Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen-glucose deprivation condition
CONCLUSIONS: Together, this study revealed the protection of VPA in ex vivo OGD-induced pathological form of neuroplasticity and in vivo PTI-induced brain damage and motor dysfunction through rescuing GABAergic deficiency and the pathological hallmarks of ischemia.PMID:37695500 | DOI:10.1007/s43440-023-00525-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 11, 2023 Category: Drugs & Pharmacology Authors: Ming-Chia Chu Wei-Chang Mao Han-Fang Wu Yun-Chi Chang Ting-I Lu Chi-Wei Lee Yueh-Jung Chung Tsung-Han Hsieh Hsun-Shuo Chang Yih-Fung Chen Chia-Hsien Lin Chih-Wei Tang Hui-Ching Lin Source Type: research
Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen-glucose deprivation condition
CONCLUSIONS: Together, this study revealed the protection of VPA in ex vivo OGD-induced pathological form of neuroplasticity and in vivo PTI-induced brain damage and motor dysfunction through rescuing GABAergic deficiency and the pathological hallmarks of ischemia.PMID:37695500 | DOI:10.1007/s43440-023-00525-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 11, 2023 Category: Drugs & Pharmacology Authors: Ming-Chia Chu Wei-Chang Mao Han-Fang Wu Yun-Chi Chang Ting-I Lu Chi-Wei Lee Yueh-Jung Chung Tsung-Han Hsieh Hsun-Shuo Chang Yih-Fung Chen Chia-Hsien Lin Chih-Wei Tang Hui-Ching Lin Source Type: research
Therapeutic implications of phosphorylation- and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration
Pharmacol Rep. 2023 Sep 9. doi: 10.1007/s43440-023-00526-9. Online ahead of print.ABSTRACTNeurodegeneration is a condition of the central nervous system (CNS) characterized by loss of neural structures and function. The most common neurodegenerative disorders (NDDs) include Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), multiple sclerosis (MS), motor neuron disorders, psychological disorders, dementia with vascular dementia (VaD), Lewy body dementia (DLB), epilepsy, cerebral ischemia, mental illness, and behavioral disorders. CREB (cAMP-response element-b...
Source: Pharmacological Reports - September 9, 2023 Category: Drugs & Pharmacology Authors: Nilima Khakha Heena Khan Amarjot Kaur Thakur Gurjeet Singh Source Type: research
Therapeutic implications of phosphorylation- and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration
Pharmacol Rep. 2023 Sep 9. doi: 10.1007/s43440-023-00526-9. Online ahead of print.ABSTRACTNeurodegeneration is a condition of the central nervous system (CNS) characterized by loss of neural structures and function. The most common neurodegenerative disorders (NDDs) include Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), multiple sclerosis (MS), motor neuron disorders, psychological disorders, dementia with vascular dementia (VaD), Lewy body dementia (DLB), epilepsy, cerebral ischemia, mental illness, and behavioral disorders. CREB (cAMP-response element-b...
Source: Pharmacological Reports - September 9, 2023 Category: Drugs & Pharmacology Authors: Nilima Khakha Heena Khan Amarjot Kaur Thakur Gurjeet Singh Source Type: research
Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
Pharmacol Rep. 2023 Sep 6. doi: 10.1007/s43440-023-00520-1. Online ahead of print.ABSTRACTDisruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota have opened the scope of further understanding the various communications between these microbiota and skin immune cells. Vitamins, being one of the important micronutrients, have been reported to exert antioxidant, anti-inflammatory, and a...
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Mahika Joshi Priyanka Hiremath Jeena John Niraja Ranadive Krishnadas Nandakumar Jayesh Mudgal Source Type: research
Pten knockout affects drug resistance differently in melanoma and kidney cancer
CONCLUSIONS: The results confirmed heterogenous cell responses to PTEN loss, which may lead to a better understanding of the role of PTEN in particular types of tumors and points to PTEN as a therapeutic target for personalized medicine.PMID:37673853 | DOI:10.1007/s43440-023-00523-y (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Klaudia Brodaczewska Aleksandra Majewska Aleksandra Filipiak-Duliban Claudine Kieda Source Type: research
Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
Pharmacol Rep. 2023 Sep 6. doi: 10.1007/s43440-023-00520-1. Online ahead of print.ABSTRACTDisruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota have opened the scope of further understanding the various communications between these microbiota and skin immune cells. Vitamins, being one of the important micronutrients, have been reported to exert antioxidant, anti-inflammatory, and a...
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Mahika Joshi Priyanka Hiremath Jeena John Niraja Ranadive Krishnadas Nandakumar Jayesh Mudgal Source Type: research
Pten knockout affects drug resistance differently in melanoma and kidney cancer
CONCLUSIONS: The results confirmed heterogenous cell responses to PTEN loss, which may lead to a better understanding of the role of PTEN in particular types of tumors and points to PTEN as a therapeutic target for personalized medicine.PMID:37673853 | DOI:10.1007/s43440-023-00523-y (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Klaudia Brodaczewska Aleksandra Majewska Aleksandra Filipiak-Duliban Claudine Kieda Source Type: research
Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
Pharmacol Rep. 2023 Sep 6. doi: 10.1007/s43440-023-00520-1. Online ahead of print.ABSTRACTDisruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota have opened the scope of further understanding the various communications between these microbiota and skin immune cells. Vitamins, being one of the important micronutrients, have been reported to exert antioxidant, anti-inflammatory, and a...
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Mahika Joshi Priyanka Hiremath Jeena John Niraja Ranadive Krishnadas Nandakumar Jayesh Mudgal Source Type: research
Pten knockout affects drug resistance differently in melanoma and kidney cancer
CONCLUSIONS: The results confirmed heterogenous cell responses to PTEN loss, which may lead to a better understanding of the role of PTEN in particular types of tumors and points to PTEN as a therapeutic target for personalized medicine.PMID:37673853 | DOI:10.1007/s43440-023-00523-y (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Klaudia Brodaczewska Aleksandra Majewska Aleksandra Filipiak-Duliban Claudine Kieda Source Type: research
Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
Pharmacol Rep. 2023 Sep 5. doi: 10.1007/s43440-023-00510-3. Online ahead of print.ABSTRACTAtopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions in diverse portions of the body. The treatment of AD is exclusively focused to limit the itching, reduce inflammation, and repair the breached barrier of the skin. Several therapeutic agents for the treatment and management of AD have been reported and are in use in clinics. However, the topical treatment of AD has been an unswerving challenge for the medical fraternity owing to the impa...
Source: Pharmacological Reports - September 5, 2023 Category: Drugs & Pharmacology Authors: Vandita Kakkar Komal Saini Kamalinder K Singh Source Type: research
Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
Pharmacol Rep. 2023 Sep 5. doi: 10.1007/s43440-023-00510-3. Online ahead of print.ABSTRACTAtopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions in diverse portions of the body. The treatment of AD is exclusively focused to limit the itching, reduce inflammation, and repair the breached barrier of the skin. Several therapeutic agents for the treatment and management of AD have been reported and are in use in clinics. However, the topical treatment of AD has been an unswerving challenge for the medical fraternity owing to the impa...
Source: Pharmacological Reports - September 5, 2023 Category: Drugs & Pharmacology Authors: Vandita Kakkar Komal Saini Kamalinder K Singh Source Type: research
The long-term effects of multidrug immunosuppressive protocols based on calcineurin inhibitors and conversion to rapamycin on the morphology, apoptosis, and proliferation of rat salivary glands
CONCLUSIONS: Long-term administration of CNIs in triple regimens and after conversion to rapamycin monotherapy, causes morphological changes in the salivary glands of rats. Immunosuppressive treatment based on CNIs is associated with an increase in collagen accumulation. The effects of the conversion of treatment with CNIs to rapamycin in immunosuppressive protocols in rat salivary glands lead to decreased fibrosis, apoptosis, and proliferation. These changes may possibly prevent abnormalities resulting from the application of CNIs.PMID:37658979 | DOI:10.1007/s43440-023-00521-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 2, 2023 Category: Drugs & Pharmacology Authors: Marta Grabowska Karolina K ędzierska-Kapuza Andrzej Kram Kamil Gill Leszek Teresi ński Olimpia Sipak Ma łgorzata Piasecka Source Type: research
Pharmacologic hyperreactivity of kappa opioid receptors in periaqueductal gray matter during alcohol withdrawal syndrome in rats
CONCLUSIONS: In general, stimulation/blockade of KOR in A-withdrawal animals exert higher responses compared to A-naïve ones. SAL-A produced anxiety-like behaviors and increased alcohol consumption/preference, especially/solely in the alcohol-withdrawal condition, while PF-04455242 augmented exploration with no effects on alcohol intake/preference. Our findings suggest a possible pharmacologic hyperreactivity of the KOR in PAG during alcohol withdrawal.PMID:37658980 | DOI:10.1007/s43440-023-00522-z (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 2, 2023 Category: Drugs & Pharmacology Authors: Priscila V ázquez-León Abraham Miranda-P áez Hugo S ánchez-Castillo Bruno A Marichal-Cancino Source Type: research
The long-term effects of multidrug immunosuppressive protocols based on calcineurin inhibitors and conversion to rapamycin on the morphology, apoptosis, and proliferation of rat salivary glands
CONCLUSIONS: Long-term administration of CNIs in triple regimens and after conversion to rapamycin monotherapy, causes morphological changes in the salivary glands of rats. Immunosuppressive treatment based on CNIs is associated with an increase in collagen accumulation. The effects of the conversion of treatment with CNIs to rapamycin in immunosuppressive protocols in rat salivary glands lead to decreased fibrosis, apoptosis, and proliferation. These changes may possibly prevent abnormalities resulting from the application of CNIs.PMID:37658979 | DOI:10.1007/s43440-023-00521-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 2, 2023 Category: Drugs & Pharmacology Authors: Marta Grabowska Karolina K ędzierska-Kapuza Andrzej Kram Kamil Gill Leszek Teresi ński Olimpia Sipak Ma łgorzata Piasecka Source Type: research
