Molecular characterization and survival analysis of a cohort of glioblastoma, IDH-wildtype
This study established a cohort of 124 sequential glioblastomas from a tertiary hospital and aimed to find correlations between molecular features and survival outcomes. Comprehensive molecular characterization of the cohort revealed prevalent alterations as previously described, such as TERT promoter mutations and involvement of the PI3K-Akt-mTOR, CK4/6-CDKN2A/B-RB1, and p14ARF-MDM2-MDM4-p53 pathways. MGMT promoter methylation is a significant predictor of improved overall survival, aligned with previous data. Conversely, age showed a marginal association with higher mortality. Multivariate analysis to account for the eff...
Source: Pathology, Research and Practice - April 17, 2024 Category: Pathology Authors: Bilge Dundar Mouaz Alsawas Amr Masaadeh Kyle Conway Anthony N Snow Ramakrishna R Sompallae Aaron D Bossler Deqin Ma Osorio Lopes Abath Neto Source Type: research
MicroRNA-155 and exosomal microRNA-155: Small pieces in the cardiovascular diseases puzzle
Pathol Res Pract. 2024 Apr 1;257:155274. doi: 10.1016/j.prp.2024.155274. Online ahead of print.ABSTRACTMicroRNAs (miRs, miRNAs) are known to have a part in various human illnesses, such as those related to the heart. One particular miRNA, miR-155, has been extensively studied and has been found to be involved in hematopoietic lineage differentiation, immunity, viral infections, inflammation, as well as vascular remodeling. These processes have all been connected to cardiovascular diseases, including heart failure, diabetic heart disease, coronary artery disease, and abdominal aortic aneurysm. The impacts of miR-155 depend ...
Source: Pathology, Research and Practice - April 16, 2024 Category: Pathology Authors: Reza Eshraghi Moein Rafiei Zahra Hadian Jazi Davood Shafie Arash Raisi Hamed Mirzaei Source Type: research
MicroRNA-155 and exosomal microRNA-155: Small pieces in the cardiovascular diseases puzzle
Pathol Res Pract. 2024 Apr 1;257:155274. doi: 10.1016/j.prp.2024.155274. Online ahead of print.ABSTRACTMicroRNAs (miRs, miRNAs) are known to have a part in various human illnesses, such as those related to the heart. One particular miRNA, miR-155, has been extensively studied and has been found to be involved in hematopoietic lineage differentiation, immunity, viral infections, inflammation, as well as vascular remodeling. These processes have all been connected to cardiovascular diseases, including heart failure, diabetic heart disease, coronary artery disease, and abdominal aortic aneurysm. The impacts of miR-155 depend ...
Source: Pathology, Research and Practice - April 16, 2024 Category: Pathology Authors: Reza Eshraghi Moein Rafiei Zahra Hadian Jazi Davood Shafie Arash Raisi Hamed Mirzaei Source Type: research
POU2F3-positive small cell carcinoma of the bladder: A clinicopathologic analysis of 4 cases and literature review
Pathol Res Pract. 2024 Apr 11;257:155296. doi: 10.1016/j.prp.2024.155296. Online ahead of print.ABSTRACTPOU class 2 homeobox 3 (POU2F3)-positive small cell bladder carcinoma (SCBC) is an extremely rare entity, and its clinicopathologic features have not been fully described. Here, we investigated the clinicopathologic features of 4 cases of POU2F3-positive small cell bladder carcinoma (SCBC) and reviewed the literature. We collected 12 cases of SCBC from our departmental archives and detected the expression of POU2F3 by immunohistochemical (IHC) staining. Selected cases with or without POU2F3 expression were subjected to g...
Source: Pathology, Research and Practice - April 14, 2024 Category: Pathology Authors: Zhe Cai Xiuzhi Cheng Shousheng Liao Wanwan Zou Lixiang Li Fanrong Liu Wenyong Huang Source Type: research
Regulation of cellular responses to X-ray irradiation through the activation of lysophosphatidic acid (LPA) receptor-3 (LPA < sub > 3 < /sub > ) and LPA < sub > 2 < /sub > in osteosarcoma cells
Pathol Res Pract. 2024 Apr 5;257:155293. doi: 10.1016/j.prp.2024.155293. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) binds to its specific G protein-coupled LPA receptors (LPA1 to LPA6), resulting in the activation of various cellular functions. LPA receptor-mediated signaling facilitates tumor progression in human malignancies. In the present study, we investigated whether LPA receptor-mediated signaling contributes to cellular responses to X-ray irradiation in osteosarcoma MG-63 cells. After X-ray irradiation (2, 4 and 8 Gy), LPAR2 and LPAR3 expression levels in MG-63 cells were significantly elevated in a ...
Source: Pathology, Research and Practice - April 14, 2024 Category: Pathology Authors: Hiroko Ikeda Miwa Takai Narumi Yashiro Yuka Amano Koki Hara Mao Yamamoto Toshifumi Tsujiuchi Source Type: research
POU2F3-positive small cell carcinoma of the bladder: A clinicopathologic analysis of 4 cases and literature review
Pathol Res Pract. 2024 Apr 11;257:155296. doi: 10.1016/j.prp.2024.155296. Online ahead of print.ABSTRACTPOU class 2 homeobox 3 (POU2F3)-positive small cell bladder carcinoma (SCBC) is an extremely rare entity, and its clinicopathologic features have not been fully described. Here, we investigated the clinicopathologic features of 4 cases of POU2F3-positive small cell bladder carcinoma (SCBC) and reviewed the literature. We collected 12 cases of SCBC from our departmental archives and detected the expression of POU2F3 by immunohistochemical (IHC) staining. Selected cases with or without POU2F3 expression were subjected to g...
Source: Pathology, Research and Practice - April 14, 2024 Category: Pathology Authors: Zhe Cai Xiuzhi Cheng Shousheng Liao Wanwan Zou Lixiang Li Fanrong Liu Wenyong Huang Source Type: research
Regulation of cellular responses to X-ray irradiation through the activation of lysophosphatidic acid (LPA) receptor-3 (LPA < sub > 3 < /sub > ) and LPA < sub > 2 < /sub > in osteosarcoma cells
Pathol Res Pract. 2024 Apr 5;257:155293. doi: 10.1016/j.prp.2024.155293. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) binds to its specific G protein-coupled LPA receptors (LPA1 to LPA6), resulting in the activation of various cellular functions. LPA receptor-mediated signaling facilitates tumor progression in human malignancies. In the present study, we investigated whether LPA receptor-mediated signaling contributes to cellular responses to X-ray irradiation in osteosarcoma MG-63 cells. After X-ray irradiation (2, 4 and 8 Gy), LPAR2 and LPAR3 expression levels in MG-63 cells were significantly elevated in a ...
Source: Pathology, Research and Practice - April 14, 2024 Category: Pathology Authors: Hiroko Ikeda Miwa Takai Narumi Yashiro Yuka Amano Koki Hara Mao Yamamoto Toshifumi Tsujiuchi Source Type: research
Reevaluation of negative cervical conizations: Frequency, diagnostic errors, risk factors and management
CONCLUSIONS: The negative conization rate was 11.9%, with diagnostic errors identified across pre-surgical biopsy, cone specimen, and deeper levels. Risk factors included older age, higher parity, low expression of p16, Ki-67 and geminin (p<0.05). Recurrence represented 8.1% of the negative cones, without identification of statistically significant risk factors. Pathological review with deeper level sections and 2-year follow-up are recommended for patients with negative conizations.PMID:38614053 | DOI:10.1016/j.prp.2024.155283 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 13, 2024 Category: Pathology Authors: Larissa Chioquetta Lorenset Ana Paula Percicote Sue Hellen de Oliveira Munhos Rita Maira Zanine Source Type: research
Reevaluation of negative cervical conizations: Frequency, diagnostic errors, risk factors and management
CONCLUSIONS: The negative conization rate was 11.9%, with diagnostic errors identified across pre-surgical biopsy, cone specimen, and deeper levels. Risk factors included older age, higher parity, low expression of p16, Ki-67 and geminin (p<0.05). Recurrence represented 8.1% of the negative cones, without identification of statistically significant risk factors. Pathological review with deeper level sections and 2-year follow-up are recommended for patients with negative conizations.PMID:38614053 | DOI:10.1016/j.prp.2024.155283 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 13, 2024 Category: Pathology Authors: Larissa Chioquetta Lorenset Ana Paula Percicote Sue Hellen de Oliveira Munhos Rita Maira Zanine Source Type: research
Primary renal epithelioid dedifferentiated liposarcoma mimicking a GLI1-amplified neoplasm
Pathol Res Pract. 2024 Apr 2;257:155279. doi: 10.1016/j.prp.2024.155279. Online ahead of print.NO ABSTRACTPMID:38608370 | DOI:10.1016/j.prp.2024.155279 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 12, 2024 Category: Pathology Authors: Isidro Machado Arantxa Juaristi Abaunz Reyes Claramunt Tulio M Silva Cleofe Romagosa Marta Ses é Javier Hernandez-Losa Jos é A López-Guerrero Antonio Llombart-Bosch Source Type: research
Targeting notch-related lncRNAs in cancer: Insights into molecular regulation and therapeutic potential
Pathol Res Pract. 2024 Apr 1;257:155282. doi: 10.1016/j.prp.2024.155282. Online ahead of print.ABSTRACTCancer is a group of diseases marked by unchecked cell proliferation and the ability for the disease to metastasize to different body areas. Enhancements in treatment and early detection are crucial for improved outcomes. LncRNAs are RNA molecules that encode proteins and have a length of more than 200 nucleotides. LncRNAs are crucial for chromatin architecture, gene regulation, and other cellular activities that impact both normal growth & pathological processes, even though they are unable to code for proteins. LncR...
Source: Pathology, Research and Practice - April 12, 2024 Category: Pathology Authors: Raihan Siddique Gaurav Gupta Johar Mgm Ashwani Kumar Harpreet Kaur I A Ariffin Atreyi Pramanik Waleed Hassan Almalki Haider Ali Moyad Shahwan Neeraj Patel Krishna Murari Riya Mishra Riya Thapa Asif Ahmad Bhat Source Type: research
The value of oestrogen receptor, progesterone receptor and keratins 5 and 14 immunohistochemistry in the evaluation of epithelial proliferations at cauterised margins in breast-conserving surgery specimens
Pathol Res Pract. 2024 Apr 1;257:155280. doi: 10.1016/j.prp.2024.155280. Online ahead of print.ABSTRACTIn breast conservative surgery, it is sometimes difficult to decide whether the cauterised tissue at the inked margin represents normal / hyperplastic or neoplastic tissue. We retrospectively assessed the value of ER, PR, CK5 and CK14 IHC in clarifying the nature of cauterised tissues at the margins concerning 34 lesions of 23 patients. 27 cases belonged to lesions that could not be adequately classified on the basis of the HE stains. Two thirds of them could be classified as non-neoplastic or neoplastic and two thirds of...
Source: Pathology, Research and Practice - April 12, 2024 Category: Pathology Authors: Szintia Alm ási G ábor Cserni Source Type: research
18- β-glycyrrhetinic acid-loaded polymeric nanoparticles attenuate cigarette smoke-induced markers of impaired antiviral response in vitro
This study explores the therapeutic potential of an advanced drug delivery system encapsulating 18-β-gly in poly lactic-co-glycolic acid (PLGA) nanoparticles in addressing the impaired antiviral immunity observed in smokers and COPD patients. Exposure of BCi-NS1.1 human bronchial epithelial cells to cigarette smoke extract (CSE) resulted in reduced expression of critical antiviral chemokines (IP-10, I-TAC, MIP-1α/1β), mimicking what happens in smokers and COPD patients. Treatment with 18-β-gly-PLGA nanoparticles partially restored the expression of these chemokines, demonstrating promising therapeutic impact. The nanop...
Source: Pathology, Research and Practice - April 11, 2024 Category: Pathology Authors: Gabriele De Rubis Keshav Raj Paudel Stewart Yeung Siddiq Mohamad Swathi Sudhakar Sachin Kumar Singh Gaurav Gupta Philip Michael Hansbro Dinesh Kumar Chellappan Brian Gregory George Oliver Kamal Dua Source Type: research
Diagnostic performance of immunohistochemistry markers for malignant pleural mesothelioma diagnosis and subtypes. A systematic review and meta-analysis
CONCLUSION: Immunohistochemistry markers are essential in accurately diagnosing malignant pleural mesothelioma and its histological subtypes. This systematic review and meta-analysis provide a comprehensive insight into the diagnostic performance of these markers, facilitating their potential clinical utility in the discrimination of malignant pleural mesothelioma from other pleural pathologies and the differentiation of malignant pleural mesothelioma subtypes.PMID:38603842 | DOI:10.1016/j.prp.2024.155276 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 11, 2024 Category: Pathology Authors: Rafael Parra-Medina Juan Pablo Casta ñeda-González Viviana Chaves-Cabezas Juan Pablo Alzate Juan Jos é Chaves Source Type: research
LncRNAs: Emerging biomarkers and therapeutic targets in rectal cancer
Pathol Res Pract. 2024 Apr 4;257:155294. doi: 10.1016/j.prp.2024.155294. Online ahead of print.ABSTRACTAccording to findings, long non-coding RNAs (lncRNAs) have an important function in the onset and growth of various cancers, including rectal cancer (RC). RC offers unique issues in terms of diagnosis, treatment, and results, needing a full understanding of the cellular mechanisms that cause it to develop. This thorough study digs into the various functions that lncRNAs perform in RC, giving views into their multiple roles as well as possible therapeutic consequences. The function of lncRNAs in RC cell proliferation, apop...
Source: Pathology, Research and Practice - April 11, 2024 Category: Pathology Authors: None Abida Mohd Imran Lina Eltaib Akbar Ali Razan Abdulaziz Salem Alanazi Neelam Singla Syed Mohammed Basheeruddin Asdaq Marwan Al-Hajeili Fatemah Abdulaziz Alhakami Saleh Al-Abdulhadi Altaf A Abdulkhaliq Ali A Rabaan Source Type: research
