Pediatric Blood and Cancer
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1596 records returned
Alexander disease: An important mimicker of focal brainstem glioma
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 21, 2009 Category: Cancer & Oncology Authors: Stefan Ring, Herwig Lackner, Christian Urban, Michaela Brunner-Krainz, Barbara Plecko-Startinig Source Type: journals
Axenfeld-Rieger ocular anomaly and retinoblastoma caused by constitutional chromosome 13q deletionEmail this article to a colleague.
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We report a 2-month-old female with general development delay and dysmorphic features. AR anomaly was detected, and a retinoblastoma (RB) was diagnosed in a very early stage. De novo 13q deletion was identified. Systemic chemotherapy, focal cryotherapy, transpupillary thermotherapy, brachytherapy, and intra-arterial chemotherapy were needed to control the RB. This is the first report of an association of AR, 13q deletion, and retinoblastoma, to be disclosed in patients born with such ocular and dysmorphic features. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Ana Roche, Jaume Mora, Maria del Mar Perez, Esther Gean, Belen Perez, Mar O'Callaghan, Jaume Catala, Carmen De Torres, Ofelia Cruz, Joan Prat, Andreu Parareda Source Type: journals
Transcranial Doppler ultrasonography in infants with sickle cell disease - Is earlier identification of children at risk of stroke possible?Email this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Janet L. Kwiatkowski Source Type: journals
A predictor of unfavourable outcome in neutropenic paediatric patients presenting with fever of unknown originEmail this article to a colleague.
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No sensitive, specific marker able to discriminate favourable or unfavourable outcome of fever of unknown origin (FUO) at diagnosis has been identified. Procalcitonin, a recently assessed infection marker, may be useful in predicting the outcome of FUO.We conducted a prospective study examining the following variables: age 0.5-22 years; solid tumour diagnosis; chemotherapy-related grade-4 febrile neutropenia (FN). A complete clinical, bacteriological and biological evaluation was performed at hospital admission (H0). Other investigations depended on clinical status. FUO was considered to be of unfavourable outcome if the f...
Source: Pediatric Blood and Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Michaela Semeraro, Caroline Thomée, Estelle Rolland, Marie Cecile Le Deley, David Rosselini, Frederic Troalen, Loredana Amoroso, Marie Dubrel, Olivier Hartmann Source Type: journals
Compound heterozygous mutation with a novel splice donor region DNA sequence variant in the succinate dehydrogenase subunit B gene in malignant paragangliomaEmail this article to a colleague.
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We report a 13-year-old African American boy with diffusely metastatic PGL and compound heterozygous mutation leading to a novel splice donor region DNA sequence variant in the SDHB gene. Family history was positive for non-classical congenital adrenal hyperplasia and pituitary adenoma. After surgical resection of the primary PGL and chemotherapy, he was treated with metaiodobenzy lguanidine (MIBG) combined with arsenic trioxide. At 3-year follow-up, he had stable disease. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Suvankar Majumdar, Christopher A. Friedrich, Christian A. Koch, Gail C. Megason, Jonathan D. Fratkin, George W. Moll Source Type: journals
Resistance of stem-like cells from neuroblastoma cell lines to commonly used chemotherapeutic agentsEmail this article to a colleague.
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This study suggests that CD133+ cells are more resistant to anticancer drugs than CD133- cells. Differences in the expression and phosphorylation of kinases could be partially responsible for this difference. Targeting CD133-expressing cells could be a strategy to develop more effective treatments for neuroblastoma. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Sharada D. Vangipuram, Zhihong J. Wang, William D. Lyman Source Type: journals
Pegfilgrastim in children with severe congenital neutropeniaEmail this article to a colleague.
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Two pediatric patients affected by severe congenital neutropenia (SCN) were treated with 100 mcg/L/dose every 9-12 days within a pilot study (Observatory of the Italian Ministry of Health, Eudract Code 2005-003096-20) on the use of pegfilgrastim in patients with chronic neutropenia. Both children increased their absolute neutrophil count, reduced their infectious load, and improved their quality of life. Serum concentrations of G-CSF observed in pegfilgrastim mirrored those seen in filgrastim. These data suggest that pegfilgrastim may be beneficial in SCN patients with an exposure of hematopoietic cells to G-CSF similar to...
Source: Pediatric Blood and Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Francesca Fioredda, Michaela Calvillo, Marina Lanciotti, Tiziana Lanza, Laura Giunti, Elio Castagnola, Ines Lorenzi, Rossella Tonelli, Piero Ghezzi, Carlo Dufour Source Type: journals
Plasma protein C is a useful clinical marker for hepatic veno-occlusive disease (VOD) in stem cell transplantationEmail this article to a colleague.
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We examined levels of plasma protein C serially during the course of SCT to determine the critical level and risk factors for VOD.Of 151 children who received SCT, 12 of them (7.9%) developed VOD. The mean minimum protein C activity in patients with VOD was significantly lower compared to that in patients without VOD (P < 0.0001). Receiver operating characteristic curve analysis revealed that the critical plasma protein C activity (cut-off point) for VOD was identified to be 34.5% with high sensitivity (100%) and specificity (83.3%), and the reduction of plasma protein C below the cut-off level (day +6.50 ± 2.43) was obse...
Source: Pediatric Blood and Cancer - November 12, 2009 Category: Cancer & Oncology Authors: Akihiro Iguchi, Ryoji Kobayashi, Makoto Kaneda, Kunihiko Kobayashi Source Type: journals
Frequency and development of CNS involvement in Chinese children with hemophagocytic lymphohistiocytosisEmail this article to a colleague.
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We investigated the characteristics, frequency, and prognosis of central nervous system (CNS) involvement in patients with hemophagocytic lymphohistiocytosis (HLH).Neurological manifestations were prospectively assessed in 92 children with HLH treated from January 2004 to August 2008 at our center; 82 (89%) had associated viral infections (69 Epstein-Barr virus), one empyema, while no associated disease was identified in the remaining nine. Prior to treatment, all underwent cerebrospinal fluid (CSF) evaluation, brain computer tomography (CT) and/or magnetic resonance imaging (MRI).At diagnosis, 43 (47%) children had CNS in...
Source: Pediatric Blood and Cancer - November 12, 2009 Category: Cancer & Oncology Authors: Shuang Yang, Li Zhang, Chenguang Jia, Honghao Ma, Jan-Inge Henter, Kunling Shen Source Type: journals
Outcome of chronic idiopathic thrombocytopenic purpura in childrenEmail this article to a colleague.
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There is paucity of data on long-term probability of remission in chronic idiopathic thrombocytopenic purpura (ITP). Aim was to study the course and factors influencing remission of chronic ITP. Chronic ITP was defined as thrombocytopenia persisting >6 months following initial diagnosis.Case-records of children with chronic ITP, aged (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Deepak Bansal, Tanmay Anant Bhamare, Amita Trehan, Jasmina Ahluwalia, Neelam Varma, R.K. Marwaha Source Type: journals
It's not easy being smallEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Peter C. Adamson Source Type: journals
Trilateral retinoblastoma: Potentially curable with intensive chemotherapyEmail this article to a colleague.
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We describe a series of 13 patients treated with intensive chemotherapy, defined as the intention to include high-dose chemotherapy with autologous hematopoietic stem cell rescue.Induction chemotherapy generally included vincristine, cisplatin or carboplatin, cyclophosphamide, and etoposide. Hematopoietic stem cells typically were harvested after the first or second cycle of induction chemotherapy, usually from peripheral blood. High-dose chemotherapy regimens were thiotepa-based (n = 7) or melphalan and cyclophosphamide (n = 3).Trilateral sites were pineal (n = 11) and suprasellar (n = 2); 7 patients had localized (M-0) d...
Source: Pediatric Blood and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Ira J. Dunkel, Rima F. Jubran, Sri Gururangan, Guillermo L. Chantada, Jonathan L. Finlay, Stewart Goldman, Yasmin Khakoo, Joan M. O'Brien, Manuela Orjuela, Carlos Rodriguez-Galindo, Mark M. Souweidane, David H. Abramson Source Type: journals
Hydroxurea and sickle cell disease: Its been a long, long time comeEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: J. Paul Scott Source Type: journals
Large cell/anaplastic medulloblastoma: Outcome according to myc status, histopathological, and clinical risk factorsEmail this article to a colleague.
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To evaluate the prognostic impact of large cell/anaplastic (LC/A) histology together with molecular and clinical risk factors in childhood medulloblastoma.Three consecutive prospective medulloblastoma trials were screened for patients with the histological diagnosis of LC/A medulloblastoma. Tumors were considered as LC/A if they displayed areas of severe cytological anaplasia or a significant or predominant large cell component. Histology was centrally confirmed. Genomic DNA amplification of c-myc and n-myc, and mRNA expression of c-myc and trkC were analyzed.Twenty-eight patients with LC/A medulloblastoma with a median ag...
Source: Pediatric Blood and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Katja von Hoff, Wolfgang Hartmann, André Oscar von Bueren, Nicolas Ulrich Gerber, Michael Andreas Grotzer, Torsten Pietsch, Stefan Rutkowski Source Type: journals
Response of refractory immune thrombocytopenia after bone marrow transplantation to romiplostimEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Jill C. Beck, Michael J. Burke, Jakub Tolar Source Type: journals
Neurodegenerative central nervous system Langerhans cell histiocytosis and coincident hydrocephalus treated with vincristine/cytosine arabinosideEmail this article to a colleague.
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Central nervous system (CNS) complications of Langerhans cell histiocytosis (LCH) include mass lesions and a neurodegenerative (ND) syndrome with ataxia, dysarthria, dysmetria, learning and behavior difficulties and/or characteristic changes on brain MRIs. Hydrocephalus has rarely been reported in LCH. LCH lesions of the orbit, mastoid and temporal bones ("CNS-Risk" lesions) and diabetes insipidus predispose patients to ND-CNS-LCH. Treatment options have been limited and only a case series using trans-retinoic acid (ATRA) and intravenous immunoglobulin (IVIG) have been published.We have used cytosine arabinoside (ARA-C) wi...
Source: Pediatric Blood and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Carl E. Allen, Ricardo Flores, Ronald Rauch, Robert Dauser, Jeffrey C. Murray, Diane Puccetti, David A. Hsu, Paul Sondel, Maxine Hetherington, Stan Goldman, Kenneth L. McClain Source Type: journals
The role of interferons in the treatment of osteosarcomaEmail this article to a colleague.
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This article reviews the rationale for the use of interferon in cancer with special reference to the treatment of osteosarcoma, including all published data of clinical efficacy in this disease. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 10, 2009 Category: Cancer & Oncology Authors: Jeremy Whelan, Daniel Patterson, Martha Perisoglou, Stefan Bielack, Neyssa Marina, Sigbjorn Smeland, Mark Bernstein Source Type: journals
Getting a "Head Start": Neuropsychological functioning of young children treated for brain tumors with delayed or no cranial radiation therapyEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 9, 2009 Category: Cancer & Oncology Authors: Deborah P. Waber Source Type: journals
Inflammatory myofibroblastic tumor of the conjunctiva: Response to chemotherapy with low-dose methotrexate and vinorelbineEmail this article to a colleague.
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We report on a 12-year-old patient with an extremely rare and inoperable conjunctival location that was treated with chemotherapy using low-dose methotrexate plus vinorelbine, achieving complete tumor remission. This regimen is usually well tolerated and may be considered as the treatment of choice for cases of unresectable advanced IMT. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 5, 2009 Category: Cancer & Oncology Authors: Francesca Favini, Antonio Giordano Resti, Paola Collini, Michela Casanova, Cristina Meazza, Giovanna Trecate, Andrea Ferrari Source Type: journals
Should TCD be used to force parents to allow transfusion?Email this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 4, 2009 Category: Cancer & Oncology Authors: Robert J. Adams Source Type: journals
Isolated CNS vasculitis: Unusual presentation of relapsed Ewing sarcomaEmail this article to a colleague.
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We describe a 12-year-old boy male who presented with an expressive dysphasia after completion of treatment for unifocal Ewing sarcoma. CNS vasculitis was diagnosed by MRI/MRA and cerebral angiography. Extensive rheumatologic work-up failed to identify an underlying primary process. Restaging studies showed no evidence of tumor. Complete neurologic recovery was achieved on prednisone. Four months later the patient developed overt, extensive metastases, confirmed by biopsy to represent recurrent Ewing sarcoma. Despite intensive therapy the patient succumbed 6 months later. This case demonstrates the unique finding of isolat...
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Polina Stepensky, Elisha Waldman, Natalia Simanovsky, Iris Fried, Shoshana Revel-Vilk, Igor B. Resnick, Michael Weintraub Source Type: journals
Prognostic factors in pulmonary metastasized high-grade osteosarcomaEmail this article to a colleague.
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Resection of pulmonary metastases has previously been reported to improve outcome in high-grade osteosarcoma (OS) patients. Factors influencing survival in OS patients with pulmonary metastases are important for clinical decision making.All 88 OS patients with pulmonary metastases either at diagnosis or during follow-up treated at the Leiden University Medical Center between January 1, 1990 and January 1, 2008 under the age of 40 were included in this study, including 79 cases of conventional, 8 cases of telangiectatic and 1 case of small cell OS.In total, 56 of 88 patients with pulmonary metastases were treated by metasta...
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Emilie P. Buddingh, Jakob K. Anninga, Michel I.M. Versteegh, Antonie H.M. Taminiau, R. Maarten Egeler, Catherina S.P. van Rijswijk, Pancras C.W. Hogendoorn, Arjan C. Lankester, Hans Gelderblom Source Type: journals
Noninvasive Imaging Surrogate of Angiogenesis in OsteosarcomaEmail this article to a colleague.
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This study suggests an important role of DCE-MRI as a noninvasive imaging surrogate of tumor angiogenesis in osteosarcoma based on visual inspection of TIC. Pediatr Blood Cancer. © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Jyoti Bajpai, Shivanand Gamanagatti, Mehar C. Sharma, Rakesh Kumar, Sreenivas Vishnubhatla, Shah Alam Khan, Shishir Rastogi, Arun Malhotra, Sameer Bakhshi Source Type: journals
HLA alloimmunization is associated with RBC antibodies in multiply transfused patients with sickle cell diseaseEmail this article to a colleague.
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Alloimmunization to minor red blood cell (RBC) antigens occurs commonly in sickle cell disease (SCD). Patients with alloimmunization demonstrate increased risk for new alloantibody formation with subsequent transfusion. Alloimmunization to human leukocyte antigens (HLA) can occur with RBC transfusion and may result in graft rejection during stem cell or organ transplantation. The prevalence and risk factors for HLA alloimmunization in multiply transfused pediatric SCD patients are unknown.A cross-sectional study of HLA alloimmunization in SCD patients aged 3-21 years with a history of [ge]3 RBC transfusions was performed t...
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Marianne E. McPherson, Alan R. Anderson, Marta-Inés Castillejo, Christopher D. Hillyer, Robert A. Bray, Howard M. Gebel, Cassandra D. Josephson Source Type: journals
FDG PET imaging of childhood sarcomasEmail this article to a colleague.
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Positron-emission tomography (PET) imaging using [18F]fluorodeoxyglucose (FDG) is useful for detection, staging, and monitoring a variety of malignancies, including lymphoma, in adults, but its utility in sarcomas, especially soft tissue sarcomas (STS), in children and young adults is not clear.To evaluate the potential utility of FDG PET in the care of STS in children and young adults, we analyzed 46 PET scans in 25 patients acquired over 12 years. Scans were interpreted by two imaging physicians blinded to findings from other imaging studies and clinical information. Results were compared with computed tomography and mag...
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Rajen J. Mody, Chuong Bui, Raymond J. Hutchinson, Greg A. Yanik, Valerie P. Castle, Kirk A. Frey, Barry L. Shulkin Source Type: journals
Successful treatment of refractory donor lymphocyte infusion-induced immune-mediated pancytopenia with rituximabEmail this article to a colleague.
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A 6-year-old male with chronic granulomatous disease, who was transplanted with bone marrow and exhibited increasing mixed chimerism, subsequently received two donor lymphocyte infusions (DLI). Two weeks after the second DLI, the patient developed acute graft-versus-host disease (GVHD) and progressive pancytopenia that was associated with autoantibody production. Conventional treatment did not improve the pancytopenia. However, administration of Rituximab (RTX) (375 mg/m2/week for four consecutive weeks) resulted in a rapid resolution of the pancytopenia. The patient achieved full donor chimerism without GVHD symptoms. RTX...
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Itaru Kato, Katsutsugu Umeda, Tomonari Awaya, Yoshihiro Yui, Akira Niwa, Hisanori Fujino, Hiroshi Matsubara, Ken-Ichiro Watanabe, Toshio Heike, Naoto Adachi, Fumio Endo, Tomoyuki Mizukami, Hiroyuki Nunoi, Tatsutoshi Nakahata, Souichi Adachi Source Type: journals
Hepato-biliary late effects in survivors of childhood and adolescent cancer: A report from the Children's Oncology GroupEmail this article to a colleague.
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This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy. Pediatr Blood Cancer. © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Sharon Castellino, Andrew Muir, Ami Shah, Sheila Shope, Kevin McMullen, Kathy Ruble, Ashley Barber, Andrew Davidoff, Melissa M. Hudson Source Type: journals
Feasibility and early outcomes of supine-position craniospinal irradiationEmail this article to a colleague.
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From 2000-2007, we treated 14 patients (median age 5.8 years) with medulloblastoma (MB) with craniospinal irradiation (CSI) in the supine position for comfort, setup reproducibility and anaesthesia airway access. Acute toxicity included nausea/vomiting (N = 9), weight loss (median 10.3% (2.2-18.2), N = 10), lymphopenia (all), neutropenia (N = 3) and pancreatitis with Mallory-Weiss tear (N = 1). Five children required hospitalization during treatment. Chemotherapy was adjusted in 6, without CSI delay. After a median follow-up of 32.4 months (13.3-83.2), two patients recurred, two died of a second CNS malignancy, and one dev...
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Fleur Huang, William Parker, Carolyn R. Freeman Source Type: journals
Survival outcome in childhood acute lymphoblastic leukemia in India: ResponseEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Ketan Prasad Kulkarni, Ram Kumar Marwaha, Amita Trehan, Deepak Bansal Source Type: journals
Pre-transplant lung function is predictive of survival following pediatric bone marrow transplantationEmail this article to a colleague.
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Pulmonary toxicity is well described in recipients of bone marrow transplants (BMT), and accounts for a sizeable proportion of post-transplant mortality. The majority of the data on post-transplant pulmonary function is from adults, although several small pediatric case series have been described. In adults, pre-transplant lung function has been predictive of post-transplant respiratory failure and mortality. This use of pulmonary function testing, that is, for pre-transplant risk counseling, is novel but has never been applied to pediatric patients. We hypothesized that in children, as in adults, pre-transplant pulmonary ...
Source: Pediatric Blood and Cancer - October 29, 2009 Category: Cancer & Oncology Authors: Jill P. Ginsberg, Richard Aplenc, Joseph McDonough, James Bethel, John Doyle, Daniel J. Weiner Source Type: journals
No effect of irinotecan in patients with resistant desmoplastic small round cell tumorEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 28, 2009 Category: Cancer & Oncology Authors: Gianni Bisogno, Riccardo Riccardi, Angela Scagnellato, Giampaolo Arcamone, Lucia Miglionico, Modesto Carli Source Type: journals
Initial testing (stage 1) of mapatumumab (HGS-ETR1) by the pediatric preclinical testing programEmail this article to a colleague.
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Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that exclusively targets and activates tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). It was tested in vitro at concentrations from 0.01 to 100 µg/ml and in vivo at a dose of 10 mg/kg administered intraperitoneally using a twice-weekly schedule. Mapatumumab demonstrated limited activity against the 23 cell lines of the PPTP in vitro panel with no lines achieving 50% growth inhibition. Mapatumumab induced significant differences in event-free survival distribution compared to controls in 9 of 37 evaluable solid tumor ...
Source: Pediatric Blood and Cancer - October 23, 2009 Category: Cancer & Oncology Authors: Malcolm A. Smith, Christopher L. Morton, E. Anders Kolb, Richard Gorlick, Stephen T. Keir, Hernan Carol, Richard Lock, Min H. Kang, C. Patrick Reynolds, John M. Maris, Amy E. Watkins, Peter J. Houghton Source Type: journals
Alexander disease: An important mimicker of focal brainstem glioma - responseEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Katherine Van Poppel, David Ellison, Alberto Broniscer, Zoltan Patay, E. Brannon Morris Source Type: journals
Wilms tumor, AML, and medulloblastoma in a child with cancer prone syndrome of total premature chromatid separation and fanconi anemiaEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Blanche P. Alter, Susan B. Olson Source Type: journals
Ewing sarcoma of the neckEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Sandrin Schmidt, Herwig Lackner, Christian Urban Source Type: journals
Retrospective analysis of non-anaplastic peripheral T-cell lymphoma in pediatric patients in JapanEmail this article to a colleague.
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Reports of non-anaplastic peripheral T-cell lymphoma (PTCL) in pediatric patients are relatively rare.We performed a retrospective analysis in patients with PTCL over an 18-year period (1991-2008).We could analyze clinical data in 21 patients with non-anaplastic PTCL; 10 were female and 10 male. Median age of onset was 11 years (range: 1-21 years). There were nine patients with PTCL, not otherwise specified (PTCL-NOS); ten with extranodal NK/T-cell lymphoma, nasal type; one with angioimmunoblastic T-cell lymphoma; and one with subcutaneous panniculitis-like T-cell lymphoma. Initial lesions involved cervical lymph nodes in ...
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Ryoji Kobayashi, Kazumi Yamato, Fumiko Tanaka, Yoshifumi Takashima, Hiroko Inada, Akira Kikuchi, Masa-aki Kumagai, Shosuke Sunami, Atsuko Nakagawa, Reiji Fukano, Naoto Fujita, Tetsuo Mitsui, Masahito Tsurusawa, Tetsuya Mori, Lymphoma Committee, Japanese P Source Type: journals
Adherence to study medication and visits: Data from the BABY HUG trialEmail this article to a colleague.
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We examined associations of adherence with SES of participating families.MedAd data were available on 153 of the 191 subjects who started randomized study medication. MedAd was 101.7% of volume prescribed, with 88.9% of subjects taking at least 80% of doses. VAd data were available on 185 of the 191 subjects who started randomized study medication. VAd was 97.3%, with 82.2% of subjects having no missed visits. During dose titration, subjects had on average 12.9% higher medication adherence than subjects who were on a stable dose and had less frequent study visits. MedAd and VAd were not significantly associated with SES.Su...
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Courtney D. Thornburg, Zora R. Rogers, Michael R. Jeng, Sohail R. Rana, Rathi V. Iyer, Lane Faughnan, Leann Hassen, Jennifer Marshall, Roy P. McDonald, Winfred C. Wang, Xiangke Huang, Renée C. Rees, for the BABY HUG Investigators Source Type: journals
MGMT as a potential stratification marker in relapsed high-grade glioma of children: The HIT-GBM experienceEmail this article to a colleague.
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Studies in adults with malignant glioma suggest MGMT methylation as a stratification marker. Similar data for children are sparse. We investigated the impact of MGMT methylation and expression on survival of children with high-grade glioma (HGG) registered into the German HIT-GBM database receiving temozolomide (TMZ) as part of their treatment (n = 21 relapsed, n = 4 primary).Twenty-four patients were included retrospectively. Methylation specific PCR (MSP), calibrated combined bisulfite restriction analysis (COBRA), and immunohistochemistry (IHC) were applied. Survival analyses were performed by Kaplan-Meier and Cox propo...
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Sabrina Schlosser, Sabine Wagner, Jörg Mühlisch, Martin Hasselblatt, Joachim Gerß, Johannes E.A. Wolff, Michael C. Frühwald Source Type: journals
Rapamycin (sirolimus) in tuberous sclerosis associated pediatric central nervous system tumorsEmail this article to a colleague.
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Tuberous sclerosis complex (TSC) is associated with hamartomatous growths including subependymal giant cell astrocytomas (SEGAs). Since chemo-radiation therapies offer scant benefit, oncologists had traditionally been little involved in managing SEGAs. Recent evidence demonstrating rapamycin efficacy in adults and children with TSC-associated tumors foresee a practice change. We summarize our institutional experience and literature review that highlight potential benefits and hazards of rapamycin therapy, for TSC patients with SEGA, and other syndromal brain tumors. Pediatr Blood Cancer. © 2009 Wiley-Liss, Inc. (Source: P...
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Catherine Lam, Eric Bouffet, Uri Tabori, Donald Mabbott, Michael Taylor, Ute Bartels Source Type: journals
Adipocytokines in relation to Hodgkin lymphoma in childrenEmail this article to a colleague.
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In conclusion, elevated serum adiponectin might be a risk factor for childhood HL. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Eleni Th. Petridou, Nick Dessypris, Paraskevi Panagopoulou, Theodoros N. Sergentanis, Alexios-Fotios A. Mentis, Apostolos Pourtsidis, Sophia Polychronopoulou, Maria Kalmanti, Fani Athanasiadou-Piperopoulou, Maria Moschovi Source Type: journals
Pitfalls in the differential diagnosis of renal tumor in an adolescentEmail this article to a colleague.
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We describe an 11-year-old female with a primary intra-renal mass. Initial differential diagnoses included primitive neuroectodermal tumor (PNET), desmoplastic small round cell tumor (DSRCT), and Wilms Tumor (WT). Extensive pathologic and molecular analysis on initial and relapsed tumor samples confirmed WT. The EWS-WT1 and EWS-FLI1 rearrangements, distinctive of DSRCT and PNET were negative. The differential diagnosis on monophasic blastemal WT may be complex. Primary renal DSRCT and PNET have been rarely described. Nevertheless, molecular confirmation for these rare conditions may be necessary in selected cases. Pediatr ...
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Elvis Terci Valera, María Sol Brassesco, Maria Angélica Abdalla de Freitas Cortez, Rosane Gomes Queiroz, Angel Mauricio Castro-Gamero, Marcus Vinicius de Castro Barros, Yvone Avalloni Vicente, Silvio Tucci Junior, Carlos Alberto Scrideli, Luiz Gonzaga T Source Type: journals
Paediatric presentation of familial cerebral cavernomaEmail this article to a colleague.
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We report the case of a 13-year-old male who presented with headaches and was presumed to have a brain tumour. He was subsequently found to have multiple cerebral cavernomas with haemorrhage and positive family history. We review the literature on familial cavernomas. Cerebral cavernous malformations (CCMs) are characterized by abnormally enlarged capillary cavities without intervening brain parenchyma [Verlaan et al. Neurology 2005; 65:1982-1983] that may involve any part of the central nervous system. Focal neurologic deficit and haemorrhage occur in 45% of children, higher than in adults [Stoeter. Neurosurg Rev 2001; 24...
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Harriet Holme, Vasanta Nanduri Source Type: journals
Hemoglobin Hakkari: An autosomal dominant form of beta thalassemia with inclusion bodies arising from de novo mutation in exon 2 of beta globin geneEmail this article to a colleague.
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Certain [beta] globin gene mutations produce a thalassemia major phenotype in the heterozygous state. While most such patients have thalassemia intermedia, we describe a young Guatemalan child with a de novo mutation in the [beta] globin gene, codon 31 T [rarr] G (Hemoglobin Hakkari), who developed severe anemia at the age of 10 months and remains transfusion-dependent. The substitution of B13 leucine with arginine in the [beta] globin results in alteration of a critical heme contact point resulting in an extremely unstable variant hemoglobin and a clinical picture that is characterized by ineffective erythropoiesis and nu...
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: B. Kanathezhath, F.K. Hazard, H. Guo, J. Kidd, M. Azimi, F.A. Kuypers, E.P. Vichinsky, A. Lal Source Type: journals
Adjuvant dendritic cell-based tumour vaccination for children with malignant brain tumoursEmail this article to a colleague.
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A large experience with dendritic cell (DC)-based vaccination for malignant brain tumours has been gained in adults. Here we focus on the results obtained in children with relapsed malignant brain tumours.In total 45 children were vaccinated: 33 high grade glioma (HGG), 5 medulloblastoma (MB)/primitive neuro-ectodermal tumour (PNET), 4 ependymoma and 3 atypical teratoid-rhabdoid tumour (ATRT). Autologous, monocyte-derived DC were generated and loaded with tumour lysate, which was used as source of tumour-associated antigens.In 38 patients peripheral blood mononuclear cells (PBMC) were obtained from leukapheresis and in 7 p...
Source: Pediatric Blood and Cancer - October 21, 2009 Category: Cancer & Oncology Authors: Hilko Ardon, Steven De Vleeschouwer, Frank Van Calenbergh, Laurence Claes, Christof M. Kramm, Stefan Rutkowski, Johannes E.A. Wolff, Stefaan W. Van Gool Source Type: journals
A case of luteinizing thecoma with sclerosing peritonitis: Revisiting a link with anti-epileptic drugsEmail this article to a colleague.
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Luteinizing thecoma with sclerosing peritonitis (LTSP) is a rare ovarian tumor of unclear etiology and pathogenesis. The diagnostic entity was proposed in 1994, but a number of earlier reports described possible cases, and some suggested an association with anti-epileptic drugs (AEDs). In presenting a new case we review the literature of previous cases to evaluate the possibility of such a link. When cases in reproductively immature patients are considered, evidence for an association between LTSP and AEDs is strongly suggested despite the rarity of the condition. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pedi...
Source: Pediatric Blood and Cancer - October 21, 2009 Category: Cancer & Oncology Authors: David W. Nauen, Allison Martin, Aviva Katz, Debra Cohen, Sarangarajan Ranganathan Source Type: journals
Central nervous system relapse of acute promyelocytic leukemiaEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 20, 2009 Category: Cancer & Oncology Authors: Donna L. Johnston, Karen Mandel Source Type: journals
Impact of a pediatric palliative care programEmail this article to a colleague.
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The question of where a child should die at home or in the hospital has been a subject of recent debate. We instituted a palliative care program with advanced end-of-life planning and hypothesized that a significant number of families would prefer that their child be at home rather than at a hospital at the end-of-life and that the overall quality of care would thereby improve.Study design was single group, retrospective parent report of satisfaction with a new palliative care program. Participants were the caregivers, primarily parents, involved in the palliative care program. They completed a satisfaction survey, and the...
Source: Pediatric Blood and Cancer - October 14, 2009 Category: Cancer & Oncology Authors: Johannes Wolff, Rhonda Robert, Andre Sommerer, Marlene Volz-Fleckenstein Source Type: journals
Central nervous system relapse of acute promyelocytic leukemia - responseEmail this article to a colleague.
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No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 13, 2009 Category: Cancer & Oncology Authors: James Feusner, Jessica Chow Source Type: journals
Long-term cardiac follow-up of children treated with anthracycline doses of 300 mg/m2 or less for acute lymphoblastic leukemiaEmail this article to a colleague.
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The cardiotoxic effect of anthracyclines has been well described for moderate to high cumulative doses (>350 mg/m2). However, the question of whether sub-clinical signs of cardiomyopathy may develop and progress over time in children receiving doses of (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 13, 2009 Category: Cancer & Oncology Authors: Mathias Rathe, Niels Lauritz Torp Carlsen, Henrik Oxhøj, Gunner Nielsen Source Type: journals
Pulmonary hypertension in children and young adults with sickle cell disease: Evidence for familial clusteringEmail this article to a colleague.
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Pulmonary hypertension (PHTN) is increasingly recognized as a serious complication of sickle cell disease (SCD). Our objective was to determine the prevalence of PHTN and identify factors associated with PHTN among children and young adults with SCD in Lebanon.From June 2004 to June 2008, 90 patients were studied. Correlation of TRV with LDH, mean corpuscular volume (MCV), fetal hemoglobin (HbF), hydroxyurea use, and G6PD deficiency was performed. Transthoracic Doppler echocardiography was performed during steady-state at each patient's initial visit and yearly thereafter. PHT was defined as a tricuspid regurgitant jet vel...
Source: Pediatric Blood and Cancer - October 13, 2009 Category: Cancer & Oncology Authors: Hanane A. Dahoui, Munya N. Hayek, Paul J. Nietert, Mariam T. Arabi, Samar A. Muwakkit, Raya H. Saab, Abdallah N. Bissar, Nidal M. Jumaa, Fadi S. Farhat, Ibrahim A. Dabbous, Fadi F. Bitar, Miguel R. Abboud Source Type: journals
