Lifestyle patterns and endocrine, metabolic and immunological biomarkers in European adolescents: The HELENA study
CONCLUSIONSOur results support the existence of different interactions between metabolic health and lifestyle patterns related to PA, sedentariness and sleep, with some gender ‐specific findings. These results highlight the importance to consider multiple lifestyle related health factors in the assessment of adolescents’ health in order to plan favourable strategies.This article is protected by copyright. All rights reserved. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 24, 2018 Category: Endocrinology Authors: C ésar Agostinis‐Sobrinho,
Sonia Gómez‐Martínez,
Esther Nova,
Aurora Hernandez,
Idoia Labayen,
Antonios Kafatos,
Frederic Gottand,
Dénes Molnár,
Marika Ferrari,
Luis A. Moreno,
Nathalie Michels,
Azahara Ruperez,
Jonatan R. Ruiz,
Asce Tags: ORIGINAL ARTICLE Source Type: research
Levels of type 1 diabetes care in children and adolescents for countries at varying resource levels
This article is protected by copyright. All rights reserved. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 23, 2018 Category: Endocrinology Authors: Graham David Ogle,
Julia Elisabeth von Oettingen,
Angie Middlehurst,
Ragnar Hanas,
Trevor Orchard Tags: REVIEW ARTICLE Source Type: research
Non ‐alcoholic fatty liver disease in pediatric type 2 diabetes: metabolic and histologic characteristics in 38 subjects
ConclusionsIn children with type 2 diabetes and NAFLD, NASH is common. Having advanced fibrosis in 26% of NASH cases at this age is concerning. Better control of lipids, weight and diabetes may help avoid worsening in NAS.This article is protected by copyright. All rights reserved. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 22, 2018 Category: Endocrinology Authors: Ron S Newfield,
Carrie L Graves,
Robert O Newbury,
Jeffrey B Schwimmer,
James A Proudfoot,
Daphne S Say,
Ariel E Feldstein Tags: ORIGINAL ARTICLE Source Type: research
Individual glucose responses to prolonged moderate intensity aerobic exercise in adolescents with type 1 diabetes: The higher they start, the harder they fall
ConclusionYouth with T1D have variable glycemic responses to prolonged aerobic exercise, but this variability is partially explained by their pre ‐exercise blood glucose levels. When no implementation strategies are in place to limit the drop in glycemia, the incidence of exercise‐associated hypoglycemia is ~44% and having a high pre‐exercise blood glucose concentration is only marginally protective.This article is protected by copyright. All rights reserved. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 22, 2018 Category: Endocrinology Authors: Michael C. Riddell,
Dessi P. Zaharieva,
Michael Tansey,
Eva Tsalikian,
Gil Admon,
Zoey Li,
Craig Kollman,
Roy W. Beck Tags: ORIGINAL ARTICLE Source Type: research
The influence of cardiorespiratory fitness on clustered cardiovascular disease risk factors and the mediator role of BMI in youth: The UP & DOWN study
ConclusionsBMI is an independent predictor of CVDRF ‐I and a mediator of the association between CRF and CVDRF‐I in children and adolescents. These results help to clarify the associations between CRF, weight status and cardiovascular health, suggesting that future CVD health would benefit from maintaining an optimal weight status.This article is protected by copyright. All rights reserved. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 22, 2018 Category: Endocrinology Authors: Alejandro P érez‐Bey,
Víctor Segura‐Jiménez,
Jorge del Rosario Fernández‐Santos,
Irene Esteban‐Cornejo,
Sonia Gómez‐Martínez,
Oscar L. Veiga,
Ascensión Marcos,
Francisco B. Ortega,
José Castro‐Piñero Tags: ORIGINAL ARTICLE Source Type: research
Optimal predictive low glucose management settings during physical exercise in adolescents with type 1 diabetes
ConclusionsA PLGM threshold of 90 mg/dL during the night was associated with reduced time in hypoglycemia in adolescents doing frequent physical exercise, while maintaining 65.1% time in range during the day. However, a threshold of 70 mg/dL seems to be safe in the duration of the physical exercise. PLGM system in adolescents w ith type 1 diabetes was effective to prevent hypoglycemia during and after exercise, irrespective of the PLGM thresholds used. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 22, 2018 Category: Endocrinology Authors: Valentino Cherubini,
Rosaria Gesuita,
Edlira Skrami,
Ivana Rabbone,
Riccardo Bonfanti,
Claudia Arnaldi,
Giuseppe D'Annunzio,
Annapaola Frongia,
Fortunato Lombardo,
Elvira Piccinno,
Riccardo Schiaffini,
Sonia Toni,
Stefano Tumini,
Davide Tinti Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
Pediatric Diabetes, Volume 19, Issue 8, Page 1347-1350, December 2018. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 20, 2018 Category: Endocrinology Tags: ISSUE INFORMATION Source Type: research
Treatment adherence and BMI reduction are key predictors of HbA1c 1 year after diagnosis of childhood type 2 diabetes in the United Kingdom
ConclusionsAdherence to treatment and a reduction in BMI appear key to better outcomes a year after T2DM diagnosis. Retention and clinic attendance are concerning. The prevalence of microalbuminuria has increased 4 ‐fold in the year following diagnosis and was associated with higher HbA1c. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 20, 2018 Category: Endocrinology Authors: Toby P. Candler,
Osama Mahmoud,
Richard M. Lynn,
Abdalmonen A. Majbar,
Timothy G. Barrett,
Julian P. H. Shield Tags: ORIGINAL ARTICLE Source Type: research
Association between 14 bp insertion/deletion HLA ‐G functional polymorphism and insulin resistance in a cohort of Italian children with obesity
ConclusionsWe showed a strong association betweenHLA ‐G 14 bp ins/ins genotype and HOMA in obese children and adolescents. This association could be hypothetically modulated by subclinical inflammation. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 20, 2018 Category: Endocrinology Authors: Pierluigi Marzuillo,
Giulia Bellini,
Francesca Punzo,
Anna Di Sessa,
Stefano Guarino,
Giuseppina R. Umano,
Roberto Toraldo,
Emanuele Miraglia del Giudice,
Francesca Rossi Tags: ORIGINAL ARTICLE Source Type: research
Cyclical variation in the incidence of childhood ‐onset type 1 diabetes during 40 years in Navarra (Spain)
ConclusionsThe incidence of T1D in Navarre has increased 4 ‐fold in the last four decades but is stable since 2001. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 20, 2018 Category: Endocrinology Authors: Luis Forga,
Mar ía Jesús Chueca,
Ibai Tamayo,
Mirentxu Oyarzabal,
Marta Toni,
María José Goñi Tags: ORIGINAL ARTICLE Source Type: research
Sleep and type 1 diabetes in children and adolescents: Proposed theoretical model and clinical implications
This article is protected by copyright. All rights reserved. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 17, 2018 Category: Endocrinology Authors: Alexandra Monzon,
Ryan McDonough,
Lisa J. Meltzer,
Susana R. Patton Tags: REVIEW ARTICLE Source Type: research
Comprehensive genetic screening: The prevalence of maturity ‐onset diabetes of the young gene variants in a population‐based childhood diabetes cohort
ConclusionsThis is the first comprehensive study of MODY variants in an unselected population ‐based pediatric diabetes cohort. The observed prevalence, increasing access to rapid and affordable genetic screening, and significant clinical implications suggest that genetic screening for MODY could be considered for all children with diabetes, irrespective of other clinical features. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 14, 2018 Category: Endocrinology Authors: Stephanie R. Johnson,
Jonathan J. Ellis,
Paul J. Leo,
Lisa K. Anderson,
Uma Ganti,
Jessica E. Harris,
Jacqueline A. Curran,
Aideen M. McInerney ‐Leo,
Nirubasini Paramalingam,
Xiaoxia Song,
Louise S. Conwell,
Mark Harris,
Timothy W. Jones,
M Tags: ORIGINAL ARTICLE Source Type: research
A randomized clinical trial to evaluate the single ‐dose pharmacokinetics, pharmacodynamics, and safety of sitagliptin in pediatric patients with type 2 diabetes
ConclusionsSingle doses of sitagliptin as high as 200 mg were generally well tolerated in 10‐ to 17‐year‐old male and female study participants with T2DM, and a daily sitagliptin dose of 100 mg is appropriate for evaluation in Phase III safety and efficacy studies in pediatric patients with T2DM. (ClinicalTrials.gov: NCT00730275). (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 13, 2018 Category: Endocrinology Authors: Iain P. Fraser,
Naomi D. Neufeld,
Larry A. Fox,
Mark S. Kipnes,
Tracie L. Miller,
Philip S. Zeitler,
Henry Rodriguez,
Jocelyn H. Gilmartin,
Susan J. Lee,
Jaclyn K. Patterson,
Xiujiang S. Li,
Lata Maganti,
Wen ‐Lin Luo,
Daniel A. Tatosian,
Tags: ORIGINAL ARTICLE Source Type: research
Choosing an accurate outcome metric for pediatric obesity care
This article is protected by copyright. All rights reserved. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 12, 2018 Category: Endocrinology Authors: Michelle C. Gorecki,
Helen J Binns Tags: LETTER TO THE EDITOR Source Type: research
Fluid Treatment for Children with Diabetic Ketoacidosis: How do the Results from the Pediatric Emergency Care Applied Research Network (PECARN) Fluid Therapies Under Investigation in Diabetic Ketoacidosis (FLUID) Trial Change our Perspective?
This article is protected by copyright. All rights reserved. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - November 11, 2018 Category: Endocrinology Authors: Nicole Glaser,
Nathan Kuppermann Tags: ORIGINAL ARTICLE Source Type: research
