Pediatric DiabetesThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Psychological symptoms and insulin sensitivity in adolescentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: As has been described for adults, depressive symptoms are associated with low insulin sensitivity among healthy adolescents. Further experimental and prospective studies are required to determine the directionality of this link. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 12, 2009 Category: Endocrinology Authors: Lauren B Shomaker, Marian Tanofsky-Kraff, Deborah Young-Hyman, Joan C Han, Lisa B Yanoff, Sheila M Brady, Susan Z Yanovski, Jack A Yanovski Source Type: journals

Increasing incidence of childhood type 1 diabetes in Montenegro from 1997 to 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The incidence rate in last 5 yr places Montenegro in the group of countries with moderate risk for development of type 1 diabetes in children. The average annual increase in incidence is 4.6%. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 11, 2009 Category: Endocrinology Authors: Mira Samardzic, Jelena Marinkovic, Nikola Kocev, Natasa Curovic, Natasa Terzic Source Type: journals

Low levels of vitamin D in North Indian children with newly diagnosed type 1 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that vitamin D levels are low at the onset of T1D, and they strongly support the need for further clinical studies to prospectively evaluate the effect of vitamin D supplementation on T1D rates in this patient population. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 9, 2009 Category: Endocrinology Authors: Vibhor V Borkar, Devidayal, Savita Verma, AK Bhalla Source Type: journals

Target setting in intensive insulin management is associated with metabolic control: the Hvidoere Childhood Diabetes Study Group Centre Differences Study 2005Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Clear and consistent setting of glycaemic targets by diabetes teams is strongly associated with HbA1c outcome in adolescents. Target setting appears to play a significant role in explaining the differences in metabolic outcomes between centres. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 6, 2009 Category: Endocrinology Authors: PGF Swift, TC Skinner, CE de Beaufort, FJ Cameron, J Åman, H-J Aanstoot, L Castaño, F Chiarelli, D Daneman, T Danne, H Dorchy, H Hoey, EA Kaprio, F Kaufman, M Kocova, HB Mortensen, PR Njølstad, M Phillip, KJ Robertson, EJ Schoenle, T Urakami, M Vanelli Source Type: journals

Qualitative studies of type 1 diabetes in adolescence: a systematic literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Spencer J, Cooper H, Milton B. Qualitative studies of type 1 diabetes in adolescence: a systematic literature review. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 6, 2009 Category: Endocrinology Authors: Joy Spencer, Helen Cooper, Beth Milton Source Type: journals

An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this first study of its kind, we demonstrated directly that the observed inverse association between childhood eczema and type 1 diabetes is not likely to be explained by the established diabetes susceptibility genes HLA-DQ, CTLA4, or PTPN22. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 5, 2009 Category: Endocrinology Authors: Lars C Stene, Kjersti S Rønningen, Marit Bjørnvold, Dag E Undlien, Geir Joner Source Type: journals

A 'radical' new rural model for pediatric diabetes careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Multidisciplinary child diabetes care can be successfully achieved in rural settings using local resources with results comparable to international tertiary multidisciplinary diabetes units. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 4, 2009 Category: Endocrinology Authors: Peter W. Goss, Megan A. Paterson, Jay Renalson Source Type: journals

Obesity and family history of diabetes as risk factors of impaired fasting glucose: implications for the early detection of prediabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The presence of FHD in a first degree relative is associated with IFG, even in the absence of obesity. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 4, 2009 Category: Endocrinology Authors: Martha Rodríguez-Moran, Fernando Guerrero-Romero, Celia Aradillas-García, Rafael Violante, Luis E Simental-Mendia, Elizabeth Monreal-Escalante, Esperanza de la Cruz Mendoza Source Type: journals

The influence of physical activity on ghrelin and IGF-1/IGFBP-3 levels in children and adolescents with type 1 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We hypothesize an association between ghrelin and metabolic control in T1DM. Higher ghrelin levels might be associated with poor metabolic control. The dynamic of IGFBP-3 levels appears to be under the influence of basal ghrelin concentrations in T1DM. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - October 27, 2009 Category: Endocrinology Authors: Julia Huber, Elke Elisabeth Fröhlich-Reiterer, Karl Sudi, Elisabeth Suppan, Gudrun Weinhandl, Hildegard Jasser-Nitsche, Reingard Aigner, Martin Helmuth Borkenstein Source Type: journals

Cerebral injury and cerebral edema in children with diabetic ketoacidosis: could cerebral ischemia and reperfusion injury be involved?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glaser N, Cerebral injury and cerebral edema in children with diabetic ketoacidosis: could cerebral ischemia and reperfusion injury be involved? (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - October 9, 2009 Category: Endocrinology Authors: Nicole Glaser Source Type: journals

Ketoacidosis at presentation of type 1 diabetes in children in Kuwait: frequency and clinical characteristicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our study provides recent data on Middle Eastern population, for whom data are sparse. Although it has significantly decreased, the frequency of DKA at presentation of T1DM in children in Kuwait is still high, secondary to the high prevalence of diabetes in the community. Young children, especially those less than 2 yr old remain at high risk. Increasing the general awareness of the public as well as of pediatricians to the disease may lead to early diagnosis before the development of acidosis. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - October 9, 2009 Category: Endocrinology Authors: M Abdul-Rasoul, M Al-Mahdi, H Al-Qattan, N Al-Tarkait, M Alkhouly, R Al-Safi, F Al-Shawaf, H Mahmoud Source Type: journals

The prevalence of impaired fasting glucose and type 2 diabetes in a population-based sample of overweight/obese children in the Middle EastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although the prevalence of T2DM is low in Iranian obese children, IFG is not uncommon. Preventive measures and screening of FPG should be considered for these children. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - September 17, 2009 Category: Endocrinology Authors: Mohammad Hasan Moadab, Roya Kelishadi, Mahin Hashemipour, Masoud Amini, Parinaz Poursafa Source Type: journals

Daily vegetable intake during pregnancy negatively associated to islet autoimmunity in the offspring–The ABIS studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Brekke HK, Ludvigsson J. Daily vegetable intake during pregnancy negatively associated to islet autoimmunity in the offspring[mdash]The ABIS study.Objective: To investigate if maternal diet during pregnancy is associated with occurrence of islet autoimmunity (IA) in the offspring.Methods: Of 21 700 infants invited to the All Babies in South-east Sweden (ABIS) study, 16 004 screening questionnaires, including a 22-item food frequency questionnaire (FFQ) regarding the mothers' diet during pregnancy, were completed after delivery. Follow-up of the children (questionnaires and blood sampling) was performed at 1, 2.5 and 5 yr o...
Source: Pediatric Diabetes - September 16, 2009 Category: Endocrinology Authors: Hilde K Brekke, Johnny Ludvigsson Source Type: journals

Sociodemographic and psychosocial factors associated with continuous subcutaneous insulin infusion in adolescents with type 1 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Adolescents currently prescribed CSII therapy evidenced key differences from their counterparts using multiple daily injections (MDI) in insurance status, diabetes management behavior, and family functioning related to diabetes. Efforts to understand the role of family factors in the maintenance of CSII therapy with clinical indicators of CSII use may inform treatment effectiveness. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - September 15, 2009 Category: Endocrinology Authors: Sandra Cortina, David R. Repaske, Korey K. Hood Source Type: journals

Risk markers of future microalbuminuria and hypertension based on clinical and morphological parameters in young type 1 diabetes patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Normoalbuminuric and NT patients at risk of developing MA and HT could be identified and might benefit from an early start of antihypertensive therapy and improvement of metabolic control. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - September 15, 2009 Category: Endocrinology Authors: Nina ESS Perrin, T Torbjörnsdotter, Georg A Jaremko, Ulla B Berg Source Type: journals

Successful treatment of severe subcutaneous insulin resistance with inhaled insulin therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
van Alfen-van der Velden AAEM, Noordam C, de Galan BE, Hoorweg-Nijman JJG, Voorhoeve PG, Westerlaken C. Successful treatment of severe subcutaneous insulin resistance with inhaled insulin therapy. The potential of inhaled insulin therapy for severe resistance to subcutaneous insulin was tested in a 7-yr old boy with type 1 diabetes mellitus. The efficiency of 1 mg inhaled insulin (Exubera®) was examined by a 4-h euglycemic clamp study. During the clamp, the glucose infusion rate started to increase 25 min after inhalation and peaked 120 min after inhalation. Subsequently, a trial of inhaled insulin monotherapy was initiat...
Source: Pediatric Diabetes - September 15, 2009 Category: Endocrinology Authors: AAEM van Alfen-van der Velden, C Noordam, BE de Galan, JJG Hoorweg-Nijman, PG Voorhoeve, C Westerlaken Source Type: journals

Diagnosing monogenic diabetes: common misinterpretations of genetic findingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pediatric Diabetes)
Source: Pediatric Diabetes - August 30, 2009 Category: Endocrinology Authors: Oscar Rubio-Cabezas Source Type: journals

Initial insulin therapy in children and adolescents with type 1 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The predictive factors of insulin requirement may exert beneficial effects on the assessment and adjustment of insulin therapy in young diabetic subjects at disease onset. On the basis of a multiple, linear regression, we suggest a formula to calculate the initial insulin therapy. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - August 24, 2009 Category: Endocrinology Authors: Dieter Weitzela, Ulla Pfeffera, Axel Dost, Antje Herbstc, Ina Knerr, Reinhard Holl Source Type: journals

Detailed family history of diabetes identified children at risk of type 2 diabetes: a population-based case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Children with parental FDMH, especially the maternal FDMH, have an elevated risk for T2D. Detailed FDMH is a convenient alternative to identify children with different risks of T2D. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - August 24, 2009 Category: Endocrinology Authors: Jung-Nan Wei, Hung-Yuan Li, Yi-Chia Wang, Lee-Ming Chuang, Mao-Shin Lin, Cheng-Hsin Lin, Fung-Chang Sung Source Type: journals

Multinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycemic control 12 months after diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HB Mortensen, PGF Swift, RW Holl, P Hougaard, L Hansen, H Bjoerndalen, CE de Beaufort, M Knip. Multinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycemic control 12 months after diagnosis.Objective: To identify predictors of residual beta-cell function and glycemic control during the first 12 months after the diagnosis of type 1 diabetes (T1D).Subjects and Methods: Clinical information and blood samples were collected from 275 children. HbA1c, antibodies, HLA typing and mixed meal-stimulat...
Source: Pediatric Diabetes - August 24, 2009 Category: Endocrinology Authors: Henrik B Mortensen, Peter GF Swift, Reinhard W Holl, P Hougaard, Lars Hansen, Hilde Bjoerndalen, Carine E de Beaufort, Michael Knip Source Type: journals

Predicting islet yield in pediatric patients undergoing pancreatectomy and autoislet transplantation for chronic pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pilot data from 10 pediatric patients suggest that simple preoperative measurement of fasting plasma glucose may give a useful prediction of islet yield. Islet yield correlates with HbA1c and C-peptide levels. This information allows individual candidates to weigh the specific risk of becoming diabetic against the benefit of pain relief should they undergo TP-IAT. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - August 24, 2009 Category: Endocrinology Authors: Melena D Bellin, Juan J Blondet, Gregory J Beilman, Ty B Dunn, AN Balamurugan, William Thomas, David ER Sutherland, Antoinette Moran Source Type: journals

Early predictors of myocardial disease in children and adolescents with type 1 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Asymptomatic diabetics had evidence of subtle right and LV dysfunction with delayed myocardial relaxation which was related to metabolic control. Tissue Doppler (TD) has an additional value in evaluating ventricular filling. NT-pro-BNP is considered a sensitive, specific, and predictive marker for diastolic dysfunction. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - August 24, 2009 Category: Endocrinology Authors: Mona Salem, Soha El Behery, Amira Adly, Dina Khalil, Eman El Hadidi Source Type: journals

Oxidant/antioxidant status in obese children compared to pediatric patients with type 1 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Oxidative stress is present in both children with T1D and obesity, although it is more pronounced in the former. Obese children may suffer an additional oxidative stress in the case of developing impaired glucose metabolism. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - August 4, 2009 Category: Endocrinology Authors: Pilar Codoñer-Franch, Sara Pons-Morales, Laura Boix-García, Victoria Valls-Bellés Source Type: journals

Childhood hypo-adiponectinaemia but not hyper-leptinaemia is associated with insulin insensitivity 6 years laterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We found a direct relationship between childhood hypo-adiponectinaemia and insulin insensitivity in adolescence. This association was stronger for overweight than for normal weight children. Hyper-leptinaemia was associated with concurrent insulin insensitivity at baseline but not 6 yr later. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - August 3, 2009 Category: Endocrinology Authors: Iben Kynde, Berit Lilienthal Heitmann, Ib Christian Bygbjerg, Lars Bo Andersen, Jørn Wulff Helge Source Type: journals

The effectiveness of glucose, sucrose, and fructose in treating hypoglycemia in children with type 1 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Skittles[trade] are as effective in treating hypoglycemia as more expensive BD Glucose Tablets[trade] in children with type 1 diabetes. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - August 3, 2009 Category: Endocrinology Authors: Allison C Husband, Susan Crawford, Lesley A McCoy, Danièle Pacaud Source Type: journals

Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a male infant with permanent NDM (PNDM), born to a PNDM mother. Blood glucose began to rise on day of life (DOL) 2, and sulfonylurea (glyburide) therapy was initiated on DOL 5. Glucose was subsequently well controlled and normal at 3 months. A KATP mutation (R201H; KCNJ11) was detected in the infant, the mother, and 6-yr-old sister with PNDM; both were also subsequently transitioned off insulin onto glyburide. To our knowledge, this is the youngest NDM patient to receive oral glyburide and, importantly, the only one deliberately initiated on sulfonylureas. Strikingly, the current dose (0.017 mg/kg/d) is below the...
Source: Pediatric Diabetes - July 28, 2009 Category: Endocrinology Authors: Jennifer A Wambach, Bess A Marshall, Joseph C Koster, Neil H White, Colin G Nichols Source Type: journals

Sex hormone-binding globulin levels and metabolic syndrome and its features in adolescents#Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The associations of SHBG with MS and its components, such as abdominal obesity, high BP or insulin levels, are already present in normal adolescents. This may suggest the possibility of using SHBG levels as a biomarker for MS risk in adolescents as well as adults. Oya I, Schoppen S, Lasunción MA, Lopez-Simon L, Riestra P, Oya M, Garcés C. Sex hormone-binding globulin levels and metabolic syndrome and its features in adolescents. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - July 28, 2009 Category: Endocrinology Authors: Iria de Oya, Stefanie Schoppen, Miguel A Lasunción, Laura Lopez-Simon, Pía Riestra, Manuel de Oya, Carmen Garcés Source Type: journals

Medical and developmental impact of transition from subcutaneous insulin to oral glyburide in a 15-yr-old boy with neonatal diabetes mellitus and intermediate DEND syndrome: extending the age of KCNJ11 mutation testing in neonatal DMEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the response to glyburide in a 15-yr-old boy with severe global developmental delays resulting from the KCNJ11 mutation V59M. The patient was discovered to have diabetes mellitus at 11.5 months of age, making this the oldest age at diagnosis of a KCNJ11 mutation-related case of neonatal diabetes. Because consensus has been to screen patients for this mutation only if younger than 6 months at the time of diagnosis, we suggest that all patients under the age of 12 months at diagnosis should receive genetic testing for monogenic causes of diabetes. Mohamadi A, Clark LM, Lipkin PH, Mahone EM, Wodka EL, Plotnick LP....
Source: Pediatric Diabetes - July 20, 2009 Category: Endocrinology Authors: Ali Mohamadi, Loretta M Clark, Paul H Lipkin, E Mark Mahone, Ericka L Wodka, Leslie P Plotnick Source Type: journals

An exploration of Glo-3A antibody levels in children at increased risk for type 1 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Differing correlates of Glo-3A antibodies in IA cases and controls suggest an underlying difference in mucosal immune response. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - July 19, 2009 Category: Endocrinology Authors: M Simpson, M Mojibian, K Barriga, FW Scott, A Fasano, M Rewers, JM Norris Source Type: journals

In vitro (re)programming of human bone marrow stromal cells toward insulin-producing phenotypesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Limbert C, Seufert J. In vitro (re)programming of human bone marrow stromal cells toward insulin-producing phenotypes. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - July 13, 2009 Category: Endocrinology Authors: Catarina Limbert, Jochen Seufert Source Type: journals

Low dose (0.05 units/kg/h) is comparable with standard dose (0.1 units/kg/h) intravenous insulin infusion for the initial treatment of diabetic ketoacidosis in children with type 1 diabetes—an observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this observational study, low dose was as effective as standard dose intravenous insulin infusion in the initial treatment (less than 6 h) of DKA in children with type 1 diabetes. A randomised controlled trial is required to show true equivalence between doses and to evaluate potential safety benefits. Puttha R, Cooke D, Subbarayan A, Odeka E, Ariyawansa I, Bone M, Doughty I, Patel L, Amin R. Low dose (0.05 units/kg/h) is comparable with standard dose (0.1 units/kg/h) intravenous insulin infusion for the initial treatment of diabetic ketoacidosis in children with type 1 diabetes[mdash]an observational study ...
Source: Pediatric Diabetes - July 6, 2009 Category: Endocrinology Authors: R. Puttha, D. Cooke, A. Subbarayan, E. Odeka, I. Ariyawansa, M. Bone, I. Doughty, L. Patel, R. Amin Source Type: journals

Discontinuation of insulin pump treatment in children, adolescents, and young adults. A multicenter analysis based on the DPV database in Germany and AustriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The discontinuation rate of insulin pump therapy is, in general, low (4%). The younger the patients at the time of initiating insulin pump treatment, the lower is the discontinuation rate. The highest rate was seen in adolescents aged 10[ndash]15 yr. Girls stopped insulin pump treatment more often than boys (60.5% vs. 39.5%). (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 28, 2009 Category: Endocrinology Authors: SE Hofer, B Heidtmann, K Raile, E Fröhlich-Reiterer, E Lilienthal, MA Berghaeuser, RW Holl Source Type: journals

Necrotizing enterocolitis in neonates receiving octreotide for the management of congenital hyperinsulinismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Laje P, Halaby L, Adzick NS, Stanley CA. Necrotizing enterocolitis in neonates receiving octreotide for the management of congenital hyperinsulinism. The somatostatin analog octreotide was used for the first time in the treatment of an infant with congenital hyperinsulinism in 1986. Since then, it is commonly used in the management of congenital hyperinsulinemic hypoglycemias. Despite a wide variety of potential adverse reactions, octreotide is generally well tolerated. It has been extensively demonstrated that octreotide reduces the splanchnic blood flow in a dose-dependent manner, affecting the entire gastrointestinal tr...
Source: Pediatric Diabetes - June 25, 2009 Category: Endocrinology Authors: Pablo Laje, Lori Halaby, N Scott Adzick, Charles A Stanley Source Type: journals

The establishment of a new national network leads to quality improvement in childhood diabetes: Implementation of the ISPAD GuidelinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: During the establishment of a system for benchmarking of diabetes treatment in Norway the outcomes showed significant improvements associated with changes in management and the quality of screening assessments. Benchmarking combined with organized quality meetings and discussions was effective to improve outcome on a national level. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 24, 2009 Category: Endocrinology Authors: Hanna D Margeirsdottir, Jakob R Larsen, Siv J Kummernes, Cathrine Brunborg, Knut Dahl-Jørgensen Source Type: journals

Follow-up results on monitoring and discussing health-related quality of life in adolescent diabetes care: benefits do not sustain in routine practiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The beneficial effects of an office-based HRQoL intervention in adolescents with diabetes largely disappear 1 year after withdrawing the HRQoL assessment procedure. This finding underscores the importance of integrating standardized evaluation and discussion of HRQoL in routine care for adolescents with diabetes. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 16, 2009 Category: Endocrinology Authors: Maartje de Wit, Henriette A. Delemarre-van de Waal, Jan Alle Bokma, Krijn Haasnoot, Mieke C. Houdijk, Reinoud J. Gemke, Frank J. Snoek Source Type: journals

Hypoglycaemia in childhood onset type 1 diabetes–part villain, but not the only oneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Northam EA, Lin A. Hypoglycaemia in childhood onset type 1 diabetes [ndash]part villain, but not the only one. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 16, 2009 Category: Endocrinology Authors: Elisabeth A Northam, Ashleigh Lin Source Type: journals

Subclinical atherosclerosis in diabetic children: results of a longitudinal studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In a well-selected group of diabetic children, mean IMT progression during a 2-yr period did not exceed the physiological increase. Children with a higher HbA1c and a higher systolic blood pressure showed a progression of the IMT. Control of atherogenic risk factors in diabetic children may help to avoid subclinical atherosclerosis progression. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 11, 2009 Category: Endocrinology Authors: Robert Dalla Pozza, Heinrich Netz, Hans-Peter Schwarz, Susanne Bechtold Source Type: journals

An infant with combination gene mutations for Monogenic Diabetes of Youth (MODY) 2 and 4, presenting with Diabetes Mellitus Requiring Insulin (DMRI) at 8 months of ageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Odem J, Munzinger E, Violand S, Van Morlan A, Rife D, and Bachrach B. An infant with combination gene mutations for MODY 2 and 4, presenting with DMRI at 8 months of age. Monogenic Diabetes of Youth (MODY) is an autosomal dominant form of diabetes. [Fajans SS, et al. NEJM 2001: 345: 971[ndash]980.] There are at least six different types of MODY, all of which involve a loss of function gene mutation that results in diminished insulin production. MODY2 results from a mutation in the glucokinase gene (GCK), which decreases enzyme activity. MODY4 results from a mutation in the insulin promoter factor-1 (IPF-1) gene, a transcri...
Source: Pediatric Diabetes - June 10, 2009 Category: Endocrinology Authors: Jamie Odem, Ethan Munzinger, Sarah Violand, Amie Van Morlan, Danita Rife, Bert Bachrach Source Type: journals

Intensive vs. conventional insulin management initiated at diagnosis in children with diabetes: Should payer source influence the choice of therapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, IIM had improved glycemic control. Private insurance vs. Medicaid patients had lower mean A1c values regardless of treatment group. Considering Medicaid patients only, IIM was not inferior, and for those with private insurance, IIM was superior. IIM, initiated at diagnosis, is a reasonable approach for newly diagnosed children with diabetes regardless of payer source. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 9, 2009 Category: Endocrinology Authors: Joni K Beck, Teresa V Lewis, Kathy J Logan, Donald L Harrison, Andrew W Gardner, Kenneth C Copeland Source Type: journals

Validation of a health administrative data algorithm for assessing the epidemiology of diabetes in Canadian childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Population-based surveillance of diabetes in children is possible using administrative data. This will facilitate further study of trends in incidence but also in use of health services and outcomes. Further work to differentiate type 1 and 2 diabetes will be important. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 7, 2009 Category: Endocrinology Authors: Astrid Guttmann, Meranda Nakhla, Melanie Henderson, Teresa To, Denis Daneman, Karen Cauch-Dudek, Xuesong Wang, Kelvin Lam, Jan Hux Source Type: journals

Arterial HTN in children with T1DM—frequent and not easy to diagnoseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Children with T1DM often suffer from nocturnal, white coat- and masked HTN, which can not be assessed and predicted by the OBP. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 5, 2009 Category: Endocrinology Authors: Terezie [Scaron]uláková, Jan Janda, Jana Černá, Vlasta Jan[scaron]tová, Astrid [Scaron]uláková, Jaroslav Slaný, Janusz Feber Source Type: journals

Neonatal diabetes mellitus due to pancreas agenesis: a new case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Seick Barbarini D, Haslinger V, Schmidt K, Patch A-M, Müller G, Simma B. Neonatal diabetes mellitus due to pancreas agenesis: a new case report and review of the literature. Neonatal diabetes mellitus (NDM) is a rare condition (1:400 000 neonates) defined as hyperglycemia occurring in the first months of life, lasting more than 2 wk and requiring insulin for management. We here report on a 33-month-old girl with pancreatic agenesis, an extremely rare cause of permanent neonatal diabetes mellitus (PNDM). Timely diagnosis and adequate treatment of both endocrine and exocrine insufficiency may permit survival and normal deve...
Source: Pediatric Diabetes - June 3, 2009 Category: Endocrinology Authors: Daniela Seick Barbarini, Vera Haslinger, Katerina Schmidt, Ann-Marie Patch, Guido Müller, Burkhard Simma Source Type: journals

Neonatal diabetes mellitus with pancreatic agenesis in an infant with homozygous IPF-1 Pro63fsX60 mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with permanent neonatal diabetes mellitus and severe exocrine pancreatic insufficiency. Ultrasound examination revealed pancreatic agenesis with a suggestion of a small amount of tissue in the head of the pancreas. Genetic testing revealed that the neonate had a homozygous Pro63fsX60 IPF-1 mutation. This is the second reported case of neonatal diabetes mellitus secondary to a homozygous mutation in the IPF-1 gene and supports the previously proposed biological role of IPF-1 in the pancreatic development in human. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 3, 2009 Category: Endocrinology Authors: Inas H Thomas, Natinder K Saini, Amita Adhikari, Joyce M Lee, Josephine Z Kasa-vubu, Delia M Vazquez, Ram K Menon, Ming Chen, Stefan S Fajans Source Type: journals

Increasing incidence of childhood-onset type 1 diabetes mellitus among Estonian children in 1999–2006. Time trend analysis 1983–2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The incidence of childhood-onset T1DM in Estonia continues to rise and the age of onset of the disease becomes younger. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 3, 2009 Category: Endocrinology Authors: Tuuli Teeäär, Natalja Liivak, Kaire Heilman, Pille Kool, Riina [Scaron]or, Mare Paal, Ülle Einberg, Vallo Tillmann Source Type: journals

Type 2 diabetes mellitus in children and adolescents is still a rare disease in Germany: a population-based assessment of the prevalence of type 2 diabetes and MODY in patients aged 0–20 yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The prevalence of T2DM and MODY is considerably lower than the prevalence of type 1 diabetes. Type 2 diabetes thus continues to be a rare disease in children and adolescents in Germany, as is also the case in other European countries. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 3, 2009 Category: Endocrinology Authors: Andreas Neu, Lutz Feldhahn, Stefan Ehehalt, Regine Hub, Michael B Ranke Source Type: journals

Incidence of neonatal diabetes in Austria–calculation based on the Austrian Diabetes RegisterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The incidence of NDM in Austria is 1/160 949, with an incidence of 1/ 536 499 for PNDM and 1/229 928 for TNDM. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 3, 2009 Category: Endocrinology Authors: Barbara Wiedemann, Edith Schober, Thomas Waldhoer, Julia Koehle, Sarah E Flanagan, Deborah JG Mackay, Elisabeth Steichen, Dagmar Meraner, Lothar-Bernd Zimmerhackl, Andrew T Hattersley, Sian Ellard, Sabine Hofer Source Type: journals

Type 1 diabetes mellitus and school: a comparison of patients and healthy siblingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Parent KB, Wodrich DL, Hasan KS. Type 1 diabetes mellitus and school: a comparison of patients and healthy siblings Children and adolescents with type 1 diabetes mellitus (T1DM) are at risk for a variety of problems at school. Well-controlled studies using data collected in schools, however, are limited. The purposes of this study are to determine whether selected school problems are associated with T1DM and to investigate an association between these problems and medical variables. Teachers rated 95 diabetic students (M = 11.8; SD = 3.0 yr old) and 95 of their siblings (M = 12.1; SD = 3.0 yr old) regarding academic skills...
Source: Pediatric Diabetes - June 3, 2009 Category: Endocrinology Authors: Kelly B Parent, David L Wodrich, Khalid S Hasan Source Type: journals

Status and rationale of renoprotection studies in adolescents with type 1 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Marcovecchio ML, Tossavainen PH, Dunger DB. Status and rationale of renoprotection studies in adolescents with type 1 diabetes.Pediatric Diabetes 2009. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - June 2, 2009 Category: Endocrinology Authors: M Loredana Marcovecchio, Päivi H Tossavainen, David B Dunger Source Type: journals

Increased arterial stiffness in children and adolescents with type 1 diabetes: no association between arterial stiffness and serum levels of adiponectinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Children and adolescents with type 1 diabetes had increased arterial stiffness and reduced arterial distensibility and arterial compliance. However, no associations between arterial functional alterations and adiponectin concentrations were seen. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - May 30, 2009 Category: Endocrinology Authors: Angela Galler, Amadea Heitmann, Werner Siekmeyer, Götz Gelbrich, Thomas Kapellen, Jürgen Kratzsch, Wieland Kiess Source Type: journals

Metformin therapy to reduce weight gain and visceral adiposity in children and adolescents with neurogenic or myogenic motor deficitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, metformin treatment for 6 months was associated with a rise in insulin sensitivity and with a reduction of visceral adiposity in children and adolescents with a primary muscle disorder or with a neural tube defect. These findings suggest that insulin resistance underpins, at least partly, the overweight and visceral adiposity of these patients, who are not necessarily obese. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - May 28, 2009 Category: Endocrinology Authors: Kristina Casteels, Steffen Fieuws, Maria van Helvoirt, Carla Verpoorten, Nathalie Goemans, Walter Coudyzer, Dirk Loeckx, Francis de Zegher Source Type: journals