Can research on entactogens contribute to a deeper understanding of human sexuality?
This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolac...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Justyna Holka-Pokorska Source Type: research
The possible place for psychedelics in pharmacotherapy of mental disorders
Pharmacol Rep. 2023 Nov 7. doi: 10.1007/s43440-023-00550-9. Online ahead of print.ABSTRACTSince its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the therapeutic response and numerous adverse effects. Thus, the scope of contemporary pharmacological research shifts from drugs affecting the serotoni...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Adam Wojtas Source Type: research
Can research on entactogens contribute to a deeper understanding of human sexuality?
This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolac...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Justyna Holka-Pokorska Source Type: research
Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies
Pharmacol Rep. 2023 Nov 7. doi: 10.1007/s43440-023-00547-4. Online ahead of print.ABSTRACTThe desire to find a gold-standard therapy for depression is still ongoing. Developing one universal and effective pharmacotherapy remains troublesome due to the high complexity and variety of symptoms. Over the last decades, the understanding of the mechanism of pathophysiology of depression and its key consequences for brain functioning have undergone significant changes, referring to the monoaminergic theory of the disease. After the breakthrough discovery of ketamine, research began to focus on the modulation of glutamatergic tran...
Source: Pharmacological Reports - November 6, 2023 Category: Drugs & Pharmacology Authors: Barbara Chru ścicka-Smaga Agata Machaczka Bernadeta Szewczyk Andrzej Pilc Source Type: research
Unraveling snake venom phospholipase A < sub > 2 < /sub > : an overview of its structure, pharmacology, and inhibitors
Pharmacol Rep. 2023 Nov 6. doi: 10.1007/s43440-023-00543-8. Online ahead of print.ABSTRACTSnake bite is a neglected disease that affects millions of people worldwide. WHO reported approximately 5 million people are bitten by various species of snakes each year, resulting in nearly 1 million deaths and an additional three times cases of permanent disability. Snakes utilize the venom mainly for immobilization and digestion of their prey. Snake venom is a composition of proteins and enzymes which is responsible for its diverse pharmacological action. Snake venom phospholipase A2 (SvPLA2) is an enzyme that is present in every ...
Source: Pharmacological Reports - November 5, 2023 Category: Drugs & Pharmacology Authors: Ganesh H Sampat Kashinath Hiremath Jagadeesh Dodakallanavar Vishal S Patil Darasaguppe R Harish Prakash Biradar Rashmi K Mahadevamurthy Manish Barvaliya Subarna Roy Source Type: research
Mindfulness meditation and psychedelics: potential synergies and commonalities
Pharmacol Rep. 2023 Nov 6. doi: 10.1007/s43440-023-00551-8. Online ahead of print.ABSTRACTThere has been increasing scientific and clinical interest in studying psychedelic and meditation-based interventions in recent years, both in the context of improving mental health and as tools for understanding the mind. Several authors suggest neurophysiological and phenomenological parallels and overlaps between psychedelic and meditative states and suggest synergistic effects of both methods. Both psychedelic-assisted therapy and meditation training in the form of mindfulness-based interventions have been experimentally validated...
Source: Pharmacological Reports - November 5, 2023 Category: Drugs & Pharmacology Authors: Pawe ł Holas Justyna Kami ńska Source Type: research
Unraveling snake venom phospholipase A < sub > 2 < /sub > : an overview of its structure, pharmacology, and inhibitors
Pharmacol Rep. 2023 Nov 6. doi: 10.1007/s43440-023-00543-8. Online ahead of print.ABSTRACTSnake bite is a neglected disease that affects millions of people worldwide. WHO reported approximately 5 million people are bitten by various species of snakes each year, resulting in nearly 1 million deaths and an additional three times cases of permanent disability. Snakes utilize the venom mainly for immobilization and digestion of their prey. Snake venom is a composition of proteins and enzymes which is responsible for its diverse pharmacological action. Snake venom phospholipase A2 (SvPLA2) is an enzyme that is present in every ...
Source: Pharmacological Reports - November 5, 2023 Category: Drugs & Pharmacology Authors: Ganesh H Sampat Kashinath Hiremath Jagadeesh Dodakallanavar Vishal S Patil Darasaguppe R Harish Prakash Biradar Rashmi K Mahadevamurthy Manish Barvaliya Subarna Roy Source Type: research
Mindfulness meditation and psychedelics: potential synergies and commonalities
Pharmacol Rep. 2023 Nov 6. doi: 10.1007/s43440-023-00551-8. Online ahead of print.ABSTRACTThere has been increasing scientific and clinical interest in studying psychedelic and meditation-based interventions in recent years, both in the context of improving mental health and as tools for understanding the mind. Several authors suggest neurophysiological and phenomenological parallels and overlaps between psychedelic and meditative states and suggest synergistic effects of both methods. Both psychedelic-assisted therapy and meditation training in the form of mindfulness-based interventions have been experimentally validated...
Source: Pharmacological Reports - November 5, 2023 Category: Drugs & Pharmacology Authors: Pawe ł Holas Justyna Kami ńska Source Type: research
Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT < sub > 2C < /sub > receptor in the mouse brain
CONCLUSIONS: Our findings reveal differential effects of 5-HT depletion and ethanol cessation on 5-HT2C receptor editing. Central 5-HT depletion attenuated editing in the prefrontal cortex and the hippocampus, whereas ethanol deprivation, coinciding with reduced Tph2 expression in the hippocampus, enhanced receptor editing efficiency specifically in this brain region. This study highlights the interplay between 5-HT synthesis, ethanol cessation, and 5-HT2C receptor editing, providing potential mechanism underlying increased ethanol consumption and deprivation.PMID:37923824 | DOI:10.1007/s43440-023-00545-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 4, 2023 Category: Drugs & Pharmacology Authors: Magdalena Zaniewska Natalia Alenina Sebastian Fr öhler Wei Chen Michael Bader Source Type: research
Mitragynine inhibits hippocampus neuroplasticity and its molecular mechanism
CONCLUSION: Findings from this work reveal that a smaller dose of MIT (1 mg/kg) poses no risk to hippocampal synaptic transmission. Alteration in neuroplasticity-associated proteins may be a molecular mechanism for MIT (5 and 10 mg/kg)-induced LTP disruption and cognitive impairments. Data from this work posit that MIT acted differently from MOR on neuroplasticity and its underlying mechanisms.PMID:37924443 | DOI:10.1007/s43440-023-00541-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 4, 2023 Category: Drugs & Pharmacology Authors: Suleiman Yunusa Zurina Hassan Christian P M üller Source Type: research
Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT < sub > 2C < /sub > receptor in the mouse brain
CONCLUSIONS: Our findings reveal differential effects of 5-HT depletion and ethanol cessation on 5-HT2C receptor editing. Central 5-HT depletion attenuated editing in the prefrontal cortex and the hippocampus, whereas ethanol deprivation, coinciding with reduced Tph2 expression in the hippocampus, enhanced receptor editing efficiency specifically in this brain region. This study highlights the interplay between 5-HT synthesis, ethanol cessation, and 5-HT2C receptor editing, providing potential mechanism underlying increased ethanol consumption and deprivation.PMID:37923824 | DOI:10.1007/s43440-023-00545-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 4, 2023 Category: Drugs & Pharmacology Authors: Magdalena Zaniewska Natalia Alenina Sebastian Fr öhler Wei Chen Michael Bader Source Type: research
Mitragynine inhibits hippocampus neuroplasticity and its molecular mechanism
CONCLUSION: Findings from this work reveal that a smaller dose of MIT (1 mg/kg) poses no risk to hippocampal synaptic transmission. Alteration in neuroplasticity-associated proteins may be a molecular mechanism for MIT (5 and 10 mg/kg)-induced LTP disruption and cognitive impairments. Data from this work posit that MIT acted differently from MOR on neuroplasticity and its underlying mechanisms.PMID:37924443 | DOI:10.1007/s43440-023-00541-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 4, 2023 Category: Drugs & Pharmacology Authors: Suleiman Yunusa Zurina Hassan Christian P M üller Source Type: research
Serum levels of biomarkers that may link chronic obstructive pulmonary disease and depressive disorder
CONCLUSIONS: Higher levels of IL-18, TGF-β, RANTES, and uPAR in patients with COPD might indicate the presence of depressive disorder and suggest the need for further evaluation of the mental state of these patients.PMID:37921965 | DOI:10.1007/s43440-023-00548-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 3, 2023 Category: Drugs & Pharmacology Authors: El żbieta Małujło-Balcerska Tadeusz Pietras Witold Śmigielski Source Type: research
Therapeutic, diagnostic and prognostic values of TRIM proteins in prostate cancer
Pharmacol Rep. 2023 Nov 3. doi: 10.1007/s43440-023-00534-9. Online ahead of print.ABSTRACTProstate cancer is the second most prevalent cancer in men worldwide. The TRIM (tripartite motif) family of proteins is involved in the regulation of various cellular processes, including antiviral immunity, apoptosis, and cancer progression. In recent years, several TRIM proteins have been found to play important roles in prostate cancer initiation and progression. TRIM proteins have indicated oncogenic activity in prostate cancer by enhancing androgen or estrogen receptor signaling and promoting cancer cell growth. Inhibition of TRI...
Source: Pharmacological Reports - November 3, 2023 Category: Drugs & Pharmacology Authors: Xiaojiang Li Yuzhuo Bai Ke Feng Zhendong Chu Haijun Li Zhicheng Lin Lin Tian Source Type: research
Introduction to the thematic collection "Psychedelic Medicine: Therapeutic Applications and Implications for Future Research"
Pharmacol Rep. 2023 Oct 31. doi: 10.1007/s43440-023-00549-2. Online ahead of print.NO ABSTRACTPMID:37904067 | DOI:10.1007/s43440-023-00549-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 31, 2023 Category: Drugs & Pharmacology Authors: Krystyna Go łembiowska Source Type: research
