Progress in molecular and subcellular biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Inorganic Polyphosphate and F < sub > 0 < /sub > F < sub > 1 < /sub > -ATP Synthase of Mammalian Mitochondria
Prog Mol Subcell Biol. 2022;61:1-13. doi: 10.1007/978-3-031-01237-2_1.ABSTRACTInorganic polyphosphate is a polymer which plays multiple important roles in yeast and bacteria. In higher organisms the role of polyP has been intensively studied in last decades and involvements of this polymer in signal transduction, cell death mechanisms, energy production, and many other processes were demonstrated. In contrast to yeast and bacteria, where enzymes responsible for synthesis and hydrolysis of polyP were identified, in mammalian cells polyP clearly plays important role in physiology and pathology but enzymes responsible for syn...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Artyom Y Baev Andrey Y Abramov Source Type: research
Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology
Prog Mol Subcell Biol. 2022;61:15-26. doi: 10.1007/978-3-031-01237-2_2.ABSTRACTIn this chapter, the current understanding of the potential roles played by polyphosphate in mitochondrial function with a specific focus on energy metabolism and mitochondrial pathologies caused by stress is summarized. Here we will discuss details of the possible ion transporting mechanisms of mitochondria that might involve polyP and their role in mitochondrial physiology and pathology are discussed.PMID:35697935 | DOI:10.1007/978-3-031-01237-2_2 (Source: Progress in molecular and subcellular biology)
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Maria A Neginskaya Evgeny V Pavlov Source Type: research
Inorganic Polyphosphate, Mitochondria, and Neurodegeneration
Prog Mol Subcell Biol. 2022;61:27-49. doi: 10.1007/978-3-031-01237-2_3.ABSTRACTWith an aging population, the presence of aging-associated pathologies is expected to increase within the next decades. Regrettably, we still do not have any valid pharmacological or non-pharmacological tools to prevent, revert, or cure these pathologies. The absence of therapeutical approaches against aging-associated pathologies can be at least partially explained by the relatively lack of knowledge that we still have regarding the molecular mechanisms underlying them, as well as by the complexity of their etiopathology. In fact, a complex num...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Pedro Urquiza Maria E Solesio Source Type: research
Polyphosphate in Chronic Wound Healing: Restoration of Impaired Metabolic Energy State
Prog Mol Subcell Biol. 2022;61:51-82. doi: 10.1007/978-3-031-01237-2_4.ABSTRACTMany pathological conditions are characterized by a deficiency of metabolic energy. A prominent example is nonhealing or difficult-to-heal chronic wounds. Because of their unique ability to serve as a source of metabolic energy, inorganic polyphosphates (polyP) offer the opportunity to develop novel strategies to treat such wounds. The basis is the generation of ATP from the polymer through the joint action of two extracellular or plasma membrane-bound enzymes alkaline phosphatase and adenylate kinase, which enable the transfer of energy-rich ph...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Xiaohong Wang Hadrian Schepler Meik Neufurth Shunfeng Wang Heinz C Schr öder Werner E G M üller Source Type: research
Biomimetic Polyphosphate Materials: Toward Application in Regenerative Medicine
Prog Mol Subcell Biol. 2022;61:83-130. doi: 10.1007/978-3-031-01237-2_5.ABSTRACTIn recent years, inorganic polyphosphate (polyP) has attracted increasing attention as a biomedical polymer or biomaterial with a great potential for application in regenerative medicine, in particular in the fields of tissue engineering and repair. The interest in polyP is based on two properties of this physiological polymer that make polyP stand out from other polymers: polyP has morphogenetic activity by inducing cell differentiation through specific gene expression, and it functions as an energy store and donor of metabolic energy, especia...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Heinz C Schr öder Xiaohong Wang Meik Neufurth Shunfeng Wang Werner E G M üller Source Type: research
Effects of Polyphosphate on Leukocyte Function
Prog Mol Subcell Biol. 2022;61:131-143. doi: 10.1007/978-3-031-01237-2_6.ABSTRACTLeukocytes are immune cells derived from hematopoietic stem cells of the bone marrow which play essential roles in inflammatory and immune responses. In contrast to anucleate platelets and erythrocytes, leukocytes are differentiated from other blood cells by the presence of a nucleus, and consist of monocytes, neutrophils, lymphocytes, basophils, and eosinophils. Factors released from platelets mediate immune responses in part by recruitment and regulation of leukocyte activity. Platelet dense granules contain the highly anionic polymer polyph...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Patrick M Suess Source Type: research
Polyphosphate in Antiviral Protection: A Polyanionic Inorganic Polymer in the Fight Against Coronavirus SARS-CoV-2 Infection
Prog Mol Subcell Biol. 2022;61:145-189. doi: 10.1007/978-3-031-01237-2_7.ABSTRACTPolyanions as polymers carrying multiple negative charges have been extensively studied with regard to their potential antiviral activity. Most studies to date focused on organic polyanionic polymers, both natural and synthetic. The inorganic polymer, polyphosphate (polyP), despite the ubiquitous presence of this molecule from bacteria to man, has attracted much less attention. More recently, and accelerated by the search for potential antiviral agents in the fight against the pandemic caused by the coronavirus SARS-CoV-2, it turned out that p...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Werner E G M üller Xiaohong Wang Meik Neufurth Heinz C Schr öder Source Type: research
Inorganic Polyphosphate and F < sub > 0 < /sub > F < sub > 1 < /sub > -ATP Synthase of Mammalian Mitochondria
Prog Mol Subcell Biol. 2022;61:1-13. doi: 10.1007/978-3-031-01237-2_1.ABSTRACTInorganic polyphosphate is a polymer which plays multiple important roles in yeast and bacteria. In higher organisms the role of polyP has been intensively studied in last decades and involvements of this polymer in signal transduction, cell death mechanisms, energy production, and many other processes were demonstrated. In contrast to yeast and bacteria, where enzymes responsible for synthesis and hydrolysis of polyP were identified, in mammalian cells polyP clearly plays important role in physiology and pathology but enzymes responsible for syn...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Artyom Y Baev Andrey Y Abramov Source Type: research
Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology
Prog Mol Subcell Biol. 2022;61:15-26. doi: 10.1007/978-3-031-01237-2_2.ABSTRACTIn this chapter, the current understanding of the potential roles played by polyphosphate in mitochondrial function with a specific focus on energy metabolism and mitochondrial pathologies caused by stress is summarized. Here we will discuss details of the possible ion transporting mechanisms of mitochondria that might involve polyP and their role in mitochondrial physiology and pathology are discussed.PMID:35697935 | DOI:10.1007/978-3-031-01237-2_2 (Source: Progress in molecular and subcellular biology)
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Maria A Neginskaya Evgeny V Pavlov Source Type: research
Inorganic Polyphosphate, Mitochondria, and Neurodegeneration
Prog Mol Subcell Biol. 2022;61:27-49. doi: 10.1007/978-3-031-01237-2_3.ABSTRACTWith an aging population, the presence of aging-associated pathologies is expected to increase within the next decades. Regrettably, we still do not have any valid pharmacological or non-pharmacological tools to prevent, revert, or cure these pathologies. The absence of therapeutical approaches against aging-associated pathologies can be at least partially explained by the relatively lack of knowledge that we still have regarding the molecular mechanisms underlying them, as well as by the complexity of their etiopathology. In fact, a complex num...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Pedro Urquiza Maria E Solesio Source Type: research
Polyphosphate in Chronic Wound Healing: Restoration of Impaired Metabolic Energy State
Prog Mol Subcell Biol. 2022;61:51-82. doi: 10.1007/978-3-031-01237-2_4.ABSTRACTMany pathological conditions are characterized by a deficiency of metabolic energy. A prominent example is nonhealing or difficult-to-heal chronic wounds. Because of their unique ability to serve as a source of metabolic energy, inorganic polyphosphates (polyP) offer the opportunity to develop novel strategies to treat such wounds. The basis is the generation of ATP from the polymer through the joint action of two extracellular or plasma membrane-bound enzymes alkaline phosphatase and adenylate kinase, which enable the transfer of energy-rich ph...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Xiaohong Wang Hadrian Schepler Meik Neufurth Shunfeng Wang Heinz C Schr öder Werner E G M üller Source Type: research
Biomimetic Polyphosphate Materials: Toward Application in Regenerative Medicine
Prog Mol Subcell Biol. 2022;61:83-130. doi: 10.1007/978-3-031-01237-2_5.ABSTRACTIn recent years, inorganic polyphosphate (polyP) has attracted increasing attention as a biomedical polymer or biomaterial with a great potential for application in regenerative medicine, in particular in the fields of tissue engineering and repair. The interest in polyP is based on two properties of this physiological polymer that make polyP stand out from other polymers: polyP has morphogenetic activity by inducing cell differentiation through specific gene expression, and it functions as an energy store and donor of metabolic energy, especia...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Heinz C Schr öder Xiaohong Wang Meik Neufurth Shunfeng Wang Werner E G M üller Source Type: research
Effects of Polyphosphate on Leukocyte Function
Prog Mol Subcell Biol. 2022;61:131-143. doi: 10.1007/978-3-031-01237-2_6.ABSTRACTLeukocytes are immune cells derived from hematopoietic stem cells of the bone marrow which play essential roles in inflammatory and immune responses. In contrast to anucleate platelets and erythrocytes, leukocytes are differentiated from other blood cells by the presence of a nucleus, and consist of monocytes, neutrophils, lymphocytes, basophils, and eosinophils. Factors released from platelets mediate immune responses in part by recruitment and regulation of leukocyte activity. Platelet dense granules contain the highly anionic polymer polyph...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Patrick M Suess Source Type: research
Polyphosphate in Antiviral Protection: A Polyanionic Inorganic Polymer in the Fight Against Coronavirus SARS-CoV-2 Infection
Prog Mol Subcell Biol. 2022;61:145-189. doi: 10.1007/978-3-031-01237-2_7.ABSTRACTPolyanions as polymers carrying multiple negative charges have been extensively studied with regard to their potential antiviral activity. Most studies to date focused on organic polyanionic polymers, both natural and synthetic. The inorganic polymer, polyphosphate (polyP), despite the ubiquitous presence of this molecule from bacteria to man, has attracted much less attention. More recently, and accelerated by the search for potential antiviral agents in the fight against the pandemic caused by the coronavirus SARS-CoV-2, it turned out that p...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Werner E G M üller Xiaohong Wang Meik Neufurth Heinz C Schr öder Source Type: research
Inorganic Polyphosphate and F < sub > 0 < /sub > F < sub > 1 < /sub > -ATP Synthase of Mammalian Mitochondria
Prog Mol Subcell Biol. 2022;61:1-13. doi: 10.1007/978-3-031-01237-2_1.ABSTRACTInorganic polyphosphate is a polymer which plays multiple important roles in yeast and bacteria. In higher organisms the role of polyP has been intensively studied in last decades and involvements of this polymer in signal transduction, cell death mechanisms, energy production, and many other processes were demonstrated. In contrast to yeast and bacteria, where enzymes responsible for synthesis and hydrolysis of polyP were identified, in mammalian cells polyP clearly plays important role in physiology and pathology but enzymes responsible for syn...
Source: Progress in molecular and subcellular biology - June 13, 2022 Category: Molecular Biology Authors: Artyom Y Baev Andrey Y Abramov Source Type: research
