"The forest and the trees": a narrative medicine curriculum by residents for residents
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03142-2. Online ahead of print.ABSTRACTA 7-session narrative medicine (NM) curriculum was designed and facilitated by pediatrics residents for pediatrics residents in order to unpack challenging experiences during clinical training and strengthen relationships with colleagues and patients. The primary facilitator, a resident with a master's degree in NM, provided facilitator training to her co-residents with whom she co-led the workshops in the curriculum. We conducted, transcribed, and analyzed individual interviews of 15 residents, with three resultant themes: reflection ...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Anoushka Sinha Carly S Slater Alyson Lee Harini Sridhar Deepthiman Gowda Source Type: research

Combining activity and grimace scores reflects perinatal stability in infants & lt;32 weeks gestational age
CONCLUSION: Scoring of activity and grimace was consistent between clinicians. Independently, activity and grimace did not correlate with perinatal stabilisation. Combined scoring showed non-vigorous infants had greater resuscitation requirements.IMPACT: Our study evaluates the precision and accuracy of activity and grimace to predict perinatal stability, which has not been validated in infants <32 weeks gestational age. We found strong score agreement between assessors, indicating video review is a practical and precise method for grading of activity and grimace. Combined scoring to allow a dichotomous evaluation of in...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Zachary Tuttle Calum Roberts Peter Davis Atul Malhotra Kenneth Tan Risha Bhatia Lindsay Zhou Elizabeth Baker Kate Hodgson Douglas Blank Source Type: research

Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03105-7. Online ahead of print.ABSTRACTThe hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. In human fetal development, hippocampal neurogenesis is principally complete by mid-gestation, with subsequent maturation comprising dendritogenesis and synaptogenesis in the third trimester of pregnancy and infancy. Dendritogenesis and synaptogenesis underpin connectivity. Hippocampal development is exquisitely sensitive to perturbations du...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Tegan A White Suzanne L Miller Amy E Sutherland Beth J Allison Emily J Camm Source Type: research

Perinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03144-0. Online ahead of print.ABSTRACTThe hippocampus is a vital brain structure deep in the medial temporal lobe that mediates a range of functions encompassing emotional regulation, learning, memory, and cognition. Hippocampal development is exquisitely sensitive to perturbations and adverse conditions during pregnancy and at birth, including preterm birth, fetal growth restriction (FGR), acute hypoxic-ischaemic encephalopathy (HIE), and intrauterine inflammation. Disruptions to hippocampal development due to these conditions can have long-lasting functional impacts. Her...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Tegan A White Suzanne L Miller Amy E Sutherland Beth J Allison Emily J Camm Source Type: research

Unveiling the impact of maternal gestational diabetes mellitus on cord blood CD71+ erythroid cell transcriptome
This study reveals the effects of maternal gestational diabetes mellitus (GDM) on the transcriptome of CD71+ erythroid cells (CECs) in cord blood. It highlights the role of CECs in immunosuppressive function and identifies potential mechanisms linking GDM to adverse outcomes in offspring. This understanding might lead to improved strategies for managing and preventing adverse outcomes in infants born to mothers with GDM.PMID:38519796 | DOI:10.1038/s41390-024-03139-x (Source: Pediatric Research)
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Min Yin Yan Zhang Xinyu Li Xia Li Source Type: research

"The forest and the trees": a narrative medicine curriculum by residents for residents
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03142-2. Online ahead of print.ABSTRACTA 7-session narrative medicine (NM) curriculum was designed and facilitated by pediatrics residents for pediatrics residents in order to unpack challenging experiences during clinical training and strengthen relationships with colleagues and patients. The primary facilitator, a resident with a master's degree in NM, provided facilitator training to her co-residents with whom she co-led the workshops in the curriculum. We conducted, transcribed, and analyzed individual interviews of 15 residents, with three resultant themes: reflection ...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Anoushka Sinha Carly S Slater Alyson Lee Harini Sridhar Deepthiman Gowda Source Type: research

Combining activity and grimace scores reflects perinatal stability in infants & lt;32 weeks gestational age
CONCLUSION: Scoring of activity and grimace was consistent between clinicians. Independently, activity and grimace did not correlate with perinatal stabilisation. Combined scoring showed non-vigorous infants had greater resuscitation requirements.IMPACT: Our study evaluates the precision and accuracy of activity and grimace to predict perinatal stability, which has not been validated in infants <32 weeks gestational age. We found strong score agreement between assessors, indicating video review is a practical and precise method for grading of activity and grimace. Combined scoring to allow a dichotomous evaluation of in...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Zachary Tuttle Calum Roberts Peter Davis Atul Malhotra Kenneth Tan Risha Bhatia Lindsay Zhou Elizabeth Baker Kate Hodgson Douglas Blank Source Type: research

Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03105-7. Online ahead of print.ABSTRACTThe hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. In human fetal development, hippocampal neurogenesis is principally complete by mid-gestation, with subsequent maturation comprising dendritogenesis and synaptogenesis in the third trimester of pregnancy and infancy. Dendritogenesis and synaptogenesis underpin connectivity. Hippocampal development is exquisitely sensitive to perturbations du...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Tegan A White Suzanne L Miller Amy E Sutherland Beth J Allison Emily J Camm Source Type: research

Perinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03144-0. Online ahead of print.ABSTRACTThe hippocampus is a vital brain structure deep in the medial temporal lobe that mediates a range of functions encompassing emotional regulation, learning, memory, and cognition. Hippocampal development is exquisitely sensitive to perturbations and adverse conditions during pregnancy and at birth, including preterm birth, fetal growth restriction (FGR), acute hypoxic-ischaemic encephalopathy (HIE), and intrauterine inflammation. Disruptions to hippocampal development due to these conditions can have long-lasting functional impacts. Her...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Tegan A White Suzanne L Miller Amy E Sutherland Beth J Allison Emily J Camm Source Type: research

Unveiling the impact of maternal gestational diabetes mellitus on cord blood CD71+ erythroid cell transcriptome
This study reveals the effects of maternal gestational diabetes mellitus (GDM) on the transcriptome of CD71+ erythroid cells (CECs) in cord blood. It highlights the role of CECs in immunosuppressive function and identifies potential mechanisms linking GDM to adverse outcomes in offspring. This understanding might lead to improved strategies for managing and preventing adverse outcomes in infants born to mothers with GDM.PMID:38519796 | DOI:10.1038/s41390-024-03139-x (Source: Pediatric Research)
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Min Yin Yan Zhang Xinyu Li Xia Li Source Type: research

"The forest and the trees": a narrative medicine curriculum by residents for residents
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03142-2. Online ahead of print.ABSTRACTA 7-session narrative medicine (NM) curriculum was designed and facilitated by pediatrics residents for pediatrics residents in order to unpack challenging experiences during clinical training and strengthen relationships with colleagues and patients. The primary facilitator, a resident with a master's degree in NM, provided facilitator training to her co-residents with whom she co-led the workshops in the curriculum. We conducted, transcribed, and analyzed individual interviews of 15 residents, with three resultant themes: reflection ...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Anoushka Sinha Carly S Slater Alyson Lee Harini Sridhar Deepthiman Gowda Source Type: research

Combining activity and grimace scores reflects perinatal stability in infants & lt;32 weeks gestational age
CONCLUSION: Scoring of activity and grimace was consistent between clinicians. Independently, activity and grimace did not correlate with perinatal stabilisation. Combined scoring showed non-vigorous infants had greater resuscitation requirements.IMPACT: Our study evaluates the precision and accuracy of activity and grimace to predict perinatal stability, which has not been validated in infants <32 weeks gestational age. We found strong score agreement between assessors, indicating video review is a practical and precise method for grading of activity and grimace. Combined scoring to allow a dichotomous evaluation of in...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Zachary Tuttle Calum Roberts Peter Davis Atul Malhotra Kenneth Tan Risha Bhatia Lindsay Zhou Elizabeth Baker Kate Hodgson Douglas Blank Source Type: research

Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03105-7. Online ahead of print.ABSTRACTThe hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. In human fetal development, hippocampal neurogenesis is principally complete by mid-gestation, with subsequent maturation comprising dendritogenesis and synaptogenesis in the third trimester of pregnancy and infancy. Dendritogenesis and synaptogenesis underpin connectivity. Hippocampal development is exquisitely sensitive to perturbations du...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Tegan A White Suzanne L Miller Amy E Sutherland Beth J Allison Emily J Camm Source Type: research

Perinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03144-0. Online ahead of print.ABSTRACTThe hippocampus is a vital brain structure deep in the medial temporal lobe that mediates a range of functions encompassing emotional regulation, learning, memory, and cognition. Hippocampal development is exquisitely sensitive to perturbations and adverse conditions during pregnancy and at birth, including preterm birth, fetal growth restriction (FGR), acute hypoxic-ischaemic encephalopathy (HIE), and intrauterine inflammation. Disruptions to hippocampal development due to these conditions can have long-lasting functional impacts. Her...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Tegan A White Suzanne L Miller Amy E Sutherland Beth J Allison Emily J Camm Source Type: research

Unveiling the impact of maternal gestational diabetes mellitus on cord blood CD71+ erythroid cell transcriptome
This study reveals the effects of maternal gestational diabetes mellitus (GDM) on the transcriptome of CD71+ erythroid cells (CECs) in cord blood. It highlights the role of CECs in immunosuppressive function and identifies potential mechanisms linking GDM to adverse outcomes in offspring. This understanding might lead to improved strategies for managing and preventing adverse outcomes in infants born to mothers with GDM.PMID:38519796 | DOI:10.1038/s41390-024-03139-x (Source: Pediatric Research)
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Min Yin Yan Zhang Xinyu Li Xia Li Source Type: research