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Beta ‐amyloid PET imaging for Alzheimer's dementia diagnosis
Alzheimer's dementia is the most commonly diagnosed dementia. Despite this, diagnosis can be especially complex in certain circumstances. Any additional, novel diagnostic aids can positively add to the diagnostic process, overall accuracy and ultimately to patient care and treatment. Beta ‐amyloid (Aβ) positron emission tomography (PET) imaging is utilised as an important diagnostic tool in NHS dementia research in the UK and worldwide. Aβ PET imaging is now licensed for clinical use in the UK. This review explores the potential for the use of Aβ PET imaging in clinical practice highlighting recent evidence base follo...
Source: Progress in Neurology and Psychiatry - November 19, 2018 Category: Neurology Authors: Andrew Byrne, James Prichard Tags: Review Source Type: research

Eponyms revisited
Progress in Neurology and Psychiatry, Volume 22, Issue 4, Page 22-22, October/ November/ December 2018. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 19, 2018 Category: Neurology Authors: AJ Larner Tags: Letter Source Type: research

Screening for depression in patients with cognitive impairment: a local audit
Depression is highly prevalent in cognitive impairment and is considered one of the most common comorbid conditions in dementia.1 Despite this, underlying depressive symptoms can easily be missed2 by health care providers, mainly due to lack of awareness and lack of routine screening for depressive symptoms. Here, the authors examine the results of their local audit in Oxleas NHS Foundation Trust screening for depression in those diagnosed with dementia and discuss what their recommendations are for improving this aspect of clinical care in the future. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 19, 2018 Category: Neurology Authors: Felicity Juliette Wood, Azka Nabi, Israel Adebekun Tags: Original research Source Type: research

Rapidly progressive dementia with psychosis caused by CJD
Rapidly progressive dementias are conditions that typically cause dementia over weeks or months. They are a particular challenge for psychiatrists and neurologists as the differential diagnosis is often different from the more typical, slowly progressive dementias. Early and accurate diagnosis is essential, as many of the aetiologies are treatable. CreutzfeldtJakob Disease (CJD) is a very rare, progressive and lethal illness caused by prions. Here, the authors present a case of CJD that manifested itself as rapidly progressive dementia, with psychosis, without any neurological signs and symptoms initially. (Source: Progres...
Source: Progress in Neurology and Psychiatry - November 19, 2018 Category: Neurology Authors: Georgios Mousailidis, Carlo Lazzari, Shafalica Bhan ‐Kotwal, Ahmed Shoka Tags: Case notes Source Type: research

A case for adding fluvoxamine to clozapine
Treatment ‐refractory schizophrenia affects at least 30% of all patients with schizophrenia. Clozapine remains the gold standard treatment as the chances of response with another non clozapine medication are very low. However, initiating and then maintaining patients on clozapine can be a challenge due to a complex titration regimen, dose‐related side‐effects and the requirement for regular monitoring. In this article, Dr Sharma describes the successful addition of fluvoxamine to clozapine in a patient to achieve a therapeutic level of clozapine. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 19, 2018 Category: Neurology Authors: Avneet Sharma Tags: Case notes Source Type: research

Eye drop psychosis in Parkinson's disease: a cautionary tale
Anticholinergic agents are used in a number of conditions ranging from overactive bladder and bradycardia to travel sickness but side ‐effects such as hallucinations, impaired memory and restlessness are increasingly recognised, though still under‐reported in clinical practice. In Parkinson's disease anticholinergics such as atropine are recommended by NICE for the management of excessive drooling. Dr Ferris et al. present suc h a case where commencing sublingual atropine drops caused a patient to develop hyperactive delirium and psychosis. They also discuss the subsequent clinical management steps. (Source: Progress i...
Source: Progress in Neurology and Psychiatry - November 19, 2018 Category: Neurology Authors: Amy Ferris, Biju Mohamed, Chris Thomas Tags: Case notes Source Type: research

Cognitive screeners for MCI: is correction of skewed data necessary?
Correct identification of mild cognitive impairment (MCI) may provide the opportunity for intervention with disease ‐modifying therapeutics. Pending the development of widely applicable diagnostic biomarkers, use of cognitive screening instruments (CSIs) as part of clinical assessment may represent the best method for early MCI diagnosis. However, skewing of CSI test scores may jeopardise test utility. Here, Dr Larner examines various short CSIs in a secondary care setting to assess whether or not the assumption of normality is valid. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 19, 2018 Category: Neurology Authors: Andrew J Larner Tags: Original research Source Type: research

Genetic investigation in dementia: new interpretive challenges
Genetic testing is increasingly used in the assessment and investigation of individuals with dementia and cognitive impairment. Next generation sequencing dementia panels allow simultaneous parallel examination of multiple genes. But with this increased diagnostic power comes also the possibility of incidental findings, of identifying sequence variants which are benign rather than pathogenic. Dr Larner and colleagues discuss two such cases. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 19, 2018 Category: Neurology Authors: John C Williamson, Michael Bonello, Andrew J Larner Tags: Case notes Source Type: research

GLAD to study genetic links in anxiety and depression
A major new study aims to recruit 40 000 people, who will sign up online to take part in trailblazing research into the genetic links to anxiety and depression. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 19, 2018 Category: Neurology Authors: Joy Ogden Tags: Comment Source Type: research

17th Latest Advances in Psychiatry Symposium 2018
Progress in Neurology and Psychiatry,Volume 22, Issue 3, Page 30-33, July/ August/ September 2018. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 22, 2018 Category: Neurology Authors: Felix David Source Type: research

QEEG phenotypes, depression and TMS
Progress in Neurology and Psychiatry,Volume 22, Issue 3, Page 23-26, July/ August/ September 2018. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 22, 2018 Category: Neurology Authors: Natalia Hackett Source Type: research

Functional cognitive disorders: memory clinic study
Progress in Neurology and Psychiatry,Volume 22, Issue 3, Page 19-22, July/ August/ September 2018. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 22, 2018 Category: Neurology Authors: Viraj Bharambe BM, BSc, MRCP , Andrew J Larner MD, PhD Source Type: research

Confusion ‐inducing drugs in a memory assessment service: an audit
Progress in Neurology and Psychiatry,Volume 22, Issue 3, Page 15-18, July/ August/ September 2018. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 22, 2018 Category: Neurology Authors: Eva Bowditch MBBS, MRCPsych , Prianka Padmanathan MBChB , Clara Martinez ‐Clavera MBChB, MRCPsych, PGCME , Tarun Kuruvilla FRCPsych Source Type: research

Functional tremors in older people: an individualised approach is required
Progress in Neurology and Psychiatry,Volume 22, Issue 3, Page 12-14, July/ August/ September 2018. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 22, 2018 Category: Neurology Authors: Joe Chalkley BM BS , Shamim Ruhi MRCPsych Source Type: research

Primary hyperparathyroidism and neuropsychiatric symptoms
Progress in Neurology and Psychiatry,Volume 22, Issue 3, Page 9-11, July/ August/ September 2018. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 22, 2018 Category: Neurology Authors: Usha Narayana MBBS, MRCPsych, PGCE Higher Ed , Katy Ashton MBBS , Emma Rivers MBBS , Pratibha Nirodi FRCPsych Source Type: research