Cardioprotective Effects of Aloysia polystachya Essential Oil on a Rat Model with Multiple Cardiovascular Risk Factors
This study aimed to investigate the protective effects of the essential oil extracted from the leaves of A. polystachya in a rat model that simulates multiple cardiovascular risk factors. We evaluate the acute toxicity, as well as the cardioprotective effects, by giving different doses of A. polystachya essential oil (1.47 mg/kg, 4.40 mg/kg, and 13.20 mg/kg) over a period of 42 days. The control group was treated with rosuvastatin (5 mg/kg). At the end of the treatments, the renal function, electrocardiography, blood pressure, vascular reactivity, serum biochemical profile, and organ histopathology were evaluated...
Source: Planta Medica - April 17, 2024 Category: Drugs & Pharmacology Authors: Moreno, Karyne Garcia Tafarelo Marques, Aline Aparecida Macedo da Silva, Gabriela Pereira Bertoncelo, Luana Ale Pessoal, Luciane Barbosa Gon çalves, Larissa Dantas dos Santos, Ariany Carvalho Souza, Roosevelt Isa ías Carvalho Silva, Denise Brentan Gaspa Tags: Original Papers Source Type: research
Bioprotective Role of Phytocompounds Against the Pathogenesis of Non-alcoholic Fatty Liver Disease to Non-alcoholic Steatohepatitis: Unravelling Underlying Molecular Mechanisms
Planta Med DOI: 10.1055/a-2277-4805Non-alcoholic fatty liver disease (NAFLD), with a global prevalence of 25%, continues to escalate, creating noteworthy concerns towards the global health burden. NAFLD causes triglycerides and free fatty acids to build up in the liver. The excessive fat build-up causes inflammation and damages the healthy hepatocytes, leading to non-alcoholic steatohepatitis (NASH). Dietary habits, obesity, insulin resistance, type 2 diabetes, and dyslipidemia influence NAFLD progression. The disease burden is complicated due to the paucity of therapeutic interventions. Obeticholic acid is the only approv...
Source: Planta Medica - April 15, 2024 Category: Drugs & Pharmacology Authors: Banerjee, Tanmoy Sarkar, Arnab Ali, Sk Zeeshan Bhowmik, Rudranil Karmakar, Sanmoy Halder, Amit Kumar Ghosh, Nilanjan Tags: Reviews Source Type: research
Correction: Purification, Molecular Docking and Cytotoxicity Evaluation of Bioactive Pentacyclic Polyhydroxylated Triterpenoids from Salvia urmiensis
Planta Med DOI: 10.1055/a-2299-7492 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Planta Medica)
Source: Planta Medica - April 15, 2024 Category: Drugs & Pharmacology Authors: Farimani, Mahdi Moridi Abbas-Mohammadi, Mahdi Ghorbannia-Dellavar, Samira Nejad-Ebrahimi, Samad Hamburger, Matthias Tags: Correction Source Type: research
Rationalising Optimal Dosing of Phytotherapeutics For Use In Children: Current Status – Potential Solutions – Actions Needed
Planta Med DOI: 10.1055/a-2294-5259“Children are not small adults with respect to the treatment with medicinal products.” This statement of the WHO was the basis for the initiative of the European Commission for the establishment of a paediatric regulation in 2007 to improve the health of children by facilitating the development of medicines for children and adolescents. Seventeen years later, in the field of herbal medicinal products, results are still sobering. Therefore, the Foundation Plants for Health, Society for Medicinal Plants and Natural Products Research, and German Society for Phytotherapy organised a sympo...
Source: Planta Medica - April 11, 2024 Category: Drugs & Pharmacology Authors: Hensel, Andreas Bauer, Rudolf Heinrich, Michael Hempel, Georg Kelber, Olaf Kraft, Karin Lehmann, Birka Med à, Montserrat Mesegué Nieber, Karen Roether, Bernd Rollinger, Judith Maria Wiebelitz, R üdiger Tags: Perspectives Source Type: research
Storage Conditions Influence the Quality of Ginger – A Stability Study Inspired by Clinical Trials
Planta Med DOI: 10.1055/a-2283-8147Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger, determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhi...
Source: Planta Medica - April 10, 2024 Category: Drugs & Pharmacology Authors: T óth, Barbara Horv áth, Attila Laczkovich, Orsolya J ójártné Bir ó, Zsófia Dalma Matuz, M ária Csupor, Dezs ő Tags: Original Papers Source Type: research
Vasorelaxant Activity of (2S)-Sakuranetin and Other Flavonoids Isolated from the Green Propolis of the Caatinga Mimosa tenuiflora
Planta Med DOI: 10.1055/a-2294-7042Some in vitro and in vivo evidence is consistent with the cardiovascular beneficial activity of propolis. As the single actors responsible for this effect have never been identified, an in-depth investigation of flavonoids isolated from the green propolis of the Caatinga Mimosa tenuiflora was performed and their mechanism of action was described. A comprehensive electrophysiology, functional, and molecular docking approach was applied. Most flavanones and flavones were effective CaV1.2 channel blockers with a potency order of (2S)-sakuranetin > eriodictyol-7,3′-methyl ether > quer...
Source: Planta Medica - April 10, 2024 Category: Drugs & Pharmacology Authors: Son, Ninh The Gianibbi, Beatrice Panti, Alice Spiga, Ottavia Bastos, Jairo Kenupp Fusi, Fabio Tags: Original Papers Source Type: research
The Potential Pharmacological Effects of Natural Product
Withaferin A in Cancer: Opportunities and Challenges for Clinical
Translation
Planta Med DOI: 10.1055/a-2289-9600Cancer is one of the biggest health concerns with a complex pathophysiology.
Currently, available chemotherapeutic drugs are showing deleterious side
effects, and tumors often show resistance to treatment. Hence, extensive
research is required to develop new treatment strategies to fight against
cancer. Natural resources from plants are at the forefront of hunting novel
drugs to treat various types of cancers. Withaferin A (WA) is a naturally
occurring withanolide, a biologically active component obtained from the plant
...
Source: Planta Medica - April 8, 2024 Category: Drugs & Pharmacology Authors: Devabattula, Geetanjali Panda, Biswajit Yadav, Rachana Godugu, Chandraiah Tags: Reviews Source Type: research
Antibacterial Activities of the Algal Bromophenol Methylrhodomelol Against Pseudomonas aeruginosa
Planta Med DOI: 10.1055/a-2289-2423Methylrhodomelol (1) is a bromophenol from the red alga Vertebrata lanosa that has been associated with antimicrobial properties. The aim of the current study was, therefore, to assess the antimicrobial potential of this compound in more detail against the gram-negative pathogen Pseudomonas aeruginosa. 1 exerted weak bacteriostatic activity against different strains when grown in minimal medium, whereas other phenolics were inactive. In addition, 1 (35 and 10 µg/mL) markedly enhanced the susceptibility of multidrug-resistant P. aeruginosa toward the aminoglycoside gentamicin, while it ...
Source: Planta Medica - April 5, 2024 Category: Drugs & Pharmacology Authors: Jacobtorweihen, Joshua Hartmann, Anja Hofer, Stefanie Spiegler, Verena Tags: Original Papers Source Type: research
Eye Diseases: When the Solution Comes from Plant Alkaloids
Planta Med DOI: 10.1055/a-2283-2350Plants are an incredible source of metabolites showing a wide range of biological activities. Among these, there are the alkaloids, which have been exploited for medical purposes since ancient times. Nowadays, many plant-derived alkaloids are the main components of drugs used as therapy for different human diseases. This review deals with providing an overview of the alkaloids used to treat eye diseases, describing the historical outline, the plants from which they are extracted, and the clinical and molecular data supporting their therapeutic activity. Among the different alkaloids that ...
Source: Planta Medica - April 2, 2024 Category: Drugs & Pharmacology Authors: Lorrai, Riccardo Cavaterra, Dario Giammaria, Sara Sbardella, Diego Tundo, Grazia Raffaella Boccaccini, Alessandra Tags: Reviews Source Type: research
Purification, Molecular Docking and Cytotoxicity Evaluation of Bioactive Pentacyclic Polyhydroxylated Triterpenoids from Salvia urmiensis
Planta Med DOI: 10.1055/a-2244-8706Triterpenoids, as one of the largest classes of naturally occurring secondary metabolites in higher plants, are of interest due to their high structural diversity and wide range of biological activities. In addition to several promising pharmacological activities such as antimicrobial, antiviral, antioxidant, anti-inflammatory and hepatoprotective effects, a large number of triterpenoids have revealed high potential for cancer therapy through their strong cytotoxicity on cancer cell lines and, also, low toxicity in normal cells. So, this study was aimed at discovering novel and potentiall...
Source: Planta Medica - March 18, 2024 Category: Drugs & Pharmacology Authors: Farimani, Mahdi Moridi Abbas-Mohammadi, Mahdi Ghorbannia-Dellavar, Samira Nejad-Ebrahimi, Samad Hamburger, Matthias Tags: Original Papers Source Type: research
Abrus precatorius Leaf Extract Stimulates Insulin-mediated Muscle Glucose Uptake: In vitro Studies and Phytochemical Analysis
This study evaluated the effect of a 50% ethanolic (v/v) A. precatorius leaf extract on (1) insulin-stimulated glucose uptake and (2) related gene expression in differentiated C2C12 myotubes using rosiglitazone as a positive control, and (3) generated a comprehensive phytochemical profile of A. precatorius leaf extract using liquid chromatography-high resolution mass spectrometry to elucidate its antidiabetic compounds.
A. precatorius leaf extract significantly increased insulin-stimulated glucose uptake, and insulin receptor substrate 1 and Akt substrate of 160 kDa gene expression; however, it had no effect on g...
Source: Planta Medica - March 15, 2024 Category: Drugs & Pharmacology Authors: Lankatillake, Chintha Huynh, Tien Dias, Daniel A Tags: Original Papers Source Type: research
Chemical Constituents from Agave applanata and Its Antihyperglycemic,
Anti-inflammatory, and Antimicrobial Activities Associated with Its Tissue Repair
Capability
In this study, the
chemical composition of this ethanol tonic is established and its association with
antihyperglycemic, anti-inflammatory, antimicrobial, and wound healing activities is
discussed. The fresh leaves of A. applanata were extracted with
ethanol : H2O (85 : 15). A fraction of this extract was lyophilized, and the
remainder was partitioned into CH2Cl2, n-BuOH, and water.
CH2Cl2 and n-BuOH fractions were subjected to a successive
open column chromatography process. The structure of the isolated compounds was
established using nuclear magnetic resonance and mass sp...
Source: Planta Medica - March 12, 2024 Category: Drugs & Pharmacology Authors: Aguilar-Guadarrama, A. Berenice D íaz-Román, Mónica Aideé Osorio-Garc ía, Maribel D éciga-Campos, Myrna Rios, Mar ía Yolanda Tags: Original Papers Source Type: research
Research Progress of Natural Product Photosensitizers in Photodynamic
Therapy
In conclusion, natural product
photosensitizers have potential in photodynamic therapy and represent a promising area of
research for cancer treatment. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - February 29, 2024 Category: Drugs & Pharmacology Authors: Zhou, Xiaoxia Ying, Xufang Wu, Linjie Liu, Liqin Wang, Ying He, Ying Han, Min Tags: Reviews Source Type: research
Unveiling Gambogenic Acid as a Promising Antitumor Compound: A
Review
Planta Med DOI: 10.1055/a-2258-6663Gambogenic acid is a derivative of gambogic acid, a polyprenylated xanthone isolated from
Garcinia hanburyi. Compared with the more widely studied gambogic acid, gambogenic
acid has demonstrated advantages such as a more potent antitumor effect and less systemic
toxicity than gambogic acid according to early investigations. Therefore, the present
review summarizes the effectiveness and mechanisms of gambogenic acid in different cancers
and highlights the mechanisms of action. In addition, drug delivery systems to improve the
bioavailability of gambogenic acid...
Source: Planta Medica - February 29, 2024 Category: Drugs & Pharmacology Authors: Mi, Li Xing, Zhichao Zhang, Yujie He, Ting Su, Anping Wei, Tao Li, Zhihui Wu, Wenshuang Tags: Reviews Source Type: research
Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra
Species
This study aimed at identifying specific Ephedra species used
traditionally in Morocco for therapeutic purposes. The plant parts, their preparation
process, and the treated pathologies were identified and analyzed. The results revealed
five ethnobotanically important species of Ephedra: Ephedra alata Decne, Ephedra
altissima Desf., Ephedra distachya L., Ephedra fragilis Desf., and
Ephedra nebrodensis Tineo. These species are used traditionally in Morocco for
treating people with diabetes, cancer, rheumatism, cold and asthma, hypertension,
influenza virus infection, and respiratory ailment...
Source: Planta Medica - February 29, 2024 Category: Drugs & Pharmacology Authors: Chroho, Mounia Bailly, Christian Bouissane, Latifa Tags: Reviews Source Type: research
