Antimicrobial Activity Classification of Imidazolium Derivatives Predicted by Artificial Neural Networks
ConclusionsThe study concludes that the MLP neural network, along with CART and PCA, is a robust tool for predicting the antimicrobial activity class of imidazolium chlorides against Klebsiella pneumoniae. CART and PCA, used in this study, allowed input variable reduction without significant information loss. High classification accuracy and associated metrics affirm the method ’s potential utility in pre-synthesis assessments, offering valuable insights for antimicrobial compound design. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 17, 2024 Category: Drugs & Pharmacology Source Type: research
Machine Learning Exploration of the Relationship Between Drugs and the Blood –Brain Barrier: Guiding Molecular Modification
ConclusionsThe machine learning models developed can accurately predict BBB permeability, and many drug molecules are likely to have increased BBB penetration if the number of Hydrogen Bond Donors and Acceptors are reduced. These findings suggest that molecular modifications can enhance the efficacy of CNS drugs and provide practical strategies for drug design and development. This is particularly relevant for improving drug penetration of the BBB.Graphical Abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 11, 2024 Category: Drugs & Pharmacology Source Type: research
A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution
ConclusionThe study demonstrated the potential of the radial diffusion-based model to describe dissolution of drug powders. In contrast, the classic Nernst-Brunner equation could under-estimate drug dissolution rate, largely due to the underlying assumption of translational diffusion. Moreover, the study indicated that not all surfaces on a drug particle contribute to dissolution. Therefore, relying on the experimentally-determined specific surface area for predicting drug dissolution is not advisable. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 8, 2024 Category: Drugs & Pharmacology Source Type: research
Combating Alcohol Adduct Impurity in Immunosuppressant Drug Product Manufacturing: A Scientific Investigation for Enhanced Process Control
ConclusionsManufacturing Process II, selectively locates Tacrolimus within the micellar core of HCO-60, this prevent direct contact of ethanol with Tacrolimus which minimizes impurity alcohol adduct formation. This research contributes to the understanding of tacrolimus formulations, offering ways to safeguard product integrity and stability during manufacturing and storage. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Antibiotic Development: Lessons from the Past and Future Opportunities
AbstractThe challenge of antimicrobial resistance is broadly appreciated by the clinical and scientific communities. To assess progress in the development of medical countermeasures to combat bacterial infections, we deployed information gleaned from clinical trials conducted from 2000 to 2021. Whereas private sector interest in cancer grew dramatically over this period, activity to combat bacterial infections remained stagnant. The comparative ambivalence to antimicrobial resistance is reflected in the number of investigative drugs under clinical investigation, their stage of development and most troublingly, a declining ...
Source: Pharmaceutical Research - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Development and Validation of Matrix of Chemistry, Manufacturing, and Control (MoCMC) System for Intramammary Drug Products (IMM)
ConclusionThis research showed that theMoCMC approach can be used as a tool for intra batch variabilities, genericsversus brand products comparisons, post-approval formulations changes, manufacturing changes, and formulation variabilities. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Combating Alcohol Adduct Impurity in Immunosuppressant Drug Product Manufacturing: A Scientific Investigation for Enhanced Process Control
ConclusionsManufacturing Process II, selectively locates Tacrolimus within the micellar core of HCO-60, this prevent direct contact of ethanol with Tacrolimus which minimizes impurity alcohol adduct formation. This research contributes to the understanding of tacrolimus formulations, offering ways to safeguard product integrity and stability during manufacturing and storage. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Antibiotic Development: Lessons from the Past and Future Opportunities
AbstractThe challenge of antimicrobial resistance is broadly appreciated by the clinical and scientific communities. To assess progress in the development of medical countermeasures to combat bacterial infections, we deployed information gleaned from clinical trials conducted from 2000 to 2021. Whereas private sector interest in cancer grew dramatically over this period, activity to combat bacterial infections remained stagnant. The comparative ambivalence to antimicrobial resistance is reflected in the number of investigative drugs under clinical investigation, their stage of development and most troublingly, a declining ...
Source: Pharmaceutical Research - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Development and Validation of Matrix of Chemistry, Manufacturing, and Control (MoCMC) System for Intramammary Drug Products (IMM)
ConclusionThis research showed that theMoCMC approach can be used as a tool for intra batch variabilities, genericsversus brand products comparisons, post-approval formulations changes, manufacturing changes, and formulation variabilities. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia
ConclusionThe pharmacokinetics of PEGasparaginase in infants diagnosed under one year of age with ALL is comparable to that of older children (1 –18 years). We recommend a PEGasparaginase dosing at 1,500 IU/m2 for infants without dose adaptations according to age, and implementing therapeutic drug monitoring as standard practice. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 27, 2024 Category: Drugs & Pharmacology Source Type: research
Quantification of Unencapsulated Drug in Target Tissues Demonstrates Pharmacological Properties and Therapeutic Effects of Liposomal Topotecan (FF-10850)
ConclusionsTissue pharmacokinetics of unencapsulated topotecan elucidated the favorable pharmacological properties of FF-10850. Evaluation of tissue exposure to an unencapsulated drug with appropriate pharmacodynamic markers can be valuable in optimizing liposomal drugs and dosing regimens. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 27, 2024 Category: Drugs & Pharmacology Source Type: research
The Use of Global Sensitivity Analysis to Assess the Oral Absorption of Weakly Basic Compounds: A Case Example of Dipyridamole
ConclusionsThis work shows the value of GSA utilization in early development to guidein vitro experimentation and build more confidence in identifying the critical parameters for the mathematical models. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 27, 2024 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia
ConclusionThe pharmacokinetics of PEGasparaginase in infants diagnosed under one year of age with ALL is comparable to that of older children (1 –18 years). We recommend a PEGasparaginase dosing at 1,500 IU/m2 for infants without dose adaptations according to age, and implementing therapeutic drug monitoring as standard practice. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 27, 2024 Category: Drugs & Pharmacology Source Type: research
