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Cardiowest temporary total artificial heart.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: It is evident that the advancement of modern engineering and medicine has made way for a reliable and durable device that provides a promising future in the field of end-stage heart failure. PMID: 19917572 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - November 16, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Platis AG, Larson D Tags: Perfusion Source Type: journals

Outcomes comparison of 5 coated cardiopulmonary bypass circuits versus an uncoated control group of patients undergoing cardiac surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: We compared all 5 coated circuits approved for clinical use in Canada against an uncoated control circuit. Three of the 5 coated circuits (Trillium, Phisio and Bioline BCC) were found to improve ventilator and ICU time compared to Control. Further studies are indicated to validate these results and their impact upon approval criteria, purchasing choices and safe clinical practice, especially as applied to higher risk diabetic patients. PMID: 19906771 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - November 11, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Marcoux J, Sohn N, Rosin M, Mycyk T, Lim H Tags: Perfusion Source Type: journals

Clinical evaluation of the new BMU 40 in-Line blood analysis monitor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The BMU 40 is a precise, accurate and reliable continuous in-line blood parameter measuring system that can easily be used within a standard CPB setup. However, present data suggest an in vivo calibration of the BMU 40 should be performed. PMID: 19880664 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - October 30, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Schaarschmidt J, Seeburger J, Borger MA, Grosse FO, Kraemer K, Mohr FW Tags: Perfusion Source Type: journals

CPB-assisted aortic valve replacement in a pregnant 27 year old with endocarditis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 27-year-old, G3P2A0 female with acute Staph aureus (SA) endocarditis successfully underwent CPB-assisted aortic valve replacement with a bioprosthetic aortic valve at 22 weeks' gestation. This patient's presentation of acute endocarditis complicated by septic shock, congestive heart failure, severe aortic insufficiency, multiple septic embolic events and borderline renal failure appeared on the daunting background of chronic heavy tobacco usage, hepatitis C positivity, longterm IV drug abuse and a pregnancy into its twenty-second week. Optimal treatment strategies implemented for both mother and fetus throughout the ...
Source: Perfusion - October 29, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Marcoux J, Rosin M, Mycyk T Tags: Perfusion Source Type: journals

Does CO2 flushing of the empty CPB circuit decrease the number of gaseous emboli in the prime?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, CO2 flushing of the empty circuit decreases the number of gaseous emboli in the prime compared with a conventional circuit that contains air before being primed with fluid. Knocking of the oxygenator releases gaseous emboli and the duration of re-circulating the circuit with prime influences the number of microemboli. PMID: 19864467 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - October 28, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Nyman J, Rundby C, Svenarud P, van der Linden J Tags: Perfusion Source Type: journals

The impact of different biocompatible coated cardiopulmonary bypass circuits on inflammatory response and oxidative stress.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was to compare the impact of different biocompatible coated circuits on inflammatory response and oxidative stress induced during cardiopulmonary bypass (CPB). Seventy-eight patients undergoing elective coronary artery bypass grafting (CABG) with CPB were randomly assigned to five groups with different biocompatible coated circuits: Trillium, Bioline, Phosphorylcholine, Polymethoxyethyl acrylate (PMEA), and the uncoated control group. Blood was drawn at three different time points: before CPB, 6 and 72 hours post CPB. Unlike the Trillium group, serum levels of TNF-alpha in the Bioline and Phosphorylcholine group...
Source: Perfusion - October 26, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Sohn N, Marcoux J, Mycyk T, Krahn J, Meng QH Tags: Perfusion Source Type: journals

Small, smaller, smallest. Steps towards bloodless neonatal and infant cardiopulmonary bypass.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In open heart surgery in neonates and small children, the cardiopulmonary bypass circuit surface and the priming volume are relatively large in relation to patient size and blood volume. Therefore, the use of allogeneic blood is inevitable to maintain the optimal hematocrit level during bypass. To avoid the deleterious effects of blood transfusion, as well as to reduce the contact surface of blood with artificial materials, we stepwise reduced the bypass circuit size. Use of the commercially available minimized elements and an adjusted set-up of the system allowed us to reduce usage of allogeneic blood in the prime and...
Source: Perfusion - October 19, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Golab HD, Bogers JJ Tags: Perfusion Source Type: journals

Effect of preoperative atorvastatin therapy on paraoxonase activity and oxidative stress after coronary artery bypass grafting.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, 15 days of preoperative atorvastatin therapy does not significantly change either the serum PON1 activity or the oxidative stress after CABG. PMID: 19843623 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - October 19, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Kurban S, Mehmetoglu I, Ege E Tags: Perfusion Source Type: journals

Effects of Epidural Anesthesia to Intrathoracic Blood Volume and Extravascular Lung Water During on-Pump Cardiac Surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Epidural anesthesia / analgesia does not increase interstitial lung fluids by increasing intrathoracic blood volume or the amount of infusion fluids in patients undergoing cardiac surgery under cardiopulmonary bypass. There is, also, a decreased duration of mechanical lung ventilation. PMID: 19808745 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - October 5, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Lenkutis T, Benetis R, Sirvinskas E, Raliene L, Judickaite L Tags: Perfusion Source Type: journals

Serum level of sCD163, a soluble receptor for hemoglobin, is influenced by cardiac surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Serum level of sCD163 scavenger molecule for hemoglobin is elevated at the end of surgery and at the 1(st) postoperative day, being little influenced by cardiopulmonary bypass. PMID: 19808746 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - October 5, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Kolackova M, Lonsky V, Trojackova Kudlova M, Mandak J, Kunes P, Svitek V, Jankovicova K, Vlaskova D, Andrys C, Krejsek J Tags: Perfusion Source Type: journals

Venoarterial Extracorporeal Membrane Oxygenation in Adult Patients: Predictors of Mortality.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Extracorporeal membrane oxygenation is a justifiable alternative treatment for postoperative refractory cardiac and pulmonary dysfunction which could rescue more than sixty percent of otherwise fatal patients. Patients with pre-extracorporeal membrane oxygenation lactate levels above 12.6mmol/L are at higher risks for in-hospital death. Evidence-based therapy for this group of high risk patients is needed. PMID: 19808747 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - October 5, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Li J, Long C, Lou S, Hei F, Yu K, Wang S, Hu S, Xu J, Chang Q, Liu P, Zhang H, Sun H, Wang W Tags: Perfusion Source Type: journals

Treatment of massive pulmonary embolism utilizing a multidisciplinary approach: a case study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Massive pulmonary embolism (PE) is associated, historically, with a high mortality rate. Treatment options include systemic anticoagulation, catheter-directed thrombolytic therapy, surgical embolectomy, fragmentation techniques, and catheter embolectomy. Extracorporeal membrane oxygenation (ECMO) repeatedly has demonstrated effectiveness in providing cardiopulmonary support for the patient with a massive PE too unstable to undergo thrombolysis or embolectomy. The present case study describes a morbidly obese patient, status post gastric bypass surgery, who presented with PE, and acute respiratory and cardiac failure. A...
Source: Perfusion - September 29, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Griffith KE, Haft J, Jenkins E Tags: Perfusion Source Type: journals

Increase in plasma free haemoglobin during cardiopulmonary bypass in heart valve surgery: assessment of renal dysfunction by RIFLE classification.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heart valve surgery carries a high risk of renal insufficiency as an independent risk factor due to prolonged cardiopulmonary bypass. Multiple causes of cardiopulmonary bypass-associated renal damage have been described, and haemoglobin-induced renal injury is presently being investigated. Forty-three patients scheduled for heart valve surgery (mostly combined) were enrolled in the prospective study. Plasma free haemoglobin (PFH) levels were evaluated by photocolorimetric measurement at the start of procedures (t0) and before the end of extracorporeal circulation (t1). A statistically significant increase in PFH levels...
Source: Perfusion - September 23, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Vanek T, Snircova J, Spegar J, Straka Z, Horak J, Maly M Tags: Perfusion Source Type: journals

Risk factors for bleeding in pediatric post-cardiotomy patients requiring ECLS.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The majority of pediatric post-cardiotomy ECLS bleeding occurs early after support initiation. Longer CPB time and thrombocytopenia increased bleeding 0-6h post-ECLS. Since early bleeding may be coagulopathic in origin, an approach to minimize bleeding includes protamine administration and aggressive blood product replacement with target platelet counts of 100-120K. Surgical exploration should follow if additional hemostasis is necessary. PMID: 19767331 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 17, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Nardell K, Annich GM, Hirsch J, Fahrner C, Brownlee P, King K, Fleming G, Gajarski RJ Tags: Perfusion Source Type: journals

Analysis of the risk factors of postoperative respiratory dysfunction of type A aortic dissection and lung protection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The longer duration of CA and the higher temperature in the bladder during CA were found to be the independent risk factors of postoperative RD after type A aortic dissection surgery. Attention should be paid to lung protection for these patients and the adjunct of continuing descending aortic perfusion and cerebral perfusion should be a safe and feasible procedure and it would be valuable to perform a prospective trial. PMID: 19767332 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 17, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Luo HY, Hu KJ, Zhou JY, Wang CS Tags: Perfusion Source Type: journals

Regional cerebral perfusion for surgical correction of neonatal aortic arch obstruction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One-stage repair of aortic arch obstruction and associated cardiac anomalies is a surgical challenge in infants. The purpose of the present study is to review the current outcome using regional cerebral perfusion (RCP) during a procedure correcting interrupted aortic arch (IAA) and also isolated aortic coarctation (CoA) and CoA combined with hypoplastic aortic arch (CoA-HyAA) in our center. Between January 2007 and July 2008, 24 infant patients with interrupted aortic arch (IAA) (n=3), isolated aortic coarctation (iCoA) (n=9) and aortic coarctation with hypoplastic aortic arch (CoA-HyAA) (n=12) underwent one-stage surg...
Source: Perfusion - September 15, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Zhang H, Cheng P, Hou J, Li L, Liu H, Liu R, Ji B, Luo Y Tags: Perfusion Source Type: journals

Clinical evaluation of minimized extracorporeal circulation in high-risk coronary revascularization : impact on air handling, inflammation, hemodilution and myocardial function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Mini-CPB provided a comfort and safety level similar to conventional control via satisfactory air handling, attenuated inflammatory response and hemodilution, with a better clinical outcome in patients undergoing high-risk CABG. PMID: 19755462 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 14, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Gunaydin S, Sari T, McCusker K, Schonrock U, Zorlutuna Y Tags: Perfusion Source Type: journals

The Use of a Mini bypass Circuit for Minimally Invasive Mitral Valve Surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The Medtronic Resting Heart System(R) alleviates many factors, such as high shear stress, turbulence, air to blood interface and decreased oncotic pressure caused by hemodilution, providing more efficient perfusion to our MIMVS patients. We demonstrate, with minor circuit modifications and attention to venous air issues, that this minicircuit can be used safely and effectively, while being associated with improvements in patient outcomes. PMID: 19755463 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 14, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Fernandes P, Macdonald J, Cleland A, Mayer R, Fox S, Kiaii B Tags: Perfusion Source Type: journals

Does remote ischemic preconditioning prevent delayed hippocampal neuronal death following transient global cerebral ischemia in rats?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Second window of the RIPC does not prevent hippocampal CA1 neuronal death at 7 days after transient global cerebral ischemia. PMID: 19755464 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 14, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Saxena P, Bala A, Campbell K, Meloni B, d'Udekem Y, Konstantinov IE Tags: Perfusion Source Type: journals

Bloodless aortic valve and ascending aorta replacement surgery requiring circulatory arrest: two case studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Blood and/or blood product transfusions are common during and after complicated cardiac procedures. Replacement of the aortic valve, ascending aorta, and coronary implantation requiring circulatory arrest are high-risk procedures. Blood product transfusions only add to the morbidity and mortality rates associated with these types of procedures. Perfusion strategies must be incorporated to decrease the effects of hemodiluton due to cardiopulmonary bypass (CPB), and preserve platelets and clotting factors needed for hemostasis, post-operatively. We are reporting two consecutive cases where the patients presented with aor...
Source: Perfusion - September 14, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Schill DM Tags: Perfusion Source Type: journals

Preoperative Screening and Management of Carotid Artery Disease in Patients Undergoing Cardiac Surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Careful clinical examination together with detailed previous history taking can identify the majority of patients with CAS. Further data are required for the construction of a scientifically valid policy as a guideline. PMID: 19755466 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 14, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Anastasiadis K, Karamitsos TD, Velissaris I, Makrygiannakis K, Kiskinis D Tags: Perfusion Source Type: journals

Case control study of gastrointestinal complications after cardiopulmonary bypass heart surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Gastrointestinal complications after CPB surgery could be predictive in the presence of the above risk factors. This study suggests that GIC can be reduced by maintenance of higher perfusion pressure and shortening the time on CPB and ventilation. PMID: 19755467 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 14, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Zhang G, Wu N, Liu H, Lv H, Yao Z, Li J Tags: Perfusion Source Type: journals

Editorial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19654145 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Toomasian J Tags: Perfusion Source Type: journals

Successful treatment of peripartum cardiomyopathy with extracorporeal membrane oxygenation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 24-year-old female developed heart failure within four months of delivering her first child. Echocardiogram revealed a moderately dilated left ventricle with severely reduced systolic function. She continued to decompensate, requiring intubation and inotropic support. When the use of an intra-aortic balloon pump failed to stabilize the patient, the decision was made to place her on ECMO. The circuit consisted of a Quadrox D membrane oxygenator and a CentriMag(R) centrifugal pump. After 11 days of support, the patient met the weaning criteria and was successfully removed from ECMO. She was discharged one month after h...
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Palanzo D, Baer L, El-Banayosy A, Stephenson E, Mulvey S, McCoach R, Wise R, Woitas K, Pae W Tags: Perfusion Source Type: journals

Commentary on: Successful treatment of peripartum cardiomyopathy with extracorporeal membrane oxygenation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19654147 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Palanzo D Tags: Perfusion Source Type: journals

First American experience with the Terumo DuraHeartTM left ventricular assist system.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the operating characteristics of the DuraHeart LVAS (Terumo Heart, Inc., Ann Arbor, MI). The DuraHeart LVAS is a magnetically-levitated centrifugal pump that began a FDA-approved clinical trial for evaluation of bridge to transplant indication in July of 2008. Magnetic levitation of the spinning-pump impeller is hypothesized to improve long-term mechanical reliability and biological compatibility of the pump. Other design features make the DuraHeart LVAS particularly suited for implantation without cardiopulmonary bypass (CPB). A description of the implant procedure for the first six American implants of the Du...
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Griffith K, Jenkins E, Pagani F Tags: Perfusion Source Type: journals

Commentary on: First American experience with the Terumo DuraHeartTM ventricular assist system.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19654149 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Griffith K Tags: Perfusion Source Type: journals

The relationship between heparin level and activated clotting time in the adult cardiac surgery population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined institutional databases for all patients who underwent CPB at a single US academic institution from February 2005 until July 2007. Baseline ACT, predicted and actual heparin dose response (HDR), target and actual ACT, heparin concentration and heparin bolus dose were recorded. We examined the ACT and HL after the initial heparin bolus dose (Post-Hep) and 10 minutes after the initiation of CPB (CPB+10). The Post-Hep and CPB+10 ACT and HL are reported for 3802 patients. The distribution of ACTs for HL of 0.7, 1.4, 2.0, 2.7 and 3.4 units heparin/mL blood at both time points are reported. Additional analysis of the...
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Fitzgerald Dj, Patel A, Body S, Garvin S Tags: Perfusion Source Type: journals

Commentary on: The relationship between heparin level and activated clotting time in the adult cardiac surgery population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19654151 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Fitzgerald D Tags: Perfusion Source Type: journals

Aprotinin protects the cerebral microcirculation during cardiopulmonary bypass.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Aprotinin reduces cerebral leukocyte activation and accelerates neurologic recovery in a dose-dependent fashion. Aprotinin has no measurable impact on standard indices of renal function in young piglets. The current lack of availability of aprotinin is a serious disadvantage for pediatric patients undergoing cardiopulmonary bypass. PMID: 19654152 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Ishibashi N, Iwata Y, Zurakowski D, Lidov H, Jonas R Tags: Perfusion Source Type: journals

Evaluation of air handling in a new generation neonatal oxygenator with integral arterial filter.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on the first use of the Terumo((R)) CAPIOX((R)) FX05 (Baby-FX) oxygenator with integral arterial filter, prime volume 43 ml, evaluating performance and air-handling of six Baby-FX versus thirteen Baby-RX oxygenators. The Terumo Baby-FX primes and performs as easily as the Baby-RX series. A significant prime component in the neonatal CPB circuit can be the arterial line filter (ALF). Removal of the ALF may lead to significant reduction in prime volume, decreased exposure to foreign surfaces with subsequent reduction in inflammation, and potential elimination or reduction in blood product exposures. PMID: 19654...
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Gomez D, Preston T, Olshove V, Phillips A, Galantowicz M Tags: Perfusion Source Type: journals

Commentary on: Evaluation of a new generation neonatal oxygenator with integral arterial filter.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19654154 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Gomez D Tags: Perfusion Source Type: journals

BelmontTM Hyperthermia Pump in the conduct of intra-operative heated chemotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intra-operative heated chemotherapy (IOHC) has been performed in the Thoracic surgical department of Brigham and Women's Hospital (BWH, Boston, MA, USA) for over a decade. A "home-grown" system was developed for this purpose with limited improvements made to it through the years. This technology is used for neo-adjuvant therapy in the conduct of extra-pleural pneumonectomy and pleurectomy for treatment of mesothelioma. Improvements to the traditional BWH system were sought due to the hazardous nature of the chemotherapy solution and the relative complexity of the IOHC circuit. Belmont Instrument (Belmont Instrument Cor...
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Riley W Tags: Perfusion Source Type: journals

Commentary on: BelmontTM Hyperthermia Pump in the conduct of intraoperative heated chemotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19654156 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Riley W Tags: Perfusion Source Type: journals

Continuous selective bilateral antegrade cerebral perfusion through anomalous innominate artery for repair of root, ascending aortic and arch aneurysm - challenges, vagaries and opportunities of bovine arch variant anatomy and review of literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the repair of a root, ascending aortic and arch aneurysm in a 69-year-old man with a bioprosthetic Shelhigh conduit and cylinder, employing continuous bilateral antegrade cerebral perfusion through an anomalous innominate artery with a bovine arch variant anatomy. The origin of both the innominate artery and the left common carotid artery from a common stem from the arch in this bovine arch variant puts the whole cerebral circulation at risk, on one hand, yet provides an opportunity of continuous bilateral antegrade cerebral perfusion through the right brachial, right axillary, right subclavian or innominate ar...
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Kaul P, Javangula K, Ganti S, Balaji S, Sivananthan M, Gough M, Lindsay S Tags: Perfusion Source Type: journals

Bioline(R) heparin-coated ECMO with bivalirudin anticoagulation in a patient with acute heparin-induced thrombocytopenia: the immune reaction appeared to continue unabated.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heparin-induced thrombocytopenia (HIT) is a serious, antibody-mediated complication of heparin which significantly confers risks of thrombosis and devastating outcomes. Once diagnosed, it requires immediate cessation of heparin and therapy with an alternative anticoagulant. No data are available in the literature on the pathophysiology and clinical implications of performing prolonged extracorporeal membrane oxygenation with a heparin-coated system in a patient with acute HIT treated with bivalirudin. PMID: 19654158 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Pappalardo F, Maj G, Scandroglio A, Sampietro F, Zangrillo A, Koster A Tags: Perfusion Source Type: journals

Renal dysfunction in cardiac surgery: identifying potential risk factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study included a total of 716 patients, divided into three groups; aprotinin (n = 436), tranexamic acid (n = 61), and off-pump coronary artery bypass (OPCAB) (n = 219). Epsilon aminocaproic acid (AMICAR) was given by the anesthesiologist to the majority of the remaining 510 patients and was not recorded on the bypass record. Therefore, patients given AMICAR were not included in this study. Outcomes included renal dialysis after surgery and mortality. Risk factors were identified and compared to patients in a study published by Mangano in the New England Journal of Medicine (N Engl J Med 2006; 354: 353-365). Aprotinin ...
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Barnum J, Sistino J Tags: Perfusion Source Type: journals

Commentary on: Renal dysfunction in cardiac surgery: identifying potential risk factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19654160 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - March 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Barnum J Tags: Perfusion Source Type: journals

Editorial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19567541 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - January 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Punjabi MP Tags: Perfusion Source Type: journals

Bivalirudin anticoagulation during cardiac surgery: a single-center experience in 141 patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The feasibility of bivalirudin for anticoagulation during cardiac surgery has been confirmed in four multicenter clinical trials. Here, we report our single-center experience with bivalirudin anticoagulation in "on-pump" and "off-pump" cardiac surgery in a large number of patients with and without heparin antibodies. Data of patients who underwent cardiac surgery with bivalirudin anticoagulation between 06/2003 and 12/2007 at our institution were reviewed. Assessment included procedural success, blood loss, transfusion requirements, re-exploration rates and drug-related complications during the procedures. There were 1...
Source: Perfusion - January 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Koster A, Buz S, Krabatsch T, Yeter R, Hetzer R Tags: Perfusion Source Type: journals

Clinical experience with a novel endotoxin adsorbtion device in patients undergoing cardiac surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endotoxaemia is thought to occur in cardiac surgery using extracorporeal circulation (ECC) and a positive correlation has been proposed between the magnitude of endotoxaemia and risk for postoperative complications. We studied the effects of a new endotoxin adsorber device (Alteco(R) LPS adsorber) in patients undergoing cardiac surgery with ECC, with special reference to safety and ease of use. Fifteen patients undergoing coronary artery bypass and/or valvular surgery were studied. In 9 patients, the LPS Adsorber was included in the bypass circuit between the arterial filter and the venous reservoir. Flow through the a...
Source: Perfusion - January 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Blomquist S, Gustafsson V, Manolopoulos T, Pierre L Tags: Perfusion Source Type: journals

Bicarbonate-buffered ultrafiltration during pediatric cardiac surgery prevents electrolyte and acid-base balance disturbances.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study shows that bicarbonate-buffered ultrafiltration is an efficient, simple and safe method for performing hemofiltration, both of the priming solution and during the entire bypass time. The use of a physiological restitution solution prevents electrolyte and acid-base balance disturbances. The elimination of inflammatory mediators seems to be as effective as other ultrafiltration methods. PMID: 19567544 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - January 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Osthaus W, Görler H, Sievers J, Rahe-Meyer N, Optenhöfel J, Breymann T, Theilmeier G, Suempelmann R Tags: Perfusion Source Type: journals

Propofol requirement titrated to bispectral index: a comparison between hypothermic and normothermic cardiopulmonary bypass.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Though propofol requirement is expected to decrease during cardiopulmonary bypass (CPB), a few studies have failed to demonstrate this. The factors affecting pharmacokinetics of propofol and, therefore, the requirement, are different during hypothermic and normothermic CPB. We evaluated and compared the requirement of propofol during hypothermic and normothermic CPB. Fifty adult patients scheduled for elective cardiac surgery on CPB were recruited and randomly allocated into hypothermic CPB (28-30(0) C) (Group H) and normothermic CPB (35-37(0) C) (Group N) groups. Patients were induced and maintained with propofol titr...
Source: Perfusion - January 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Mathew P, Puri G, Dhaliwal R Tags: Perfusion Source Type: journals

Aortic valve endocarditis with aortic wall thickening requires close follow-up for a possible abscess formation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 67-year-old woman was admitted with aortic valve endocarditis and aortic wall thickening (AWT). Physical examination and laboratory findings yielded infective endocarditis. Echocardiography revealed several small vegetations on the aortic valve, leading to moderate aortic insufficiency together with a small ventricular septal defect. We also became aware of the AWT on and over the aortic root by transesophageal echocardiography (Figure 1). At the one month follow-up period, we also noticed an abscess formation originating from the AWT, which grew into a mature abscess form, day by day (Figure 2). The aortic valve end...
Source: Perfusion - January 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Yeter E, Bayram N, Akçay M, Keles T, Durmaz T Tags: Perfusion Source Type: journals

Beneficial effects of modern perfusion concepts in aortic valve and aortic root surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Minimized perfusion circuits (MPC) were found to reduce side effects of standard extracorporeal circulation (ECC). We evaluated the safety and efficacy of the ROCsafe MPC for aortic valve and aortic root surgery. One hundred and seventy patients were randomized for surgery using either MPC [n = 85, 30 female/55 male, mean age: 69.8 +/- 11.8 years; aortic valve replacement (AVR): n = 40; AVR + coronary artery bypass graft (CABG): n = 31; David operation: n = 3; aortic root replacement (ARR): n = 11] or ECC [n = 85, 29 female/56 male, mean age: 67.7 +/- 9.5 years; AVR: n = 39; AVR+CABG: n = 35, David operation: n = 2; AR...
Source: Perfusion - January 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Kutschka I, Skorpil J, El Essawi A, Hajek T, Harringer W Tags: Perfusion Source Type: journals

Extracorporeal membrane oxygenation support for 59 days without changing the ECMO circuit: a case of Legionella pneumonia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the successful use of veno-venous extracorporeal membrane oxygenation (ECMO) in a 53-year-old patient with Legionella pneumonia and acute respiratory distress syndrome (ARDS) with severe barotraumas. The patient was supported for 59 days without any changes in the ECMO circuit. This is probably the longest support ever reported using the same oxygenator. PMID: 19567548 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - January 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Thiara A, Høyland V, Norum H, Aasmundstad T, Karlsen H, Fiane A, Geiran O Tags: Perfusion Source Type: journals

Successful use of a new hand-held ECMO system in cardiopulmonary failure and bleeding shock after thrombolysis in massive post-partal pulmonary embolism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a 27-year-old mother in childbirth who developed a massive post-partal PE and cardiac arrest. Despite mechanical resuscitation, return of spontaneous circulation (ROSC) could not be achieved. After systemic thrombolysis, ROSC returned, but cardiopulmonary failure was persisting, complicated by massive bleeding shock. By using a newly developed, hand-held ECMO system, systemic blood flow and oxygenation were restored and emergency medical services for advanced surgical treatment (hysterectomy and pulmonary embolectomy) were possible. The patient recovered completely. We assume that this newly developed hand-hel...
Source: Perfusion - January 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Arlt M, Philipp A, Iesalnieks I, Kobuch R, Graf B Tags: Perfusion Source Type: journals

Case report: plasma leakage in a polymethylpentene oxygenator during extracorporeal life support.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe here a case of ECLS which was affected by the rapid occurrence of plasma leakage in oxygenators with polymethylpentene fibers. To our knowledge, this is the first report of the phenomenon since the introduction of this new generation of oxygenators. PMID: 19567550 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - January 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Puis L, Ampe L, Hertleer R Tags: Perfusion Source Type: journals

Editorial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19454558 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - November 1, 2008 Category: Cardiovascular & Thoracic Surgery Authors: Mulholland J Tags: Perfusion Source Type: journals

Cardiopulmonary bypass and edema: physiology and pathophysiology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Edema is a common morbidity following cardiopulmonary bypass (CPB) and can result in injury to many organs, including the heart, lungs, and brain. Generalized edema is also common and can lead to increased post-operative hospital stay and other morbidities. Pediatric patients are more susceptible to post-CPB edema and the consequences are more severe for this population. Hemodilution and systemic inflammatory responses are two suspected causes of CPB-related edema; however, the mechanisms involved are far from understood. Also, the common strategies to improve edema have not been completely successful and there is a ne...
Source: Perfusion - November 1, 2008 Category: Cardiovascular & Thoracic Surgery Authors: Hirleman E, Larson D Tags: Perfusion Source Type: journals