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ERK-regulated differential expression of the Mitf 6a/b splicing isoforms in melanoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The master regulator of the melanocyte lineage Mitf is intimately involved in development as well as melanoma, controlling cell survival, differentiation, proliferation and metastasis/migration. Consistent with its central role, Mitf expression and Mitf post-translational modifications are tightly regulated. An additional potential level of regulation is afforded by differential splicing of Mitf exon-6 leading to the generation of two isoforms that differ by the presence of 6 amino-acids in the MITF(+) isoform and which have differential effects on cell cycle progression. However, whether the ratio of the two isoforms ...
Source: Pigment Cell and Melanoma Research - November 6, 2009 Category: Cytology Authors: Primot A, Mogha A, Corre S, Roberts K, Debbache J, Adamski H, Dreno B, Khammari A, Lesimple T, Mereau A, Goding CR, Galibert MD Tags: Pigment Cell Melanoma Res Source Type: journals

Transgenic expression of Notch in melanocytes demonstrates RBP-Jkappa-dependent signaling.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19895548 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - November 6, 2009 Category: Cytology Authors: Schouwey K, Larue L, Radtke F, Delmas V, Beermann F Tags: Pigment Cell Melanoma Res Source Type: journals

Moesin/ezrin: a specific role for these proteins in cell metastasis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19863757 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 24, 2009 Category: Cytology Authors: Dominique L, Monique A Tags: Pigment Cell Melanoma Res Source Type: journals

So long, and thanks for all the...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19845872 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 23, 2009 Category: Cytology Authors: Goding C Tags: Pigment Cell Melanoma Res Source Type: journals

Shocking ... and ... stunning.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19845873 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 23, 2009 Category: Cytology Authors: Hammelsoe P Tags: Pigment Cell Melanoma Res Source Type: journals

SKI knockdown inhibits human melanoma tumor growth in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The SKI protein represses the TGF-beta tumor suppressor pathway by associating with the Smad transcription factors. SKI is upregulated in human malignant melanoma tumors in a disease-progression manner and its overexpression promotes proliferation and migration of melanoma cells in vitro. The mechanisms by which SKI antagonizes TGF-beta signaling in vivo have not been fully elucidated. Here we show that human melanoma cells in which endogenous SKI expression was knocked down by RNAi produced minimal orthotopic tumor xenograft nodules that displayed low mitotic rate and prominent apoptosis. These minute tumors exhibited...
Source: Pigment Cell and Melanoma Research - October 23, 2009 Category: Cytology Authors: Chen D, Lin Q, Box N, Roop D, Ishii S, Matsuzaki K, Fan T, Hornyak TJ, Reed JA, Stavnezer E, Timchenko NA, Medrano EE Tags: Pigment Cell Melanoma Res Source Type: journals

Society for melanoma research 2009 international congress.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19845875 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 23, 2009 Category: Cytology Tags: Pigment Cell Melanoma Res Source Type: journals

22nd meeting of the Japanese society for pigment cell research.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19845876 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 23, 2009 Category: Cytology Tags: Pigment Cell Melanoma Res Source Type: journals

List of referees 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19845877 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 23, 2009 Category: Cytology Tags: Pigment Cell Melanoma Res Source Type: journals

TYRO3-mediated regulation of MITF: a novel target in melanoma?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843245 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 19, 2009 Category: Cytology Authors: Rudloff U, Samuels Y Tags: Pigment Cell Melanoma Res Source Type: journals

AKT2 is a downstream target of metabotropic glutamate receptor 1 (mGlu1).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reported earlier on the oncogenic properties of Grm1 by demonstrating that stable Grm1-mouse-melanocytic clones proliferate in the absence of growth supplement and anchorage in vitro. In addition these clones also exhibit aggressive tumorigenic phenotypes in vivo with short latency in tumor formation in both immunodeficient and syngeneic mice. We also detected strong activation of AKT in allograft tumors specifically AKT2 as the predominant isoform involved. In parallel we assessed several human melanoma biopsy samples and found again that AKT2 was the predominantly activated AKT in these human melanoma biopsies. In cul...
Source: Pigment Cell and Melanoma Research - October 19, 2009 Category: Cytology Authors: Shin SS, Wall BA, Goydos JS, Chen S Tags: Pigment Cell Melanoma Res Source Type: journals

The Wellcome Trust Functional Genomics Cell Bank: holdings.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19843247 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 19, 2009 Category: Cytology Tags: Pigment Cell Melanoma Res Source Type: journals

Dormancy of metastatic melanoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Metastatic dormancy of melanoma has not received sufficient attention, most likely because once detectable, metastasis is almost invariably fatal and, understandably, the focus has been on finding ways to prolong life of patients with overt recurrences. Nevertheless, analysis of the published clinical and experimental data on melanoma indicates that some aspect of melanoma biology imitate traits recently associated with dormancy in other solid cancers. Among them the ability of some melanomas to disseminate early during primary tumor progression and once disseminated, to remain undetected (dormant) for years. ...
Source: Pigment Cell and Melanoma Research - October 18, 2009 Category: Cytology Authors: Ossowski L, Aguirre-Ghiso JA Tags: Pigment Cell Melanoma Res Source Type: journals

Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SUMMARY Strial melanocytes are required for normal development and correct functioning of the cochlea. Hearing deficits have been reported in albino individuals from different species, although melanin appears to be not essential for normal auditory function. We have analyzed the auditory brainstem responses (ABR) of two transgenic mice: YRT2, carrying the entire mouse tyrosinase (Tyr) gene expression-domain and undistinguishable from wild-type pigmented animals; and TyrTH, non-pigmented but ectopically expressing tyrosine hydroxylase (Th) in melanocytes, which generate the precursor metabolite, L-DOPA, but not melanin...
Source: Pigment Cell and Melanoma Research - October 18, 2009 Category: Cytology Authors: Murillo-Cuesta S, Contreras J, Zurita E, Cediel R, Cantero M, Varela-Nieto I, Montoliu L Tags: Pigment Cell Melanoma Res Source Type: journals

Androgen, estrogen and progesterone receptors in acquired bilateral nevus of Ota-like macules.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19793384 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - September 29, 2009 Category: Cytology Authors: Long TF, Liu L, He L, Shen LD, Gu H, Yang Z, Tu Y, Ruan RH, Liu Y Tags: Pigment Cell Melanoma Res Source Type: journals

Molecular pathogenesis of malignant melanoma: A different perspective from the studies of melanocytic nevus and acral melanoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary The Clark model for melanoma progression emphasizes a series of histopathological changes beginning from benign melanocytic nevus to melanoma via dysplastic nevus. Several models of the genetic basis of melanoma development and progression are based on this Clark's multi-step model, and predict that the acquisition of a BRAF mutation can be a founder event in melanocytic neoplasia. However, our recent investigations have challenged this view, showing the polyclonality of BRAF mutations in melanocytic nevi. Furthermore, it is suggested that many melanomas, including acral and mucosal melanomas, arise de novo, no...
Source: Pigment Cell and Melanoma Research - September 24, 2009 Category: Cytology Authors: Takata M, Murata H, Saida T Tags: Pigment Cell Melanoma Res Source Type: journals

Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4/Tyr-Nras mice following neonatal UVR.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary To further investigate the use of DNA repair-enhancing agents for skin cancer prevention, we treated Cdk4(R24C/R24C)/Nras(Q61K) mice topically with the T4 endonuclease V DNA repair enzyme (known as Dimericine) immediately prior to neonatal ultraviolet radiation (UVR) exposure, which has a powerful effect in exacerbating melanoma development in the mouse model. Dimericine has been shown to reduce the incidence of basal-cell and squamous cell carcinoma. Unexpectedly, we saw no difference in penetrance or age of onset of melanoma after neonatal UVR between Dimericine-treated and control animals, although the drug ...
Source: Pigment Cell and Melanoma Research - September 23, 2009 Category: Cytology Authors: Hacker E, Konrad Muller H, Hayward N, Fahey P, Walker G Tags: Pigment Cell Melanoma Res Source Type: journals

Keratinocytes in Culture Accumulate Phagocytosed Melanosomes in the Perinuclear Area.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary There are many techniques for evaluating melanosome transfer to keratinocytes but the spectrophotometric quantification of melanosomes incorporated by keratinocyte phagocytosis has not been previously reported. Here we describe a new method that allows the spectrophotometric visualization of melanosome uptake by normal human keratinocytes in culture. Fontana-Masson staining of keratinocytes incubated with isolated melanosomes showed the accumulation of incorporated melanosomes in the perinuclear areas of keratinocytes within 48 hr. Electron microscopic observations of melanosomes ingested by keratinocytes revea...
Source: Pigment Cell and Melanoma Research - September 14, 2009 Category: Cytology Authors: Ando H, Niki Y, Yoshida M, Ito M, Akiyama K, Kim JH, Yoon TJ, Lee JH, Matsui MS, Ichihashi M Tags: Pigment Cell Melanoma Res Source Type: journals

New insights into the active site structure and catalytic mechanism of tyrosinase and its related proteins.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW INSIGHTS INTO THE ACTIVE SITE STRUCTURE AND CATALYTIC MECHANISM OF TYROSINASE AND ITS RELATED PROTEINS. Pigment Cell Melanoma Res. 2009 Sep 7; Authors: Olivares C, Solano F SUMMARY. Tyrosinases are widely distributed in nature. They are copper-containing oxidases belonging to the type 3 copper protein family, together with catechol oxidases and hemocyanins. Tyrosinases are essential enzymes in melanin biosynthesis and therefore responsible for pigmentation of skin and hair in mammals, where two more enzymes, the Tyrosinase-related proteins (Tyrps), participate in the pathway. The structure and catalytic mec...
Source: Pigment Cell and Melanoma Research - September 6, 2009 Category: Cytology Authors: Olivares C, Solano F Tags: Pigment Cell Melanoma Res Source Type: journals

Mutated ERBB4: a novel drug target in metastatic melanoma?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19735458 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - September 6, 2009 Category: Cytology Authors: Kurppa K, Elenius K Tags: Pigment Cell Melanoma Res Source Type: journals

Recent advances and hurdles in melanoma immunotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Worldwide incidence of malignant melanoma has been constantly increasing during the last years. Surgical excision is effective when primary tumors are thin. At later disease stages patients often succumb, due to failure of metastasis control. Therefore, great efforts have been made to develop improved strategies to treat metastatic melanoma patients. In the search for novel treatments during the last two decades, immunotherapy has occupied a prominent place. Numerous early phase immunotherapy clinical trials, generally involving small numbers of patients each time, have been reported: significant tumor-specifi...
Source: Pigment Cell and Melanoma Research - September 6, 2009 Category: Cytology Authors: Jandus C, Speiser D, Romero P Tags: Pigment Cell Melanoma Res Source Type: journals

Protein nitration is specifically associated with melanin production and reveals redox imbalance as a new correlate of cell maturation in the ink gland of Sepia officinalis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19735455 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - September 2, 2009 Category: Cytology Authors: Fiore G, Mattiello T, Tedeschi G, Nonnis S, d'Ischia M, Palumbo A Tags: Pigment Cell Melanoma Res Source Type: journals

Distinct receptor/ligand signaling mechanisms influence the fate of melanocyte populations in different tissues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19735456 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - September 2, 2009 Category: Cytology Authors: Uehara S, Kawasaki A, Yamamoto H Tags: Pigment Cell Melanoma Res Source Type: journals

The eyes have it.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19712249 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 29, 2009 Category: Cytology Authors: Goding C Tags: Pigment Cell Melanoma Res Source Type: journals

15th Meeting of the European Society for Pigment Cell Research (ESPCR - 2009) September 20-23, 2009 Münster, Germany.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
15th Meeting of the European Society for Pigment Cell Research (ESPCR - 2009) September 20-23, 2009 Münster, Germany. Pigment Cell Melanoma Res. 2009 Oct;22(5):652-97 Authors: PMID: 19712250 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 29, 2009 Category: Cytology Tags: Pigment Cell Melanoma Res Source Type: journals

Double stranded RNA tricks melanoma cells into committing suicide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19725927 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 28, 2009 Category: Cytology Authors: Goldszmid RS, Hasan UA, Trinchieri G Tags: Pigment Cell Melanoma Res Source Type: journals

Involvement of ABC Transporters in Melanogenesis and the Development of Multidrug Resistance of Melanoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Because melanomas are intrinsically resistant to conventional radiotherapy and chemotherapy, many alternative treatment approaches have been developed such as biochemotherapy and immunotherapy. The most common cause of multidrug resistance (MDR) in human cancers is the expression and function of one or more ATP-binding cassette (ABC) transporters that efflux anticancer drugs from cells. Melanoma cells express a group of ABC transporters (such as ABCA9, ABCB1, ABCB5, ABCB8, ABCC1, ABCC2, and ABCD1) that may be associated with the resistance of melanoma cells to a broad range of anticancer drugs and/or of melano...
Source: Pigment Cell and Melanoma Research - August 28, 2009 Category: Cytology Authors: Chen KG, Valencia JC, Gillet JP, Hearing VJ, Gottesman MM Tags: Pigment Cell Melanoma Res Source Type: journals

Melanocyte and RPE-specific expression in transgenic mice by mouse MART-1/Melan-A/mlana regulatory sequences.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19712205 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 26, 2009 Category: Cytology Authors: Aydin IT, Beermann F Tags: Pigment Cell Melanoma Res Source Type: journals

Inhibition of Siah2 ubiquitin ligase by Vitamin K3 (Menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary The E3 ubiquitin ligase Siah2 has been implicated in the regulation of the hypoxia response, as well as in the control of Ras, JNK/p38/NF-kappaB signaling pathways. Both Ras/MAPK and hypoxia pathways are important for melanoma development and progression, pointing to the possible use of Siah2 as target for treatment of this tumor type. In the present study, we have established a high-throughput electro-chemiluninescent-based assay in order to screen and identify inhibitors of Siah2 ubiquitin ligase activity. Of 1840 compounds screened, we identified and characterized menadione (MEN) as a specific inhibitor of S...
Source: Pigment Cell and Melanoma Research - August 26, 2009 Category: Cytology Authors: Shah M, Stebbins JL, Dewing A, Qi J, Pellecchia M, Ronai ZA Tags: Pigment Cell Melanoma Res Source Type: journals

Unique transforming properties of Notch1 in human melanocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19708913 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 25, 2009 Category: Cytology Authors: Bedogni B, Powell MB Tags: Pigment Cell Melanoma Res Source Type: journals

Twenty two cutaneous primary melanomas in a patient with high genetic predisposition to melanoma receiving levodopa therapy for Parkinson's disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19708914 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 25, 2009 Category: Cytology Authors: Charles J, Templier I, Leroux D, Salameire D, Robert C, Lantuejoul S, Leccia MT Tags: Pigment Cell Melanoma Res Source Type: journals

Hear the Wnt Ror: How Melanoma Cells Adjust to Changes in Wnt.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The interplay between canonical and non-canonical Wnt pathways in development and tumorigenesis is tightly regulated. In this review we will describe the yin and the yang of canonical and non-canonical Wnt signaling pathways during melanocyte development, and melanoma genesis. Canonical Wnt signaling, represented by Wnts such as Wnt1 and Wnt3A, signals via beta-catenin to promote melanocyte differentiation and tumor development. Non-canonical Wnt signaling, specifically Wnt5A, regulates canonical pathways, and signals to induce melanoma metastasis. This review will focus on the role of Wnt5A during melanoma pr...
Source: Pigment Cell and Melanoma Research - August 24, 2009 Category: Cytology Authors: O'Connell MP, Weeraratna AT Tags: Pigment Cell Melanoma Res Source Type: journals

Functional role of MITF phosphorylation. IN VIVO VERITAS?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19694979 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 18, 2009 Category: Cytology Authors: Bertolotto C, Ballotti R Tags: Pigment Cell Melanoma Res Source Type: journals

Genome-Wide Associations Studies for Melanoma and Nevi.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19686382 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 16, 2009 Category: Cytology Authors: Yeh I, Bastian B Tags: Pigment Cell Melanoma Res Source Type: journals

miR(acle)s - new players in the regulation of known suspects.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19671095 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 10, 2009 Category: Cytology Authors: Müller DW, Bosserhoff AK Tags: Pigment Cell Melanoma Res Source Type: journals

Identification of direct transcriptional targets of BRAF/MEK signalling in melanoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides a basis for understanding the molecular processes that are regulated by (V600E)BRAF/MEK signalling in melanoma cells. PMID: 19682280 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 3, 2009 Category: Cytology Authors: Packer LM, East P, Reis-Filho JS, Marais R Tags: Pigment Cell Melanoma Res Source Type: journals

Stem cell factor rescues tyrosinase expression and pigmentation in discreet anatomic locations in albino mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The K14-SCF transgenic murine model of variant pigmentation is based on epidermal expression of stem cell factor (SCF) on the C57BL/6J background. In this system, constitutive expression of SCF by epidermal keratinocytes results in retention of melanocytes in the interfollicular basal layer and pigmentation of the epidermis itself. Here we extend this animal model by developing a compound mutant transgenic amelanotic animal defective at both the melanocortin 1 receptor (Mc1r) and tyrosinase (Tyr) loci. In the presence of K14-Scf, tyrosinase-mutant animals (previously thought incapable of synthesizing melanin) ...
Source: Pigment Cell and Melanoma Research - August 3, 2009 Category: Cytology Authors: Vanover JC, Spry ML, Hamilton L, Wakamatsu K, Ito S, D'Orazio JA Tags: Pigment Cell Melanoma Res Source Type: journals

NRG1/ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neuregulin (NRG) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression. Here we show that NRG1/ERBB3 signaling inhibits melanocyte (MC) maturation and promotes undifferentiated, migratory and proliferative cellular characteristics. Embryonic analyses demonstrated that initial MC specification and distribution were not dependent on ERBB3 signaling. However NRG1/ERBB3 signaling was both necessary and sufficient to inhibit differentiation of later stages of MC development in culture. Analysis of tissue arrays of ...
Source: Pigment Cell and Melanoma Research - July 29, 2009 Category: Cytology Authors: Buac K, Xu M, Cronin J, Weeraratna AT, Hewitt SM, Pavan WJ Tags: Pigment Cell Melanoma Res Source Type: journals

Alpha-MSH Activates Immediate Defense Responses to UV-Induced Oxidative Stress in Human Melanocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides unequivocal evidence for induction of oxidative DNA damage by UV in human melanocytes and reduction of this damage by alpha-MSH. Our data unravel some mechanisms by which alpha-MSH protects melanocytes from oxidative DNA damage, which partially explain the strong association of loss-of-function MC1R with melanoma. PMID: 19659742 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 28, 2009 Category: Cytology Authors: Song X, Mosby N, Yang J, Xu A, Abdel-Malek Z, Kadekaro AL Tags: Pigment Cell Melanoma Res Source Type: journals

Pigmentary function and evolution of tyrp1 gene duplicates in fish.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The function of the tyrosinase-related protein 1 (Tyrp1) has not yet been investigated in vertebrates basal to tetrapods. Teleost fishes have two duplicates of the tyrp1 gene. Here, we show that the teleost tyrp1 duplicates have distributed the ancestral gene expression in the retinal pigment epithelium (RPE) and melanophores in a species-specific manner. In medaka embryos, tyrp1a expression is found in the RPE and in melanophores while tyrp1b is only expressed in melanophores. In zebrafish embryos, expression of tyrp1 paralogs overlaps in the RPE and in melanophores. Knockdown of each zebrafish tyrp1 duplicate alone d...
Source: Pigment Cell and Melanoma Research - July 28, 2009 Category: Cytology Authors: Braasch I, Liedtke D, Volff JN, Schartl M Tags: Pigment Cell Melanoma Res Source Type: journals

Upwards and onwards.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19624310 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 26, 2009 Category: Cytology Authors: Goding C Tags: Pigment Cell Melanoma Res Source Type: journals

GOLPH3 links the Golgi network to mTOR signaling and human cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19624311 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 26, 2009 Category: Cytology Authors: Abraham RT Tags: Pigment Cell Melanoma Res Source Type: journals

Targeting mutant BRAF and KIT in metastatic melanoma: ASCO 2009 meeting report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19624312 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 26, 2009 Category: Cytology Authors: Sondak VK, Smalley K Tags: Pigment Cell Melanoma Res Source Type: journals

Program of the XVth PanAmerican Society for Pigment Cell Research.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19624313 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 26, 2009 Category: Cytology Tags: Pigment Cell Melanoma Res Source Type: journals

Abstracts of the XVth PanAmerican Society for Pigment Cell Research.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19624314 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 26, 2009 Category: Cytology Tags: Pigment Cell Melanoma Res Source Type: journals

Carney complex and lentiginosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Initially described as the "complex of myxomas, spotty skin pigmentation and endocrine overactivity", Carney complex (CNC) is known as an autosomal dominant multiple neoplasia syndrome involving skin and cardiac myxomas, pigmented skin lesions and endocrine tumors. Pigmented cutaneous manifestations in Carney Complex (CNC) are important diagnostically because they can be used for the early detection of the disease and, thus, the prevention of life-threatening complications of CNC related to heart myxomas and endocrine abnormalities. Specific for the disease skin lesions are present in more than half of the CNC patients...
Source: Pigment Cell and Melanoma Research - July 23, 2009 Category: Cytology Authors: Horvath A, Stratakis CA Tags: Pigment Cell Melanoma Res Source Type: journals

F-box proteins FBXO31 and FBX4 in regulation of cyclin D1 degradation upon DNA damage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19645770 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 22, 2009 Category: Cytology Authors: Jia L, Sun Y Tags: Pigment Cell Melanoma Res Source Type: journals

Current Challenges in Understanding Melanogenesis: Bridging Chemistry, Biological Control, Morphology and Function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Melanin is a natural pigment produced within organelles, melanosomes, located in melanocytes. Biological functions of melanosomes are often attributed to the unique chemical properties of the melanins they contain; however, the molecular structure of melanins, the mechanism by which the pigment is produced, and how the pigment is organized within the melanosome remains to be fully understood. In this review, we examine the current understanding of the initial chemical steps in the melanogenesis. Most natural melanins are mixtures of eumelanin and pheomelanin, and so after presenting the current understating of ...
Source: Pigment Cell and Melanoma Research - July 20, 2009 Category: Cytology Authors: Simon JD, Peles D, Wakamatsu K, Ito S Tags: Pigment Cell Melanoma Res Source Type: journals

Independent regulation of hair and skin color by two G protein-coupled pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SUMMARY Hair color and skin color are frequently coordinated in mammalian species. To explore this, we have studied mutations in two different G protein coupled pathways, each of which affects the darkness of both hair and skin color. In each mouse mutant (Gnaq(Dsk1), Gna11(Dsk7) and Mc1r(e)), we analyzed the melanocyte density and the concentrations of eumelanin (black pigment) and pheomelanin (yellow pigment) in the hair or skin to determine the mechanisms regulating pigmentation. Surprisingly, we discovered that each mutation affects hair and skin color differently. Furthermore, we have found that in the epidermis, ...
Source: Pigment Cell and Melanoma Research - July 20, 2009 Category: Cytology Authors: Van Raamsdonk CD, Barsh GS, Wakamatsu K, Ito S Tags: Pigment Cell Melanoma Res Source Type: journals

Antibodies specific to melanocyte-specific proteins available from the Hearing Laboratory.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19627558 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 15, 2009 Category: Cytology Tags: Pigment Cell Melanoma Res Source Type: journals