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ESP/EPPM Joint Meeting 5-10 September 2009 Wroclaw, PolandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Photodiagnosis and Photodynamic Therapy - August 12, 2009 Category: Laser Surgery Tags: ESP/EPPM Joint Meeting Source Type: journals

ESP Overview of ProgrammeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Photodiagnosis and Photodynamic Therapy - August 12, 2009 Category: Laser Surgery Tags: ESP/EPPM Joint Meeting Source Type: journals

Overview of the Scientific Programme of EPPMEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Photodiagnosis and Photodynamic Therapy - August 12, 2009 Category: Laser Surgery Tags: ESP/EPPM Joint Meeting Source Type: journals

Abstracts of invited speakers of EPPM sessionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Photodiagnosis and Photodynamic Therapy - August 12, 2009 Category: Laser Surgery Tags: ESP/EPPM Joint Meeting Source Type: journals

Twenty years of experience with PDD and PDT in Poland—ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article is a review of laboratory and clinical research undertaken in Poland in PDD and PDT over the past 20 years. These are divided into two parallel research areas. The first is based on clinical trials where new modalities of photosensitizer synthesis, molecular mechanisms of PDT and other aspects are investigated. The second is concerned with clinical aspects of PDD and PDT in both pre-neoplastic and malignant disease. In Poland there were 2 National Congresses in 2006 and 2008 with 100 and 400 participants respectively. One of the oldest centers of Photodynamic Diagnostics and Therapy is located in Bytom. For ab...
Source: Photodiagnosis and Photodynamic Therapy - August 10, 2009 Category: Laser Surgery Authors: Aleksander Sieroń, Sebastian Kwiatek Tags: Review Source Type: journals

Cholangiocarcinoma: Improving biliary drainage with PDTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cholangiocarcinoma is a disease that is challenging to both diagnose and treat. Only a minority of patients present at a stage suitable for attempted curative surgical resection and 5 year survival rates remain as low as 5% in most series . Much of the morbidity of cholangiocarcinoma is caused by complications of biliary obstruction—a rationale for treatments such as PDT, which aim to optimise biliary drainage and thereby improve survival and quality of life.
Source: Photodiagnosis and Photodynamic Therapy - August 10, 2009 Category: Laser Surgery Authors: Michael H. Chapman, Stephen P. Pereira Tags: Editorial Source Type: journals

Induction of early apoptosis in human nasopharyngeal carcinoma cells by mTHPC-mediated photocytotoxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: mTHPC-mediated photo-cytotoxicity can effectively induce early apoptotic responses in NPC/HK1 cells which might be modulated by mitochondrial damages and Bcl-2 inhibition.
Source: Photodiagnosis and Photodynamic Therapy - August 10, 2009 Category: Laser Surgery Authors: Christine M.N. Yow, N.K. Mak, Albert W.N. Leung, Zheng Huang Tags: Articles Source Type: journals

Terahertz pulsed imaging—A potential medical imaging modality?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Terahertz imaging has progressed significantly over the last decade and there is now a significant body of research in its application to biomedical problems with the possibility of developing it into viable medical imaging modality in the future. The motivation being to fill some of the shortfalls in existing medical imaging technologies especially in detecting early stage cancers. We review the main developments in terahertz imaging to-date and highlight the most promising current areas of biomedical terahertz research. Additionally, we provide an overview of the principles behind terahertz imaging along with il...
Source: Photodiagnosis and Photodynamic Therapy - August 10, 2009 Category: Laser Surgery Authors: Emma Pickwell-MacPherson, Vincent P. Wallace Tags: Review Source Type: journals

PDT frontiersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In retrospect, papers and talks concerning new frontiers were too often distorted by inaccuracy or sensationalism. In an attempt at prognostic relevance I believe that the frontiers of PDT will involve nanotechnology and stem cells, both or neither, with a strong bet placed on serendipity. Further, while currently PDT is practiced with separate drug and light, ultimately leading to a type II PDR, this may not be the case in the future. Let us take a look in the crystal ball.
Source: Photodiagnosis and Photodynamic Therapy - August 10, 2009 Category: Laser Surgery Authors: Ron R. Allison Tags: Extended Abstract Source Type: journals

European Platform for Photodynamic Medicine (EPPM) Message from the PresidentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 13th bi-annual conference of the ESP, in conjunction with the 2nd congress of the EPPM is a great occasion for both scientists and clinicians concerned with PDPDT. The meeting in Wroclaw has provided this opportunity for the two organisations to join together from 5th to 10th September.
Source: Photodiagnosis and Photodynamic Therapy - August 10, 2009 Category: Laser Surgery Authors: Keyvan Moghissi Tags: ESP/EPPM Joint Meeting Source Type: journals

12th World Congress of the International Photodynamic Association (IPA), 11–15th June 2009, Seattle, USAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Around 300 participants from more than 20 different countries and regions travelled to Seattle, USA in June to attend the 12th International Photodynamic Association (IPA) World Congress. This was co-organised locally by SPIE. This Congress followed in the great tradition of these biennial conferences which routinely attract leading clinical and scientific researchers in the fields of photodynamic therapy (PDT) and photodiagnosis (PD) alike.
Source: Photodiagnosis and Photodynamic Therapy - August 10, 2009 Category: Laser Surgery Authors: Alison Curnow Tags: Confernence Reports Source Type: journals

A brief history of photodynamic therapy in WrocławEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: A brief history of photodynamic therapy in Wroclaw was presented in this paper.
Source: Photodiagnosis and Photodynamic Therapy - August 3, 2009 Category: Laser Surgery Authors: Beata Osiecka, Kamil Jurczyszyn, Krzysztof Symonowicz, Andrzej Bronowicz, Piotr Ziolkowski Tags: Short Communication Source Type: journals

Photo-toxic effects of 809-nm diode laser and indocyanine green on MDA-MB231 breast cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, ICG when used in combination with near-infrared light showed a very fast (within 3h) and persistent (up to 48h) photo-toxic effect on MDA-MB231 human breast cancer cells.
Source: Photodiagnosis and Photodynamic Therapy - July 31, 2009 Category: Laser Surgery Authors: Ozguncem Bozkulak, Rezan Fahrioglu Yamaci, Ozgur Tabakoglu, Murat Gulsoy Tags: Articles Source Type: journals

Comment for the review of Dr AllisonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study should permit to go further in the establishment of PDT as a standard procedure in patients with unresectable CC, and to try and understand the mechanisms by which PDT enables such a dramatic improvement of survival and quality of life in these patients.
Source: Photodiagnosis and Photodynamic Therapy - July 30, 2009 Category: Laser Surgery Authors: Stéphane Lecleire Tags: Invited Commentary Source Type: journals

Annual Scientific Meeting of British Medical Laser Association and UK-PDPDT interest group, 14 and 15 May 2009, Salisbury, UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On 15 May 2009 the Annual Scientific Meeting of the UK-PDPDT interest group was held in Salisbury District General Hospital. K. Moghissi, the co-ordinator of the group, welcomed the participants.
Source: Photodiagnosis and Photodynamic Therapy - July 16, 2009 Category: Laser Surgery Authors: K. Moghissi Tags: Confernence Reports Source Type: journals

In vitro efficiency and mechanistic role of indocyanine green as photodynamic therapy agent for human melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: ICG/PDT can efficiently and rapidly induce apoptosis in human melanoma cells and it can be considered as a new therapeutic approach for topical treatment of melanoma.
Source: Photodiagnosis and Photodynamic Therapy - July 13, 2009 Category: Laser Surgery Authors: Abdel-Megid Mamoon, Amira M. Gamal–Eldeen, Meghan E. Ruppel, Randy J. Smith, Thomas Tsang, Lisa M. Miller Tags: Articles Source Type: journals

Chlorin e6-based photosensitizers for photodynamic therapy and photodiagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Photofrin (hematoporphyrin derivative or porfimer sodium), Visudyne (benzoporphyrin derivative monoacid ring A or verteporfin), Foscan (meta-tetra(hydroxyphenyl)chlorin or Temoporfin), Levulan Kerastick (5-aminolevulinic acid), Metivx (methyl aminolevulinate) and Hexvix (hexyl aminolevulinate) are the most studied and best known photosensitizers and photosensitizer precursors approved for clinical use in photodynamic therapy (PDT) or photodiagnosis in many countries worldwide. Many new photosensitizers and precursors are continuously synthesized and investigated in laboratories, some of them in clinical trials and some are...
Source: Photodiagnosis and Photodynamic Therapy - July 3, 2009 Category: Laser Surgery Authors: Asta Juzeniene Tags: Editorial Source Type: journals

Pharmacokinetics and biodistribution of Photolon® (Fotolon®) in intact and tumor-bearing ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In general, results of the experimental study of biodistribution of Photolon® in inner organs and tissues of rats, performed as in real time (by means of intravital laser fluorimetry in situ) as ex vivo (spectrophotometric assay) can be utilized while optimizing existing regimens of PDT with the purpose to increase safety and efficacy of treatment as well as for the development of new PDT protocols with Photolon® applied for new indications. Parameters of pharmacokinetics and biodistribution of Photolon®/Fotolon® as well as its’ ability to cross an intact blood–brain barrier, are optimal for the majori...
Source: Photodiagnosis and Photodynamic Therapy - June 22, 2009 Category: Laser Surgery Authors: S.V. Shliakhtsin, T.V. Trukhachova, H.A. Isakau, Y.P. Istomin Tags: Articles Source Type: journals

Cholangiocarcinoma: An emerging indication for photodynamic therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Cholangiocarcinoma (CC) is emerging as an important treatment indication for photodynamic therapy. CCs are generally unresectable locally invasive tumors that occlude the biliary tree leading to fatal cholangitis and liver failure. Biliary decompression via stenting offers symptomatic relief but does not control tumor growth. Founded on an initial case study followed by ever more sophisticated clinical research, including randomized trials, photodynamic therapy has garnered enough momentum to be considered as part of the standard of care for these patients. Further, preliminary clinical data show the potential for...
Source: Photodiagnosis and Photodynamic Therapy - June 9, 2009 Category: Laser Surgery Authors: Ron R. Allison, Emmanuel Zervos, Claudio H. Sibata Tags: Review Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Source Type: journals

Photodynamic diagnosis and therapy in gynaecologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Photodynamic diagnostic (PDD) and therapeutic methods (PDT) have been evaluated successfully in several malignant and non-malignant gynaecologic diseases. Fluorescence diagnosis is currently employed in gynaecologic conditions such as cervical intraepithelial neoplasia (CIN), endometriosis and ovarian cancer. In the field of endometriosis, a frequent pathology where uterine mucosa is found in the abdominal cavity, PDD has been shown to be useful for the detection of active lesions. Regarding ovarian cancer, several studies show that PDD is more effective in the detection of implantation metastases then white light inspect...
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: P. Hillemanns, P. Soergel Tags: ESP/EPPM Joint Meeting Source Type: journals

PDPDT of lung cancer for optimal PDTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lung cancer is the leading cause of death from cancer throughout the world, due to the high prevalence of tobacco smoking, the environmental pollution, the aging society and detection of lung cancer at the late stage. It is also due to the treatments being difficult for patients with impaired lung function such as chronic obstructive pulmonary disease (COPD) caused by tobacco smoking.
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: Harubumi Kato Tags: ESP/EPPM Joint Meeting Source Type: journals

Expansion of indications of bronchoscopic PDT for lung cancer and, the contribution of auto-fluorescence bronchoscopy (AFB): Personal observations based on 20 years experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Surgical resection remains the primary option for lung cancer treatment when oncologically the tumour is resectable, clinically the patient is operable and surgically the subject is eligible. However, despite considerable advances in diagnostic methods, surgical and anaesthetic techniques, and immense progress in intensive therapy neither the resectability rate, nor overall outcome for patients with lung cancer has significantly improved. Resectability rate is still ≤20%, and overall survival is around 15–20%.
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: K. Moghissi Tags: ESP/EPPM Joint Meeting Source Type: journals

PDD/PDT—Recent advances in the head and neckEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Photodynamic therapy for head and neck cancer is now well established in a few centres in the EU. There are drugs with licensed indications and there are also a number of research programmes that are looking to extend applications.
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: Colin Hopper Tags: ESP/EPPM Joint Meeting Source Type: journals

Preclinical synergy in photodynamic treatment of oral cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: PD and PDT of cancer are gaining ground in numerous clinical disciplines including cranio-maxillo-facial surgery. In recent years literature presented input from many new applications. This is due to better knowledge about PD-PDT from the clinical staff, both nurses and doctors. But it is also a result of improved drug and hardware especially investigation of better photosensitizers and more efficient light sources. We here focus on some new developments regarding oral cavity, which will be discussed.
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: Heinrich Walt Tags: ESP/EPPM Joint Meeting Source Type: journals

PDT for Barrett's oesophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Brief summary: PDT is a drug and device therapy using photosensitizer drugs activated by laser light for mucosal ablation. Ps-PDT has been used extensively with proven long-term efficacy and durability for the ablation of BE with high-grade dysplasia and early esophageal adenocarcinoma. However, continued use is hampered by an associated stricture risk and prolonged photosensitivity (4–6 weeks). Promising single center European studies using other forms of PDT, such as ALA-PDT, have not been replicated elsewhere, limiting the widespread use of other forms of PDT. Over the past several years other ablation devices, such a...
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: H. Wolfsen Tags: ESP/EPPM Joint Meeting Source Type: journals

Photodynamic therapy (PDT) for high grade dysplasia in Barrett's oesophagus—10-Year experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Photodynamic therapy (PDT) is evolving to be an effective and safe ablative therapy for high grade dysplasia (HGD) within a Barrett's oesophagus. Recent studies suggest that PDT can provide outcomes comparable to oesophagectomy without exposing the patient to the excess risks attached to surgical resection . The aim of this study is to present our experience from the Yorkshire Laser Centre over a 10-year period and report outcomes, technical issues and complications.
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: Peter A. Tcherveniakov, Keyvan Moghissi, James A.C. Thorpe Tags: ESP/EPPM Joint Meeting Source Type: journals

PDT in dermatologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of topical photodynamic therapy (PDT) is well established for superficial non-melanoma skin cancer and dysplasia. Its application in other indications, including acne vulgaris and a range of other skin diseases, is also of increasing clinical and research interest. Several multicentre comparative studies have established that the efficacy of topical PDT is at least equivalent to that of other non-surgical conventional treatments such as cryotherapy or 5-fluorouracil for the treatment of superficial basal cell carcinoma, Bowen's disease and actinic keratosis but that PDT has superior cosmetic outcome. PDT also has a...
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: Sally H. Ibbotson Tags: ESP/EPPM Joint Meeting Source Type: journals

Specific aspects of PDT in dermatologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion PDT in dermatology has already gone a long way with some success in its routine clinical application. Yet a long list of necessary steps are still ahead of us: (a) broadening the acceptance and impact (which is made difficult by its position somewhere between conservative treatment modalities and procedures like surgery), (b) further optimizing the treatment procedure and (c) expanding the field of novel indications.
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: Alexis Sidoroff Tags: ESP/EPPM Joint Meeting Source Type: journals

Matrix metalloproteinases expression in tumor and non-tumor tissues after photodynamic therapy with liposomal formulation of aminolevulinic acid and its methyl esterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Liposomes consist of spherical phospholipid bilayers with number of properties making them useful for topical application of different drugs. Liposomes can be used as carriers for hydrophilic as well as lipophilic therapeutic agents because they show some amphiphilic character. Clinical studies indicated that 5-aminolevulinic acid (ALA) encapsulated in liposomes improved the quality of fluorescence diagnosis by ALA-induced porphyrins and optimized the results of photodynamic therapy (PDT). In our study, the new original approach was to use liposomal formulation of ALA and its methyl ester, metvix, both in vitro and in vivo...
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: Piotr Ziolkowski, Kamil Jurczyszyn, Beata Osiecka, Andrzej Bronowicz, Krzysztof Symonowicz, Piotr Dziegiel, Elzbieta Gebarowska, Ilona Izykowska, Grzegorz Terlecki, Elzbieta Czapinska, Katarzyna Hotowy Tags: ESP/EPPM Joint Meeting Source Type: journals

Light sources and delivery devices for photodynamic therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The primary requirement of the combination light source and delivery device used in photodynamic therapy (PDT) is to achieve the desired energy fluence throughout the target tissue volume. Lasers, light sources and the dosimetric parameters to induce controlled photochemical reactions operate below power outputs that would cause any photothermal effects of consequence for photodynamic therapy.
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: Thomas S. Mang Tags: ESP/EPPM Joint Meeting Source Type: journals

PDT dosimetry: From the sophisticated to the pragmaticEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The principle objective in measuring light dose is to help optimise treatment schedules. One of the inherent difficulties associated with PDT is that the biological response does not follow the radiometric light dose in a simple linear manner. Treatment outcome depends on drug uptake and also availability of oxygen, in addition to the added complexity of photobleaching, a phenomenon that means that light delivered in the first minute of treatment is much more effective than the same amount of light delivered at the end. However, its complexity should not deter the investigator from attempting to quantify the effective ligh...
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: Harry Moseley Tags: ESP/EPPM Joint Meeting Source Type: journals

Development of high magnification endoscopy for the rejection of false positives observed in the bladder and the tracheo-bronchial tree during the detection of early cancers by endoscopic fluorescence imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endoscopic fluorescence imaging (EFI) has been recently recognized as a useful method to detect early superficial cancers in the tracheo-bronchial tree and the bladder, including flat lesions. In the bronchi, EFI is based on the detection of the tissue autofluorescence, whereas this detection approach is based on exogenously induced fluorescence in the bladder. Indeed, a solution of the hexyl ester of aminolevulinic acid (Hexvix®) is instilled for about 1h in the bladder prior to the examination. The lesions are then enlightened by the fluorescent porphyrins, including protoporphyrin IX, that accumulate very selectively i...
Source: Photodiagnosis and Photodynamic Therapy - June 1, 2009 Category: Laser Surgery Authors: Blaise Lovisa, Patrice Jichlinski, Philippe Monnier, Bernd C. Weber, Hubert van den Bergh, Georges A. Wagnieres Tags: ESP/EPPM Joint Meeting Source Type: journals

PDT for cancers of the head and neckEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In contrast to most noncutaneous cancers, achievement of local control in head and neck squamous cell carcinoma translates directly to survival. Consequently, any intervention that improves local control for tumors of the head and neck should improve survival. On the surface, this would explain the radical approach of cutting or irradiating head and neck tumors. Ultimately, these treatments have proven to achieve high rates of local control, but at times with significant and permanent disfigurement and disability. It would seem then that a minimally invasive local therapy such as PDT would be an ideal substitute. Why then ...
Source: Photodiagnosis and Photodynamic Therapy - May 1, 2009 Category: Laser Surgery Authors: Ron R. Allison, Claudia Sibata, Hiram Gay Tags: Editorial Source Type: journals

Is photodynamic therapy a good alternative to surgery and radiotherapy in the treatment of head and neck cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The mainstay treatments for head and neck carcinomas are surgery, radiotherapy and chemotherapy. These treatment options may be associated with considerable complications. Radical radiotherapy and chemotherapy can generally be employed only once, which presents difficulties in cases of recurrent disease or second primaries within the irradiated field. Salvage surgery at the same site is often difficult, due to progressive tissue loss. In this respect photodynamic therapy (PDT) seems to be a good alternative treatment option for small, localized tumors; with a good outcome and with excellent functional and cosmetic...
Source: Photodiagnosis and Photodynamic Therapy - May 1, 2009 Category: Laser Surgery Authors: Heike J. Nyst, I. Bing Tan, Fiona A. Stewart, Alfons J.M. Balm Tags: Review Source Type: journals

The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema—In vivo kinetic study of 5-aminolevulinic acid and talaporfin sodiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Objective: We aimed to clarify the optimal timing for the fluorescence imaging of brain tumor tissue differentiated from brain edema after the administration of photosensitizers.Methods: We have performed an in vivo study of the kinetics of 5-aminolevulinic acid (5-ALA) in comparison with talaporfin sodium using the rat brain tumor model and rat vasogenic edema model produced by cold injury. The in vivo kinetics of 5-ALA and talaporfin sodium in brain tumor model and the vasogenic edema model was determined by a fluorescence macroscope and a microplate reader.Results: The in vivo kinetic study of 5-ALA showed mild...
Source: Photodiagnosis and Photodynamic Therapy - May 1, 2009 Category: Laser Surgery Authors: Takao Tsurubuchi, Alexander Zoboronok, Tetsuya Yamamoto, Kei Nakai, Fumiyo Yoshida, Makoto Shirakawa, Masahide Matsuda, Akira Matsumura Tags: Articles Source Type: journals

Clinical and immunohistochemical assessment of vulval intraepithelial neoplasia following photodynamic therapy using a novel bioadhesive patch-type system loaded with 5-aminolevulinic acidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Treatment of VIN lesions using a novel bioadhesive patch induced changes in cell cycle and apoptotic proteins in response to PDT with possible utilisation of apoptotic pathways. The efficacy of PDT in treating VIN could be improved by a better understanding of these apoptotic mechanisms, the influence of factors, such as HPV status, and of the need for effective pain management.
Source: Photodiagnosis and Photodynamic Therapy - May 1, 2009 Category: Laser Surgery Authors: A. Zawislak, R.F. Donnelly, W.G. McCluggage, J.H. Price, H.R. McClelland, A.D. Woolfson, S. Dobbs, P. Maxwell, P.A. McCarron Tags: Articles Source Type: journals

How we treat Bowen's disease with topical photodynamic therapy in DundeeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: We have more than 10 years experience in the Photobiology Unit, in the use of topical photodynamic therapy (PDT) for non-melanoma skin cancer and other skin diseases. During this time we have undertaken approximately 5000 treatments and this article details the practical aspects of how we treat Bowen's disease with topical PDT.
Source: Photodiagnosis and Photodynamic Therapy - May 1, 2009 Category: Laser Surgery Authors: Sasi Kiran Attili, Sally H. Ibbotson Tags: Articles Source Type: journals

Biodistribution and phototherapeutic properties of Zinc (II) 2,9,16,23-tetrakis (methoxy) phthalocyanine in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we have tested the efficiency of ZnPc(OCH3)4 liposomal formulation on mice. Biodistribution studies were performed in tumor-free mice and tumor-bearing mice at various time points up to 24h after ZnPc(OCH3)4-PDT treatment. The tumor sizes were evaluated over different period in parallel experiments. The maximal efficiency and selectivity of photosensitizer accumulation in tumor tissue take place at 24h after drug administration of 0.2mg/kg bw ZnPc(OCH3)4. In the tumor sections for biochemical studies, apoptosis was visualized by activation of caspase-3. ZnPc(OCH3)4-PDT tumors showed a significant delay in gr...
Source: Photodiagnosis and Photodynamic Therapy - April 15, 2009 Category: Laser Surgery Authors: E. Inés Yslas, César Prucca, Silvia Romanini, Edgardo N. Durantini, Mabel Bertuzzi, Viviana Rivarola Tags: Articles Source Type: journals

Hypericin and 5-aminolevulinic acid-induced protoporphyrin IX induce enhanced phototoxicity in human endometrial cancer cells with non-coherent white lightEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study demonstrated that treatment of endometrial cancer cells with both 5-ALA and hypericin followed by illumination with white light induced a significantly higher phototoxicity as revealed by colony formation. This setting which generated an in vitro effect similar to the patient's situation, might be applied in the future as an affordable and effective photodynamic therapy (PDT) modality.
Source: Photodiagnosis and Photodynamic Therapy - March 16, 2009 Category: Laser Surgery Authors: Xiaoye Schneider-Yin, Aida Kurmanaviciene, Marion Roth, Malgorzata Roos, André Fedier, Elisabeth I. Minder, Heinrich Walt Tags: Articles Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Photodiagnosis and Photodynamic Therapy - March 1, 2009 Category: Laser Surgery Source Type: journals

Interactions of protoporphyrin IX and its derivatives with benzodiazepine receptorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The aim of this study was to determine binding affinities of the Peripheral benzodiazepine receptor (PBR) with protoporphyrin IX, haematoporphyrin (Hp), and two arginized derivatives: Hp(Arg)2 and PP(Arg)2. The quenching of protein fluorescence was used to measure association constants during titration of PBR solution with PP derivatives in a function of concentration. The experimental data was fitted to theoretical curves, assuming strong and weak binding model with one binding site. As a result of this early study affinity constants were determined. The highest affinity toward PBR showed PPIX and Hp, Hp(Arg)2, P...
Source: Photodiagnosis and Photodynamic Therapy - February 26, 2009 Category: Laser Surgery Authors: Aneta Bombalska, Alfreda Graczyk Tags: Articles Source Type: journals

Mechanistic insight of the photodynamic inactivation of Escherichia coli by a tetracationic zinc(II) phthalocyanine derivativeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Photodynamic inactivation (PDI) of Escherichia coli has been studied in cultures treated with zinc(II) 2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]phthalocyanine (ZnPPc+4) to obtain insight about the mechanism of damage. This phthalocyanine is rapidly bound to cells, reaching a value of ∼0.8nmol/106 cells when the cultures were incubated with 2μM sensitizer. After 30min of irradiation, a 4log decrease of E. coli survival was observed. The photocytotoxic action was investigated in plasmid and genomic DNA by electrophoretic analysis. Absorption spectroscopic studies showed that this cationic phthalocyanine interact...
Source: Photodiagnosis and Photodynamic Therapy - February 9, 2009 Category: Laser Surgery Authors: Mariana B. Spesia, Daniel A. Caminos, Patricia Pons, Edgardo N. Durantini Tags: Articles Source Type: journals