New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study
CONCLUSIONS: TGS 121, 404, and 702 present anti-tumor potential and are an attractive therapeutic option for colorectal cancer.PMID:38082190 | DOI:10.1007/s43440-023-00558-1 (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 11, 2023 Category: Drugs & Pharmacology Authors: Jakub W łodarczyk Julia Krajewska Marcin Talar Łukasz Szeleszczuk Agata Gurba Szymon Lipiec Przemys ław Taciak Remigiusz Szczepaniak Izabela M łynarczuk-Biały Jakub Fichna Source Type: research

New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study
CONCLUSIONS: TGS 121, 404, and 702 present anti-tumor potential and are an attractive therapeutic option for colorectal cancer.PMID:38082190 | DOI:10.1007/s43440-023-00558-1 (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 11, 2023 Category: Drugs & Pharmacology Authors: Jakub W łodarczyk Julia Krajewska Marcin Talar Łukasz Szeleszczuk Agata Gurba Szymon Lipiec Przemys ław Taciak Remigiusz Szczepaniak Izabela M łynarczuk-Biały Jakub Fichna Source Type: research

Impact of metformin on hypothalamic-pituitary-thyroid axis activity in women with autoimmune and non-autoimmune subclinical hypothyroidism: a pilot study
CONCLUSIONS: The obtained results suggest that, despite differences in thyroid output, the impact of metformin on TSH levels is similar in hypothyroid women with and without thyroid autoimmunity.PMID:38051473 | DOI:10.1007/s43440-023-00556-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 5, 2023 Category: Drugs & Pharmacology Authors: Robert Krysiak Karolina Kowalcze Bogus ław Okopień Source Type: research

Impact of metformin on hypothalamic-pituitary-thyroid axis activity in women with autoimmune and non-autoimmune subclinical hypothyroidism: a pilot study
CONCLUSIONS: The obtained results suggest that, despite differences in thyroid output, the impact of metformin on TSH levels is similar in hypothyroid women with and without thyroid autoimmunity.PMID:38051473 | DOI:10.1007/s43440-023-00556-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 5, 2023 Category: Drugs & Pharmacology Authors: Robert Krysiak Karolina Kowalcze Bogus ław Okopień Source Type: research

Impact of metformin on hypothalamic-pituitary-thyroid axis activity in women with autoimmune and non-autoimmune subclinical hypothyroidism: a pilot study
CONCLUSIONS: The obtained results suggest that, despite differences in thyroid output, the impact of metformin on TSH levels is similar in hypothyroid women with and without thyroid autoimmunity.PMID:38051473 | DOI:10.1007/s43440-023-00556-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 5, 2023 Category: Drugs & Pharmacology Authors: Robert Krysiak Karolina Kowalcze Bogus ław Okopień Source Type: research

Impact of metformin on hypothalamic-pituitary-thyroid axis activity in women with autoimmune and non-autoimmune subclinical hypothyroidism: a pilot study
CONCLUSIONS: The obtained results suggest that, despite differences in thyroid output, the impact of metformin on TSH levels is similar in hypothyroid women with and without thyroid autoimmunity.PMID:38051473 | DOI:10.1007/s43440-023-00556-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 5, 2023 Category: Drugs & Pharmacology Authors: Robert Krysiak Karolina Kowalcze Bogus ław Okopień Source Type: research

Impact of metformin on hypothalamic-pituitary-thyroid axis activity in women with autoimmune and non-autoimmune subclinical hypothyroidism: a pilot study
CONCLUSIONS: The obtained results suggest that, despite differences in thyroid output, the impact of metformin on TSH levels is similar in hypothyroid women with and without thyroid autoimmunity.PMID:38051473 | DOI:10.1007/s43440-023-00556-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 5, 2023 Category: Drugs & Pharmacology Authors: Robert Krysiak Karolina Kowalcze Bogus ław Okopień Source Type: research

Impact of metformin on hypothalamic-pituitary-thyroid axis activity in women with autoimmune and non-autoimmune subclinical hypothyroidism: a pilot study
CONCLUSIONS: The obtained results suggest that, despite differences in thyroid output, the impact of metformin on TSH levels is similar in hypothyroid women with and without thyroid autoimmunity.PMID:38051473 | DOI:10.1007/s43440-023-00556-3 (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 5, 2023 Category: Drugs & Pharmacology Authors: Robert Krysiak Karolina Kowalcze Bogus ław Okopień Source Type: research

AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis
CONCLUSIONS: AM1172 cannot be used separately as a chemotherapeutic drug, but it can be combined with PACX, DOCX, MTX, and CDDP, offering additive interactions in terms of the anti-proliferative effects in various malignant melanoma cell lines.PMID:38019413 | DOI:10.1007/s43440-023-00557-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 29, 2023 Category: Drugs & Pharmacology Authors: Pawe ł Marzęda Paula Wr óblewska-Łuczka Magdalena Florek- Łuszczki Agnieszka G óralczyk Jarogniew J Łuszczki Source Type: research

AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis
CONCLUSIONS: AM1172 cannot be used separately as a chemotherapeutic drug, but it can be combined with PACX, DOCX, MTX, and CDDP, offering additive interactions in terms of the anti-proliferative effects in various malignant melanoma cell lines.PMID:38019413 | DOI:10.1007/s43440-023-00557-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 29, 2023 Category: Drugs & Pharmacology Authors: Pawe ł Marzęda Paula Wr óblewska-Łuczka Magdalena Florek- Łuszczki Agnieszka G óralczyk Jarogniew J Łuszczki Source Type: research

AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis
CONCLUSIONS: AM1172 cannot be used separately as a chemotherapeutic drug, but it can be combined with PACX, DOCX, MTX, and CDDP, offering additive interactions in terms of the anti-proliferative effects in various malignant melanoma cell lines.PMID:38019413 | DOI:10.1007/s43440-023-00557-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 29, 2023 Category: Drugs & Pharmacology Authors: Pawe ł Marzęda Paula Wr óblewska-Łuczka Magdalena Florek- Łuszczki Agnieszka G óralczyk Jarogniew J Łuszczki Source Type: research

AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis
CONCLUSIONS: AM1172 cannot be used separately as a chemotherapeutic drug, but it can be combined with PACX, DOCX, MTX, and CDDP, offering additive interactions in terms of the anti-proliferative effects in various malignant melanoma cell lines.PMID:38019413 | DOI:10.1007/s43440-023-00557-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 29, 2023 Category: Drugs & Pharmacology Authors: Pawe ł Marzęda Paula Wr óblewska-Łuczka Magdalena Florek- Łuszczki Agnieszka G óralczyk Jarogniew J Łuszczki Source Type: research

AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis
CONCLUSIONS: AM1172 cannot be used separately as a chemotherapeutic drug, but it can be combined with PACX, DOCX, MTX, and CDDP, offering additive interactions in terms of the anti-proliferative effects in various malignant melanoma cell lines.PMID:38019413 | DOI:10.1007/s43440-023-00557-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 29, 2023 Category: Drugs & Pharmacology Authors: Pawe ł Marzęda Paula Wr óblewska-Łuczka Magdalena Florek- Łuszczki Agnieszka G óralczyk Jarogniew J Łuszczki Source Type: research

Imperatorin interacts additively with novel antiseizure medications in the mouse maximal electroshock-induced seizure model: an isobolographic transformation
CONCLUSIONS: The additive interactions of IMP with LCM, OXC, PGB, and TPM in the mouse MES model accompanied by no pharmacokinetic changes in the total brain content of ASMs are worthy of recommendation for further studies.PMID:38015370 | DOI:10.1007/s43440-023-00555-4 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 28, 2023 Category: Drugs & Pharmacology Authors: Jarogniew J Łuszczki Ewelina Kochman-Moskal Hubert Bojar Magdalena Florek- Łuszczki Krystyna Skalicka-Wo źniak Source Type: research

Lipid-lowering drugs and cancer: an updated perspective
Pharmacol Rep. 2023 Nov 28. doi: 10.1007/s43440-023-00553-6. Online ahead of print.ABSTRACTStatins and non-statin medications used for the management of dyslipidemia have been shown to possess antitumor properties. Since the use of these drugs has steadily increased over the past decades, more knowledge is required about their relationship with cancer. Lipid-lowering agents are heterogeneous compounds; therefore, it remains to be revealed whether anticancer potential is a class effect or related to them all. Here, we reviewed the literature on the influence of lipid-lowering medications on various types of cancer during de...
Source: Pharmacological Reports - November 28, 2023 Category: Drugs & Pharmacology Authors: Azin Alizadehasl Maryam Sadat Alavi Shabnam Boudagh Mohaddeseh Sadat Alavi Somaye Mohebi Leila Aliabadi Mahsa Akbarian Parisa Ahmadi Massimo R Mannarino Amirhossein Sahebkar Source Type: research