Changes in expression of mesothelial BBS genes in 2D and 3D after lithium chloride and ammonium sulphate induction of primary cilium disturbance: a pilot study
CONCLUSIONS: These data indicate distinct BBSome molecular profiles in human benign and MPM cells cultured in 2D and 3D dimensions and support the notion that PC genes should be investigated as potential MPM therapeutic targets.PMID:37542187 | DOI:10.1007/s43440-023-00513-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 4, 2023 Category: Drugs & Pharmacology Authors: Erasmia Rouka Rajesh M Jagirdar Ioannis Sarrigeorgiou Eleanna Pitaraki Sotirios I Sinis Charalambos Varsamas Eleftherios D Papazoglou Ourania S Kotsiou Peggy Lymberi Anastasios Giannou Chrissi Hatzoglou Konstantinos I Gourgoulianis Sotirios G Zarogiannis Source Type: research
Changes in expression of mesothelial BBS genes in 2D and 3D after lithium chloride and ammonium sulphate induction of primary cilium disturbance: a pilot study
CONCLUSIONS: These data indicate distinct BBSome molecular profiles in human benign and MPM cells cultured in 2D and 3D dimensions and support the notion that PC genes should be investigated as potential MPM therapeutic targets.PMID:37542187 | DOI:10.1007/s43440-023-00513-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 4, 2023 Category: Drugs & Pharmacology Authors: Erasmia Rouka Rajesh M Jagirdar Ioannis Sarrigeorgiou Eleanna Pitaraki Sotirios I Sinis Charalambos Varsamas Eleftherios D Papazoglou Ourania S Kotsiou Peggy Lymberi Anastasios Giannou Chrissi Hatzoglou Konstantinos I Gourgoulianis Sotirios G Zarogiannis Source Type: research
Anticancer effect of terpenes: focus on malignant melanoma
Pharmacol Rep. 2023 Jul 29. doi: 10.1007/s43440-023-00512-1. Online ahead of print.ABSTRACTMelanoma is a highly aggressive and life-threatening form of skin cancer that accounts for a significant proportion of cancer-related deaths worldwide. Although conventional cancer therapies, such as surgical excision, chemotherapy, and radiation, have been used to treat malignant melanoma, their efficacy is often limited due to the development of resistance and adverse side effects. Therefore, there is a growing interest in developing alternative treatment options for melanoma that are more effective and less toxic. Terpenes, a dive...
Source: Pharmacological Reports - July 29, 2023 Category: Drugs & Pharmacology Authors: Paula Wr óblewska-Łuczka Justyna Cabaj Julia Bargie ł Jarogniew J Łuszczki Source Type: research
A multi-tiered hierarchical Bayesian approach to derive toxic equivalency factors for dioxin-like compounds
Regul Toxicol Pharmacol. 2023 Jul 27;143:105464. doi: 10.1016/j.yrtph.2023.105464. Online ahead of print.ABSTRACTIn 2005, the World Health Organization (WHO) re-evaluated Toxic Equivalency factors (TEFs) developed for dioxin-like compounds believed to act through the Ah receptor based on an updated database of relative estimated potency (REP)(REP2004 database). This re-evalution identified the need to develop a consistent approach for dose-response modeling. Further, the WHO Panel discussed the significant heterogeneity of experimental datasets and dataset quality underlying the REPs in the database. There is a critical ne...
Source: Pharmacological Reports - July 29, 2023 Category: Drugs & Pharmacology Authors: Caroline Ring Alexander Blanchette William D Klaren Seneca Fitch Laurie Haws Matthew W Wheeler Michael DeVito Nigel Walker Daniele Wikoff Source Type: research
Anticancer effect of terpenes: focus on malignant melanoma
Pharmacol Rep. 2023 Jul 29. doi: 10.1007/s43440-023-00512-1. Online ahead of print.ABSTRACTMelanoma is a highly aggressive and life-threatening form of skin cancer that accounts for a significant proportion of cancer-related deaths worldwide. Although conventional cancer therapies, such as surgical excision, chemotherapy, and radiation, have been used to treat malignant melanoma, their efficacy is often limited due to the development of resistance and adverse side effects. Therefore, there is a growing interest in developing alternative treatment options for melanoma that are more effective and less toxic. Terpenes, a dive...
Source: Pharmacological Reports - July 29, 2023 Category: Drugs & Pharmacology Authors: Paula Wr óblewska-Łuczka Justyna Cabaj Julia Bargie ł Jarogniew J Łuszczki Source Type: research
