim of Pharmacologic Success.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Functional neuroendocrine tumors are often low-grade malignant neoplasms that can be cured by surgery if detected early, and such detection may in turn be accelerated by the recognition of neuropeptide hypersecretion syndromes. Uniquely, however, relief of peptic symptoms induced by hypergastrinemia is now available from acid-suppressive drugs such as proton-pump inhibitors (PPIs). Here we describe a clinical case in which time to diagnosis from the onset of peptic symptoms was delayed more than 10 years, in part reflecting symptom masking by continuous prescription of the PPI omeprazole. We propose diagnostic criteria...
Source: Pathology Oncology Research - August 19, 2009 Category: Pathology Authors: Wong H, Yau T, Chan P, Ng IO, Chan G, Hui P, Law WL, Lo CM, Hedley AJ, Epstein RJ Tags: Pathol Oncol Res Source Type: journals

Stereologic Analysis of Tissue Compartments of Gunshot-injured and Blunt-injured Spleen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The spleen is composed of several tissue compartments and the respective histoquantitative data are essential for complete understanding of immune or pathological processes in this organ. The aim of our study was to determine and compare the stereologic parameters of all tissue compartments of the gunshot-injured and blunt-injured human spleen. The model-based stereology with point-counting method was utilized to study the volume densities of red pulp, perifollicular zone, marginal zone, white pulp (follicles and periarteriolar lymphoid sheath), and connective tissue. The areal numerical density (the number of follicle...
Source: Pathology Oncology Research - August 8, 2009 Category: Pathology Authors: Milićević NM, Trbojević-Stanković JB, Drachenberg CB, Milićević Z Tags: Pathol Oncol Res Source Type: journals

Decreased p21 Expression in HPV-18 Positive Cervical Carcinomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to investigate the relationship between different human papillomaviruse (HPV) genotypes and the expression of p53, p21 and p27 in cervical carcinomas. A total of 103 cases of cervical carcinomas were assayed for expression of p53, p21 and p27 by immunohistochemistry. HPV typing was carried out by two polymerase chain reaction-based methods. Overall, HPV prevalence was 97.1% among the cervical carcinomas in this study. HPV-16 was detected in 66% of the tumors, HPV-18 in 7.8%, HPV-16/18 in 7.8% and other HPV types in 15.5%. The expression of p53 and p27 was not related to HPV genotype. However, ...
Source: Pathology Oncology Research - August 5, 2009 Category: Pathology Authors: Huang LW, Seow KM, Lee CC, Lin YH, Pan HS, Chen HJ Tags: Pathol Oncol Res Source Type: journals

A Case of Primary Histiocytic Sarcoma Arising from Thyroid Gland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of HS arising from thyroid gland in a 69 year-old man. Following subtotal thyroidectomy, a histopathologic, immunohistologic, and genotypic examination revealed HS. This tumor was composed of large spindle or round epithelioid cells with abundant eosinophilic cytoplasm. The neoplastic cells were positive for macrophage-associated antigen CD68, CD163, and lysozymes, as well as CD45, HLA- DR, DP, DQ, and S100, most consistent with a diagnosis of HS. The BIOMED-2 multiplex PCR analysis showed polyclonal B- and T-cell populations. To our knowledge, this is the first report of a rare entity HS involving thyroid...
Source: Pathology Oncology Research - August 4, 2009 Category: Pathology Authors: Yu L, Yang SJ Tags: Pathol Oncol Res Source Type: journals

Prognostic Factors and Survival of Renal Clear Cell Carcinoma Patients with Bone Metastases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In our retrospective study the pathological and clinical factors, influencing the survival of 65 renal clear cell carcinoma patients operated for bone metastasis between 1990 and 2008 were examined. Based on Kaplan-Meier curves age, gender, clinical symptoms, pathological fracture, progression to the soft tissues, localization and size of the metastasis, whether the occurrence of multiplex metastases is multiorganic or only located to the skeletal system and the stage and grade of primary renal cancer did not influence the survival. The survival significantly improved if the bone metastases were solitary, low Fuhrman g...
Source: Pathology Oncology Research - July 28, 2009 Category: Pathology Authors: Szendrői A, Dinya E, Kardos M, Szász AM, Németh Z, Ats K, Kiss J, Antal I, Romics I, Szendrői M Tags: Pathol Oncol Res Source Type: journals

Changes of AXIN-1 and Beta-Catenin in Neuroepithelial Brain Tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present study changes of components of Wnt signaling pathway-axin (AXIN1) and beta-catenin (CTNNB1) in a sample of 72 neuroepithelial brain tumors were investigated. AXIN-1 gene was tested by PCR/loss of heterozygosity (LOH). Immunostaining and image analysis revealed the quantity and localization of relevant proteins. Polymorphic marker for AXIN-1, showed LOH in 11.1% of tumors. LOH was distributed to 6.3% of glioblastomas, one was found in neuroepithelial dysembrioplastic tumor and one in medulloblastoma. Down regulation of axin expression and up regulation of beta-catenin were detected in the analyzed tumors....
Source: Pathology Oncology Research - July 24, 2009 Category: Pathology Authors: Nikuševa Martić T, Pećina-Šlaus N, Kušec V, Kokotović T, Mušinović H, Tomas D, Zeljko M Tags: Pathol Oncol Res Source Type: journals

Effects of the Inhibition of Cyclooxygenase-2 on Human Esophageal Cancer Cells: Inhibition of Cell Proliferation and Induction of Apoptosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cyclooxygenase-2 (COX-2) has been shown to be upregulated in a variety of tumors so that COX-2 may be a potential target in the treatment of cancer. In order to further explore the mechanism, we used RNA interference to study effects of the inhibition of COX-2 on esophageal squamous cell carcinoma (ESCC) lines. Western blot analysis demonstrated that COX-2 expression was significantly reduced in ESCC cells treated with the COX-2-specific siRNA. Furthermore, the COX-2 siRNA treatment inhibited cell proliferation and induced apoptosis in ESCC cells. In addition, the combination treatment of COX-2 siRNA and acidum acetil ...
Source: Pathology Oncology Research - July 24, 2009 Category: Pathology Authors: Zhang L, Tu J, Yu ZL, Wu YD, Xu CM, Zhang ST Tags: Pathol Oncol Res Source Type: journals

Expression of Matrix Metalloproteinase 2 and Extracellular Matrix Metalloproteinase Inducer are Unfavorable Postoperative Prognostic Factors in Intrahepatic Cholangiocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many investigators have indicated that overexpression and amplification of matrix metalloproteinase 2 (MMP-2) and extracellular matrix metalloproteinase inducer (EMMPRIN) are independent prognostic factors for primary tumors. We studied expression of them in tissues from intrahepatic cholangiocarcinoma (IHCCA) and normal bile ducts, and discussed the occurrence and development of IHCCA. Another goal was to explore possible association of MMP-2 and EMMPRIN with clinicopathologic parameters and prognosis of IHCCA. MMP-2 and EMMPRIN expression in 106 cases of IHCCA tissues and 15 cases of normal bile ducts were examined b...
Source: Pathology Oncology Research - July 24, 2009 Category: Pathology Authors: Zhang C, Tu Z, Du S, Wang Y, Wang Q Tags: Pathol Oncol Res Source Type: journals

Comparison of Osteopontin, beta-catenin and hnRNP B1 Expression in Lung Carcinomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was performed to compare osteopontin (OPN), beta-catenin and heterogeneous nuclear ribonucleoprotein B1 (hnRNP B1) immunreactivities in small cell lung carcinomas (SCLC) and non-small cell lung carcinomas (NSCLC). Correlation of these three antibodies with grade and clinicopathologic stage of the tumor in NSCLC was also investigated. Twenty-nine SCLC, 6 large cell carcinoma, 36 adenocarcinoma and 30 squamous cell carcinoma (SCC), totally 101 cases, were included in this study. OPN, beta-catenin and hnRNP B1 expressions were immunohistochemically evaluated. OPN positivity was 6.9% in SCLC and 67% in NSCLC. When N...
Source: Pathology Oncology Research - July 16, 2009 Category: Pathology Authors: Guldur ME, Kıbar Y, Denız H, Bakır K Tags: Pathol Oncol Res Source Type: journals

HER2/neu Expression: A Predictor for Differentiation and Survival in Children With Wilms Tumor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wilms tumor is a mixed embroynal neoplasm of the kidney . HER2 is an onco-protein. Its over-expression could be implicated in the development of many tumors. The clinico-demographic and pathological data of 28 Wilms tumor patients were , reviewed. The tissue samples were examined by light Microscopy then immunohistochemical staining for HER2/neu expression. Additional 28 normal surrounding renal tissue specimens were included. There was significant differences between HER2/neu positive and HER2/neu negative Wilms tumors in relation to stage, histological phase and epithelial differentiation (P > 0.05 for all). The o...
Source: Pathology Oncology Research - July 16, 2009 Category: Pathology Authors: Ragab SM, Samaka RM, Shams TM Tags: Pathol Oncol Res Source Type: journals

Nasal-type NK/T-cell Lymphoma with Palatal Ulcer as the Earliest Clinical Manifestation: A Case Report with Literature Review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Extranodal nasal natural killer (NK)/T-cell lymphoma is a very rare kind of lymphoma, Oral cavity involvement of extranodal natural killer/T-cell lymphoma, nasal type is extremely rare, and its clinicopathologic features are also poorly understood. Recently, we experienced an unusual case of Epstein-Barr virus-associated, extranodal NK/T-cell type with a unhealed palatal ulcer as the earliest clinical feature. It is a challenge for oral medicine specialists to make the early diagnosis for this special type of tumor. PMID: 19590983 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - July 10, 2009 Category: Pathology Authors: Meng W, Zhou Y, Zhang H, Jiang L, Wang Z, Li X, Zhou H, Chen Q, Zeng X Tags: Pathol Oncol Res Source Type: journals

Primary Large Cell Neuroendocrine Carcinoma of the Kidney.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 56-year-old male with a primary large cell neuroendocrine renal carcinoma. Grossly, the left kidney was enlarged by a solid tumor that measured 145 x 125 x 100 mm. Histologically, the tumor consisted of large cells with a moderate to abundant amount of eosinophilic cytoplasm. The nuclei were irregular, some of them with finely or coarsely granular chromatin, others with vesicular chromatin and prominent nucleoli. The tumor cells showed multiple mitotic figures (up to 32 mitoses/10 HPF). In some areas, the tumor cells were arranged in solid sheets; however, the predominant pattern was solid-alveolar, t...
Source: Pathology Oncology Research - July 6, 2009 Category: Pathology Authors: Dundr P, Pešl M, Povýšil C, Bauerová L, Soukup V Tags: Pathol Oncol Res Source Type: journals

High Expression of Claudin-1 Protein in Papillary Thyroid Tumor and its Regional Lymph Node Metastasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we aimed at determining the pattern of claudin-1 expression in various types of thyroid lesions at the protein level and investigating the immunolocalization of beta-catenin reported to regulate claudin-1 expression. Samples included 19 PTCs, ten cases of corresponding regional lymph node metastasis, eight papillary microcarcinomas (PMC), 17 follicular thyroid carcinomas (FTC) and 19 follicular adenomas (FA). All cases were evaluated by quantitative immunohistochemistry. Conspicuous claudin-1 immunostaining was detected in the majority of PTC/PMC primary tumors and lymph node metastases (19/27 and 9/10, resp...
Source: Pathology Oncology Research - July 4, 2009 Category: Pathology Authors: Németh J, Németh Z, Tátrai P, Péter I, Somorácz A, Szász AM, Kiss A, Schaff Z Tags: Pathol Oncol Res Source Type: journals

The Possible Role of Isolated Lymphoid Follicles in Colonic Mucosal Repair.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The continuous reformation and rapid repair of the colonic mucosa is essential for avoiding the aggregation of pernicious mutations induced by bacterial, toxic, or mitogenic factors. Gut-associated lymphoid tissue is supposed to play a central role in the organization of the repair mechanisms. In inflammatory conditions, the number, the diameter and the density of isolated lymphoid follicles (ILFs) are increasing. They are involved not just in immune surveillance, but their presence is also indispensable in normal mucosal regeneration of the colon. The relation of ILFs to the components of mucosal renewal such as bone ...
Source: Pathology Oncology Research - June 25, 2009 Category: Pathology Authors: Sipos F, Műzes G, Galamb O, Spisák S, Krenács T, Tóth K, Tulassay Z, Molnár B Tags: Pathol Oncol Res Source Type: journals

Reduced APRIL Expression Induces Cellular Senescence via a HSPG-Dependent Pathway.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we analyzed APRIL and HSPG expression in the colon carcinoma cell line, SW480 by Western blot and RT-PCR. And the up-regulation of APRIL and HSPG expression was found in SW480. We also observed that knockdown of APRIL levels in SW480, prominently reversed cell proliferation and partially resulted in senescence phenotypes. Furthermore, cellular senescence due to a decreased level of APRIL expression was associated with engagement of HSPG. Thus, our results suggest that low levels of APRIL play an essential role in cellular senescence via a HSPG-dependent signaling pathway in SW480. PMID: 19466596 [PubMed ...
Source: Pathology Oncology Research - May 25, 2009 Category: Pathology Authors: Ding W, Ju S, Jiang S, Zhu L, Wang Y, Wang H Tags: Pathol Oncol Res Source Type: journals

Expression and Methylation Pattern of p16 in Neuroblastoma Tumorigenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study included 23 cases (11 male; 12 female) and 31 samples from archival paraffin embedded tissues. P16 was studied in 5 samples of normal adrenal medullar tissue, 5 samples of adrenal tissue including blastic rests, 5 samples of neuroblastoma in situ tissue and in 8 samples of neuroblastoma tissues primary and after chemotherapy in each group. The adrenal gland tissues were obtained from paediatric autopsy cases. Expression of p16 was searched by immunohistochemistry. Methylation specific PCR was used to detect the methylation rate of p16. The age range of autopsy cases was between 20 weeks of foetal age and 36 mont...
Source: Pathology Oncology Research - May 22, 2009 Category: Pathology Authors: Aktas S, Celebiler AC, Zadeoğluları Z, Diniz G, Kargı A, Olgun N Tags: Pathol Oncol Res Source Type: journals

Diagnostic Concordance in Reporting Breast Needle Core Biopsies using the B Classification-A Panel in Italy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The widespread implementation of mammography screening has resulted in an increased frequency of needle core biopsies (NCB). The aim of this study was that of evaluating the diagnostic reproducibility on breast NCB, according to the B-classification, among several pathologists from different Italian regions. Fifty single slides of NCBs performed for non palpable breast lesions were selected to evaluate the diagnostic reproducibility, according to the B classification, among 31 pathologists from different Italian areas, involved in the pathologic diagnosis of screen-detected breast lesions. According to the study majori...
Source: Pathology Oncology Research - May 16, 2009 Category: Pathology Authors: Bianchi S, Caini S, Cattani MG, Vezzosi V, Biancalani M, Palli D Tags: Pathol Oncol Res Source Type: journals

Predicting Non-Sentinel Lymph Node Status After Positive Sentinel Biopsy in Breast Cancer: What Model Performs the Best in a Czech Population?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several models have previously been proposed to predict the probability of non-sentinel lymph node (NSLN) metastases after a positive sentinel lymph node (SLN) biopsy in breast cancer. The aim of this study was to assess the accuracy of two previously published nomograms (MSKCC, Stanford) and to develop an alternative model with the best predictive accuracy in a Czech population. In the basic population of 330 SLN-positive patients from the Czech Republic, the accuracy of the MSKCC and the Stanford nomograms was tested by the area under the receiver operating characteristics curve (AUC). A new model (MOU nomogram) was ...
Source: Pathology Oncology Research - May 14, 2009 Category: Pathology Authors: Coufal O, Pavlík T, Fabian P, Bori R, Boross G, Sejben I, Maráz R, Koča J, Krejčí E, Horáková I, Foltinová V, Vrtělová P, Chrenko V, Eliza Tekle W, Rajtár M, Svébis M, Fait V, Cserni G Tags: Pathol Oncol Res Source Type: journals

Post-Translational Regulation of Cathepsin B, but not of Other Cysteine Cathepsins, Contributes to Increased Glioblastoma Cell Invasiveness In Vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cells that migrate away from a central tumour into brain tissue are responsible for inefficient glioblastoma treatment. This migratory behaviour depends partially on lysosomal cysteine cathepsins. Reportedly, the expression of cathepsins B, L and S gradually increases in the progression from benign astrocytoma to the malignant glioblastoma, although their specific roles in glioma progression have not been revealed. The aim of this study was to clarify their specific contribution to glioblastoma cell invasion. The differences between the matrix invading cells and non-invading core cells from spheroids derived from gliob...
Source: Pathology Oncology Research - May 12, 2009 Category: Pathology Authors: Gole B, Durán Alonso MB, Dolenc V, Lah T Tags: Pathol Oncol Res Source Type: journals

Overexpression of Caveolin-1 in Hepatocellular Carcinoma with Metastasis and Worse Prognosis: Correlation with Vascular Endothelial Growth Factor, Microvessel Density and Unpaired Artery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Caveolin-1 is the major structural protein in caveolae, implicated in oncogenesis and angiogenesis. The connections between caveolin-1 and progression and angiogenesis of hepatocellular carcinoma (HCC) is still not clear. Thus we investigated the relationship of caveolin-1 expression, vascular endothelial growth factor (VEGF) expression, microvessel density (MVD), and unpaired artery (UA) with the clinicopathologic features of patients with HCC. Formalin-fixed, paraffin-embedded tissue sections of HCC from 75 patients who had undergone an initial hepatectomy were stained immunohistochemically with specific antibodies a...
Source: Pathology Oncology Research - May 11, 2009 Category: Pathology Authors: Zhang ZB, Cai L, Zheng SG, Xiong Y, Dong JH Tags: Pathol Oncol Res Source Type: journals

Differential Expression of Notch Family Members in Astrocytomas and Medulloblastomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Notch signaling pathway plays an integral role in determining cell fates in development. Growing evidence demonstrates that Notch signaling pathway has versatile effects in tumorigenesis depending on the tumor type, grade and stage. Notch signaling pathway is deregulated in some brain tumors. To examine the differential expression of Notch family members (Notch1, 2, 3, 4) in human astrocytomas and medulloblastomas, and to evaluate their roles in the development of both tumor types. Immunohistochemical staining and Western blot analysis were used to detect Notch1, 2, 3, 4 expression in tissue microarray and freshly rese...
Source: Pathology Oncology Research - May 7, 2009 Category: Pathology Authors: Xu P, Yu S, Jiang R, Kang C, Wang G, Jiang H, Pu P Tags: Pathol Oncol Res Source Type: journals

The Expression and Prognosis of FOXO3a and Skp2 in Human Hepatocellular Carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the role of FOXO3a and Skp2 in human hepatocellular carcinoma progression. Immunohistochemical analysis was performed on formalin-fixed paraffin sections of 91 specimens. Furthermore in vitro, western-blot analysis and protein stabilization studies were used to study the relationship between FOXO3a and Skp2. We found that the expression of FOXO3a was negatively related with Skp2 expression (r = -0.583; p < 0.05) and FOXO3a expression correlated significantly with histological grade (p = 0.000), cirrhosis (p = 0.015), and tumor size (p = 0.043) while Skp2 expression correlated significantly...
Source: Pathology Oncology Research - April 29, 2009 Category: Pathology Authors: Lu M, Ma J, Xue W, Cheng C, Wang Y, Zhao Y, Ke Q, Liu H, Liu Y, Li P, Cui X, He S, Shen A Tags: Pathol Oncol Res Source Type: journals

Differential Expression of Ki-67 and Sex Steroid Hormone Receptors Between Genders in Peritoneal Mesothelioma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gender influence on survival in mesothelioma has been observed in several large clinical series. However, this gender effect has not been investigated. Female patients often have less aggressive tumors and survive longer. However, few studies in the literature have explained the molecular basis of this finding. Understanding this difference at a molecular level may offer the hope of improving survival via hormonal manipulation.We investigate the expression of Ki-67 and sex steroid receptors; estrogen receptors (ER), progesterone receptors (PR) and androgen receptors (AR) to elucidate any pathognomonic difference that c...
Source: Pathology Oncology Research - April 28, 2009 Category: Pathology Authors: Chua TC, Yao P, Akther J, Young L, Bao S, Samaraweera U, Yan TD, Morris DL Tags: Pathol Oncol Res Source Type: journals

Adult Extrarenal Wilms' Tumor Mimicking Mixed Epithelial and Stromal Tumor in the Retroperitoneum: A Case Report with Immunohistochemical Study and Review of the Literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an extremely rare case of adult extrarenal Wilms' tumor (WT) in a 52-year-old woman who presented with fever and abdominal distension. Computed tomography revealed a well-defined mass lesion measuring 15.0 cm in the right retroperitoneum and that was in contact with the right kidney. The mass and kidney were surgically removed. Grossly, the mass was well-defined, measuring 16.3 x 11.0 x 9.8 cm, and appearing grayish-white in color. The border between the mass and the kidney was well-defined. Histologically, the tumor showed a triphasic pattern consisting of stromal, epithelial and blastemal components. The stroma...
Source: Pathology Oncology Research - April 23, 2009 Category: Pathology Authors: Kadota K, Haba R, Kushida Y, Katsuki N, Hayashi T, Miyai Y, Bando K, Taoka R, Kakehi Y Tags: Pathol Oncol Res Source Type: journals

Primary Intraosseous Adenoid Cystic Carcinoma of the Mandible: Histopathological and Immunohistochemical Analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a central ACC involving the mandible of a 46-year-old man. He presented an indurated swelling on the vestibular aspect of the left mandibular body and ipsilateral paraesthesia of the lower lip. A panoramic radiography revealed a large radiolucent area, with irregular margins, involving the body and ramus of the left mandible, and CT scan confirmed that the lesion was confined within the mandibular bone. The histopathological features were of an ACC. CT scan also revealed multiple nodular lesions in both lungs suggestive of metastases. The patient was surgically treated by hemi-mandibulectomy. The patie...
Source: Pathology Oncology Research - April 20, 2009 Category: Pathology Authors: Carlos-Bregni R, Vidaurre EC, Carolina Netto A, León JE, Almeida OP Tags: Pathol Oncol Res Source Type: journals

Clinicopathologic and Molecular Features of Epidermal Growth Factor Receptor T790M Mutation and c-MET Amplification in Tyrosine Kinase Inhibitor-resistant Chinese Non-small Cell Lung Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To investigate the clinicopathologic and molecular features of the T790M mutation and c-MET amplification in a cohort of Chinese non-small cell lung cancer (NSCLC) patients resistant to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). EGFR TKI-resistant NSCLC patients (n = 29) and corresponding tumor specimens, and 53 samples of postoperative TKI-naïve NSCLC patients were collected. EGFR exon 19, 20, and 21 mutations were analyzed. And c-MET gene copy number was determined. The EGFR T790M mutation in exon 20 was not detected in the population of 53 TKI-naïve patients, but found in 48...
Source: Pathology Oncology Research - April 20, 2009 Category: Pathology Authors: Chen HJ, Mok TS, Chen ZH, Guo AL, Zhang XC, Su J, Wu YL Tags: Pathol Oncol Res Source Type: journals

GABA Receptor Expression in Benign and Malignant Thyroid Tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study represents the first demonstration of GABA receptor expression in human thyroid tissue and suggests that the GABAergic system is involved in thyroid carcinogenesis. PMID: 19381877 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - April 18, 2009 Category: Pathology Authors: Roberts SS, Mendonça-Torres MC, Jensen K, Francis GL, Vasko V Tags: Pathol Oncol Res Source Type: journals

Histochemical Contributions to the Binding Mechanism of Complement (CR1, CR2) Receptors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Complement receptors (CR1, CR2, CR3), and their ligands (C3b, C3d, iC3b) are essentially involved in germinal center development and in binding, trapping, and retaining immunocomplexes. Methods studying complement receptor (CR1/CR2)-ligand (C3b/C3d) interactions mostly involve coating of sheep erythrocytes (E), sheep erythrocyte-antisheep erythrocyte antibody (EA complexes) and whole human (h) or mouse (m) sera as a source of complement, EACh/m complexes, as reagents. The observation of Dukor et al. (1970), that EACm complexes in native cryostat sections bind selectively and very strongly to the B lymphocyte regions of...
Source: Pathology Oncology Research - April 8, 2009 Category: Pathology Authors: Baranyay F Tags: Pathol Oncol Res Source Type: journals