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Administration of Caffeic Acid Worsened Bone Mechanical Properties in Female RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, high intake of caffeic acid may unfavorably affect the skeletal system.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Intestinal and Blood-Brain Barrier Permeability of Ginkgolides and Bilobalide: In Vitro and In Vivo ApproachesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study intestinal and blood-brain barrier (BBB) permeability of ginkgolides A, B, C, J and bilobalide, isolated from (Ginkgoaceae), was evaluated in Caco-2 and MDR1-MDCK cell monolayer models. The transport was examined for 2 hours in both absorptive and secretory directions. Quantitation was performed by UPLC‐MS. In the Caco-2 model, each compound (100 µM) displayed a pH-dependent transport in the absorptive direction. A low permeability of ginkgolides was observed across the MDR1-MDCK model in the absorptive direction. An efflux was observed for all compounds in both the models. The efflux ratio was m...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Cytotoxicity of Natural Compounds Isolated from the Seeds of Garcinia afzeliiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240627AbstractThe new compounds guttiferone O () and 3-methoxycheffouxanthone () have been isolated from the seeds of Engl., together with nine known compounds: 2-hydroxy-1,7-dimethoxyxanthone (), smeathxanthone A (), 1,5-dihydroxyxanthone (), 1,6-dihydroxy-5-methoxyxanthone (), cheffouxanthone (), 1,3,5-trihydroxyxanthone (), smeathxanthone B (), isoxanthochymol () and guttiferone E (). Their structures were elucidated by means of 1D and 2D‐NMR techniques. All the isolates showed high cytotoxic activity and were found inactive when tested against HIV and influenza viruses.[...]© Georg...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Minor Secondary Metabolic Products from the Stem Bark of Plumeria rubra Linn. Displaying Antimicrobial ActivitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240611AbstractFour new iridoids viz., plumeridoids A (), B (), and C () and epiplumeridoid C () were isolated from the stem bark of Linn. together with twenty-four known compounds viz., 1-(-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, --coumaric acid, 2,6-dimethoxy--benzoquinone, scopoletin, cycloart-25-en-3,24-diol, 2,4,6-trimethoxyaniline, ajunolic acid, ursolic acid, oleanolic acid, -amyrin acetate, betulinic acid, lupeol and its acetate, 2,3-dihydroxypropyl octacosanoate, glucoside of -sitosterol, and a mixture ...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Effects of α-Asarone on the Glutamate Transporter EAAC1 in Xenopus OocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240613AbstractThe major excitatory neurotransmitter transporter EAAC1 in the mammalian central nervous system is considered a possible target for Chinese herbal medicine. Extracts of (Schott) were tested for their effects on EAAC1 activity. oocytes with heterologously expressed EAAC1 were used as the model system. Rate of glutamate uptake was determined by means of the isotopic tracer technique. Glutamate-induced current was recorded under a two-electrode voltage clamp. As a highly effective component, -asarone was identified. The rate of glutamate uptake was stimulated by 200 µM of -a...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

The Corrected Structure of Rosmaridiphenol, a Bioactive Diterpene from Rosmarinus officinalisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240629AbstractFrom the aerial parts of a Chilean sample of L., a diterpene was isolated whose spectroscopic data and physical constants were coincident with that of rosmaridiphenol. However, careful examination of the spectroscopic data and chemical reactions led to a different structure, where the carbonyl function has to be placed at C-1 instead of C-20. The correct structure of rosmaridiphenol should therefore be changed to 11,12-dihydroxy-8,11,13-icetexatrien-1-one.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

New Phenolic Compounds of Acmella ciliataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240621AbstractThe phytochemical analysis of a butanolic fraction of Kunth. afforded a total of 15 hydrophilic compounds. Seven flavonol 3--glycosides were isolated, including two new natural products, quercetin-3--(3-acetyl--D-glucuronopyranoside) and quercetin-3--(2-acetyl--L-rhamnopyranosyl-(1 → 6)--D-glucopyranoside). Furthermore, a variety of caffeoylquinic acid derivatives could be identified using ESI‐MS and NMR-spectroscopy.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Green Tea Catechins: Inhibitors of Glycerol-3-Phosphate DehydrogenaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240623AbstractGreen tea catechins, especially (−)-epigallocatechin-3-gallate (EGCG), are known to regulate obesity and fat accumulation. We performed a kinetic analysis in a cell-free system to determine the mode of inhibition of glycerol-3-phosphate dehydrogenase (GPDH; EC 1.1.1.8) by EGCG. GPDH catalyzes the -nicotinamide adenine dinucleotide (NADH)-dependent reduction of dihydroxyacetone phosphate (DHAP) to yield glycerol-3-phosphate, which serves as one of the major precursors of triacylglycerols. We found that EGCG dose-dependently inhibited GPDH activity at a concentration of appr...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Semi-Synthesis of Dihydrochalcone Derivatives and Their in Vitro Antimicrobial ActivitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the semi-synthesis of dihydrochalcone derivatives and their antimicrobial activities. These compounds were prepared by modifying two naturally occurring antimicrobial dihydrochalcones, erioschalcones A and B, reported by us earlier. The structures of the compounds were assigned on the basis of spectroscopic evidence and by comparing their physical and spectroscopic data with those reported in the literature. All the compounds were subjected to antimicrobial assays against a panel of pathogenic microorganisms, including gram-positive and gram-negative bacteria, and fungi. The antimicrobial efficacies of this cla...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Cardiac and Electrophysiological Effects of Primary and Refined Extracts from Leonurus Cardiaca L. (Ph.Eur.)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240602AbstractAlthough several antiarrhythmic drugs of chemical origin are in clinical use since decades, their application is often limited by their adverse effects and especially by their inherited proarrhythmic risk, which can lead to a significantly increased mortality in patients receiving these compounds. On the other hand, aqueous extracts from the aerial parts of the European Lamiaceae (Ph.Eur.) have been used for centuries as a remedy against tachyarrhythmia and other cardiac disorders. Nevertheless, a scientific basis for the claim of direct cardiac electrophysiological, antiarrhyth...
Source: Planta Medica - November 17, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Effects of Topical Boswellic Acid on Photo and Age-Damaged Skin: Clinical, Biophysical, and Echographic Evaluations in a Double-Blind, Randomized, Split-Face StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240581AbstractBoswellic acids (BAs) are pentacyclic triterpenes with strong anti-inflammatory activity; their most important source is the extract of the gum resin of , a tropical tree that grows in India and Africa. In the present randomized, double-blind, split-face, comparative study we have assessed efficacy, tolerability, and safety of a base cream containing 0.5 % BAs as compared to the same cream without these active ingredients in the treatment of clinical manifestations of photoaging of facial skin. Fifteen female volunteers were enrolled; they applied creams once daily for 30 ...
Source: Planta Medica - November 17, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Rosemary (Rosmarinus officinalis L.) Leaf Extract Limits Weight Gain and Liver Steatosis in Mice Fed a High-Fat DietEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our results demonstrate that consumption of 200 mg/kg BW of RE can limit weight gain induced by a high-fat diet and protect against obesity-related liver steatosis.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - November 17, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Inhibitory Activity of a Phytochemically Characterized Fraction from Streptocaulon juventas on Lung Cancer in Nude MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240600AbstractIn the present study, a 75 % ethanol extract of (SJ), which had a strong inhibitory effect on the proliferation of human lung A549 adenocarcinoma cells, was subjected to bioassay-guided fractionation. The most active fraction (SJF) was obtained using a macroreticular resin column followed by a silica-gel column. Then its effect on lung cancer was investigated in athymic nude mice with A549 tumors while its effects on body weight, blood biochemical indicators, and organ indices were monitored. The results showed that SJF inhibited the tumor growth significantly at day 10 an...
Source: Planta Medica - November 17, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Puerarin Inhibits Acid-Sensing Ion Channels and Protects against Neuron Death Induced by AcidosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240583AbstractPuerarin, the main isoflavone found in the root of the wild leguminous creeper (Willd.) Ohwi, is known to protect the brain from ischemia-induced injuries. However, its effect on acidosis, a byproduct of brain ischemia and one factor promoting cell death, remains unknown. The purpose of this study was to investigate the effects of puerarin on acid-sensing ion channels (ASICs), which are reported to be activated by extracellular acidosis. Using the MTT assay and Hoechst/PI staining, we showed that puerarin could prevent hippocampal cell death during extracellular low pH. Data fro...
Source: Planta Medica - November 17, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Antioxidative and Hepatoprotective Diarylheptanoids from the Bark of Alnus japonicaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240595AbstractThe present study to evaluate the potential of constituents of the bark of as a functional food with medicinal properties led to the identification of one new diarylheptanoid, named alusenone (), and 11 known ones ( and –). Their antioxidative and hepatoprotective activities were accessed by, respectively, a TOSC assay and a BH-induced hepatotoxicity rat model. Mixtures –, and showed good antioxidative and hepatoprotective effects as compared with the positive controls.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstrac...
Source: Planta Medica - November 17, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Ultrastructural Changes on Entamoeba histolytica HM1-IMSS Caused by the Flavan-3-Ol, (−)-EpicatechinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240599AbstractThe flavan-3-ol, (−)-epicatechin has been previously identified as the most important antiamoebic compound among the extracts from two medicinal plants: and Here we report the effects of epicatechin on morphology, analyzed by electronic microscopy. trophozoites were incubated for 48 h at 37 °C in the presence of 1.9 µg/mL epicatechin and processed for electronic microscopy analysis. Epicatechin induced nuclear and cytoplasmic changes in the treated trophozoites. These morphological alterations are identical to the cellular changes experienced by trophoz...
Source: Planta Medica - November 17, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Triterpenoids with Acetylcholinesterase Inhibition from Chuquiraga erinacea D. Don. subsp. erinacea (Asteraceae)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240582AbstractA bioactivity-guided approach was taken to identify the acetylcholinesterase (AChE) inhibitory agents in the ethanolic extract of D. Don. subsp. leaves using a bioautographic method. This permitted the isolation of the pentacyclic triterpenes calenduladiol (), faradiol (), heliantriol B2 (), lupeol (), and a mixture of -and -amyrin ( and ) as active constituents. Pseudotaraxasterol () and taraxasterol () were also isolated from this extract and showed no activity at the same analytical conditions. Compound showed the highest AChE inhibitory activity with 31.2 % of inhibiti...
Source: Planta Medica - November 17, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Ameliorative Effect of the Cinnamon Oil from Cinnamomum zeylanicum upon Early Stage Diabetic NephropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186237AbstractThe current study was designed to evaluate the ameliorative effect of the cinnamon oil upon early stage diabetic nephropathy owing to its antioxidant and antidiabetic effect. Cinnamon oil was extracted by hydro-distillation of the dried inner bark of Blume. Further characterization of the extracted oil was carried out using IR, H‐NMR, and C‐NMR techniques. Early stage of diabetic nephropathy was induced by administration of alloxan (150 mg/kg, ). Cinnamon oil was administered at varying doses (5, 10, 20 mg/kg; ) while the level of fasting blood glucose, t...
Source: Planta Medica - October 30, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Erratum for: Analysis of Rhaponticum carthamoides (Willd.) Iljin crude extracts composition and ability to simulate cell proliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta Med 2009; 75: 1461-1461DOI: 10.1055/s-0029-1240569© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | FREE: Full text (Source: Planta Medica)
Source: Planta Medica - October 28, 2009 Category: Drugs & Pharmacology Tags: Erratum Source Type: journals

Erratum for: Inhibitory Effect of Triterpenoid Saponins from the Leaves of Ilex kudingcha on Aggregated LDL-Induced Lipid Deposition in MacrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta Med 2009; 75: 1414-1414DOI: 10.1055/s-0029-1240570© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | FREE: Full text (Source: Planta Medica)
Source: Planta Medica - October 28, 2009 Category: Drugs & Pharmacology Tags: Erratum Source Type: journals

HPTLC Densitometric Evaluation of Tissue Culture Extracts of Nothapodytes foetida Compared to Conventional Extracts for Camptothecin Content and Antimicrobial ActivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186219AbstractTissue culture technique is becoming popular because of its well-known ability to enhance the content of secondary metabolites in plants. Callus tissue cultures of were developed using 250 different medium compositions to optimize this procedure. Methanolic extracts of callus (MEC) and of various parts of were comparatively analyzed for camptothecin content, and a high performance thin layer chromatography method was developed for its quantitation. Chloroform-ethylacetate-methanol (4 : 5 : 0.5 v/v) was used as the mobile phase. The method was valida...
Source: Planta Medica - October 28, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Standardization and In Vivo Antioxidant Activity of Ethanol Extracts of Fruit and Leaf of Piper sarmentosumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186279AbstractThe present study aimed to investigate standardized ethanol extracts of fruit and leaves of for their antioxidant activity in rats using a CCl-induced oxidative stress model. The standardization was based on the quantification of the markers pellitorine, sarmentine and sarmentosine by high performance liquid chromatography (HPLC), and determination of total primary and secondary metabolites. The rats, divided into 7 groups each (n = 6), were used as follows: group 1 (CCl, negative control), group 2 (untreated, control), groups 3 and 4 (fruit extract 250 and 500 ...
Source: Planta Medica - October 28, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Ligustilide Suppresses the Biological Properties of Danggui Buxue Tang: A Chinese Herbal Decoction Composed of Radix Astragali and Radix Angelica sinensisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186222AbstractDanggui Buxue Tang (DBT), a herbal decoction composed of Radix Astragali (RA) and Radix Angelica sinensis (RAS), has been used for treating menopausal irregularity in women for more than 800 years in China. According to the old tradition, RAS had to be processed with yellow wine before DBT preparation, which markedly reduced the amount of ligustilide in RAS and DBT, as well as enhanced the bioactivities of DBT. Here, we hypothesized that ligustilide would be an ingredient that possessed suppressive effects on DBT's functions. In the presence of ligustilide, the amount of astraga...
Source: Planta Medica - October 22, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Chemical Constituents from the Rhizome of Acorus calamus L.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186217AbstractThree new sesquiterpenes, 1,7(H)-cadinane-46,10-triol (), 15-guaiane-10-O-ethyl-4,6-diol (), and 6,7(H)-cadinane-1,4, 10-triol (), together with 25 known ones, were isolated from the rhizome of L. Their chemical structures were established on the basis of interpretation of spectroscopic data and comparison with those of the related known compounds.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - October 22, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Development of a Fast and Convenient Method for the Isolation of Triterpene Saponins from Actaea racemosa by High-speed Countercurrent Chromatography Coupled with Evaporative Light Scattering DetectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186236AbstractIn the present work, a fast and simple method for the separation and purification of triterpene saponins from was successfully established. Accelerated solvent extraction was used for defatting and extracting of the subaerial parts, giving a triterpene enriched crude extract. Size exclusion chromatography was used to separate actein and 23‐epi-26‐deoxyactein from other triterpenoids, which were collected in a third fraction. This most complex third fraction was applied to high-speed countercurrent chromatography, a well-established technique for the separation of sap...
Source: Planta Medica - October 22, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Antibacterial Compounds from Mushrooms II: Lanostane Triterpenoids and an Ergostane Steroid with Activity Against Bacillus cereus Isolated from Fomitopsis pinicolaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186227AbstractAnti− bioassay-guided fractionation of a crude extract of the American mushroom, , was performed using thin-layer chromatography, Sephadex LH-20 column chromatography, and preparative-scale HPLC. Five lanostane triterpenoids (–) and one ergostane steroid () were isolated and identified. Compound is a new lanostane triterpenoid, and its structure was determined using 1D and 2D NMR experiments, HR‐MS, and physical data. Each of the purified compounds (–) was tested for antibacterial activity against using standard MIC assays. Compounds – had MIC...
Source: Planta Medica - October 22, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Goji (Lycium barbarum and L. chinense): Phytochemistry, Pharmacology and Safety in the Perspective of Traditional Uses and Recent PopularityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186218AbstractSince the beginning of this century, Goji berries and juice are being sold as health food products in western countries and praised in advertisements and in the media for well-being and as an anti-aging remedy. The popularity of Goji products has rapidly grown over the last years thanks to efficient marketing strategies. Goji is a relatively new name given to and , two close species with a long tradition of use as medicinal and food plants in East Asia, in particular in China. While only is officinal, the fruit (fructus Lycii) and the root bark (cortex Lycii radicis) of both spe...
Source: Planta Medica - October 21, 2009 Category: Drugs & Pharmacology Tags: Reviews Source Type: journals

Sodium Bisulfite Improves Rhizome Yield and Quality in Paris polyphyllaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186223AbstractRhizomes of the perennial herb have been used in traditional Chinese medicine for hundreds of years. Agricultural production of the rhizomes requires 7–10 years, which is too long to meet the demand of the medicinal industry. Therefore, studies on improving the yield of the herb and shortening the culturing period are imperative. The present work aimed to investigate the effect of sodium bisulfite (NaHSO) on rhizome yield and quality, as well as some related metabolic features of . The rhizome yield was improved by NaHSO treatment in long-term experiments conducted during ...
Source: Planta Medica - October 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Physicochemical Stability and Biological Activity of Withania somnifera Extract under Real-Time and Accelerated Storage ConditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study may help in proposing suitable guidance for storage conditions and shelf life of ashwagandha formulations.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - October 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Acetogenin and Prenylated Flavonoids from Helminthostachys zeylanica with Inhibitory Activity on Superoxide Generation and Elastase Release by NeutrophilsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186221AbstractOne new acetogenin, 6-hydroxy-8-pentadecyloxocane-2,7-dione (), and four new prenylated flavonoids, 4′′a,5′′,6′′,7′′,8′′,8′′a-hexahydro-5,3′,4′-trihydroxy-5′′,5′′,8′′a-trimethyl-4-chromeno[2′′,3′′:7,6]flavone (), 4′′a,5′′,6′′,7′′,8′′,8′′a-hexahydro-5,3′,4′,‐trihydroxy-5′′,5′′,8′′a-trimethyl-4-chromeno[2′R...
Source: Planta Medica - October 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Identification of Lonicera japonica by PCR-RFLP and Allele-Specific Diagnostic PCR Based on Sequences of Internal Transcribed Spacer RegionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186235AbstractThe flower buds of Thunb. are widely used in Chinese medicine for their anti-inflammatory prosperities. Some closely related species of which have similar morphology but weaker biological activity are also used medicinally. The discrimination of from its adulterants is currently limited to methods of morphology and chemical fingerprinting. The analysis of sequence variation in the nuclear ribosomal DNA (nrDNA) internal transcribed spacer (ITS) has recently become an effective method for identification of medicinal herbs. In the present study, we found that nrDNA ITS sequences di...
Source: Planta Medica - October 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Successful Isolation and PCR Amplification of DNA from National Institute of Standards and Technology Herbal Dietary Supplement Standard Reference Material Powders and ExtractsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186225AbstractTwenty-four herbal dietary supplement powder and extract reference standards provided by the National Institute of Standards and Technology (NIST) were investigated using three different commercially available DNA extraction kits to evaluate DNA availability for downstream nucleotide-based applications. The material included samples of , and . Protocols from Qiagen, MoBio, and Phytopure were used to isolate and purify DNA from the NIST standards. The resulting DNA concentration was quantified using SYBR Green fluorometry. Each of the 24 samples yielded DNA, though the concentrat...
Source: Planta Medica - October 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Cytotoxic Activity and G1 Cell Cycle Arrest of a Dienynone from Echinacea pallidaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186224AbstractIn the present study, a further investigation of the cytotoxic activity of an acetylenic constituent of roots, namely, pentadeca-(8,13)-dien-11-yn-2-one, was performed, revealing a concentration-dependent cytotoxicity on several human cancer cell lines, including leukemia (Jurkat and HL-60), breast carcinoma (MCF-7), and melanoma (MeWo) cells. As part of its mechanism of action, the ability of this constituent to arrest the cell cycle in the G1 phase was demonstrated on HL-60 cells. Furthermore, a stability test of the target compound over 72 h was carried out, indicating ...
Source: Planta Medica - October 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Two New Peltogynoids from Acacia nilotica Delile with Kinase Inhibitory ActivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186226AbstractTwo new peltogynoids, acanilol A () and acanilol B (), were isolated from the stem bark of (L.) Delile, together with the known triterpene lupenone. The structures of the new compounds were established on the basis of their spectral data, mainly UV, NMR, and mass spectrometry. The new compounds were tested as kinase inhibitors against CDK1, GSK3, CK1, and DYRK1A, and acanilol B was identified as a DYRK1A inhibitor, with an IC of 19 µM.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - October 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Intestinal Permeability of Sesquiterpenes in the Caco-2 Cell Monolayer ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186195AbstractThe intestinal permeability of eight sesquiterpenes which are active constituents of some traditional Chinese medicines, were studied by using the Caco-2 cell monolayer; they include tanacetin, artesin, magnolialide, crossostephin, atractylon, isocalamenediol (ICL), bisabolangelone (BSE) and (3)-des--methyllasiodiplodin (DML). The bidirectional permeability of the eight sesquiterpenes was studied from the apical (AP) side to the basolateral (BL) side or from the BL side to the AP side. The eight compounds were assayed by HPLC. Transport parameters and apparent permeability coeff...
Source: Planta Medica - October 15, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Effects of Red Ginseng Extract on Visual Sensitivity and ERG b-wave of Bullfrog's EyeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186196AbstractThe purpose of the present study was to investigate the effect of red ginseng ( extracts on the visual process in bullfrog's eye. The results obtained indicated that both dark-adapted and light-adapted ERG b-wave peak amplitude was increased with red ginseng treatment. Furthermore, the ERG sensitivity was elevated by 1.4 log units of light intensity. It was found that red ginseng acts as a retinal neural antagonist but not as a GABA receptor antagonist. Red ginseng improved the alcohol dehydrogenase activity and speeded up the delivery of 11 -retinal from retinal pigment epithel...
Source: Planta Medica - October 15, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Luteolin Inhibits Lysophosphatidylcholine-Induced Apoptosis in Endothelial Cells by a Calcium/Mithocondrion/Caspases-Dependent PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to investigate the effects of luteolin on lysophosphatidylcholine (LPC)-induced apoptosis, a key event in the pathogenesis of atherosclerosis, in endothelial cells. Luteolin reduced not only LPC-induced cell death but also lactate dehydrogenase (LDH) leakage. Luteolin inhibition of LPC-induced apoptosis in endothelial cells demonstrated its protection against the cytotoxicity of LPC. LPC-induced apoptosis is characterized by a calcium-dependent mitochondrial pathway, involving calcium influx, activation of calpains, cytochrome C release and caspases activation. Luteolin reduced calcium influx. It also inhib...
Source: Planta Medica - October 15, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Anti-HIV‐1 and Anti-Inflammatory Lupanes from the Leaves, Twigs, and Resin of Garcinia hanburyiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186193AbstractTwo new lupanes, 2-acetoxy-3-hydroxy-19-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) () and 2-hydroxy-3-acetoxy-19-hydrogen-lup-20(29)-en-28-oic acid (3-acetoxyalphitolic acid) (), together with the known betulinic acid (), betulin (), and stimasterol-3----glucopyranoside (), were isolated from the leaves and twigs of . Compounds – were also isolated from the resin of this plant. The structure of was confirmed by single-crystal X-ray diffraction analysis. All of the lupanes (–) displayed anti-HIV‐1 activities in the anti-HIV‐1 reverse tra...
Source: Planta Medica - October 15, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Terpene Glycosides and Cytotoxic Constituents from the Seeds of Amomum xanthioidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186194AbstractColumn chromatographic isolation of the MeOH extract of the seeds of afforded a new diterpene glycoside, amoxanthoside A (), two new monoterpene glycosides, (1,4,5)-5--hydroxycamphor 5----glucopyranoside () and (1,4,5)-5--hydroxycamphor 5----glucopyranoside (), together with four known compounds, hedychiol A (), pygmol (), (1,4,6)-(+)-6--hydroxycamphor (), and dihydroyashabushiketol (). The structures of the new compounds were determined through spectral analysis, including extensive 2D NMR data. The isolated compounds were tested for their cytotoxicity against four human ...
Source: Planta Medica - October 15, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Anti-Leishmanial Lindenane Sesquiterpenes from Hedyosmum angustifoliumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186192AbstractThe aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of . We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, ), one compound isolated for the first time from a natural source (hedyosmone, ), and three known sesquiterpenes (onoseriolide, ; chloranthalactone A, ; and spathulenol, ) that had not been previously isolated from . The biological activities of − showed that onoseriolide () was the most active compound against axenic amastigotes from and . Moreover, it wa...
Source: Planta Medica - October 15, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Taxomyces andreanae: A Presumed Paclitaxel Producer Demystified?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186181AbstractThe 1990s brought an abundance of reports on paclitaxel-producing endophytes, initially heralded as a discovery having tremendous implications for cancer therapy. As the vision of large-scale fermentation tanks producing vast quantities of relatively inexpensive paclitaxel and novel taxanes has faded and has been replaced by controversial silence, we carried out an in-depth investigation of – the very first presumed endophytic synthesizer of the diterpenoid. On one hand, metabolic profiling by means of chromatographic, spectroscopic and immunoenzymatic techniques predomina...
Source: Planta Medica - October 7, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Transformed Cell Suspension Culture of Galphimia glauca Producing Sedative Nor-friedelanesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186166AbstractThe Mexican species (Cav.) Kuntze (Malphigiaceae) synthesises a family of sedative and anxiolytic nor-secofriedelanes, designated as galphimines. These active principles accumulate at low concentration in the aerial parts of plants from wild populations. Transformed calluses and cell suspension cultures of this species were established in order to induce a greater production of nor-friedelanes. The cell suspension line GgBa was selected and grown over a period of two years of continuous subculturing in MS nutrient medium in the absence of growth regulators. PCR and Southern blot...
Source: Planta Medica - October 7, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Root Colonization by Symbiotic Arbuscular Mycorrhizal Fungi Increases Sesquiterpenic Acid Concentrations in Valeriana officinalis L.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the effects of three different AM treatments on biomass and sesquiterpenic acid concentrations in two propagated genotypes of valerian ( L., Valerianaceae) were investigated. Valerenic, acetoxyvalerenic and hydroxyvalerenic acid levels were analyzed in the rhizome and in two root fractions. Two of the AM treatments significantly increased the levels of sesquiterpenic acids in the underground parts of valerian. These treatments, however, influenced the biomass of rhizomes and roots negatively. Therefore this observed increase was not accompanied by an increase in yield of sesquiterpenic acids per plant. Furth...
Source: Planta Medica - October 7, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Benzopyranones and Their Sulfate Esters from Pelargonium sidoidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186167AbstractInvestigation of the benzopyranones from the roots of led to the identification of 15 benzopyranones, among them the novel compounds and . Furthermore, benzopyranones and were detected in for the first time. Structure determinations were performed by one- and two-dimensional NMR spectroscopy. An HPLC system for the discrimination of these benzopyranones has been developed.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - October 7, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Impact of Thymol in Thyme Extracts on Their Antispasmodic Action and Ciliary ClearanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the data show that in various models of antispasmodic effect (ileum and trachea) and by measuring ciliary activity, thymol (and carvacrol) is (are) active, although other not identified components of thyme extract appear to be very important as well, since extracts with very low thymol contents are active. On the basis of these results the standardization on thymol alone appears not to be justified.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - October 7, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Anti-herpetic Properties of Hydroalcoholic Extracts and Pressed Juice from Echinacea pallidaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, hydroalcoholic extracts interfere with free herpesvirus but pressed juice is able to interact with herpesvirus inside and outside the cell as well as to protect cells against viral infection, probably by interfering with virus attachment. Hydroalcoholic extracts and pressed juice from demonstrated high selectivity indices, a necessary prerequisite for a potential topical treatment of herpetic infections. Different types of preparations, such as commercial tinctures, tablets, and teas, are expected to offer different antiviral profiles.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of...
Source: Planta Medica - September 30, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Metabolomic Profiling of Liquid Echinacea Medicinal Products with In Vitro Inhibitory Effects on Cytochrome P450 3A4 (CYP3A4)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186152Abstract is a popular and widely used herbal medicinal product and consequently, studies of its interactions with conventional drugs are of particular importance. We have shown that preparations and some common alkylamides weakly inhibit several cytochrome P450 (CYP) isoforms, with considerable variation in potency. We now report a detailed analysis of six commercial liquid preparations, with emphasis on the metabolomic characterisation of the compounds responsible for inhibiting CYP3A4. We separated each preparation into its ethanol- and water-soluble components, and then used H‐...
Source: Planta Medica - September 30, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Potent in vitro Inhibition of CYP3A4 and P-Glycoprotein by Rhodiola roseaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186153AbstractSix clones of , obtained from plants originating from widely different areas in Norway, were investigated for their inhibitory potential on CYP3A4-mediated metabolism and P‐gp efflux transport activity. Presumed active constituents in the ethanol extracts of the different clones were quantified. C‐DNA baculovirus expressed CYP3A4 and Caco-2 cells were used for inhibitory assays, and as positive control inhibitors ketoconazole and verapamil were applied, respectively. A validated HPLC methodology was used to quantify the formation of 6-β‐OH-testosterone and...
Source: Planta Medica - September 30, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

A Simplified Method for Identifying the Panax ginseng Cultivar Gumpoong Based on 26S rDNAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186161AbstractMolecular identification of (Korean ginseng) cultivars is very important for their management. We have developed a simple and reliable method for specific identification of the superior cultivar “Gumpoong.” The 26S rDNA was targeted for our molecular analysis, and a single-nucleotide polymorphism (SNP) was identified between Gumpoong and the other cultivars within the sequence data. From this SNP site, a modified allele-specific primer and a novel primer set have been developed to identify the Gumpoong cultivar via multiplex PCR. The established multiplex PCR method ...
Source: Planta Medica - September 30, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Three New Phenolic Glycosides and a New Triterpenoid from the Stems of Scolopia chinensisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1186157AbstractThree new phenolic glycosides, scolochinenosides C–E (–), and a new triterpenoid, scolopianate A (), were isolated from the stems of , along with 15 known compounds. The structures of the new compounds were elucidated by means of extensive spectroscopic and chemical methods. Compound contains a novel highly oxygenated lactone bridge ring attached at the aglycone. Six lanostane triterpenoids (–) were discovered for the first time in a species other than (Polyporaceae). In addition, the phenolic glycosides were evaluated for their inhibitory activity against snak...
Source: Planta Medica - September 30, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals