Lafutidine Ameliorates Indomethacin-Induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota
Conclusion: LAF may protect against NSAID enteropathy via enhancing the intestinal mucosal barrier, inhibiting inflammation, and regulating microbiota.Pharmacology (Source: Pharmacology)
Source: Pharmacology - April 6, 2023 Category: Drugs & Pharmacology Source Type: research
Oncostatin M and Nivolumab Affect the Cytotoxic T-Cell Proportions and the Susceptibility to TRAIL-Induced Death in Non-Leukocyte Cell Subpopulations in Soft Tissue Sarcomas
Conclusion: In conclusion, the biological efficacy of OSM is reflected in the tumor microenvironment rather than in the peripheral blood of the patients in our cohort, and nivolumab could potentiate its mechanism of action in selected cases. Nevertheless, more histotype-tailored studies are needed to fully understand the functions of OSM in STSs.Pharmacology (Source: Pharmacology)
Source: Pharmacology - March 30, 2023 Category: Drugs & Pharmacology Source Type: research
Research Progress on the Anticancer Molecular Mechanism of Targets Regulating Cell Autophagy
Background: Autophagy is a lysosome-mediated catabolic process that maintains cell homeostasis and survival. It occurs not only in normal cells such as cardiac muscle cells, neurons, and pancreatic acinar cells but also in various benign and malignant tumors. The abnormal level of intracellular autophagy is closely related to multiple pathophysiological processes, including aging, neurodegeneration, infectious diseases, immune disorders, and cancer. Autophagy mainly plays a dual role in life and death by regulating cell survival, proliferation, and death, thus being involved in the occurrence, development, and treatment of...
Source: Pharmacology - March 8, 2023 Category: Drugs & Pharmacology Source Type: research
Cardiometabolic Risk Factors in Atorvastatin-Treated Women with Euthyroid Autoimmune Thyroiditis
Conclusion: The obtained results indicate that euthyroid women with Hashimoto ’s thyroiditis may benefit to a lesser degree from atorvastatin treatment than other populations of women with hypercholesterolemia.Pharmacology (Source: Pharmacology)
Source: Pharmacology - March 6, 2023 Category: Drugs & Pharmacology Source Type: research
Dantrolene Significantly Improves Cerebral Blood Flow in a Rat Model of Hemorrhagic Vasospasms
Conclusion: Altogether, our results indicate that 2.5 mg/kg dantrolene significantly reduces BFV in the MCA without altering systemic hemodynamic parameters to a similar extent than the highest dose of nimodipine or the combination of dantrolene and the lowest dose of nimodipine. Therefore, dantrolene may provide a promising alternative to lower the risk, or partially revert, CVSP.Pharmacology (Source: Pharmacology)
Source: Pharmacology - March 6, 2023 Category: Drugs & Pharmacology Source Type: research
Rosuvastatin Potentiates Gonadotropin-Lowering Effects of Metformin in Postmenopausal Women: A Pilot Study
Conclusion: The obtained results indicate that statin therapy may enhance gonadotropin-lowering effects of metformin.Pharmacology (Source: Pharmacology)
Source: Pharmacology - February 15, 2023 Category: Drugs & Pharmacology Source Type: research
Erratum
Pharmacology (Source: Pharmacology)
Source: Pharmacology - February 9, 2023 Category: Drugs & Pharmacology Source Type: research
Alkaloids in < b > < i > Withania somnifera < /i > < /b > (L.) Dunal Root Extract Contribute to Its Anti-Inflammatory Activity
The anti-inflammatory properties of the medicinal plantWithania somnifera (L.) Dunal (WS) are generally related to withanolides; consistently, several strategies are under investigation to increase the concentration of these compounds in WS extracts. However, a potential toxicity of withanolides has been highlighted, thus questioning the safety of such preparations. At variance, the relative contribution of alkaloids is underrated, in spite of preliminary evidence underlining a possible pharmacological relevance. Starting from these considerations, the efficacy/safety profile of WS root extract (WSE) was compared with thos...
Source: Pharmacology - February 8, 2023 Category: Drugs & Pharmacology Source Type: research
