Opioid use disorder (OUD) and treatment for opioid problems among OUD symptom subtypes in individuals misusing opioids
CONCLUSIONS: There were considerable differences in OUD symptom patterns and substance use treatment among individuals who misused opioids. The findings indicate a substantial unmet need for OUD treatment and point to patterns of heterogeneity within OUD that can inform development of treatment programs.PMID:38414666 | PMC:PMC10897812 | DOI:10.1016/j.dadr.2024.100220 (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 28, 2024 Category: Drugs & Pharmacology Authors: Emily A Miller Angela M DeVeaugh-Geiss Howard D Chilcoat Source Type: research
Opioid use disorder (OUD) and treatment for opioid problems among OUD symptom subtypes in individuals misusing opioids
CONCLUSIONS: There were considerable differences in OUD symptom patterns and substance use treatment among individuals who misused opioids. The findings indicate a substantial unmet need for OUD treatment and point to patterns of heterogeneity within OUD that can inform development of treatment programs.PMID:38414666 | PMC:PMC10897812 | DOI:10.1016/j.dadr.2024.100220 (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 28, 2024 Category: Drugs & Pharmacology Authors: Emily A Miller Angela M DeVeaugh-Geiss Howard D Chilcoat Source Type: research
Diagnostic, prognostic, and therapeutic potential of exosomal microRNAs in renal cancer
Pharmacol Rep. 2024 Feb 22. doi: 10.1007/s43440-024-00568-7. Online ahead of print.ABSTRACTRenal cell carcinoma (RCC) arises from the tubular epithelial cells of the nephron. It has the highest mortality rate among urological cancers. There are no effective therapeutic approaches and no non-invasive biomarkers for diagnosis and follow-up. Thus, suitable novel biomarkers and therapeutic targets are essential for improving RCC diagnosis/prognosis and treatment. Circulating exosomes such as exosomal microRNAs (Exo-miRs) provide non-invasive prognostic/diagnostic biomarkers and valuable therapeutic targets, as they can be easi...
Source: Pharmacological Reports - February 22, 2024 Category: Drugs & Pharmacology Authors: Xiaodong Yu Zhongbo Du Pingyu Zhu Bo Liao Source Type: research
Diagnostic, prognostic, and therapeutic potential of exosomal microRNAs in renal cancer
Pharmacol Rep. 2024 Feb 22. doi: 10.1007/s43440-024-00568-7. Online ahead of print.ABSTRACTRenal cell carcinoma (RCC) arises from the tubular epithelial cells of the nephron. It has the highest mortality rate among urological cancers. There are no effective therapeutic approaches and no non-invasive biomarkers for diagnosis and follow-up. Thus, suitable novel biomarkers and therapeutic targets are essential for improving RCC diagnosis/prognosis and treatment. Circulating exosomes such as exosomal microRNAs (Exo-miRs) provide non-invasive prognostic/diagnostic biomarkers and valuable therapeutic targets, as they can be easi...
Source: Pharmacological Reports - February 22, 2024 Category: Drugs & Pharmacology Authors: Xiaodong Yu Zhongbo Du Pingyu Zhu Bo Liao Source Type: research
Diagnostic, prognostic, and therapeutic potential of exosomal microRNAs in renal cancer
Pharmacol Rep. 2024 Feb 22. doi: 10.1007/s43440-024-00568-7. Online ahead of print.ABSTRACTRenal cell carcinoma (RCC) arises from the tubular epithelial cells of the nephron. It has the highest mortality rate among urological cancers. There are no effective therapeutic approaches and no non-invasive biomarkers for diagnosis and follow-up. Thus, suitable novel biomarkers and therapeutic targets are essential for improving RCC diagnosis/prognosis and treatment. Circulating exosomes such as exosomal microRNAs (Exo-miRs) provide non-invasive prognostic/diagnostic biomarkers and valuable therapeutic targets, as they can be easi...
Source: Pharmacological Reports - February 22, 2024 Category: Drugs & Pharmacology Authors: Xiaodong Yu Zhongbo Du Pingyu Zhu Bo Liao Source Type: research
Diagnostic, prognostic, and therapeutic potential of exosomal microRNAs in renal cancer
Pharmacol Rep. 2024 Feb 22. doi: 10.1007/s43440-024-00568-7. Online ahead of print.ABSTRACTRenal cell carcinoma (RCC) arises from the tubular epithelial cells of the nephron. It has the highest mortality rate among urological cancers. There are no effective therapeutic approaches and no non-invasive biomarkers for diagnosis and follow-up. Thus, suitable novel biomarkers and therapeutic targets are essential for improving RCC diagnosis/prognosis and treatment. Circulating exosomes such as exosomal microRNAs (Exo-miRs) provide non-invasive prognostic/diagnostic biomarkers and valuable therapeutic targets, as they can be easi...
Source: Pharmacological Reports - February 22, 2024 Category: Drugs & Pharmacology Authors: Xiaodong Yu Zhongbo Du Pingyu Zhu Bo Liao Source Type: research
Safety of non-standard regimen of systemic steroid therapy in patients with Graves' orbitopathy: a single-centre experience
CONCLUSIONS: Active GO treatment with high-dose systemic GCs is not associated with serious side effects. Hyperglycemia is the most common steroid-induced complication.PMID:38273183 | PMC:PMC10830746 | DOI:10.1007/s43440-023-00567-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 25, 2024 Category: Drugs & Pharmacology Authors: Nadia Sawicka-Gutaj Dawid Gruszczy ński Natalia Zawalna Kacper Nijakowski Agnieszka Skiba Mateusz Pochylski Jerzy Sowi ński Marek Rucha ła Source Type: research
Safety of non-standard regimen of systemic steroid therapy in patients with Graves' orbitopathy: a single-centre experience
CONCLUSIONS: Active GO treatment with high-dose systemic GCs is not associated with serious side effects. Hyperglycemia is the most common steroid-induced complication.PMID:38273183 | PMC:PMC10830746 | DOI:10.1007/s43440-023-00567-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 25, 2024 Category: Drugs & Pharmacology Authors: Nadia Sawicka-Gutaj Dawid Gruszczy ński Natalia Zawalna Kacper Nijakowski Agnieszka Skiba Mateusz Pochylski Jerzy Sowi ński Marek Rucha ła Source Type: research
Safety of non-standard regimen of systemic steroid therapy in patients with Graves' orbitopathy: a single-centre experience
CONCLUSIONS: Active GO treatment with high-dose systemic GCs is not associated with serious side effects. Hyperglycemia is the most common steroid-induced complication.PMID:38273183 | PMC:PMC10830746 | DOI:10.1007/s43440-023-00567-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 25, 2024 Category: Drugs & Pharmacology Authors: Nadia Sawicka-Gutaj Dawid Gruszczy ński Natalia Zawalna Kacper Nijakowski Agnieszka Skiba Mateusz Pochylski Jerzy Sowi ński Marek Rucha ła Source Type: research
Safety of non-standard regimen of systemic steroid therapy in patients with Graves' orbitopathy: a single-centre experience
CONCLUSIONS: Active GO treatment with high-dose systemic GCs is not associated with serious side effects. Hyperglycemia is the most common steroid-induced complication.PMID:38273183 | PMC:PMC10830746 | DOI:10.1007/s43440-023-00567-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 25, 2024 Category: Drugs & Pharmacology Authors: Nadia Sawicka-Gutaj Dawid Gruszczy ński Natalia Zawalna Kacper Nijakowski Agnieszka Skiba Mateusz Pochylski Jerzy Sowi ński Marek Rucha ła Source Type: research
Safety of non-standard regimen of systemic steroid therapy in patients with Graves' orbitopathy: a single-centre experience
CONCLUSIONS: Active GO treatment with high-dose systemic GCs is not associated with serious side effects. Hyperglycemia is the most common steroid-induced complication.PMID:38273183 | PMC:PMC10830746 | DOI:10.1007/s43440-023-00567-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 25, 2024 Category: Drugs & Pharmacology Authors: Nadia Sawicka-Gutaj Dawid Gruszczy ński Natalia Zawalna Kacper Nijakowski Agnieszka Skiba Mateusz Pochylski Jerzy Sowi ński Marek Rucha ła Source Type: research
Safety of non-standard regimen of systemic steroid therapy in patients with Graves' orbitopathy: a single-centre experience
CONCLUSIONS: Active GO treatment with high-dose systemic GCs is not associated with serious side effects. Hyperglycemia is the most common steroid-induced complication.PMID:38273183 | PMC:PMC10830746 | DOI:10.1007/s43440-023-00567-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 25, 2024 Category: Drugs & Pharmacology Authors: Nadia Sawicka-Gutaj Dawid Gruszczy ński Natalia Zawalna Kacper Nijakowski Agnieszka Skiba Mateusz Pochylski Jerzy Sowi ński Marek Rucha ła Source Type: research
Safety of non-standard regimen of systemic steroid therapy in patients with Graves' orbitopathy: a single-centre experience
CONCLUSIONS: Active GO treatment with high-dose systemic GCs is not associated with serious side effects. Hyperglycemia is the most common steroid-induced complication.PMID:38273183 | PMC:PMC10830746 | DOI:10.1007/s43440-023-00567-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 25, 2024 Category: Drugs & Pharmacology Authors: Nadia Sawicka-Gutaj Dawid Gruszczy ński Natalia Zawalna Kacper Nijakowski Agnieszka Skiba Mateusz Pochylski Jerzy Sowi ński Marek Rucha ła Source Type: research
Systematic update to the mammalian relative potency estimate database and development of best estimate toxic equivalency factors for dioxin-like compounds
This study systematically updated the relative potency (REP) database underlying the 2005 WHO TEFs and applied advanced methods for quantitative integration of study quality and dose-response. Data obtained from fifty-one publications more than doubled the size of the previous REP database (∼1300 datasets). REP quality and relevance for these data was assessed via application of a consensus-based weighting framework. Using Bayesian dose-response modeling, available data were modeled to produce standardized dose/concentration-response Hill curves. Study quality and REP data were synthesized via Bayesian meta-analysis to i...
Source: Pharmacological Reports - January 20, 2024 Category: Drugs & Pharmacology Authors: S Fitch A Blanchette L C Haws K Franke C Ring M DeVito M Wheeler N Walker L Birnbaum K I Van Ede E C Antunes Fernandes D S Wikoff Source Type: research
The role of bidirectional communication between the adipokines and the endogenous opioid system in an experimental mouse model of colitis-associated colorectal cancer
CONCLUSION: EOS and adiponectin-related signaling may play a role in the pathogenesis of CRC and these systems may present some additivity during carcinogenesis.PMID:38236555 | DOI:10.1007/s43440-023-00566-1 (Source: Pharmacological Reports)
Source: Pharmacological Reports - January 18, 2024 Category: Drugs & Pharmacology Authors: Agata Szymaszkiewicz Miko łaj Mierzejewski Emilia Januszkiewicz Weronika Machelak Marcin Talar Jakub W łodarczyk Miko łaj Świerczyński Radzis ław Kordek Jakub Fichna Marta Zieli ńska Source Type: research
