Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Correction: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
Pharmacol Rep. 2024 Apr 4. doi: 10.1007/s43440-024-00591-8. Online ahead of print.NO ABSTRACTPMID:38573564 | DOI:10.1007/s43440-024-00591-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 4, 2024 Category: Drugs & Pharmacology Authors: Jongtae Roh Jun-Pil Jang Taehoon Oh Jihong Kim Byeongsan Lee Young-Soo Hong Jae-Hyuk Jang Sung-Kyun Ko Source Type: research
Correction: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
Pharmacol Rep. 2024 Apr 4. doi: 10.1007/s43440-024-00591-8. Online ahead of print.NO ABSTRACTPMID:38573564 | DOI:10.1007/s43440-024-00591-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 4, 2024 Category: Drugs & Pharmacology Authors: Jongtae Roh Jun-Pil Jang Taehoon Oh Jihong Kim Byeongsan Lee Young-Soo Hong Jae-Hyuk Jang Sung-Kyun Ko Source Type: research
Correction: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
Pharmacol Rep. 2024 Apr 4. doi: 10.1007/s43440-024-00591-8. Online ahead of print.NO ABSTRACTPMID:38573564 | DOI:10.1007/s43440-024-00591-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 4, 2024 Category: Drugs & Pharmacology Authors: Jongtae Roh Jun-Pil Jang Taehoon Oh Jihong Kim Byeongsan Lee Young-Soo Hong Jae-Hyuk Jang Sung-Kyun Ko Source Type: research
Correction: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
Pharmacol Rep. 2024 Apr 4. doi: 10.1007/s43440-024-00591-8. Online ahead of print.NO ABSTRACTPMID:38573564 | DOI:10.1007/s43440-024-00591-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 4, 2024 Category: Drugs & Pharmacology Authors: Jongtae Roh Jun-Pil Jang Taehoon Oh Jihong Kim Byeongsan Lee Young-Soo Hong Jae-Hyuk Jang Sung-Kyun Ko Source Type: research
Neuroprotective effect of apelin-13 and other apelin forms-a review
Pharmacol Rep. 2024 Apr 3. doi: 10.1007/s43440-024-00587-4. Online ahead of print.ABSTRACTNeurodegenerative diseases, which occur when neurons begin to deteriorate, affect millions of people worldwide. These age-related disorders are becoming more common partly because the elderly population has increased in recent years. While no treatments are accessible, every year an increasing number of therapeutic and supportive options become available. Various substances that may have neuroprotective effects are currently being researched. One of them is apelin. This review aims to illustrate the results of research on the neuropro...
Source: Pharmacological Reports - April 3, 2024 Category: Drugs & Pharmacology Authors: Katarzyna Kami ńska Hubert Borzuta Kasper Buczma Agnieszka Cudnoch-J ędrzejewska Source Type: research
Neuroprotective effect of apelin-13 and other apelin forms-a review
Pharmacol Rep. 2024 Apr 3. doi: 10.1007/s43440-024-00587-4. Online ahead of print.ABSTRACTNeurodegenerative diseases, which occur when neurons begin to deteriorate, affect millions of people worldwide. These age-related disorders are becoming more common partly because the elderly population has increased in recent years. While no treatments are accessible, every year an increasing number of therapeutic and supportive options become available. Various substances that may have neuroprotective effects are currently being researched. One of them is apelin. This review aims to illustrate the results of research on the neuropro...
Source: Pharmacological Reports - April 3, 2024 Category: Drugs & Pharmacology Authors: Katarzyna Kami ńska Hubert Borzuta Kasper Buczma Agnieszka Cudnoch-J ędrzejewska Source Type: research
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors
Regul Toxicol Pharmacol. 2024 Mar 26;149:105598. doi: 10.1016/j.yrtph.2024.105598. Online ahead of print.ABSTRACTIn 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs) that interact with the aryl hydrocarbon receptor (AHR)]. Their update used sophisticated statistical analysis of hundreds of published studies that reported estimation of 'Relative Effective Potency' (REP) values for individual DLC congeners. The weighting scheme used in their assessment of ea...
Source: Pharmacological Reports - March 28, 2024 Category: Drugs & Pharmacology Authors: David L Eaton Ted W Simon Norbert E Kaminski Gary H Perdew Daniel W Nebert Source Type: research
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors
Regul Toxicol Pharmacol. 2024 Mar 26;149:105598. doi: 10.1016/j.yrtph.2024.105598. Online ahead of print.ABSTRACTIn 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs) that interact with the aryl hydrocarbon receptor (AHR)]. Their update used sophisticated statistical analysis of hundreds of published studies that reported estimation of 'Relative Effective Potency' (REP) values for individual DLC congeners. The weighting scheme used in their assessment of ea...
Source: Pharmacological Reports - March 28, 2024 Category: Drugs & Pharmacology Authors: David L Eaton Ted W Simon Norbert E Kaminski Gary H Perdew Daniel W Nebert Source Type: research
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors
Regul Toxicol Pharmacol. 2024 Mar 26;149:105598. doi: 10.1016/j.yrtph.2024.105598. Online ahead of print.ABSTRACTIn 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs) that interact with the aryl hydrocarbon receptor (AHR)]. Their update used sophisticated statistical analysis of hundreds of published studies that reported estimation of 'Relative Effective Potency' (REP) values for individual DLC congeners. The weighting scheme used in their assessment of ea...
Source: Pharmacological Reports - March 28, 2024 Category: Drugs & Pharmacology Authors: David L Eaton Ted W Simon Norbert E Kaminski Gary H Perdew Daniel W Nebert Source Type: research
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors
Regul Toxicol Pharmacol. 2024 Mar 26;149:105598. doi: 10.1016/j.yrtph.2024.105598. Online ahead of print.ABSTRACTIn 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs) that interact with the aryl hydrocarbon receptor (AHR)]. Their update used sophisticated statistical analysis of hundreds of published studies that reported estimation of 'Relative Effective Potency' (REP) values for individual DLC congeners. The weighting scheme used in their assessment of ea...
Source: Pharmacological Reports - March 28, 2024 Category: Drugs & Pharmacology Authors: David L Eaton Ted W Simon Norbert E Kaminski Gary H Perdew Daniel W Nebert Source Type: research
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors
Regul Toxicol Pharmacol. 2024 Mar 26:105598. doi: 10.1016/j.yrtph.2024.105598. Online ahead of print.ABSTRACTIn 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs) that interact with the aryl hydrocarbon receptor (AHR)]. Their update used sophisticated statistical analysis of hundreds of published studies that reported estimation of 'Relative Effective Potency' (REP) values for individual DLC congeners. The weighting scheme used in their assessment of each s...
Source: Pharmacological Reports - March 28, 2024 Category: Drugs & Pharmacology Authors: David L Eaton Ted W Simon Norbert E Kaminski Gary H Perdew Daniel W Nebert Source Type: research
Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran
CONCLUSIONS: We evaluated the effect of dextran on the uptake of known substrates using OATP1B3 overexpressed in the HEK293 cell line, and we suggest that its impact on drug concentrations in liver cells may differ from the traditional role of plasma proteins and albumin.PMID:38530582 | DOI:10.1007/s43440-024-00583-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 26, 2024 Category: Drugs & Pharmacology Authors: Anna Kowal-Chwast Ewelina Gabor-Worwa Nilesh Gaud Dawid Gogola Agnieszka Pi ątek Adrian Zar ębski Peter Littlewood Marek Smoluch Krzysztof Brz ózka Kamil Ku ś Source Type: research
Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran
CONCLUSIONS: We evaluated the effect of dextran on the uptake of known substrates using OATP1B3 overexpressed in the HEK293 cell line, and we suggest that its impact on drug concentrations in liver cells may differ from the traditional role of plasma proteins and albumin.PMID:38530582 | DOI:10.1007/s43440-024-00583-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 26, 2024 Category: Drugs & Pharmacology Authors: Anna Kowal-Chwast Ewelina Gabor-Worwa Nilesh Gaud Dawid Gogola Agnieszka Pi ątek Adrian Zar ębski Peter Littlewood Marek Smoluch Krzysztof Brz ózka Kamil Ku ś Source Type: research
Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure-activity relationship, and prospects for clinical advancement
This article aimed to comprehensively review the anticancer properties of Rg5, focusing on action mechanisms, structure-activity relationship (SAR), and pharmacokinetics attributes. The in vitro and in vivo activities of Rg5 have been proven against several cancer types, such as breast, liver, lung, bone, and gastrointestinal (GI) cancers. The modulation of multiple signaling pathways critical for cancer growth and survival mediates these activities. Nevertheless, human clinical studies of Rg5 have not been addressed before, and there is still considerable ambiguity regarding its pharmacokinetics properties. In addition, a...
Source: Pharmacological Reports - March 25, 2024 Category: Drugs & Pharmacology Authors: Tilal Elsaman Ali Mahmoud Muddathir Ebtihal A M Mohieldin Irmanida Batubara Min Rahminiwati Kosei Yamauchi Magdi Awadalla Mohamed Shadila Fira Asoka Dietrich B üsselberg Solomon Habtemariam Javad Sharifi-Rad Source Type: research
