Pathophysiology of primary hypertension in children and adolescents
This article presents data from pediatric clinical trials describing the most important pathophysiological processes associated with the development of essential hypertension in children and adolescents. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Ongoing impacts of childhood-onset glomerular diseases during young adulthood
ConclusionWe analyzed the impact of childhood-onset glomerular disease and distress during the transition period from pediatric to adult care. This study highlighted the significant impact of medications and exercise restrictions on patients ’ decisions regarding higher education. Future prospective studies will be needed to examine patients’ distress in more detail and establish management approaches to enhance patient quality of life.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Hypertension in diabetes
AbstractDiabetes mellitus, a disease that affects hundreds of millions of people worldwide, is increasing in prevalence in all age groups, including children and adolescents. Much of the morbidity and mortality associated with diabetes is closely related to hypertension, often coincident with diabetes. Comorbid hypertension and diabetes often worsen the outcomes of each other, likely rooted in some overlapping pathogenic mechanisms. In this educational review, we will discuss the shared pathophysiology of diabetes and hypertension, particularly in regard to inflammation and oxidative stress, the sympathetic nervous system,...
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Volume expansion mitigates Shiga toxin-producing E. coli-hemolytic uremic syndrome in children
ConclusionsThis study suggests that volume expansion may be associated with the mitigation of the acute course of STEC-HUS, especially severe neurological involvement and the development of CKD. Prospective trials should lead to standardized protocols for volume expansion in children with STEC-HUS.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Urinary sphingolipids in adolescents and young adults with youth-onset diabetes
ConclusionUrinary sphingolipids are elevated in adolescents and young adults with youth-onset diabetes and correlate with ACR. Urinary sphingolipids may therefore represent an early biomarker of DKD.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Anterior and posterior ischemic optic neuropathy in a child with focal segmental glomerulosclerosis on hemodialysis
ConclusionsThe exact cause of our patient ’s simultaneous bilateral anterior and posterior ION, confirmed via MRI and fundoscopic examination, is unclear; however, is likely secondary to a combination of fluctuating blood pressure, anemia, anephric status, and hemodialysis. This highlights the need for close blood pressure monitoring, man agement of anemia, and more diligent ophthalmologic screening in pediatric patients on chronic hemodialysis. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Kidney biopsy findings in children with diabetes mellitus
ConclusionsWe confirm that changes better known in adults with either type 1 or type 2 diabetes mellitus can occur in children with type 1 diabetes mellitus: overt diabetic nephropathy either on its own or combined with other conditions and kidney disorders other than diabetic nephropathy.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
M üllerian anomalies in girls with congenital solitary kidney
ConclusionsThe prevalence of MA in patients with congenital SFK was 24% among those age 10 years or older, and 38% were obstructive. This justifies routine screening pelvic ultrasound in girls with congenital SFK to improve early diagnosis.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Apoptosis in post-streptococcal glomerulonephritis and mechanisms for failed of inflammation resolution
AbstractPost-streptococcal glomerulonephritis is a condition resulting from infection by group A beta-hemolytic streptococcus. The main mechanism involves the formation of immune complexes formed in the circulation or in situ on the glomerular basement membrane, which activates complement and causes various inflammatory processes. Cellular mechanisms have been reported in the induction of kidney damage represented by the infiltration of innate cells (neutrophils and monocyte/macrophages) and adaptive cells (CD4 + lymphocytes and CD8 + lymphocytes) of the immune system. These cells induce kidney damage through vari...
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
A 6-year review of acute post-streptococcal glomerulonephritis at a public children ’s hospital in Cape Town, South Africa
ConclusionsChildhood APSGN remains an important health problem in South Africa (SA) with favourable outcomes in most, apart from those with crescentic glomerulonephritis who progressed to kidney failure.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Feasibility of discontinuing immunosuppression in children with idiopathic nephrotic syndrome
ConclusionsLong-term discontinuation of immunosuppressants can be feasible in patients without a relapse on initial immunosuppressants, those with longer relapse-free interval before discontinuation of immunosuppressants, and those without a relapse for one year after discontinuation of immunosuppressants.Trial registrationNot applicable.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Childhood-onset IgA nephropathy: is long-term recovery possible?
ConclusionsApproximately one-third of patients with pediatric-onset IgAN achieve prolonged remission, in particular, very young children at disease onset without sclerotic glomerular lesions. Longer term follow-up is needed to assess if these patients have achieved permanent remission.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Adrenocortical suppression in children with nephrotic syndrome treated with corticosteroids
ConclusionsA significant proportion of children with nephrotic syndrome were detected with adrenal insufficiency on ACTH stimulation test. A cumulative steroid intake of > 0.22 mg/kg/day on an alternate day basis emerged as a risk factor for predicting adrenocortical suppression.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Provision of pediatric nephrology services in low –middle-income countries
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Factors predicting persistent proteinuria in children with acute poststreptococcal glomerulonephritis: a tertiary center experience in Japan
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
