Acetaminophen pharmacokinetics in severely obese adolescents and young adults
ConclusionCurrent recommendations of acetaminophen to a maximum dose of 1000 mg resulted in serum concentrations below detection limits in all patients within 2 hours after administration. Dose is better predicted using total body mass with allometric scaling. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 28, 2018 Category: Anesthesiology Authors: Mohammed Hakim,
Brian J. Anderson,
Hina Walia,
Dmitry Tumin,
Marc P. Michalsky,
Ahsan Syed,
Joseph D. Tobias Tags: RESEARCH REPORT Source Type: research
A Systematic Review and Narrative Synthesis on the histological and neurobehavioral long term effects of dexmedetomidine
ConclusionIn animals, dexmedetomidine was found not to induce histologic injury and to show a beneficial effect when administered with another anesthetic. No clinical results on the long term effects in children have been identified yet.This article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 26, 2018 Category: Anesthesiology Authors: Camille E. van Hoorn,
Sanne E. Hoeks,
H. Essink,
Dick Tibboel,
Jurgen C. de Graaff Tags: Systematic reviews Source Type: research
A Follow ‐up Survey of Total Intravenous Anesthesia Usage in Children in the U.K. and Ireland
ConclusionThis survey has shown that although total intravenous anesthesia is not the default anesthetic technique for most anesthetists, overall usage in children has more than doubled in the past 10 years, with many happy to use it in a wide variety of patients and procedures.This article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 25, 2018 Category: Anesthesiology Authors: Nicole Goh,
Oliver Bagshaw,
Simon Courtman Tags: Research Report Source Type: research
Sips for little lips ‐ letter to the editor
This article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 25, 2018 Category: Anesthesiology Authors: Katyayani Katyayani,
Bianca Tingle,
Neena Seth Tags: Letter Source Type: research
Physico ‐chemical stability of Plasma‐Lyte 148 ® and Plasma‐Lyte 148 ® + 5% Glucose with eight common intravenous medications
ConclusionMorphine, fentanyl, ketamine, salbutamol, aminophylline, and clonidine are stable for 24 hours when mixed with Plasma ‐Lyte 148® and Plasma ‐Lyte 148®+5% Glucose for administration at concentrations equivalent to those found at a typical Y site with maintenance fluid. Furosemide is stable at lower concentrations than those seen at a Y ‐site, but midazolam displayed instability.This article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 25, 2018 Category: Anesthesiology Authors: Rachael Dawson,
Andrew Wignell,
Paul Cooling,
David Barrett,
Harish Vyas,
Patrick Davies Tags: Research Report Source Type: research
Sedation and neurodevelopmental outcomes in PICU: identification of study groups
ConclusionsIt is not possible to randomise infants to sedation or no sedation to investigate neurodevelopmental outcomes. This phase of the project aimed to determine the comparability of 2 groups of PICU patients.These findings indicate that these groups could be enrolled as exposed and control subjects in an outcomes study.This article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 25, 2018 Category: Anesthesiology Authors: Davinia E Withington,
Razaz Mujallid,
Zainab Al Sabaa Tags: Research Report Source Type: research
Integrating intraoperative physiology data into outcome analysis for the ACS Pediatric National Surgical Quality Improvement Program
ConclusionAdding intraoperative vital signs to P ‐NSQIP data allowed identification of two modifiable risk factors: hypothermia was associated with increased wound disruption, and hypotension with increased blood transfusions and unplanned returns to the operating room. These findings may motivate prospective studies and prompt other centers a nd P‐NSQIP to augment outcome data with intraoperative physiological data. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 23, 2018 Category: Anesthesiology Authors: Matthias G örges,
Kourosh Afshar,
Nicholas West,
Shanshan Pi,
Julie Bedford,
Simon D. Whyte Tags: RESEARCH REPORT Source Type: research
Sedation effects of intranasal dexmedetomidine combined with ketamine and risk factors for sedation failure in young children during transthoracic echocardiography
ConclusionIntranasal sedation with a combination of dexmedetomidine and ketamine is effective and appears to have an acceptable safety profile for young children during transthoracic echocardiography. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 19, 2018 Category: Anesthesiology Authors: Jianxia Liu,
Min Du,
Lu Liu,
Fei Cao,
Ying Xu Tags: RESEARCH REPORT Source Type: research
Perioperative management of tracheocutaneous fistula closure in children: A review of 96 cases
ConclusionPerioperative care for children undergoing tracheocutaneous fistula closure was not standardized. Advocated tests such as preoperative “mini” sleep studies and “leak test” intraoperatively were not consistently performed. Intraoperative anesthetic complications were uncommon; however, major postoperative respiratory complications were 5%. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 19, 2018 Category: Anesthesiology Authors: Janis M. Ferns,
Mehnaz Khan,
Sanjeev Gupta,
Jonathan H. Smith Tags: RESEARCH REPORT Source Type: research
Severe outcomes of pediatric perioperative adverse events occurring in operating rooms compared to off ‐site anesthetizing locations in the Wake‐Up Safe Database
ConclusionMultivariable analysis of a large registry revealed a greater likelihood of severe outcome for adverse events occurring in cardiac catheterization suites (but not other out of the OR sites), compared to adverse events occurring in the operating room. Additional prospective studies are needed which better control for patient and environmental characteristics and their effect on severe outcomes after anesthesia.This article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 17, 2018 Category: Anesthesiology Authors: Joshua C. Uffman,
Dmitry Tumin,
Ralph J. Beltran,
Joseph D. Tobias Tags: Research Report Source Type: research
Predictive Factors for Adverse Outcomes in Pediatric Patients Undergoing Low Risk Skin and Soft Tissue Surgery: A Database Analysis of 6,730 Patients
ConclusionsPediatric patients with American Society of Anesthesiologists classification ≥ 3 and nutritional deficiency undergoing low‐risk surgery are at risk for the development of postoperative complications. Patients who develop wound and postoperative pulmonary complications are at higher risk for unplanned 30‐day readmission. Identification of these higher risk patients may allow the anesthesiologist to implement targeted therapies to minimize the likelihood of occurrence of these complications.This article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 17, 2018 Category: Anesthesiology Authors: Eric C. Cheon,
Anthony B. Longhini,
Joseph Lee,
Jennifer Hansen,
Narasimhan Jagannathan,
Gildasio S. De Oliveira,
Santhanam Suresh Tags: Research Report Source Type: research
A Study of the dosage and duration for levobupivacaine infusion by the caudal ‐epidural route in infants aged 3‐6 months
ConclusionThis study examines the pharmacokinetics of levobupivacaine after a loading dose (given over 5 minutes) followed by a maintenance infusion in infants 3 ‐6 months. The study allows the development of a pharmacokinetic model, combining levobupivacaine and α1‐acid glycoprotein data. Modelling indicates that unbound levobupivacaine quickly reaches steady state once the infusion is started. Simulations suggest that it may be possible to continue the infusion beyond 48 hours.This article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 17, 2018 Category: Anesthesiology Authors: Rita Vashisht,
Anju A Bendon,
Ijeoma Okonkwo,
Davandra Patel,
Catherine Fullwood,
Kayode Ogungbenro,
Leon Aarons,
Adam S. Darwich Tags: Research Report Source Type: research
Chronological change in oropharyngeal leak pressure of pediatric i ‐gel™
This article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 16, 2018 Category: Anesthesiology Authors: Yusuke Yoshikawa,
Hirata Naoyuki,
Nawa Yuko,
Michiaki Yamakage Tags: Letter Source Type: research
Pain Relief in the Palm of Your Hand: Harnessing Mobile Health to Manage Pediatric Pain
This article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 16, 2018 Category: Anesthesiology Authors: John F. Hunter,
Zeev N. Kain,
Michelle A. Fortier Tags: Special Interest Article (review) Source Type: research
An Open Label Pilot Study of a Dexmedetomidine ‐Remifentanil‐Caudal Anesthetic for Infant Lower Abdominal/Lower Extremity Surgery: The T REX Pilot Study
ConclusionA dexmedetomidine/remifentanil neuraxial anesthetic regimen was effective in 87.5% of infants. These findings can be used as a foundation for designing larger trials that assess alternative anesthetic regimens for anesthetic neurotoxicity in infantsThis article is protected by copyright. All rights reserved. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - November 14, 2018 Category: Anesthesiology Authors: Peter Szmuk,
Dean Andropoulos,
Francis McGowan,
Ansgar Brambrink,
Christopher Lee,
Katherine J Lee,
Mary Ellen McCann,
Yang Liu,
Rita Saynhalath,
Choon Looi Bong,
Brian J Anderson,
Charles Berde,
Jurgen C de Graaff,
Nicola Disma,
Dean Kurth, Tags: Research Report Source Type: research
