Screening and Identification of Pregnancy Zone Protein and Leucine ‐Rich Alpha‐2‐Glycoprotein as Potential Serum Biomarkers for Early‐Onset Myocardial Infarction using Protein Profile Analysis
Conclusions and clinical relevanceFive differential serum proteins are identified in early ‐onset MI using proteomic analysis. Lipoprotein‐related biomarkers further demonstrate the close relationship between lipid metabolism and the disease. Inflammation‐associated LRG and PZP may be novel biomarkers of the disease. In addition, changes in these proteins may partly reveal the possi ble mechanisms in the pathogenesis and pathophysiology of early‐onset MI. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 28, 2018 Category: Biochemistry Authors: Chao Xuan, Hui Li, Le ‐Le Li, Qing‐Wu Tian, Qing Wang, Bei‐Bei Zhang, Jun‐Jie Guo, Guo‐Wei He, Li‐Min Lun Tags: Research Article Source Type: research

iTRAQ Based Quantitative Proteomics Approach Identifies Novel Diagnostic Biomarkers that were Essential for Glutamine Metabolism and Redox Homeostasis for Gastric Cancer
Conclusions and clinical relevanceThe present study provides the quantitative proteomic analysis of gastric cancer tissues to identify prognostic biomarkers of gastric cancer. The co ‐expression level of GLS1 and GGCT is of great clinical values to serve as diagnostic and therapeutic biomarkers for early gastric cancer.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 28, 2018 Category: Biochemistry Authors: Zhen Jiang, Chenghua Zhang, Li Gan, Yuewang Jia, Yu Xiong, Yujiang Chen, Zhi Wang, Linfeng Wang, Hao Luo, Juexi Li, Rui Zhu, Xingli Ji, Qin Yu, Li Wang Tags: Research Article Source Type: research

Identification of Proteomic Markers in Head and Neck Cancer Using MALDI –MS Imaging, LC–MS/MS, and Immunohistochemistry
Conclusions and Clinical RelevanceThe combination of MALDI –MSI, LC‐MS/MS, and subsequent IHC furnishes a tool suitable for characterizing the molecular heterogeneity of tissue. It is also suited for use in identifying new representative biomarkers to enable a more individualized therapy. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 26, 2018 Category: Biochemistry Authors: Franziska Hoffmann, Claudia Umbreit, Thomas Kr üger, Daniela Pelzel, Günther Ernst, Olaf Kniemeyer, Orlando Guntinas‐Lichius, Alexander Berndt, Ferdinand Eggeling Tags: Research Article Source Type: research

MALDI Imaging for Proteomic Painting of Heterogeneous Tissue Structures
Conclusion and clinical relevance: The simultaneous characterization of morphological and proteomic features in the same tissue section adds proteomic information for histopathological diagnostics, which relies at present on conventional Hematoxylin and Eosin staining, histochemical, IHC and molecular methods.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 24, 2018 Category: Biochemistry Authors: J örg Kriegsmann, Mark Kriegsmann, Katharina Kriegsmann, Rémi Longuespée, Sören‐Oliver Deininger, Rita Casadonte Tags: Research Article Source Type: research

Alternative digestion approaches improve histone modification mapping by mass spectrometry in clinical samples
Conclusions and clinical relevance: This protocol widens the number of applications available in the toolbox of clinical epigenomics, allowing the investigation of a larger spectrum of marks in patient samples.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 24, 2018 Category: Biochemistry Authors: Camilla Restellini, Alessandro Cuomo, Michela Lupia, Marco Giordano, Tiziana Bonaldi, Roberta Noberini Tags: Technical Brief Source Type: research

MALDI ‐Imaging for Classification of Epithelial Ovarian Cancer Histotypes from a Tissue Microarray using Machine Learning Methods
Conclusion and clinical relevanceThe pilot study demonstrates the potential of MALDI ‐Imaging derived proteomic classifiers in combination with machine learning algorithms to discriminate EOC histotypes. Applications might support the development of new prognostic parameters in the assessment of EOC.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 24, 2018 Category: Biochemistry Authors: Oliver Klein, Frederic Kanter, Hagen Kulbe, Paul Jank, Carsten Denkert, Grit Nebrich, Wolfgang D. Schmitt, Zhiyang Wu, Catarina A. Kunze, Jalid Sehouli, Silvia Darb ‐Esfahani, Ioana Braicu, Jan Lellmann, Herbert Thiele, Eliane T. Taube Tags: Research Article Source Type: research

Quantitative Urinary Proteome Reveals Potential Biomarkers for Ureteropelvic Junction Obstruction
Conclusions and clinical relevance: This proteomic analysis indicated that urinary Fetuin ‐A, AGP1, AGP2, protein AMBP and PGDS may serve as noninvasive potential biomarkers and these proteins could help to further yield pathological mechanisms involved in UPJO.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 24, 2018 Category: Biochemistry Authors: Honghao Chen, Houwei Lin, Maosheng Xu, Guofeng Xu, Xiaoliang Fang, Lei He, Zhoutong Chen, Zhixiang Wu, Hongquan Geng Tags: Research Article Source Type: research

TMT ‐based quantitative proteomic analysis reveals proteomic changes involved in longevity
Conclusions and clinical relevanceThe results highlight the roles of complement and coagulation cascades, metabolism of glyco and lipid, and inflammatory and immune response might play important roles in longevity. And the DEPs may serve as clinically useful biomarkers for healthy aging and predicting longevity.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 22, 2018 Category: Biochemistry Authors: Zongkui Wang, Rong Zhang, Fengjuan Liu, Peng Jiang, Jun Xu, Haijun Cao, Xi Du, Li Ma, Fangzhao Lin, Lu Cheng, Xuefeng Zhou, Zhihui Shi, Yeheng Liu, Yaojing Huang, Shengliang Ye, Changqing Li Tags: Research Article Source Type: research

MALDI –MSI Pilot Study Highlights Glomerular Deposits of Macrophage Migration Inhibitory Factor as a Possible Indicator of Response to Therapy in Membranous Nephropathy
Conclusions and clinical relevanceDespite much effort being made in recent years to understand the pathogenesis of MN, a biomarker able to predict the outcome of these patients following therapeutic treatment is still lacking. Here, a protein (MIF), verified by immunohistochemistry, that can differentiate between these MN patients and could be a valuable starting point for a further study focused on verifying its predictive role in therapy response is highlighted. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 22, 2018 Category: Biochemistry Authors: Vincenzo L'Imperio, Andrew Smith, Elena Ajello, Isabella Piga, Martina Stella, Vanna Denti, Silvia Tettamanti, Renato Alberto Sinico, Federico Pieruzzi, Maurizio Garozzo, Gisella Vischini, Manuela Nebuloni, Fabio Pagni, Fulvio Magni Tags: Research Article Source Type: research

Identification of Protein Abundance Changes in Hepatocellular Carcinoma Tissues Using PCT –SWATH
Conclusions and clinical relevanceThe practicality of rapid proteomic analysis of biopsy ‐level fresh‐frozen HCC tissue samples with PCT–SWATH has been demonstrated and promising tumor marker candidates including MCM7 are identified. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 19, 2018 Category: Biochemistry Authors: Yi Zhu, Jiang Zhu, Cong Lu, Qiushi Zhang, Wei Xie, Ping Sun, Xiaochuan Dong, Liang Yue, Yaoting Sun, Xiao Yi, Tiansheng Zhu, Guan Ruan, Ruedi Aebersold, Shi'ang Huang, Tiannan Guo Tags: Research Article Source Type: research

Back Cover: Imaging Mass Spectrometry for Characterization of Atrial Fibrillation Subtypes
The image illustrates arterial fibrillation in the heart, with the characteristic irregular heartbeat, and the potential of imaging mass spectrometry to explore the differences in spatial proteomic levels in the myocardial tissue. This technique provides, in combination with histopathological assessment of interstitial fibrosis, an improved understanding of the pathogenesis and unsupervised discrimination of arterial fibrillation subtypes. This is reported by Oliver Klein, Thorsten Hanke, Grit Nebrich, Junfeng Yan, Benedikt Schubert, Patrick Giavalisco, Frank Noack, Herbert Thiele, Salah A. Mohamed in article number1700155...
Source: Proteomics. Clinical Applications - November 16, 2018 Category: Biochemistry Authors: Oliver Klein, Thorsten Hanke, Grit Nebrich, Junfeng Yan, Benedikt Schubert, Patrick Giavalisco, Frank Noack, Herbert Thiele, Salah A. Mohamed Tags: Back Cover Source Type: research

Front Cover: Integration of “Omics” Strategies for Biomarkers Discovery and for the Elucidation of Molecular Mechanisms Underlying Brugada Syndrome
The main characteristics of BrS are the peculiar ECG pattern. The study suggests a cooperative activity of mutated genes, deregulated miRNAs and proteins in orchestrating transcriptional and post ‐translational events concurring in the development of the Brugada cardiac phenotype. The image summarizes the integration of “‐omics” approaches (genomic, mirnomic and proteomic) in “codifying” the peculiar ECG pattern of Brugada syndrome. This is reported by Domenica Scumaci, Antonio O liva, Antonio Concolino, Antonio Curcio, Claudia Vincenza Fiumara, Laura Tammè, Oscar Campuzano, Vincenzo L. Pascali, Monica Coll, A...
Source: Proteomics. Clinical Applications - November 16, 2018 Category: Biochemistry Authors: Domenica Scumaci, Antonio Oliva, Antonio Concolino, Antonio Curcio, Claudia Vincenza Fiumara, Laura Tamm è, Oscar Campuzano, Vincenzo L. Pascali, Monica Coll, Anna Iglesias, Paola Berne, Gavino Casu, Erika Olivo, Francesco Ausania, Pietrant Tags: Front Cover Source Type: research

Masthead: Proteomics 6'18
PROTEOMICS – Clinical Applications, Volume 12, Issue 6, November 2018. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 16, 2018 Category: Biochemistry Tags: Masthead Source Type: research

Editorial Board: Proteomics 6'18
PROTEOMICS – Clinical Applications, Volume 12, Issue 6, November 2018. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 16, 2018 Category: Biochemistry Tags: Editorial Board Source Type: research

Matrix ‐Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Key Proteins in Corneal Samples from Lattice Dystrophy Patients with TGFBI‐H626R and TGFBI‐R124C Mutations
ScopeThe purpose of this study is to identify and visualize the spatial distribution of proteins present in amyloid corneal deposits ofTGFBI ‐CD patients using Mass Spectrometry Imaging (MSI) and compare it with healthy control cornea. Corneal Dystrophies (CD) constitute a group of genetically inherited protein aggregation disorders that affects different layers of the cornea. With accumulated protein deposition, the cornea becomes opaque with decreased visual acuity. CD affecting the stroma and Bowman's membrane, is associated with mutations in transforming growth factor β‐induced (TGFBI) gene.MethodsMALDI ‐Mass Sp...
Source: Proteomics. Clinical Applications - November 15, 2018 Category: Biochemistry Authors: Anandalakshmi Venkatraman, Guillaume Hochart, David Bonnel, Jonathan Stauber, Shigeto Shimmura, Lakshminaryanan Rajamani, Konstantin Pervushin, Jodhbir S. Mehta Tags: Technical Brief Source Type: research