Preclinical models of treatment-resistant depression: challenges and perspectives
Pharmacol Rep. 2023 Oct 26. doi: 10.1007/s43440-023-00542-9. Online ahead of print.ABSTRACTTreatment-resistant depression (TRD) is a subgroup of major depressive disorder in which the use of classical antidepressant treatments fails to achieve satisfactory treatment results. Although there are various definitions and grading models for TRD, common criteria for assessing TRD have still not been established. However, a common feature of any TRD model is the lack of response to at least two attempts at antidepressant pharmacotherapy. The causes of TRD are not known; nevertheless, it is estimated that even 60% of TRD patients ...
Source: Pharmacological Reports - October 26, 2023 Category: Drugs & Pharmacology Authors: Magdalena Kolasa Agata Faron-G órecka Source Type: research
Preclinical models of treatment-resistant depression: challenges and perspectives
Pharmacol Rep. 2023 Oct 26. doi: 10.1007/s43440-023-00542-9. Online ahead of print.ABSTRACTTreatment-resistant depression (TRD) is a subgroup of major depressive disorder in which the use of classical antidepressant treatments fails to achieve satisfactory treatment results. Although there are various definitions and grading models for TRD, common criteria for assessing TRD have still not been established. However, a common feature of any TRD model is the lack of response to at least two attempts at antidepressant pharmacotherapy. The causes of TRD are not known; nevertheless, it is estimated that even 60% of TRD patients ...
Source: Pharmacological Reports - October 26, 2023 Category: Drugs & Pharmacology Authors: Magdalena Kolasa Agata Faron-G órecka Source Type: research
Preclinical models of treatment-resistant depression: challenges and perspectives
Pharmacol Rep. 2023 Oct 26. doi: 10.1007/s43440-023-00542-9. Online ahead of print.ABSTRACTTreatment-resistant depression (TRD) is a subgroup of major depressive disorder in which the use of classical antidepressant treatments fails to achieve satisfactory treatment results. Although there are various definitions and grading models for TRD, common criteria for assessing TRD have still not been established. However, a common feature of any TRD model is the lack of response to at least two attempts at antidepressant pharmacotherapy. The causes of TRD are not known; nevertheless, it is estimated that even 60% of TRD patients ...
Source: Pharmacological Reports - October 26, 2023 Category: Drugs & Pharmacology Authors: Magdalena Kolasa Agata Faron-G órecka Source Type: research
Cardiovascular safety of psychedelic medicine: current status and future directions
Pharmacol Rep. 2023 Oct 24. doi: 10.1007/s43440-023-00539-4. Online ahead of print.ABSTRACTPsychedelics are powerful psychoactive substances that alter perception and mood processes. Their effectiveness in the treatment of psychiatric diseases was known before their prohibition. An increasing number of recent studies, due to the indisputable resurgence of serotonergic hallucinogens, have shown their efficacy in alleviating depression, anxiety, substance abuse therapies, and existential distress treatment in patients facing life-threatening illness. Psychedelics are generally considered to be physiologically safe with low t...
Source: Pharmacological Reports - October 24, 2023 Category: Drugs & Pharmacology Authors: Agnieszka Ws ół Source Type: research
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum
CONCLUSIONS: Modulatory effect of olanzapine on cellular mechanisms of gasotransmitter synthesis may be an alternative way of their pharmacological action.PMID:37874531 | DOI:10.1007/s43440-023-00538-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 24, 2023 Category: Drugs & Pharmacology Authors: Artur Pa łasz Julia Kistowska Aleksandra Suszka- Świtek Marek Krzystanek Iwona B łaszczyk Itiana Castro Menezes Łukasz Filipczyk Katarzyna Bogus Source Type: research
Cardiovascular safety of psychedelic medicine: current status and future directions
Pharmacol Rep. 2023 Oct 24. doi: 10.1007/s43440-023-00539-4. Online ahead of print.ABSTRACTPsychedelics are powerful psychoactive substances that alter perception and mood processes. Their effectiveness in the treatment of psychiatric diseases was known before their prohibition. An increasing number of recent studies, due to the indisputable resurgence of serotonergic hallucinogens, have shown their efficacy in alleviating depression, anxiety, substance abuse therapies, and existential distress treatment in patients facing life-threatening illness. Psychedelics are generally considered to be physiologically safe with low t...
Source: Pharmacological Reports - October 24, 2023 Category: Drugs & Pharmacology Authors: Agnieszka Ws ół Source Type: research
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum
CONCLUSIONS: Modulatory effect of olanzapine on cellular mechanisms of gasotransmitter synthesis may be an alternative way of their pharmacological action.PMID:37874531 | DOI:10.1007/s43440-023-00538-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 24, 2023 Category: Drugs & Pharmacology Authors: Artur Pa łasz Julia Kistowska Aleksandra Suszka- Świtek Marek Krzystanek Iwona B łaszczyk Itiana Castro Menezes Łukasz Filipczyk Katarzyna Bogus Source Type: research
Cardiovascular safety of psychedelic medicine: current status and future directions
Pharmacol Rep. 2023 Oct 24. doi: 10.1007/s43440-023-00539-4. Online ahead of print.ABSTRACTPsychedelics are powerful psychoactive substances that alter perception and mood processes. Their effectiveness in the treatment of psychiatric diseases was known before their prohibition. An increasing number of recent studies, due to the indisputable resurgence of serotonergic hallucinogens, have shown their efficacy in alleviating depression, anxiety, substance abuse therapies, and existential distress treatment in patients facing life-threatening illness. Psychedelics are generally considered to be physiologically safe with low t...
Source: Pharmacological Reports - October 24, 2023 Category: Drugs & Pharmacology Authors: Agnieszka Ws ół Source Type: research
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum
CONCLUSIONS: Modulatory effect of olanzapine on cellular mechanisms of gasotransmitter synthesis may be an alternative way of their pharmacological action.PMID:37874531 | DOI:10.1007/s43440-023-00538-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 24, 2023 Category: Drugs & Pharmacology Authors: Artur Pa łasz Julia Kistowska Aleksandra Suszka- Świtek Marek Krzystanek Iwona B łaszczyk Itiana Castro Menezes Łukasz Filipczyk Katarzyna Bogus Source Type: research
Development and application of a systematic and quantitative weighting framework to evaluate the quality and relevance of relative potency estimates for dioxin-like compounds (DLCs) for human health risk assessment
Regul Toxicol Pharmacol. 2023 Oct 20:105500. doi: 10.1016/j.yrtph.2023.105500. Online ahead of print.ABSTRACTThe toxic equivalency factors (TEFs) approach for dioxin-like chemicals (DLCs) is currently based on a qualitative assessment of a heterogeneous data set of relative estimates of potency (REPs) spanning several orders of magnitude with highly variable study quality and relevance. An effort was undertaken to develop a weighting framework to systematically evaluate and quantitatively integrate the quality and relevance for development of more robust TEFs. Six main-study characteristics were identified as most importan...
Source: Pharmacological Reports - October 22, 2023 Category: Drugs & Pharmacology Authors: Daniele Wikoff Caroline Ring Michael DeVito Nigel Walker Linda Birnbaum Laurie Haws Source Type: research
Development and application of a systematic and quantitative weighting framework to evaluate the quality and relevance of relative potency estimates for dioxin-like compounds (DLCs) for human health risk assessment
Regul Toxicol Pharmacol. 2023 Oct 20:105500. doi: 10.1016/j.yrtph.2023.105500. Online ahead of print.ABSTRACTThe toxic equivalency factors (TEFs) approach for dioxin-like chemicals (DLCs) is currently based on a qualitative assessment of a heterogeneous data set of relative estimates of potency (REPs) spanning several orders of magnitude with highly variable study quality and relevance. An effort was undertaken to develop a weighting framework to systematically evaluate and quantitatively integrate the quality and relevance for development of more robust TEFs. Six main-study characteristics were identified as most importan...
Source: Pharmacological Reports - October 22, 2023 Category: Drugs & Pharmacology Authors: Daniele Wikoff Caroline Ring Michael DeVito Nigel Walker Linda Birnbaum Laurie Haws Source Type: research
Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
CONCLUSIONS: Overall, data underline the role of miR-378a in maintaining basal cardiac structural integrity while pointing to miR-378a-independent hyperglycemia-driven cardiac hypertrophy and associated dysfunction.PMID:37851320 | DOI:10.1007/s43440-023-00535-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 18, 2023 Category: Drugs & Pharmacology Authors: Urszula Florczyk-Soluch Katarzyna Polak Reece Sabo Alicja Martyniak Jacek St ępniewski J ózef Dulak Source Type: research
Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
CONCLUSIONS: Overall, data underline the role of miR-378a in maintaining basal cardiac structural integrity while pointing to miR-378a-independent hyperglycemia-driven cardiac hypertrophy and associated dysfunction.PMID:37851320 | DOI:10.1007/s43440-023-00535-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 18, 2023 Category: Drugs & Pharmacology Authors: Urszula Florczyk-Soluch Katarzyna Polak Reece Sabo Alicja Martyniak Jacek St ępniewski J ózef Dulak Source Type: research
Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
CONCLUSIONS: Overall, data underline the role of miR-378a in maintaining basal cardiac structural integrity while pointing to miR-378a-independent hyperglycemia-driven cardiac hypertrophy and associated dysfunction.PMID:37851320 | DOI:10.1007/s43440-023-00535-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 18, 2023 Category: Drugs & Pharmacology Authors: Urszula Florczyk-Soluch Katarzyna Polak Reece Sabo Alicja Martyniak Jacek St ępniewski J ózef Dulak Source Type: research
Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
CONCLUSIONS: Overall, data underline the role of miR-378a in maintaining basal cardiac structural integrity while pointing to miR-378a-independent hyperglycemia-driven cardiac hypertrophy and associated dysfunction.PMID:37851320 | DOI:10.1007/s43440-023-00535-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 18, 2023 Category: Drugs & Pharmacology Authors: Urszula Florczyk-Soluch Katarzyna Polak Reece Sabo Alicja Martyniak Jacek St ępniewski J ózef Dulak Source Type: research
