AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis
CONCLUSIONS: AM1172 cannot be used separately as a chemotherapeutic drug, but it can be combined with PACX, DOCX, MTX, and CDDP, offering additive interactions in terms of the anti-proliferative effects in various malignant melanoma cell lines.PMID:38019413 | DOI:10.1007/s43440-023-00557-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 29, 2023 Category: Drugs & Pharmacology Authors: Pawe ł Marzęda Paula Wr óblewska-Łuczka Magdalena Florek- Łuszczki Agnieszka G óralczyk Jarogniew J Łuszczki Source Type: research
Imperatorin interacts additively with novel antiseizure medications in the mouse maximal electroshock-induced seizure model: an isobolographic transformation
CONCLUSIONS: The additive interactions of IMP with LCM, OXC, PGB, and TPM in the mouse MES model accompanied by no pharmacokinetic changes in the total brain content of ASMs are worthy of recommendation for further studies.PMID:38015370 | DOI:10.1007/s43440-023-00555-4 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 28, 2023 Category: Drugs & Pharmacology Authors: Jarogniew J Łuszczki Ewelina Kochman-Moskal Hubert Bojar Magdalena Florek- Łuszczki Krystyna Skalicka-Wo źniak Source Type: research
Lipid-lowering drugs and cancer: an updated perspective
Pharmacol Rep. 2023 Nov 28. doi: 10.1007/s43440-023-00553-6. Online ahead of print.ABSTRACTStatins and non-statin medications used for the management of dyslipidemia have been shown to possess antitumor properties. Since the use of these drugs has steadily increased over the past decades, more knowledge is required about their relationship with cancer. Lipid-lowering agents are heterogeneous compounds; therefore, it remains to be revealed whether anticancer potential is a class effect or related to them all. Here, we reviewed the literature on the influence of lipid-lowering medications on various types of cancer during de...
Source: Pharmacological Reports - November 28, 2023 Category: Drugs & Pharmacology Authors: Azin Alizadehasl Maryam Sadat Alavi Shabnam Boudagh Mohaddeseh Sadat Alavi Somaye Mohebi Leila Aliabadi Mahsa Akbarian Parisa Ahmadi Massimo R Mannarino Amirhossein Sahebkar Source Type: research
Imperatorin interacts additively with novel antiseizure medications in the mouse maximal electroshock-induced seizure model: an isobolographic transformation
CONCLUSIONS: The additive interactions of IMP with LCM, OXC, PGB, and TPM in the mouse MES model accompanied by no pharmacokinetic changes in the total brain content of ASMs are worthy of recommendation for further studies.PMID:38015370 | DOI:10.1007/s43440-023-00555-4 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 28, 2023 Category: Drugs & Pharmacology Authors: Jarogniew J Łuszczki Ewelina Kochman-Moskal Hubert Bojar Magdalena Florek- Łuszczki Krystyna Skalicka-Wo źniak Source Type: research
Lipid-lowering drugs and cancer: an updated perspective
Pharmacol Rep. 2023 Nov 28. doi: 10.1007/s43440-023-00553-6. Online ahead of print.ABSTRACTStatins and non-statin medications used for the management of dyslipidemia have been shown to possess antitumor properties. Since the use of these drugs has steadily increased over the past decades, more knowledge is required about their relationship with cancer. Lipid-lowering agents are heterogeneous compounds; therefore, it remains to be revealed whether anticancer potential is a class effect or related to them all. Here, we reviewed the literature on the influence of lipid-lowering medications on various types of cancer during de...
Source: Pharmacological Reports - November 28, 2023 Category: Drugs & Pharmacology Authors: Azin Alizadehasl Maryam Sadat Alavi Shabnam Boudagh Mohaddeseh Sadat Alavi Somaye Mohebi Leila Aliabadi Mahsa Akbarian Parisa Ahmadi Massimo R Mannarino Amirhossein Sahebkar Source Type: research
Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer
Curr Pharmacol Rep. 2023 Oct;9(5):261-274. doi: 10.1007/s40495-023-00333-z. Epub 2023 Sep 19.ABSTRACTPURPOSE OF REVIEW: Castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to androgen deprivation therapy and anti-androgens. Here, we review the emerging role of Wnt signaling in therapeutic resistance of CRPC.RECENT FINDINGS: Convincing evidence have accumulated that Wnt signaling is aberrantly activated through genomic alterations and autocrine and paracrine augmentations. Wnt signaling plays a critical role in a subset of CRPC and in resistance to anti-...
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Chandra Kishore Xiaolin Zi Source Type: research
Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
This article outlines the protective effects of melatonin against fibrosis, including its safety and potential therapeutic effects. The goal of this article is to provide a summary of data accumulated to date and to encourage further experimentation with melatonin and increase its use as an anti-fibrotic agent in clinical settings.PMID:37995089 | DOI:10.1007/s43440-023-00554-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Mohammad Hossein Pourhanifeh Shiva Amiri Mohammad Sheibani Rana Irilouzadian Russel J Reiter Saeed Mehrzadi Source Type: research
Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer
Curr Pharmacol Rep. 2023 Oct;9(5):261-274. doi: 10.1007/s40495-023-00333-z. Epub 2023 Sep 19.ABSTRACTPURPOSE OF REVIEW: Castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to androgen deprivation therapy and anti-androgens. Here, we review the emerging role of Wnt signaling in therapeutic resistance of CRPC.RECENT FINDINGS: Convincing evidence have accumulated that Wnt signaling is aberrantly activated through genomic alterations and autocrine and paracrine augmentations. Wnt signaling plays a critical role in a subset of CRPC and in resistance to anti-...
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Chandra Kishore Xiaolin Zi Source Type: research
Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
This article outlines the protective effects of melatonin against fibrosis, including its safety and potential therapeutic effects. The goal of this article is to provide a summary of data accumulated to date and to encourage further experimentation with melatonin and increase its use as an anti-fibrotic agent in clinical settings.PMID:37995089 | DOI:10.1007/s43440-023-00554-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Mohammad Hossein Pourhanifeh Shiva Amiri Mohammad Sheibani Rana Irilouzadian Russel J Reiter Saeed Mehrzadi Source Type: research
Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer
Curr Pharmacol Rep. 2023 Oct;9(5):261-274. doi: 10.1007/s40495-023-00333-z. Epub 2023 Sep 19.ABSTRACTPURPOSE OF REVIEW: Castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to androgen deprivation therapy and anti-androgens. Here, we review the emerging role of Wnt signaling in therapeutic resistance of CRPC.RECENT FINDINGS: Convincing evidence have accumulated that Wnt signaling is aberrantly activated through genomic alterations and autocrine and paracrine augmentations. Wnt signaling plays a critical role in a subset of CRPC and in resistance to anti-...
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Chandra Kishore Xiaolin Zi Source Type: research
Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
This article outlines the protective effects of melatonin against fibrosis, including its safety and potential therapeutic effects. The goal of this article is to provide a summary of data accumulated to date and to encourage further experimentation with melatonin and increase its use as an anti-fibrotic agent in clinical settings.PMID:37995089 | DOI:10.1007/s43440-023-00554-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Mohammad Hossein Pourhanifeh Shiva Amiri Mohammad Sheibani Rana Irilouzadian Russel J Reiter Saeed Mehrzadi Source Type: research
Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer
Curr Pharmacol Rep. 2023 Oct;9(5):261-274. doi: 10.1007/s40495-023-00333-z. Epub 2023 Sep 19.ABSTRACTPURPOSE OF REVIEW: Castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to androgen deprivation therapy and anti-androgens. Here, we review the emerging role of Wnt signaling in therapeutic resistance of CRPC.RECENT FINDINGS: Convincing evidence have accumulated that Wnt signaling is aberrantly activated through genomic alterations and autocrine and paracrine augmentations. Wnt signaling plays a critical role in a subset of CRPC and in resistance to anti-...
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Chandra Kishore Xiaolin Zi Source Type: research
Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
This article outlines the protective effects of melatonin against fibrosis, including its safety and potential therapeutic effects. The goal of this article is to provide a summary of data accumulated to date and to encourage further experimentation with melatonin and increase its use as an anti-fibrotic agent in clinical settings.PMID:37995089 | DOI:10.1007/s43440-023-00554-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Mohammad Hossein Pourhanifeh Shiva Amiri Mohammad Sheibani Rana Irilouzadian Russel J Reiter Saeed Mehrzadi Source Type: research
Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer
Curr Pharmacol Rep. 2023 Oct;9(5):261-274. doi: 10.1007/s40495-023-00333-z. Epub 2023 Sep 19.ABSTRACTPURPOSE OF REVIEW: Castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to androgen deprivation therapy and anti-androgens. Here, we review the emerging role of Wnt signaling in therapeutic resistance of CRPC.RECENT FINDINGS: Convincing evidence have accumulated that Wnt signaling is aberrantly activated through genomic alterations and autocrine and paracrine augmentations. Wnt signaling plays a critical role in a subset of CRPC and in resistance to anti-...
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Chandra Kishore Xiaolin Zi Source Type: research
The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14;146:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double t...
Source: Pharmacological Reports - November 16, 2023 Category: Drugs & Pharmacology Authors: Michael DeVito Bas Bokkers Majorie B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthe Source Type: research
